Research
Melatonin
254 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis.
Network meta-analysis of RCTs evaluating pharmacologic agents combined with platelet-rich fibrin (PRF) for periodontal regeneration in chronic periodontitis. PRF with metformin, alendronate, and rosuvastatin showed the highest efficacy for clinical attachment level gain and bone fill. Melatonin and atorvastatin combinations showed modest effects.
Melatonin in cancer treatment.
Systematic review and meta-analysis of 30 RCTs involving 5093 cancer patients evaluating melatonin's effects on quality of life and sleep. Evidence is very uncertain about melatonin's impact on quality of life and sleep scores. Melatonin likely reduces fatigue and may reduce nausea when used alongside standard cancer treatment, but the evidence is of low certainty due to high risk of bias and small sample sizes.
Oral preventive medications for migraine in adults aged 18-65: a network meta-analysis.
This network meta-analysis evaluated the efficacy and safety of oral pharmacological therapies for migraine prevention in adults. It confirmed the significant efficacy of topiramate, valproate, and propranolol, and identified potential benefits of memantine, melatonin, vitamin D3, and combination therapies. The study included 44 trials with 4,612 participants.
Melatonin Use in the ICU: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 32 RCTs involving 3895 ICU patients. Melatonin may reduce delirium, slightly reduce ICU length of stay, and improve reported sleep quality. Evidence was uncertain for other outcomes, and certainty was affected by bias and inconsistency.
Pharmacological or non-pharmacological therapies? The impact of different therapies on sleep in children with autism spectrum disorder: A systematic review and network meta-analysis.
This systematic review and network meta-analysis evaluated the efficacy of various therapies on sleep disturbances in children with autism spectrum disorder, analyzing 35 RCTs. Physical activity showed the largest effect size, followed by melatonin and behavioral interventions. Melatonin supplements were effective but had side effects like morning drowsiness.
Efficacy and safety of insomnia pharmacotherapies: Convergent evidence from Bayesian network meta-regression and FAERS-based disproportionality analysis.
This meta-analysis evaluated the efficacy and safety of various insomnia pharmacotherapies, including melatonin, in 2408 patients. Melatonin 6 mg/d showed significant superiority over placebo in improving sleep parameters within a specific time window, but its overall efficacy was mixed compared to other treatments. The study suggests prioritizing certain medications based on insomnia type and safety profiles.
Benefits of melatonin on mortality in severe-to-critical COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials.
This meta-analysis reviewed RCTs on the treatment of severe-to-critical COVID-19 with melatonin compared to placebo. Melatonin significantly reduced in-hospital mortality in these patients, suggesting it should be considered for severe-to-critical COVID-19 treatment.
The effect of melatonin supplementation on glycemic control in patients with type 2 diabetes.
Meta-analysis of nine RCTs involving 427 participants with type 2 diabetes mellitus. Melatonin supplementation significantly reduced HbA1c levels compared to placebo, suggesting potential benefits for long-term glycemic control, though no significant effect was observed on fasting plasma glucose levels.
The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of eight studies with 409 Parkinson's disease patients assessing melatonin's effect on sleep disturbances. Melatonin improved sleep quality, sleep onset latency, and total sleep time, but did not significantly impact objective sleep parameters or REM Sleep Behaviour Disorder. No significant differences were found between melatonin and clonazepam in some measures.
The effect of melatonin on sleep quality and daytime sleepiness in Parkinson's disease: A systematic review and meta-analysis of randomized placebo-controlled trials.
Systematic review and meta-analysis of five RCTs with 206 patients with Parkinson's disease. Melatonin, particularly in doses >4 mg and immediate-release formulations, improved sleep quality and modestly reduced daytime sleepiness, especially with short-term use.
Factors influencing the effect of melatonin on sleep quality in children with autism spectrum disorder: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effects of melatonin on sleep disturbances in children with autism spectrum disorder. Melatonin significantly improves sleep quality and total sleep time, with optimal effectiveness at approximately 5.7 mg and better results in children aged 10 years and older.
Effect of melatonin as an adjunct to non-surgical periodontal therapy in the treatment of periodontitis: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effect of melatonin as an adjunct to non-surgical periodontal therapy in the treatment of periodontitis. The analysis included 3 studies with a 6-month follow-up, showing that melatonin may positively impact bone healing and management of periodontitis.
