Research
Magnesium L-Threonate (MgT)
22 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial
This randomized, double-blind, placebo-controlled trial studied the effects of magnesium L-threonate (Magtein®) supplementation on cognitive performance and sleep quality in 100 adults. Magtein® improved overall cognitive performance, cognitive age, working memory, reaction time, heart rate, and heart rate variability. It also improved some subjective measures of sleep but not objective measures.
Corrigendum/Erratum to "Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial" [Sleep Med: X 8 (2024) 100121].
Corrigendum/Erratum for a study on magnesium-L-threonate improving sleep quality and daytime functioning in adults with self-reported sleep problems.
Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial
RCT of 80 adults with self-reported sleep problems comparing 1 g/day of magnesium L-threonate to placebo for 21 days. Magnesium L-threonate improved sleep quality, especially deep/REM sleep stages, and enhanced mood, energy, alertness, and daily productivity. It was safe and well tolerated.
A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Therapeutic Effect of Magnesium-L-Threonate Supplementation for Persistent Pain After Breast Cancer Surgery
This randomized, double-blind, placebo-controlled trial evaluated the effect of magnesium-L-threonate supplementation on persistent pain after breast cancer surgery in 109 patients. The study found no significant differences in pain, mood, sleep disorder, or cognitive function between the magnesium and placebo groups after 12 weeks.
Oral application of magnesium‐L‐threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients—A randomized, double‐blind, placebo‐controlled trial
The study investigates the effects of oral administration of magnesium-L-threonate on the analgesic effect of opioids in patients with advanced cancer. It is a randomized, double-blind, placebo-controlled trial.
A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
Double-blind, placebo-controlled study of Magtein®PS, a magnesium L-threonate and phosphatidylserine-based formulation, in 109 healthy Chinese adults. The study found significant improvements in memory and cognition, particularly in older participants, compared to placebo.
Safety Assessment: Magnesium L-threonate as a novel food for use in food supplements
The paper discusses the safety assessment of magnesium L-threonate monohydrate as a novel food for use in food supplements. The Food Standards Agency and Food Standards Scotland concluded that the novel food is safe under the proposed conditions of use and not nutritionally disadvantageous.
Magnesium-L-threonate Ameliorates Cognitive Deficit by Attenuating Adult Hippocampal Neurogenesis Impairment in a Mouse Model of Alzheimer’s Disease
This study investigates the effects of magnesium-L-threonate (MgT) on cognitive deficits in a mouse model of Alzheimer's disease. MgT treatment improved memory impairment and increased neurogenesis markers in the hippocampus, potentially through ERK/CREB activation.
Oral application of magnesium-L-threonate alleviates radicular pain by inhibiting neuro-inflammation dependent central sensitization of rats.
The study investigates the effect of oral magnesium-L-threonate (L-TAMS) on radicular pain in a rat model of lumbar disc herniation. L-TAMS was found to alleviate pain by inhibiting neuro-inflammation and central sensitization, reducing pro-inflammatory cytokines and microglia activation.
Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder.
The study investigates the effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination, and blood-brain barrier integrity in a mouse model of neuromyelitis optica spectrum disorder (NMOSD). Magnesium L-threonate pretreatment alleviated NMO-IgG-induced effects, suggesting potential protective effects against NMOSD through preservation of blood-brain barrier integrity and reduction of neuroinflammation and demyelination.
Changes in the urinary proteome of rats after short-term intake of magnesium L-threonate(MgT)
The study analyzed the urinary proteome of rats before and after gavage of magnesium threonate using LC-MS/MS. It found significant alterations in the urinary proteome after short-term intake of magnesium supplements, suggesting that urinary proteomics can reflect the effects of nutrient intake.
Anisotropic Microspheres-Cryogel Composites Loaded with Magnesium l-Threonate Promote Osteogenesis, Angiogenesis, and Neurogenesis for Repairing Bone Defects.
The study developed anisotropic microspheres-cryogel composites loaded with magnesium l-threonate to promote osteogenesis, angiogenesis, and neurogenesis for bone defect repair. The composites facilitated vascular ingrowth and significantly promoted osteogenic differentiation, tubular formation, and neuronal differentiation in vitro, as well as early vascularization, neurogenesis, and bone regeneration in rat femoral condyle defects.
