Research
Mangosteen
22 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of Garcinia mangostana Peel Extract on Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review of Human Studies.
Systematic review of human studies evaluating the effects of mangosteen peel extract on glycemic control in type 2 diabetes mellitus. Limited evidence suggests potential improvements in insulin sensitivity and fasting glucose, but conclusions are constrained by small sample sizes and variability in extract formulations.
A Systematic Review of Neuroprotective Effects of Mangosteen and its Xanthones Against Oxidative Stress and Inflammation.
This systematic review examines the antioxidative and anti-inflammatory effects of mangosteen and its xanthones, highlighting their neuroprotective potential against neurodegenerative conditions. The review included 40 studies and found that mangosteen extracts consistently reduced oxidative markers and pro-inflammatory cytokines, suggesting neuroprotective capabilities.
Efficacy of mangosteen as local drug delivery for improving periodontal health in adults with periodontitis: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy of mangosteen as a local drug delivery for improving periodontal health in adults with periodontitis. The analysis showed significant reductions in periodontal pocket depth and clinical attachment level in the mangosteen-treated group, suggesting substantial clinical benefits for periodontal health.
The efficacy of adjunctiveLinn. (mangosteen) pericarp extract for bipolar depression: 24-week randomised controlled trial.
This 28-week randomised, double-blind, placebo-controlled trial investigated mangosteen pericarp extract as an adjunct to treatment-as-usual for bipolar depression. The study found limited efficacy for mood and functional symptoms, with greater improvements in mood symptoms and social functioning at 24 weeks compared to baseline, but these differences were not sustained at 28 weeks post-discontinuation.
Clinical and Immunological Efficacy of Mangosteen and Propolis Extracted Complex in Patients with Gingivitis: A Multi-Centered Randomized Controlled Clinical Trial.
RCT of 104 patients with gingivitis or incipient periodontitis comparing daily intake of mangosteen and propolis extracts (MAEC) to placebo for eight weeks. The test group showed significant improvements in modified gingival index, reduced crevicular IL-6, and increased salivary MMP-9, indicating reduced gingival inflammation.
AdjunctiveLinn. (Mangosteen) Pericarp for Schizophrenia: A 24-Week Double-blind, Randomized, Placebo Controlled Efficacy Trial: Péricarpe d'appoint Garcinia mangostana Linn (mangoustan) pour la schizophrénie : un essai d'efficacité de 24 semaines, à double insu, randomisé et contrôlé par placebo.
A 24-week double-blind randomized placebo-controlled trial evaluated the efficacy of adjunctive mangosteen pericarp (1,000 mg/day) in treating schizophrenia. The study involved 148 participants, with no significant differences found between the mangosteen and placebo groups in symptom improvement, functioning, or quality of life measures.
Clinical and antioxidant efficacy of 4% mangosteen gel as a local drug delivery in the treatment of chronic periodontitis: A placebo-controlled, split-mouth trial.
A placebo-controlled, split-mouth trial evaluated the efficacy of 4% mangosteen gel as an adjunct to scaling and root planing in 25 patients with chronic periodontitis. The experimental group showed significant improvements in clinical parameters and gingival crevicular fluid antioxidant capacity compared to the control group.
Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: an 8-week, double-blinded, randomized, controlled trial.
RCT of 60 patients with mild to moderate acne vulgaris comparing herbal extracts containing mangosteen to a vehicle for 8 weeks. The herbal extracts group showed significant decreases in both inflammatory and non-inflammatory acne lesion counts, as well as decreased expressions of IL-1α, IL-8, and keratin 16. No serious adverse events were reported.
Clinical and microbiological efficacy of 4% Garcinia mangostana L. pericarp gel as local drug delivery in the treatment of chronic periodontitis: A randomized, controlled clinical trial.
RCT assessing the efficacy of 4% Garcinia mangostana gel as an adjunct to scaling and root planing in 50 periodontitis patients. The mangostana gel group showed significant improvements in periodontal status and reduction in red complex microorganisms compared to placebo.
Efficacy and tolerability of Meratrim for weight management: a randomized, double-blind, placebo-controlled study in healthy overweight human subjects.
RCT of 60 overweight participants comparing 400 mg Meratrim twice daily to placebo for 16 weeks. Meratrim group showed significant reductions in body weight, BMI, waist and hip size, and improvements in serum LDL, triglycerides, and total cholesterol compared to placebo. No adverse events were noted.
Efficacy and tolerability of an herbal formulation for weight management.