The role of melatonin and circadian rhythms in the pathogenesis of diabetic retinopathy: A systematic review.
Systematic review investigating systemic melatonin levels and circadian timing in diabetic retinopathy (DR). The review analyzed twelve articles and found evidence of reduced nocturnal melatonin production in DR, with no significant changes in melatonin circadian timing.
Impact of Melatonin Supplementation on Glycemic Parameters in Patients with Type 2 Diabetes: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis assessed the impact of melatonin supplementation on glycemic parameters in patients with type 2 diabetes. The analysis included eight RCTs and found that melatonin supplementation significantly decreased fasting blood glucose, insulin, hemoglobin A1c, and HOMA-IR, suggesting improved glycemic control.
The effect of melatonin administration on motor recovery after spinal cord injury in animal models: a systematic review and meta-analysis.
Systematic review and meta-analysis of preclinical studies on the effects of melatonin on motor function recovery after spinal cord injury in animal models. Melatonin showed a significant strong effect on motor recovery, reduced inflammatory factors, apoptosis, and neuronal cell death, and increased the number of viable neurons.
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.
This systematic review and dose-response meta-analysis evaluated the effects of melatonin supplementation on cardiometabolic risk factors across 63 RCTs. Melatonin significantly reduced hip circumference, systolic blood pressure, fasting blood glucose, LDL cholesterol, total cholesterol, C-reactive protein, malondialdehyde, TNF-alpha, IL-6, and alanine aminotransferase, while increasing serum total antioxidant capacity and HDL cholesterol.
Melatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis investigating the effect of melatonin on heart failure. Results showed increased ejection fraction, improved NYHA class, and elevated quality of life. Melatonin reduced fatigue and NT-Pro BNP, while improving sleep quality, appetite, and FMD.
Melatonin secretion across puberty: A systematic review and meta-analysis.
Systematic review and meta-analysis of 21 studies examining melatonin levels in children and adolescents during puberty. The analysis found that Tanner stages were significantly associated with decreasing average and peak concentrations of melatonin.
The effect of exogenous melatonin and melatonin receptor agonists on intensive care unit and hospital length of stay: A systematic review and meta-analysis.
Systematic review and meta-analysis of 20 RCTs assessing the effect of exogenous melatonin and melatonin receptor agonists on ICU and hospital length of stay (LOS) among adults. No overall statistically significant difference in mean ICU or hospital LOS was found, but subgroup analysis showed significant improvements for coronary artery bypass graft surgery patients and COVID-19 patients.
Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
Systematic review and network meta-analysis comparing the efficacy, tolerability, and acceptability of melatonin, aerobic exercise, and pharmaceutical drugs (donanemab, lecanemab, aducanumab) on cognitive function in mild cognitive impairment and mild Alzheimer's disease. Melatonin was found to be significantly more effective than the drugs and placebo, with no significant heterogeneity in sensitivity analysis excluding exercise.
Efficacy and safety of perioperative melatonin for postoperative delirium in patients undergoing surgery: a systematic review and meta-analysis.
Systematic review and meta-analysis of 16 RCTs with 1981 patients assessing perioperative melatonin and melatonin agonists for preventing postoperative delirium (POD). High-dose melatonin reduced POD incidence, especially in the early postoperative period and after cardiopulmonary surgery, without severe adverse events.
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis.
Systematic review and meta-analysis of 26 RCTs evaluating melatonin's effect on sleep-related parameters in patients with insomnia and healthy volunteers. Findings suggest that a dose of 4mg/day and administration 3 hours before bedtime optimizes melatonin's efficacy in reducing sleep onset latency and increasing total sleep time.
Effects of melatonin supplementation on markers of inflammation and oxidative stress in patients with diabetes: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 14 RCTs with 823 participants evaluating melatonin supplementation in diabetic patients. Melatonin significantly reduced markers of inflammation and oxidative stress, and increased antioxidant capacity.
Efficacy of melatonin vs. midazolam for oral premedication in children: a systematic review and meta-analysis.
Systematic review and meta-analysis of randomized controlled trials comparing melatonin and midazolam as premedication in children aged 1-15 years. The review found no significant differences between melatonin and midazolam in achieving sedation or reducing anxiety in the preoperative room and during induction of anesthesia.
