Research
Maitake
7 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Antitumor activities of Grifola frondosa (Maitake) polysaccharide: A meta-analysis based on preclinical evidence and quality assessment.
Meta-analysis of 24 animal studies assessing the antitumor activity of Grifola frondosa polysaccharide (GFP). GFP significantly inhibited tumor growth, improved tumor remission rates, and enhanced immune function, although the quality of included studies was not high.
Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration.
Systematic review evaluating scientific evidence on maitake mushroom, including its efficacy, dosing, interactions, and adverse effects. Discusses indications for cancer, diabetes, and immunostimulation, highlighting a lack of systematic study on safety and effectiveness in humans.
Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial.
RCT of 47 healthy older Japanese individuals consuming bread with maitake mushroom strains Y10M or C5304 versus placebo for 18 weeks. The Y10M group showed significant improvement in cognitive function and increased natural killer cell activity compared to placebo, suggesting maitake mushrooms may help inhibit cognitive decline.
Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate.
Open trial with 80 PCOS patients comparing Maitake mushroom extract (MSX) and clomiphene citrate (CC) for ovulation induction. MSX showed a 76.9% ovulation rate in monotherapy and was effective in combination therapy for patients who failed CC monotherapy.
Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study.
Phase II trial of Maitake mushroom extract in myelodysplastic syndromes (MDS) patients. Maitake increased endogenous neutrophil and monocyte function, with enhanced ROS production response. Asymptomatic eosinophilia occurred in 4 patients. Maitake was well tolerated and showed beneficial immunomodulatory potential.
A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects.
Phase I/II dose escalation trial of Maitake mushroom extract in 34 postmenopausal breast cancer patients. The study found that Maitake extract had both immunologically stimulatory and inhibitory effects, with non-monotonic dose-response curves. No dose-limiting toxicity was observed, though some side effects were reported.
Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes), and Its Neurotrophic Properties: A Mini-Review.
This mini-review discusses the neuroprotective effects and chemical composition of Grifola frondosa (maitake mushroom). It highlights the mushroom's potential as a therapeutic agent for neurodegenerative diseases like Alzheimer's and Parkinson's, emphasizing its antioxidative, anti-inflammatory, and neurogenesis-promoting activities.