Research
Lycopene
118 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of clinical studies on lycopene supplementation and male fertility outcomes. Lycopene significantly improved sperm concentration and nonprogressive motility, but had no significant effects on other fertility-related outcomes. Larger, high-quality trials are needed to confirm these findings.
Dietary intake of tomato and lycopene, blood levels of lycopene, and risk of total and specific cancers in adults: a systematic review and dose-response meta-analysis of prospective cohort studies.
Systematic review and dose-response meta-analysis of 121 prospective studies examining the association between tomato/lycopene intake and blood levels of lycopene with cancer risk and mortality. High lycopene intake and levels were associated with reduced overall cancer risk and mortality, with specific inverse associations for prostate and lung cancer.
Enhancing Anticancer Treatment Efficacy With Lycopene: A Comprehensive Review of Clinical and Preclinical Evidence.
Systematic review of lycopene's efficacy in combination with anticancer agents, demonstrating modulation of oncogenic signaling pathways and cellular processes. The review includes 45 studies showing lycopene's potential to enhance anticancer treatment efficacy, though clinical validation is needed.
Influence of Lycopene Intake on Mental Health: A Systematic Review of Randomized Controlled Trials (RCTs).
Systematic review of RCTs analyzing the influence of lycopene on mental health. Six RCTs were included, assessing quality of life, depression, anxiety, stress, and mood states. The review found no confirmed influence of lycopene on mental health, with a mix of low and high risk of bias in the studies.
Potential Use of Tomato Peel, a Rich Source of Lycopene, for Cancer Treatment.
This systematic review, using PRISMA 2020 methodology, examined studies on the potential of tomato peel as a source of lycopene and carotenoids for cancer treatment. The findings suggest that tomato peel extracts exhibit promising anticancer properties, highlighting the need for further investigation into therapeutic applications.
Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease.
This systematic review and meta-analysis evaluated the antioxidant effect of lycopene as an adjuvant treatment for periodontal disease. The meta-analysis found statistical significance in the assessment of plaque index and other periodontal parameters, suggesting that lycopene could be useful as an adjunctive treatment for periodontal disease.
The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials.
Systematic review and meta-analysis of intervention trials assessing the effects of tomato and lycopene on UV-induced skin deterioration. Supplementation with tomato and lycopene was associated with reductions in skin erythema, pigmentation, and molecular markers of skin damage, while increasing skin thickness and density.
Drug treatment for oral submucous fibrosis: an update.
Systematic review evaluating medicinal interventions for oral submucous fibrosis (OSF). High-quality evidence supports the use of lycopene, curcumin, and aloe vera, among others, for OSF treatment. Lycopene is noted for low side effects, while aloe vera is effective for severe burning sensation.
Effect of Lycopene Intake on the Fasting Blood Glucose Level: A Systematic Review with Meta-Analysis.
Systematic review and meta-analysis of human interventional studies on the effect of oral lycopene intake on fasting blood glucose levels. The analysis included 11 trial arms with 750 participants, showing a tendency towards a significant decrease in fasting blood glucose levels, particularly in type 2 diabetes patients.
Efficacy of lycopene for management of oral potentially malignant disorders: A systematic review and meta-analysis.
Systematic review and meta-analysis of 27 clinical trials assessing the efficacy of lycopene in managing oral potentially malignant disorders (OPMDs) such as oral submucosa fibrosis (OSF), oral lichen planus (OLP), and leukoplakia. Lycopene was found to be efficacious in reducing signs and symptoms of these conditions, with comparable efficacy to prednisolone and conventional controls in certain measures.
The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
Systematic review of 72 human and animal studies evaluating lycopene supplementation in cancer prevention and treatment. Most studies confirmed lycopene's anti-cancer activities, particularly in prostate cancer, through mechanisms like regulation of oxidative and inflammatory processes, apoptosis induction, and inhibition of cell division, angiogenesis, and metastasis.
The effect of lycopene supplement from different sources on prostate specific antigen (PSA): A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of randomized controlled trials evaluating the effect of supplemental lycopene on PSA levels. The pooled analysis of 6 studies showed no significant differences in PSA levels between lycopene or tomato extract and control.
Advances in engineering the production of the natural red pigment lycopene: A systematic review from a biotechnology perspective.
Systematic review of biotechnological advances in lycopene production. Discusses microbial fermentation, genetic engineering, and metabolic engineering strategies to enhance lycopene yield, with a focus on microbial cultivation and plant bioreactors.