Local Delivery of Melatonin Along With Bone Grafts to Improve Osteogenesis.
Systematic review investigating the effects of local delivery of melatonin along with bone grafts to improve osteogenesis. The review included 24 in vivo and in vitro studies, with 91.7% reporting better outcomes compared to control groups. Melatonin may stimulate bone healing and enhance peri-implant bone response.
Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effects of melatonin on assisted reproductive technologies. Melatonin improved fertilization rate and other outcomes like Mature Oocytes (MII) and antral follicle count, but no significant effect on clinical pregnancy rate was found.
Pharmacological interventions to improve sleep in people with Alzheimer's disease: a meta-analysis of randomized controlled trials.
This meta-analysis evaluates RCTs of pharmacological interventions for improving sleep in Alzheimer's patients. Melatonin was the most investigated but showed no significant effect on sleep. Eszopiclone and orexin antagonists positively affected sleep efficiency.
Melatonin as an add-on treatment for epilepsy: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of melatonin as an add-on treatment for epilepsy. It included 10 RCTs and found that melatonin improved sleep latency and seizure severity compared to placebo. Adverse events were reported in only one trial.
A meta-analysis of photosynthetic efficiency and stress mitigation by melatonin in enhancing wheat tolerance.
Meta-analysis of 31 studies examining the effects of melatonin on wheat under abiotic stress conditions. Melatonin improved photosynthetic rates, stomatal conductance, transpiration rates, and fluorescence yields, and enhanced leaf water content and chlorophyll pigments, demonstrating its role in stress mitigation and photosynthetic efficiency.
The effects of melatonin supplementation on neurobehavioral outcomes and clinical severity in rodent models of multiple sclerosis; a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effects of melatonin supplementation on neurobehavioral and clinical outcomes in animal models of multiple sclerosis. The study found that melatonin may improve behavioral and cognitive outcomes in preclinical MS models with acceptable safety profiles.
Efficacy of melatonin and ramelteon for the acute and long-term management of insomnia disorder in adults: A systematic review and meta-analysis.
A systematic review and meta-analysis of 22 studies with 4875 participants assessed the efficacy of melatonin and ramelteon compared with placebo on sleep quantity and quality in insomnia disorder. PR melatonin showed small to medium effect sizes on sleep onset latency and sleep efficiency, particularly efficacious in individuals aged 55 and older. Ramelteon demonstrated large effect sizes on total sleep time and sleep onset latency both acutely and long-term.
Efficacy and moderators of prevention and treatment of delirium with melatonin receptor agonists: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 33 RCTs involving 4850 participants to investigate the effects of melatonin and melatonin receptor agonists on delirium prevention and treatment. The meta-analysis found a significant preventive effect on delirium and a reduction in mortality rate, but no significant therapeutic effect.
Melatonin intervention to prevent delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of randomized controlled trials assessing melatonin's effect on preventing delirium in ICU patients. Melatonin did not reduce delirium incidence in general ICU patients but did reduce it in cardiovascular care unit patients.
Prophylactic effect of exogenous melatonin and melatonin receptor agonists on postoperative delirium in elderly patients: a systemic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 11 RCTs assessing the prophylactic effect of melatonin and melatonin receptor agonists on postoperative delirium in elderly patients. The meta-analysis found that melatonin significantly reduced the occurrence of postoperative delirium, while ramelteon and tryptophan had no significant impact.
Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis.
Systematic review and meta-analysis of 11 studies with 1244 patients examining the effect of melatonin on postoperative delirium (POD) incidence in adults. The combined odds ratio of developing POD in the melatonin groups versus control was 0.41, suggesting melatonin may reduce POD incidence. However, studies showed inconsistency in methodology and outcome reporting.
Melatonin and Ramelteon for the treatment of delirium: A systematic review and meta-analysis.
Systematic review and meta-analysis assessing the efficacy of melatonin and ramelteon for treating delirium in hospitalized patients. Included three RCTs and six observational studies with a total of 1211 participants. Melatonin showed a statistical reduction in the duration of delirium compared to placebo in RCTs, but data quality is limited.
Melatonin or its analogs as premedication to prevent emergence agitation in children: a systematic review and meta-analysis.