Magnesium-L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis
The study investigates the effects of magnesium-L-threonate on the microbiota-gut-brain axis in Alzheimer’s disease model mice. Magnesium-L-threonate improved cognition, reduced oxidative stress and inflammation, modulated gut microbiota, and repaired intestinal barrier dysfunction in APP/PS1 mice.
Role of magnesium-L-Threonate in alleviating skin/muscle incision and retraction induced mechanical allodynia and anxiodepressive-like behaviors in male rats.
The study examined the effects of magnesium-L-threonate (L-TAMS) on surgery-induced mechanical allodynia and anxiodepressive-like behaviors in a rat model. L-TAMS administration increased magnesium levels in serum and CSF, reversed mechanical allodynia and anxiodepressive-like behaviors, and suppressed glial activation and proinflammatory cytokine expression in the ACC of SMIR-injured rats.
Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer’s disease mouse model
The study investigated the neuroprotective effects of Magnesium-L-threonate (MgT) against oxidative stress in Aβ25-35-treated HT22 cells and an Alzheimer's disease mouse model. MgT improved cell viability, reduced ROS levels, and decreased apoptosis in vitro, while also ameliorating cognitive deficits and reducing neuronal apoptosis in APP/PS1 mice.
Effects of Vitamin C and Magnesium L-threonate Treatment on Learning and Memory in Lead-poisoned Mice
Animal study investigating the effects of vitamin C and magnesium L-threonate on learning and memory in lead-poisoned mice. The study found that lead acetate impaired learning and memory, while supplementation with vitamin C and magnesium L-threonate showed mixed effects on brain health, with some improvements in catalase activity in brain tissue.
Safety of magnesium l‐threonate as a novel food pursuant to regulation (EU) 2015/2283 and bioavailability of magnesium from this source in the context of Directive 2002/46/EC
The EFSA Panel on Nutrition, Novel Foods and Food Allergens evaluated the safety and bioavailability of magnesium l-threonate as a novel food. The panel concluded that magnesium is bioavailable from this source and that it is safe for use in food supplements at a maximum intake level of 3000 mg per day for adults, excluding pregnant and lactating women.
Enhanced Neuroprotective Synergy of Atorvastatin and Magnesium L-Threonate in a Rat Model of Alzheimer’s Disease Induced by Aluminum Chloride
Animal study using a rat model of Alzheimer's disease induced by aluminum chloride to test the effects of atorvastatin and magnesium L-threonate. The combination improved cognitive functions, reduced oxidative stress, and showed neuroprotective effects compared to atorvastatin alone.
Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-α/NF-κB signaling in female rats
The study investigated the effects of Magnesium-L-Threonate (L-TAMS) supplementation on mechanical allodynia, depressive-like behaviors, and memory deficits in a rat model of cyclophosphamide-induced cystitis. L-TAMS prevented magnesium deficiency, attenuated mechanical allodynia, normalized depressive-like behaviors and short-term memory deficits, and inhibited TNF-α/NF-κB signaling and normalized NR2B expression.
Saturation of long-term potentiation in the dorsal cochlear nucleus and its pharmacological reversal in an experimental model of tinnitus.
The study used a murine model to investigate the effects of acoustic over-exposure on long-term potentiation (LTP) in the dorsal cochlear nucleus (DCN) and its pharmacological reversal. In vivo administration of magnesium-threonate restored LTP at DCN multisensory synapses and reduced gap detection deficits following acoustic over-exposure, suggesting potential therapeutic intervention for tinnitus.
Magnesium supplement enhances spatial-context pattern separation and prevents fear overgeneralization.
Study on Sprague-Dawley male rats treated with magnesium-L-threonate (MgT) for 4 weeks. MgT treatment enhanced spatial-context discrimination and pattern separation, suggesting potential benefits for brain health and preventing fear overgeneralization.
Kalzium ist nicht alles.
Narrative review discussing the effects of magnesium threonate on cognition in young and old rats. The study highlights that elevation of cerebral Mg2+ enhances cognition and increases hippocampal NR2B expression and bouton density.