Effect of tomato, lycopene and related products on blood pressure: A systematic review and network meta-analysis.
A systematic review and network meta-analysis of RCTs assessed the hypotensive effects of tomato, lycopene, and related products. Standardized tomato extract (STE) significantly decreased systolic blood pressure compared to placebo, especially in hypertensive patients. Other forms of tomato and lycopene did not show consistent effects.
Investigating into anti-cancer potential of lycopene: Molecular targets.
Systematic review of lycopene's anticancer potential, focusing on its molecular mechanisms and targets. Lycopene is highlighted for its antioxidant activity and its role in inhibiting tumor development through various pathways, including PI3K/Akt and modulation of insulin-like growth factors.
Efficacy of Lycopene in the Treatment of Oral Submucous Fibrosis: A Meta-analysis of Randomized Controlled Trials.
This meta-analysis evaluated the efficacy of lycopene in improving maximum mouth opening and other clinical symptoms in patients with oral submucous fibrosis (OSF). The analysis included 7 randomized controlled trials with 758 patients, showing that lycopene significantly improved maximum mouth opening compared to placebo, but had no significant effect on burning sensation, pain, or tongue protrusion.
Anti-Cancer Effects of Lycopene in Animal Models of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of lycopene's anticancer effects in animal models of hepatocellular carcinoma (HCC). Lycopene significantly reduced tumor incidence, number, and growth in animal models, suggesting potential anti-cancer properties.
Lycopene Does Not Affect Prostate-Specific Antigen in Men with Non-Metastatic Prostate Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of RCTs investigating lycopene supplementation on serum PSA levels in non-metastatic prostate cancer patients. Overall, lycopene did not significantly affect PSA levels, but a significant reduction was observed in patients with higher baseline PSA levels.
The effects of lycopene supplementation on serum insulin-like growth factor 1 (IGF-1) levels and cardiovascular disease: A dose-response meta-analysis of clinical trials.
Meta-analysis of seven clinical trials examining the effects of lycopene supplementation on serum IGF-1 levels and cardiovascular disease. Lycopene intake was not associated with reduced serum IGF-1 levels overall, but showed significant effects at doses >15 mg/d, for <12 weeks, in healthy individuals, and in patients aged ≥60 years. Lycopene supplementation exhibited potential health benefits in managing cardiac disorders.
Effect of Dietary and Supplemental Lycopene on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 43 studies assessing the effect of dietary and supplemental lycopene on cardiovascular risk factors. The review found no significant differences between lycopene intervention and control groups for blood pressure and lipid levels, with conflicting findings across studies.
[Efficacy of lycopene intake in primary prevention of prostate cancer: a systematic review of the literature and meta-analysis.].
Systematic review and meta-analysis evaluating the efficacy of lycopene intake in the primary prevention of prostate cancer. The analysis included 27 studies, with a total of 13,999 prostate cancer cases and 22,028 controls in case-control studies, and 187,417 patients in cohort studies. The meta-analysis found a statistically significant inverse association between lycopene intake and prostate cancer, but the association was weak and based on observational studies.
Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis.
Systematic review and meta-analysis of 42 studies with 692,012 participants examining the association between dietary and circulating lycopene and prostate cancer risk. Both dietary intake and circulating concentrations of lycopene were significantly associated with reduced prostate cancer risk, with dose-response relationships observed. Lycopene was not associated with reduced risk of advanced prostate cancer.
Association of Candidate Single-Nucleotide Polymorphism Genotypes With Plasma and Skin Carotenoid Concentrations in Adults Provided a Lycopene-Rich Juice.
This randomized controlled trial investigated the relationship between 13 candidate SNPs and skin and plasma carotenoid concentrations in 80 adults consuming lycopene-rich vegetable juice for 8 weeks. The study found significant associations between specific SNP genotypes and skin carotenoid concentrations, highlighting genetic variation's role in carotenoid metabolism.
Effectiveness of non-pharmaceutical intervention on sperm quality: a systematic review and network meta-analysis.
This network meta-analysis investigated the efficacy of non-pharmaceutical interventions on sperm quality. Lycopene, omega-3 fatty acids, CoQ10, zinc, selenium, and carnitine were found to improve sperm concentration and motility, suggesting potential benefits for treating male infertility.
Topical lycopene emulgel significantly improves biophysical parameters of human skin.