This systematic review and meta-analysis included nine studies with 951 participants to assess the effects of melatonin or its analogs as premedication on preventing emergence agitation (EA) in children after general anesthesia. Melatonin significantly reduced the incidence of EA compared with placebos and midazolam, although dexmedetomidine was more effective than melatonin.
Efficacy and Safety of Preoperative Melatonin for Women Undergoing Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.
Systematic review and meta-analysis of 7 RCTs with 754 pregnant women undergoing cesarean section. Preoperative melatonin reduced postoperative pain and increased time to first analgesic request compared to placebo, with no significant side effects.
Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
Systematic review and meta-analysis of eight studies with 516 participants examining the effects of melatonin on postoperative sleep quality. The analysis found that melatonin did not improve sleep quality compared to placebo, with a mean difference of -0.75 mm on the VAS.
Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of RCTs evaluating melatonin's effects on depression and anxiety in postmenopausal women. Melatonin significantly reduced menopausal depression and improved menopausal anxiety, suggesting its potential as a treatment for these conditions.
Is melatonin as an ergogenic hormone a myth? a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of melatonin supplementation on physical performance and recovery. Melatonin supplementation did not affect aerobic or strength performance but improved post-exercise recovery. Melatonin secretion was not altered by exercise.
Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models.
Systematic review and meta-analysis of 41 animal studies evaluating melatonin's protective effects against physical, heat, and ischemic damage to testicular tissue. Melatonin therapy improved testicular histopathological characteristics, sperm parameters, and oxidative stress markers in rodents.
Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared the protective effects of melatonin and vitamins against reproductive toxicity caused by bisphenols in male rats. Melatonin improved sperm concentration, viability, and testosterone levels, while vitamins showed lower sperm concentration and testosterone levels. Vitamin E showed the best binding affinity in molecular docking simulations.
Protective effects of melatonin against oxidative stress induced by metabolic disorders in the male reproductive system: a systematic review and meta-analysis of rodent models.
Systematic review and meta-analysis of 24 studies on melatonin's effects on metabolic disorder-induced infertility in male rodents. Melatonin reduced damage to gonadal tissue and improved sperm count, motility, and morphology, with significant effects on histopathological characteristics and some oxidative stress markers.
Effect of melatonin on otoprotection in rodents: a systematic review with meta-analysis.
Systematic review and meta-analysis of melatonin's otoprotective efficacy in rodent models. Melatonin provided protection against ototoxic effects of cisplatin and aminoglycosides at higher frequencies (5000, 6000, and 8000 Hz), minimizing reduction in Otoacustic Emissions amplitude. The effect was not observed at lower frequencies.
Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: A systematic review and meta-analysis of animal studies.
Systematic review and meta-analysis of 31 animal studies evaluating melatonin's protective effects against oxidative stress on testicular tissue caused by environmental pollutants and heavy metals. Melatonin therapy improved sperm count, motility, viability, and various testicular and hormonal parameters, suggesting potential benefits for male infertility.
PROTECTIVE ROLE OF MELATONIN FOR ACUTE KIDNEY INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Systematic review and meta-analysis of six randomized controlled trials assessing the efficacy of melatonin in preventing acute kidney injury (AKI). The results showed that melatonin increased the estimated glomerular filtration rate and effectively inhibited the occurrence of AKI, though reductions in serum creatinine and urea nitrogen levels were not statistically significant.
Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies.
Systematic review and meta-analysis of 38 animal studies examining melatonin's protective effects against oxidative stress in rodent testicular tissue caused by anti-cancer therapies. Melatonin therapy improved sperm quantity and quality, reproductive hormones, and reduced oxidative markers in testicular tissues.
Multidimensional sleep health and diabetic retinopathy: Systematic review and meta-analysis.
Systematic review and meta-analysis exploring associations between multidimensional sleep health, obstructive sleep apnea (OSA), melatonin, and diabetic retinopathy (DR). Long sleep and poor sleep satisfaction were significantly associated with DR. Those with DR had significantly lower melatonin/melatonin metabolite levels. Mixed results were observed for treating OSA with CPAP.
Associations between systemic melatonin and human myopia: A systematic review.
This systematic review summarizes literature on melatonin circadian rhythms in relation to myopia. It includes seven studies measuring melatonin in biological fluids of myopes and non-myopes, showing conflicting findings on melatonin concentrations and rhythms. The review highlights the need for future studies with uniform methodologies to clarify the relationship between melatonin dysregulation and myopia.
Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.
Systematic review and meta-analysis of 12 trials with 2538 ICU patients evaluating prophylactic melatonin for delirium prevention. Melatonin was associated with a lower incidence of delirium compared to placebo, but sensitivity analysis and trial sequential analysis suggest caution in interpreting these results. Further studies are needed to confirm melatonin's effectiveness in reducing ICU delirium.
Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
Systematic review and meta-analysis of 34 RCTs assessing melatonin's efficacy and tolerability in individuals with sleep or mental disorders. Melatonin significantly improved sleep onset latency and total sleep time in children/adolescents with neurodevelopmental disorders and adults with delayed sleep phase disorder. No significant differences in tolerability between melatonin and placebo.
Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of randomized controlled trials assessing the effects of melatonin supplements and melatonin agonists on sleep-wake cycle and circadian rhythms in healthy participants and psychiatric patients. The analysis showed advancing effects on sleep-wake cycle in both groups, suggesting potential efficacy in correcting circadian rhythms.
Clinical efficacy of melatonin as adjunctive therapy to non-surgical treatment of periodontitis: a systematic review and meta-analysis.
Systematic review and meta-analysis of 7 RCTs with 412 participants evaluating melatonin as an adjunctive therapy for periodontitis. Melatonin supplementation significantly improved probing depth, clinical attachment loss, and gingival index compared to non-surgical treatment alone.
The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis.
Systematic review and meta-analysis of six studies with 338 participants evaluating melatonin as an adjunctive treatment for COVID-19. Melatonin showed a beneficial effect on the total effective rate, but no significant differences were found in CRP, SaO2, or WBC between the melatonin and control groups.
Effect and Mechanism of Exogenous Melatonin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis of melatonin's effects on cognitive deficits in animal models of Alzheimer's disease. Melatonin improved learning ability and memory by reducing escape latency and increasing dwell time in the Morris Water Maze. It also reduced Aβ deposition in the cortex, ameliorating symptoms of Alzheimer's disease.
Melatonin and Triclofos Sodium to Execute Sleep Electroencephalography in Pediatric Patients: A Cost-Effectiveness Analysis Alongside a Randomized Controlled Trial.
This study evaluated the cost-effectiveness of melatonin versus triclofos sodium for performing sleep EEG in pediatric patients. Melatonin was found to be more cost-effective than triclofos, with a lower cost per successful and abnormal EEG recorded.
Renal Protective Effects of Melatonin in Animal Models of Diabetes Mellitus-Related Kidney Damage: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 15 studies with 224 animals examining the effects of melatonin on diabetic nephropathy. Melatonin showed renal protective effects by reducing serum creatinine, blood urea nitrogen, and urinary albumin excretion rate, while improving oxidative stress markers. Fasting blood glucose was also reduced in the experimental group.
Effect of melatonin on oxidative stress indicators in animal models of fibrosis: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the antioxidant effect of melatonin in animal models of fibrosis. Melatonin supplementation significantly reduced oxidative indicators like MDA, LPO, and NO, and increased antioxidant indicators such as GSH, GPx, and SOD, suggesting a positive effect on oxidative stress in fibrotic diseases.
Efficacy of melatonin in the treatment of patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effect of melatonin on clinical outcomes in COVID-19 patients. Three RCTs were included, showing that melatonin improved clinical recovery rates compared to placebo, with a higher recovery rate and numerically lower risks of ICU admission and mortality.
Effects of melatonin supplementation on BDNF concentrations and depression: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis evaluated the effects of melatonin supplementation on BDNF concentration and depression. Melatonin showed no significant effect on BDNF levels but improved depression scores. Subgroup analysis indicated a significant effect on BDNF levels in specific conditions.
Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials.
Umbrella review of meta-analyses based on RCTs evaluating melatonin supplementation for various health outcomes. Significant improvements were observed in sleep onset latency, first analgesic requirement time in surgical patients, and survival at one year for cancer patients. Mixed results were found for women's health outcomes related to artificial reproductive technologies.
Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated the efficacy of melatonin receptor agonists (MRAs) in preventing delirium. The analysis found that melatonin reduced the incidence of delirium compared to placebo, but ramelteon did not show significant efficacy. Neither substance was effective in elderly patients. The study suggests cautious use of MRAs for delirium prevention and calls for further research.