Two randomized, double-blind, placebo-controlled trials assessed the effects of an herbal formulation containing Sphaeranthus indicus and Garcinia mangostana on weight management in 100 subjects with BMI 30-40 kg/m². The herbal group showed significant reductions in body weight, BMI, waist and hip circumference, and improvements in serum adiponectin, fasting blood glucose, cholesterol, and triglyceride levels compared to placebo after 8 weeks.
Efficacy and tolerability of a novel herbal formulation for weight management.
RCT of 60 subjects with BMI between 30 and 40 kg/m(2) comparing 400 mg herbal capsules containing Sphaeranthus indicus and Garcinia mangostana to placebo. The herbal group showed significant reductions in body weight, BMI, and waist circumference, and an increase in serum adiponectin concentration over 8 weeks.
Effect of a mangosteen dietary supplement on human immune function: a randomized, double-blind, placebo-controlled trial.
A randomized, double-blind, placebo-controlled trial tested the effect of a mangosteen product containing multivitamins and essential minerals on immune function and well-being in 59 healthy adults. The mangosteen product increased peripheral T-helper cell frequency, reduced serum C-reactive protein, and improved self-reported health status compared to placebo.
Bioavailability and antioxidant effects of a xanthone-rich Mangosteen (Garcinia mangostana) product in humans.
This study investigated the absorption and antioxidant effects of a xanthone-rich mangosteen liquid in healthy human volunteers after acute consumption. Results showed that alpha-mangostin and vitamins B(2) and B(5) were bioavailable, with increased antioxidant capacity measured by the ORAC assay, demonstrating the bioavailability and in vivo antioxidant effects of the mangosteen product.
Topical application of Garcinia mangostana L. pericarp gel as an adjunct to periodontal treatment.
RCT evaluating the effects of Garcinia mangostana L. pericarp gel as an adjunct to periodontal treatment. The test group receiving the GM gel showed significantly higher reduction in probing pocket depth, Gingival Index, and bleeding on probing compared to the control group at the 3rd month after treatment.
Effects of herbal mouthwash containing the pericarp extract of Garcinia mangostana L on halitosis, plaque and papillary bleeding index.
RCT of 60 subjects with mild or moderate chronic gingivitis comparing herbal mouthwash containing Garcinia mangostana pericarp extract to placebo. The herbal mouthwash significantly affected volatile sulfur compound levels, plaque index, and papillary bleeding index compared to baseline and placebo.
Combined extracts of Garcinia mangostana fruit rind and Cinnamomum tamala leaf supplementation enhances muscle strength and endurance in resistance trained males
A 42-day double-blind placebo-controlled trial evaluated the effects of GMCT, a supplement containing Garcinia mangostana and Cinnamomum tamala extracts, on muscle strength and endurance in resistance-trained males. The GMCT group showed significant improvements in 1-RM bench press, leg press, leg extension repetitions, arm circumference, and lean mass compared to placebo. No significant changes were observed in free testosterone, IGF-1, insulin, or lactate levels.
Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study.
Prospective RCT evaluating mangosteen extract in obese female patients with insulin resistance. The mangosteen group showed significant improvement in insulin sensitivity and no side effects, suggesting a potential supplementary role in treating obesity, insulin resistance, and inflammation.
Acute Garcinia mangostana (mangosteen) supplementation does not alleviate physical fatigue during exercise: a randomized, double-blind, placebo-controlled, crossover trial.
A randomized, double-blind, placebo-controlled, crossover trial with 12 healthy adults evaluated the effect of acute mangosteen supplementation on physical fatigue during exercise. The study found no significant differences in fatigue-related parameters between the mangosteen and placebo treatments, except for a positive impact on the Profile of Mood States (POMS) examination.
Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults.
The study investigated the bioavailability of xanthones from 100% mangosteen juice in 10 healthy adults. Xanthones were absorbed and partially conjugated when ingested with a high-fat meal, with variations in serum and urine concentrations. The release of xanthones from pericarp particles during digestion was limited.
Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study.
This 8-week randomized, double-blind, placebo-controlled study evaluated the effect of a proprietary Mangosteen Juice blend on inflammation markers in obese patients with elevated CRP levels. The highest dose group showed a significant reduction in CRP levels compared to placebo, although other inflammation markers did not show significant differences. The juice was administered safely with no reported side effects.
Biological Activities and Bioavailability of Mangosteen Xanthones: A Critical Review of the Current Evidence
This narrative review critically addresses recent reports on the bioavailability and metabolism of mangosteen xanthones, updates in vitro and in vivo data on their anti-cancer and anti-inflammatory activities, and suggests areas for further research on absorption, metabolism, and efficacy.