RCT investigating a lycopene-based topical emulgel on human skin. The formulation significantly improved skin hydration and elasticity, and reduced erythema, melanin, and sebum contents over 12 weeks. The study highlights the antioxidant potential of lycopene in a stable formulation.
Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)
Randomized cross-over clinical trial in 61 obese children with fatty liver, 52 completed. Compared calorie-restricted regimen alone vs. with lycopene-rich tomato juice supplementation for 60 days each. Tomato-supplemented group showed greater reductions in BMI, HOMA-IR, cholesterol, triglycerides, liver size, and steatosis. Tomato juice improved glucose and lipid metabolism, oxidative and inflammatory state, and modulated T-cell mitochondrial metabolism, enhancing immune surveillance.
Lycopene and Metabolic Syndrome: A Systematic Review of the Literature.
Systematic review investigating the relation between circulating lycopene or dietary intake of lycopene and metabolic syndrome (MetS) and its risk factors. The review included 11 studies, with significant protective associations reported in both cross-sectional and intervention studies. Lycopene was associated with favorable alterations to MetS components, though effects varied across different components.
Lycopene and cognitive function.
Systematic review assessing the relationship between lycopene and cognitive function, including dementia. Among studies on maintained cognition, three reported significant positive relationships with lycopene. However, studies on dementia development and pre-existing dementia showed mixed results, with only one study finding significant associations between lower lycopene levels and Alzheimer's disease mortality.
Can Lycopene Impact the Androgen Axis in Prostate Cancer?: A Systematic Review of Cell Culture and Animal Studies.
Systematic review of 18 studies (5 in vivo, 13 in vitro) evaluating the impact of tomato and lycopene on androgen signaling in prostate cancer. The review found that tomato and lycopene treatment commonly inhibited androgen-related outcomes, suggesting potential down-regulation of androgen metabolism and signaling in prostate cancer.
Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence.
Systematic review and meta-analysis of 28 studies examining the association between lycopene and tomato consumption and cardiovascular health. High lycopene intake or serum concentration was associated with reduced risk of stroke, mortality, and cardiovascular diseases.
Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies.
Meta-analysis of 14 observational studies investigating the association between lycopene and cardiovascular disease (CVD) risk. Lycopene exposure was inversely associated with CVD risk, with a pooled risk ratio of 0.83. Dietary lycopene intake showed significant associations with reduced risk of coronary heart disease and stroke.
Lycopene Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies.
Meta-analysis of 15 observational studies assessing the association between lycopene consumption and colorectal cancer risk. No significant association was found overall, but a significant inverse association was observed for cancer in the colon. The study quality was rated very low.
Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies
Systematic review and dose-response meta-analysis of 34 studies on carotenoids intake and prostate cancer risk. Dietary α-carotene and lycopene intake were associated with reduced risk of prostate cancer, but not advanced prostate cancer. β-carotene showed no association with prostate cancer risk.
Meta-analysis of the association between dietary lycopene intake and ovarian cancer risk in postmenopausal women.
Meta-analysis of 10 studies investigating the relationship between dietary lycopene intake and ovarian cancer risk in postmenopausal women. The study found an insignificant reverse association, suggesting no statistically significant protective effect of lycopene against ovarian cancer risk.
Effect of lycopene supplementation on oxidative stress: an exploratory systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of randomized controlled trials on oral lycopene supplementation's effects on oxidative stress. Lycopene significantly decreases DNA tail length in comet assays, indicating reduced oxidative stress, but does not significantly affect LDL lag time.
Lycopene supplement and blood pressure: an updated meta-analysis of intervention trials.
Updated meta-analysis of intervention trials on lycopene supplementation and blood pressure. The pooled analysis showed a significant reduction in systolic blood pressure, particularly with higher dosages (>12 mg/day) and among Asians or those with higher baseline SBP. No significant effect was found on diastolic blood pressure.
Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies.
Systematic review and meta-analysis of 11 cohort studies and 6 nested case-control studies assessing lycopene and tomato intake on prostate cancer risk. Higher intake of raw and cooked tomatoes and lycopene showed a modest reduction in prostate cancer incidence, though results were not statistically significant.
The role of tomato products and lycopene in the prevention of gastric cancer: a meta-analysis of epidemiologic studies.
Meta-analysis of cohort and case-control studies examining the association between tomato products and lycopene consumption with gastric cancer risk. Consumption of large amounts of tomato products was associated with a reduced risk of gastric cancer, though further studies are needed due to potential confounding factors.
Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review.
Systematic review of eight RCTs examining lycopene for prevention and treatment of BPH and prostate cancer. Meta-analysis found no significant decrease in BPH or prostate cancer incidence, but a decrease in PSA levels in prostate cancer patients receiving lycopene. Limited RCTs and varying study quality prevent definitive conclusions.
Lycopene for the prevention of prostate cancer.
This meta-analysis reviewed three RCTs with a total of 154 participants to assess the effect of lycopene on prostate cancer prevention. The studies showed no statistical difference in PSA levels or lycopene levels between the lycopene and control groups. Only one study reported a lower incidence of prostate cancer in the lycopene group, but overall evidence is insufficient to support or refute lycopene's effectiveness in preventing prostate cancer.
[Meta-analysis on the role of lycopene in type 2 diabetes mellitus].
Meta-analysis examining the role of lycopene as an antioxidant in type 2 diabetes mellitus. Lycopene intake increases plasma levels and decreases malonyldialdehyde and lipid peroxidation, suggesting a beneficial effect on oxidative stress in diabetic patients. No evidence found for lycopene intake reducing the risk of developing diabetes.
Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials.
Meta-analysis of intervention trials assessing the effect of lycopene on serum lipids and blood pressure. Lycopene at doses ≥25mg daily significantly reduced total serum cholesterol and LDL cholesterol, and showed a significant blood pressure reducing effect.
Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review.
Systematic review evaluating the association between lycopene intake and prostate cancer progression. An inverse association was observed between lycopene intake and PSA levels in six studies, and lower progression rates in one RCT. Lycopene lowered cancer-related symptoms without severe toxicity, but evidence is insufficient for firm conclusions.
Tomato-Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity.
RCT with 12 adults with obesity comparing tomato-soy juice to low carotenoid tomato juice. Tomato-soy intake increased plasma lycopene, reduced pro-inflammatory cytokines, and altered urine metabolomic profiles, suggesting anti-inflammatory effects.
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients.
Phase I trial to identify the optimum dose of synthetic lycopene in combination with docetaxel and ADT in metastatic prostate cancer patients. The maximum tolerated dose was 150 mg/day of lycopene, which increased plasma exposure to docetaxel and showed effects on angiogenesis and insulin-like growth factor 1 signaling.
Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial.
RCT comparing the effects of lycopene and systemic corticosteroids on symptoms and oxidative stress in patients with resistant oral lichen planus. Lycopene significantly reduced 8-isoprostane levels, a biomarker of lipid peroxidation, and was found to be a safe and effective treatment.
A double-blind, placebo-controlled randomized trial of skin-lightening cream containing lycopene and wheat bran extract on melasma.
A double-blind, placebo-controlled RCT tested a skin-lightening cream containing 0.05% tomato lycopene and 3.45% wheat bran extract on 22 patients with melasma. The intervention group showed a significant decrease in MASI score and skin discoloration compared to placebo, indicating skin improvement.
Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study.
This double-blind, randomized, placebo-controlled study investigated the effects of a carotenoid-rich tomato nutrient complex on UVB-induced erythema and inflammation in 149 healthy volunteers. The supplement significantly protected against UVB-induced erythema formation and upregulation of proinflammatory cytokines, with increased carotenoid plasma levels observed.
Effect of green tea and lycopene on the insulin-like growth factor system: the ProDiet randomized controlled trial.
RCT investigating the effect of lycopene and green tea on circulating insulin-like growth factor peptides in men at increased risk of prostate cancer. The study found little evidence that lycopene or green tea interventions significantly influenced serum levels of IGF-I, IGF-II, IGFBP-3, and IGFBP-2, though some trends may justify larger trials.
A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males.
RCT of 60 healthy males investigating the effect of 14 mg daily lactolycopene for 12 weeks on semen quality. While there was no significant change in motile sperm concentration, the proportion of fast progressive sperm and sperm with normal morphology improved significantly.
Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease
RCT investigating the effects of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease. Lycosome-formulated lycopene significantly increased serum lycopene levels, reduced Chlamydia pneumoniae IgG, inflammatory oxidative damage marker, and oxidized LDL, and improved tissue oxygenation and flow-mediated dilation. Lactolycopene showed no significant changes.
Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial.
RCT investigating the effects of lycopene and green tea supplementation on the serum metabolome of 128 men at risk of prostate cancer. Lycopene supplementation altered metabolites such as acetate, valine, pyruvate, and docosahexaenoic acid. Mendelian randomisation suggested a causal relationship between reduced pyruvate levels and decreased prostate cancer risk.