Controlled-release oral melatonin supplementation for hypertension and nocturnal hypertension: A systematic review and meta-analysis.
This systematic review and meta-analysis investigated the effects of oral melatonin supplementation on blood pressure and sleep quality in patients with hypertension. Controlled-release melatonin reduced asleep systolic blood pressure but not diastolic blood pressure significantly. Melatonin improved sleep efficacy and total sleep time and was well-tolerated. The quality of evidence was low due to the limited number of high-quality trials.
Safety of higher doses of melatonin in adults: A systematic review and meta-analysis.
Systematic review and meta-analysis of 79 studies with 3861 participants investigating the safety of high-dose melatonin (≥10 mg) in adults. The analysis found no significant increase in serious adverse events or withdrawals due to adverse events, but an increased risk of adverse events such as drowsiness, headache, and dizziness. Overall, melatonin appears to have a good safety profile, though better safety reporting in future trials is needed.
Effects of exogenous melatonin on sleep quality and menopausal symptoms in menopausal women: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs evaluating melatonin intake in menopausal women. Melatonin improved physical symptoms but did not significantly affect sleep quality, general menopausal symptoms, mood states, estradiol levels, or BMI.
WWOM VII: Effectiveness of systemic pharmacotherapeutic interventions in the management of BMS: A systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs evaluating systemic pharmacotherapeutic interventions for burning mouth syndrome (BMS). The study found low evidence for the effectiveness of trazodone and melatonin, and moderate evidence for herbal compounds in improving symptoms. Pain intensity was the primary outcome assessed.
Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis.
Systematic review and meta-analysis of randomized, placebo-controlled studies assessing the effect of daily melatonin treatment on fasting glucose, insulin, insulin sensitivity, and HbA1c levels in healthy adults and patients with metabolic diseases. Melatonin did not significantly change fasting glucose or HbA1c levels but slightly reduced fasting insulin levels and trended towards reduced insulin resistance.
Melatonin and melatonin-agonists for metabolic syndrome components in patients treated with antipsychotics: A systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs involving melatonin and melatonin-agonists for antipsychotic-induced metabolic changes. Melatonin/ramelteon outperformed placebo on composite metabolic outcomes and individual components of metabolic syndrome, except waist circumference.
Melatonin for neuroprotection in neonatal encephalopathy: A systematic review & meta-analysis of clinical trials.
Systematic review and meta-analysis of clinical trials evaluating melatonin for neuroprotection in neonatal encephalopathy. Included five RCTs with 215 neonates. One study reported higher cognition scores at 18 months, but overall evidence quality was very low. No significant reduction in mortality was found in the combined hypothermia and melatonin group.
Melatonin and the cardiovascular system in animals: systematic review and meta-analysis.
Systematic review and meta-analysis of melatonin's effects on the cardiovascular system in animal models of myocardial infarction. Melatonin was found to reduce infarct size, improve cardiac function, exert antioxidant effects, and decrease lactate dehydrogenase activity, suggesting potential therapeutic benefits for cardiovascular diseases.
The efficacy of combined bright light and melatonin therapies on sleep and circadian outcomes: A systematic review.
Systematic review of eight papers on combined melatonin and bright light therapies for sleep and circadian outcomes. Combined therapy outperformed single therapies in phase advancing but not in delaying DLMO. It was more beneficial than single therapy in elderly populations but not in DSWPD patients. Adverse effects of melatonin in elderly populations were noted.
Differential role of melatonin in healthy brain aging: a systematic review and meta-analysis of the SAMP8 model.
Systematic review and meta-analysis of the role of melatonin in oxidative stress-induced senescence in the SAMP8 mouse model. Melatonin treatment was associated with reduced lipid peroxidation and carbonylated protein, and enhanced glutathione ratio, suggesting improved physiological stability during aging.
Efficacy of melatonin in animal models of intracerebral hemorrhage: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effectiveness of melatonin in animal models of intracerebral hemorrhage. Meta-analysis revealed a positive effect on neurobehavioral outcomes and reduced cerebral edema, though results should be interpreted considering methodological limitations.
The effects of melatonin therapy on the treatment of patients with Non-alcoholic steatohepatitis: A systematic review and Meta-analysis on clinical trial studies.