A comparative study to evaluate the efficacy of lycopene and curcumin in oral submucous fibrosis patients: A randomized clinical trial
RCT comparing the efficacy of lycopene and curcumin in 60 oral submucous fibrosis patients. Lycopene showed better results than curcumin in improving mouth opening, while both substances were equally effective in decreasing burning sensation.
Modulatory effect of lycopene against carbofuran toxicity in African catfish, Clarias gariepinus.
The study investigated the modulatory effect of lycopene against carbofuran toxicity in African catfish. Lycopene administration alleviated the negative effects of carbofuran on biochemical and oxidative stress biomarkers, with improvements more pronounced at higher doses. Lycopene reduced behavioral changes, histopathological alterations, and restored altered biochemical parameters and antioxidant biomarkers to near normal levels.
Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA.
RCT of 79 prostate cancer patients testing a lycopene-rich tomato intervention on PSA levels. No overall difference in PSA changes between intervention and control groups, but significant PSA decrease in intermediate risk patients and those with high plasma lycopene levels.
Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β-carotene, and Lactobacillus johnsonii: results from a randomized, placebo-controlled, double-blinded study.
RCT assessing the efficacy of a nutritional supplement containing lycopene, β-carotene, and Lactobacillus johnsonii in reducing skin lesions induced by UVA1 exposure in 60 PLE patients. The supplement significantly reduced PLE scores after one exposure and decreased ICAM-1 mRNA expression, indicating protection against UVA-induced PLE lesions.
Nutrition intervention to decrease symptoms in patients with advanced heart failure.
This double-blind, placebo-controlled RCT tests a 6-month nutrition intervention combining dietary sodium reduction with lycopene and omega-3 fatty acid supplementation in 175 patients with advanced heart failure. The study aims to assess effects on symptom burden, health-related quality of life, and time to heart failure rehospitalization or all-cause death.
A phase II randomised double-blind placebo-controlled clinical trial investigating the efficacy and safety of ProstateEZE Max: a herbal medicine preparation for the management of symptoms of benign prostatic hypertrophy.
Phase II randomized double-blind placebo-controlled clinical trial evaluating ProstateEZE Max, a herbal preparation, in 57 men with benign prostate hypertrophy. The active group showed significant reductions in IPSS scores and urinary frequency compared to placebo over 3 months.
Gene Expression and Biological Pathways in Tissue of Men with Prostate Cancer in a Randomized Clinical Trial of Lycopene and Fish Oil Supplementation
RCT examining the effects of lycopene and fish oil supplementation on prostate gene expression in 84 men with low risk prostate cancer. No significant individual genes were associated with supplementation, but exploratory pathway analyses suggested modulation of androgen and estrogen metabolism, arachidonic acid metabolism, and Nrf2-mediated oxidative stress response.
Oxidative and antioxidant status in plasma of runners: effect of oral supplementation with natural antioxidants.
RCT investigating the effect of oral supplementation with lycopene and isoflavones on plasma antioxidant capacity and oxidative stress markers in long distance runners. Supplementation significantly reduced lipid peroxidation and enhanced plasma nonproteic antioxidant defense.
A randomized trial of lycopene supplementation in Tobago men with high prostate cancer risk.
This unblinded, randomized Phase I clinical trial evaluated lycopene supplementation in 81 Afro-Caribbean men with high prostate cancer risk. The study found that while serum lycopene levels doubled in the intervention group, serum PSA levels declined initially but returned to baseline by month 4, showing no significant long-term effect of lycopene on PSA levels.
Efficacy of lycopene in the management of oral submucous fibrosis.
RCT evaluating the efficacy of oral lycopene therapy in 58 patients with oral submucous fibrosis. Patients were divided into three groups: lycopene, lycopene with steroid injections, and placebo. Mouth-opening values increased significantly in the lycopene groups compared to placebo, suggesting lycopene as a potential first-line therapy.
Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.
RCT investigating the photoprotective effects of synthetic lycopene, Lyc-o-Mato, and Lyc-o-Guard-Drink on UV-light-induced erythema. After 12 weeks, significant increases in serum lycopene, phytofluene, and phytoene levels were observed, with a decrease in erythema intensity, particularly in the Lyc-o-Mato and Lyc-o-Guard-Drink groups.
The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial.
This randomized, double-blind, placebo-controlled trial evaluated the effect of lycopene supplementation on spermatogram and seminal oxidative stress in 44 infertile men with oligozoospermia. The lycopene group showed significant improvements in total sperm count, concentration, and oxidative stress biomarkers compared to placebo.
Lycopene dietary intervention: a pilot study in patients with heart failure.
Pilot RCT of 40 heart failure patients testing lycopene dietary intervention via V8 juice. Plasma lycopene levels increased in the intervention group, and C-reactive protein levels decreased significantly in women, suggesting a positive effect on inflammation and heart health.
Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia.
RCT investigating the relevance of plasma and prostate concentration of lycopene after a lycopene-enriched diet in 32 patients with high-grade prostatic intraepithelial neoplasia (HGPIN). Prostatic lycopene concentration below a 1 ng/mg threshold was associated with prostate cancer at 6-month follow-up biopsy, but no overall benefits from lycopene supplementation were observed in terms of HGPIN progression to prostate cancer.
Lycopene in the management of oral lichen planus: a placebo-controlled study.
This prospective, randomized, double-blind, placebo-controlled study assessed the efficacy of systemic lycopene in managing oral lichen planus (OLP) in 30 patients. Lycopene showed a higher reduction in burning sensation and overall treatment response compared to placebo, indicating its effectiveness in OLP management.
Cutaneous lycopene and beta-carotene levels measured by resonance Raman spectroscopy: high reliability and sensitivity to oral lactolycopene deprivation and supplementation.
A double-blind placebo-controlled randomized study in 25 volunteers assessed the effects of oral lactolycopene supplementation on skin and plasma levels of lycopene and beta-carotene. The study found that cutaneous levels of these carotenoids were sensitive to lycopene deprivation and supplementation, with oral intake of lactolycopene enriching both lycopene and beta-carotene levels in the skin.
Results of a Randomized Clinical Trial of the Action of Several Doses of Lycopene in Localized Prostate Cancer: Administration Prior to Radical Prostatectomy
Phase II RCT evaluating the safety and effect of lycopene supplementation in 45 men with localized prostate cancer. Lycopene increased plasma levels without toxicity, decreased serum free testosterone, and increased total estradiol, but did not significantly affect PSA or Ki-67 compared to control.
Dietary tomato paste protects against ultraviolet light-induced erythema in humans.
RCT investigating the effect of dietary tomato paste, a natural source of lycopene, on UV-induced erythema in humans. Over 10 weeks, 9 volunteers consumed tomato paste, resulting in a 40% reduction in erythema compared to controls who received olive oil only. Serum lycopene levels increased in the supplemented group.
Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers.
RCT examining the effect of increased intake of carotenoid-rich vegetables on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. Nonsmokers showed a significant increase in LDL resistance to oxidation with lycopene supplementation, while smokers did not.
Preparation of microgels loaded with lycopene/NMN and their protective mechanism against acute liver injury.
The study investigated the protective effects of microgels loaded with lycopene and NMN against LPS-induced acute liver injury in mice. The microgels significantly reduced liver injury, inflammation, and oxidative stress, and regulated the gut microbiota by enriching beneficial bacteria and reducing harmful ones.
Assessment of Antimicrobial Activity of Lycopene, Vitamin E, and Lycopene-Vitamin E Combination Against Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis, and Candida albicans: An In Vitro Study
In vitro study assessing the antimicrobial activity of lycopene, vitamin E, and their combination against oral pathogens. The combination showed the highest antimicrobial effect, with C. albicans being the most susceptible. Vitamin E had the least antimicrobial effect.
Facilitating Pro-survival Mitophagy for Alleviating Parkinson's Disease via Sequence-Targeted Lycopene Nanodots.
The study synthesized lycopene nanodots using recombinant human H-ferritin nanocages for targeted delivery to neurons. These nanodots protect neuronal mitochondrial function and promote mitophagy, alleviating Parkinson-like symptoms in model mice.
Comparative Potential of Zinc Sulfate, L-Carnitine, Lycopene, and Coenzyme Q10 on Cadmium-Induced Male Infertility
The study investigated the effects of coenzyme Q10, lycopene, L-carnitine, and zinc sulfate on cadmium-induced infertility in male Wistar rats. All treatments improved sperm count, morphology, serum testosterone, and reduced testicular oxidative stress. Lycopene and a high-dose combination of L-carnitine and CoQ10 were most effective in treating cadmium-induced infertility.