Systematic review and meta-analysis evaluating melatonin's effect on plasma levels of liver enzymes and lipids in NAFLD patients. Melatonin treatment significantly lowered alanine transaminase, aspartate aminotransferase, alkaline phosphatase, triglyceride, cholesterol, and gamma-glutamyl transpeptidase levels, suggesting potential benefits for managing NAFLD.
Melatonin supplementation and anthropometric indicators of obesity: A systematic review and meta-analysis.
Systematic review and meta-analysis of randomized clinical trials evaluating melatonin supplementation's effects on anthropometric indicators of obesity in adults. Melatonin supplementation significantly reduced body weight, but results for BMI and waist circumference were null.
Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 22 randomized controlled trials examining melatonin treatment in Alzheimer's disease, insomnia, and healthy subjects. Melatonin improved mini-mental state examination scores in Alzheimer's patients, particularly in mild stages, but decreased accuracy in healthy subjects. Melatonin may be preferable to traditional hypnotics for insomnia management.
A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary insomnia.
Systematic review evaluating the efficacy and safety of OTC sleep aids in older adults with primary insomnia. Melatonin showed a statistically significant positive impact on sleep measures without safety issues. Diphenhydramine increased sedation and decreased awakenings but had no safety advantage over other products. Valerian showed no effect on sleep outcomes.
Efficacy of Functional Foods, Beverages, and Supplements Claiming to Alleviate Air Travel Symptoms: Systematic Review and Meta-Analysis.
Systematic review and meta-analysis evaluated the efficacy of functional foods, beverages, and supplements for alleviating air travel symptoms. Melatonin was found to reduce self-reported jetlag, and Pycnogenol reduced edema scores. Overall, 12 of 183 ingredients in 199 products had evidence to support claims.
Melatonin for preoperative and postoperative anxiety in adults.
Meta-analysis of 27 RCTs involving 2319 participants assessing melatonin for preoperative and postoperative anxiety. Melatonin reduced preoperative anxiety compared to placebo and had similar effects to benzodiazepines. The effect on postoperative anxiety was smaller and of uncertain clinical relevance.
Association between night-shift work and level of melatonin: systematic review and meta-analysis.
This systematic review and meta-analysis examined the association between night-shift work and melatonin levels. It included 33 studies with 1845 night-shift workers and 3414 controls. The analysis found that night-shift workers had significantly lower levels of melatonin and its metabolite aMT6s compared to day workers, indicating suppression of melatonin production among night-shift workers.
Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis.
This systematic review and meta-analysis examined the effect of melatonin and ramelteon on delirium prevention in hospitalized patients. The analysis included 14 studies with 1712 participants and found that melatonin/ramelteon significantly reduced delirium incidence in surgical and ICU patients, but not in medical patients. Improvements in sleep quality and reduced sedative consumption were also noted, though no significant effects on delirium duration, hospital stay length, or mortality were observed.
Zolpidem reduces pain intensity postoperatively: a systematic review and meta-analysis of the effect of hypnotic medicines on post-operative pain intensity
Systematic review and meta-analysis investigating the effect of hypnotic medicines, including zolpidem, melatonin, and benzodiazepines, on postoperative pain intensity. Zolpidem showed moderate-quality evidence of reducing pain intensity when used with analgesics, while melatonin showed no significant effect compared to placebo.
Effect of Melatonin on Postoperative Pain and Perioperative Opioid Use: A Meta-analysis and Trial Sequential Analysis.
Meta-analysis of 15 studies with 1,102 patients assessing the effect of melatonin on postoperative pain and opioid use. Melatonin was associated with decreased VAS scores and reduced postoperative opioid use, but the evidence quality was low and results were inconclusive.
The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial.
Double-blind, randomized, placebo-controlled study in ICU patients to evaluate the effects of 10mg oral melatonin on sleep quality. Melatonin improved sleep quality compared to placebo, with better scores on the Richards Campbell Questionnaire Sleep. No significant differences were found in analgesic or sedative use, duration of night sleep, or occurrence of delirium, pain, and anxiety.