NLRP3 inflammasome is involved in the mechanism of the mitigative effect of lycopene on sulfamethoxazole-induced inflammatory damage in grass carp kidneys.
The study investigates the mitigative effect of lycopene on sulfamethoxazole-induced renal inflammatory injury in grass carp. Lycopene administration alleviated oxidative stress and inflammation markers, suggesting a protective effect against kidney damage caused by sulfamethoxazole.
Dietary Lycopene Supplementation Could Alleviate Aflatoxin B1 Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers
The study evaluated the effects of lycopene supplementation on intestinal immune function, barrier function, and antioxidant capacity in broilers fed with an aflatoxin B1 contaminated diet. Lycopene supplementation improved intestinal health by reducing inflammatory cytokines and enhancing antioxidant enzyme activities, suggesting it can alleviate AFB1-induced damage.
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
The study explored the therapeutic effect of lycopene on sulfamethoxazole-induced intestinal injury in grass carp. Lycopene significantly suppressed intestinal epithelial cell damage, reduced oxidative stress, inflammation, and apoptosis, and restored autophagy-related gene expression to original levels.
Bioremediation of hemotoxic and oxidative stress induced by polyethylene microplastic in Clarias gariepinus using lycopene, citric acid, and chlorella.
The study investigated the protective role of lycopene, citric acid, and chlorella against microplastic-induced toxicity in African catfish. Co-treatment with these supplements ameliorated hematological, biochemical, and erythron profile alterations, and slightly enhanced antioxidant activity.
Lycopene Reduces Cholesterol Absorption and Prevents Atherosclerosis in ApoE-/- Mice by Downregulating HNF-1α and NPC1L1 Expression.
The study investigated the effects of lycopene supplementation on cholesterol absorption and atherosclerosis in ApoE-/- mice fed a high-fat diet. Lycopene reduced serum total cholesterol and LDL-C levels, increased HDL-C levels, and decreased atherosclerotic lesions by downregulating NPC1L1 and HNF-1α expression.
Lycopene and bone: an in vitro investigation and a pilot prospective clinical study
The study investigated the effects of lycopene on osteoblast cells and bone health in postmenopausal women. Lycopene activated the WNT/β-catenin and ERK1/2 pathways, upregulated RUNX2, alkaline phosphatase, COL1A, and downregulated RANKL in Saos-2 cells. In a pilot clinical study, lycopene-rich tomato sauce intake prevented bone density loss in postmenopausal women compared to controls.
Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factor-kappa B (NF-κB) pathway
In vitro study on HeLa cells showing that lycopene acts synergistically with cisplatin to inhibit cervical cancer cell growth. Lycopene increased Bax expression, decreased Bcl-2 expression, activated Nrf2, and suppressed NF-κB signaling, enhancing the anticancer effects of cisplatin.
Enhanced antitumor efficacy and attenuated cardiotoxicity of doxorubicin in combination with lycopene liposomes
The study evaluated lycopene-loaded liposomes (L-LYC) for their effects on the antitumor efficacy and cardiotoxicity of doxorubicin (DOX). L-LYC combined with DOX showed increased cytotoxicity in vitro and reduced tumor size in B16 melanoma-bearing mice in vivo. Additionally, L-LYC decreased DOX-induced cardiotoxicity.
Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
The study investigates the cancer preventive effects of lycopene on chemically-induced cutaneous tumors in mice and cell models. Lycopene was found to attenuate tumor incidence and multiplicity by enhancing the activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation.
Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair
In vitro study on A549 human lung cancer epithelial cells showing that lycopene at lower doses inhibits cigarette smoke-induced oxidative stress and promotes genome stability by increasing DNA repair enzyme expression. Lycopene was more effective in smoke-exposed cells than in non-exposed cells.
Lycopene isomerisation takes place within enterocytes during absorption in human subjects.
The study investigates lycopene isomerisation during absorption in human subjects, using in vitro and in vivo models. It finds that lycopene isomerisation occurs inside intestinal cells, resulting in 29% of lycopene as Z-isomers, with no selection in the release of lycopene isomers from enterocytes.
Ingestion by men of a combined dose of beta-carotene and lycopene does not affect the absorption of beta-carotene but improves that of lycopene.
A double-blind study in 10 healthy men investigated serum responses after ingestion of individual and combined doses of beta-carotene and lycopene. The study found that a combined dose improved lycopene absorption but had little effect on beta-carotene absorption.