Endogenous Melatonin Levels and Therapeutic Use of Exogenous Melatonin in Migraine: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the use of melatonin in migraine prophylaxis. It reviewed case-control studies on endogenous melatonin levels in migraine patients and synthesized results from RCTs and non-randomized studies on exogenous melatonin use. Melatonin showed potential benefits in migraine prevention in adults, but further high-quality RCTs are needed.
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effect of melatonin and its analogue ramelteon on the prevention of postoperative delirium (POD). Results showed that both substances decreased the incidence of POD in the adult surgical population, with higher doses of melatonin being particularly effective.
The effect of melatonin supplementation on liver indices in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of RCTs evaluating the effect of melatonin supplementation on liver enzymes in patients with non-alcoholic fatty liver disease. Melatonin showed a significant effect on AST, ALP, and GGT, but not on ALT. More RCTs with larger sample sizes are needed.
Effects of melatonin supplementation on oxidative stress: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of randomized controlled trials assessing the effect of melatonin supplementation on oxidative stress. Melatonin significantly increased total antioxidant capacity and reduced protein carbonyl and malondialdehyde levels, indicating a promising effect on reducing oxidative stress.
Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials.
Systematic review and meta-analysis of randomized trials assessing melatonin treatment in assisted reproductive technology (ART) cycles. Melatonin significantly increased clinical pregnancy rate and the number of oocytes collected, matured oocytes, and good quality embryos, but did not significantly affect live birth rate or miscarriage rate.
Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.
Systematic review and meta-analysis of 12 RCTs assessing the effect of melatonin supplementation on oxidative stress parameters. Melatonin intake was associated with increased total antioxidant capacity, glutathione levels, superoxide dismutase, glutathione peroxidase, and glutathione reductase activities, and a reduction in malondialdehyde levels. No significant effect was found on nitric oxide levels or catalase activity.
The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis.
Systematic review and meta-analysis of 16 trials with 1634 patients examining the effect of melatonin on delirium in hospitalized patients. The analysis found no significant reduction in delirium incidence with melatonin, but a shorter ICU stay was observed. The evidence was of low certainty and inconclusive, with high heterogeneity across trials.
Melatonin for the prevention of postoperative delirium in older adults: a systematic review and meta-analysis.
Systematic review and meta-analysis assessing whether perioperative melatonin decreases the incidence of delirium in older adults undergoing surgical procedures. The analysis included 6 studies with 1155 patients, showing that melatonin significantly reduced the incidence of delirium with an odds ratio of 0.63.
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the influence of melatonin levels on breast cancer risk. The analysis included 9 studies with 963 breast cancer patients and 1332 controls, showing lower melatonin levels in breast cancer patients, suggesting low melatonin might be a risk factor.
Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials.
This meta-analysis of 13 studies with 749 participants evaluated the effect of melatonin supplementation on inflammatory biomarkers. Melatonin significantly decreased TNF-α and IL-6 levels, with a marginal effect on CRP levels, suggesting its potential in reducing inflammation.
The effect of melatonin supplementation on lipid profile and anthropometric indices: A systematic review and meta-analysis of clinical trials.
Systematic review and meta-analysis of 12 trials with 641 participants examining the effect of melatonin supplementation on lipid profile and anthropometric indices. Melatonin may improve LDL-C and triglyceride levels, but no significant effect was found on HDL-C and anthropometric indices.
Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.
Systematic review and meta-analysis of 13 RCTs (n=682) assessing melatonin for sleep problems in children with neurodevelopmental disorders. Melatonin significantly improved total sleep time and sleep onset latency compared to placebo, with no serious adverse events reported.
The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of RCTs evaluated the effect of melatonin supplementation on inflammatory markers in individuals with metabolic syndrome and related disorders. Melatonin significantly reduced C-reactive protein (CRP) and interleukin 6 (IL-6) concentrations, but not tumor necrosis factor-alpha (TNF-α) levels.
Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis.
This meta-analysis evaluates the efficacy of exogenous melatonin versus placebo in managing secondary sleep disorders. Pooled data from 7 studies with 205 patients show that melatonin lowers sleep onset latency and increases total sleep time, with little effect on sleep efficiency.
Role of Melatonin in Body Weight: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 7 clinical trials with 244 patients evaluating melatonin's effects on body weight. The pooled standardized mean difference was not significant, though some studies reported varying effects. Melatonin may have a buffering role on body weight fluctuations, particularly in children and adolescents.