Lycopene: A Potent Antioxidant with Multiple Health Benefits
This narrative review discusses lycopene, a carotenoid found in tomatoes, and its health benefits as a dietary supplement. Lycopene mitigates oxidative stress-induced metabolic dysfunctions and diseases, including inflammation, obesity, and diabetes mellitus, and has protective effects on various organs and systems.
Nutraceutical delivery systems to improve the bioaccessibility and bioavailability of lycopene: A review
The review discusses the challenges of lycopene's low water solubility and stability, which limit its oral bioavailability. It explores various delivery systems like emulsions, micelles, and nanoparticles to improve lycopene's stability and bioavailability, aiming to enhance its health benefits. The paper also highlights the need for further safety and in vivo studies.
The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
The paper reviews the antioxidant activity of lycopene and its potential health-promoting effects, including inhibiting the development of cardiovascular diseases, nervous system diseases, diabetes, liver diseases, and ulcerative colitis. It highlights the need for more human research to confirm lycopene's effectiveness in treating conditions marked by chronic inflammation and oxidative stress.
Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases
This narrative review discusses the protective and ameliorative effects of lycopene on coronary artery disease and hypertension. Lycopene is highlighted as a potent antioxidant that interacts with reactive oxygen species, reduces blood pressure, and improves lipid profiles, thereby minimizing atherosclerosis and protecting against cardiovascular diseases.
Lycopene in the Prevention of Cardiovascular Diseases
This narrative review discusses the role of lycopene, a carotenoid with high antioxidant potential, in the prevention of cardiovascular diseases. It highlights the beneficial effects of lycopene consumption on heart health, despite some controversies in the literature.
Lycopene: A Potent Antioxidant for the Amelioration of Type II Diabetes Mellitus
This review summarizes the characteristics and mechanisms of action of lycopene as a potent antioxidant for type II diabetes mellitus (T2DM). It highlights evidence from animal and human studies on lycopene's effects on glycemic control and oxidative stress biomarkers in T2DM.
Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
Narrative review of lycopene, a carotenoid with strong antioxidant properties, highlighting its ability to protect lipids, proteins, and DNA from oxidative damage. Lycopene is reported to hinder cancer cell proliferation and delay cell cycle progression, contributing to its antitumor activity.
Lycopene: A Critical Review of Digestion, Absorption, Metabolism, and Excretion
This literature review examines the digestion, absorption, metabolism, and excretion of lycopene, a non-provitamin A carotenoid. It discusses the correlation between lycopene intake and reduced risk of chronic diseases, the role of genetic and dietary factors in lycopene bioavailability, and the enzymatic cleavage of lycopene by BCO1 and BCO2.
A narrative review on the potential of tomato and lycopene for the prevention of Alzheimer’s disease and other dementias
Narrative review analyzing evidence on the beneficial effects of tomatoes and lycopene on Alzheimer's disease-related processes or risk factors. The review suggests that increasing tomato intake may enhance cognitive performance and reduce cardiovascular and neoplastic risk, but extensive research is needed to confirm these effects in humans.
Lycopene: Food Sources, Biological Activities, and Human Health Benefits
This narrative review discusses the antioxidant potential and cardiovascular protection mechanism of lycopene. Lycopene, primarily found in tomatoes, is associated with positive effects on serum lipid levels, endothelial dysfunction, inflammation, blood pressure, and antioxidative potential, contributing to heart health.
New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
This review discusses the anti-cancer activities of lycopene, highlighting its ability to suppress oncogene expressions, induce proapoptotic pathways, and modulate immune cells to suppress tumor growth. Lycopene's role in resolving inflammation and its special role in suppressing lung cancer are also explored.
Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives.
This narrative review discusses recent mechanistic and epidemiological studies on the health benefits of dietary lycopene in reducing the risk and complications of chronic diseases such as cardiovascular diseases, cancer, and neurodegenerative disorders. Lycopene's antioxidant properties may alleviate proinflammatory mediators and prevent NF-κB activation, contributing to its protective effects.
Lycopene and resveratrol ameliorate zinc oxide nanoparticles-induced oxidative stress in Nile tilapia, Oreochromis niloticus.
The study examined the ameliorative effects of dietary supplementation of lycopene and/or resveratrol against zinc oxide nanoparticles-induced oxidative stress in Nile tilapia. Results showed that lycopene and resveratrol reduced oxidative stress markers and improved liver and kidney function, likely due to their antioxidant activities.