Research
Luteolin
12 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Global research landscape and multisystem health mechanisms of luteolin: a comprehensive bibliometric and network pharmacology study.
This study uses bibliometric and network pharmacology methods to analyze luteolin research trends, knowledge structure, and biological mechanisms from 2000 to 2025. It highlights luteolin's potential in nutritional health and disease prevention, identifying 239 potential targets and associations with various health conditions.
Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review.
This meta-analysis and systematic review assessed the effects of luteolin (LUT) in ulcerative colitis (UC) animal models. LUT significantly improved colon length, reduced disease activity index, alleviated body weight loss, and decreased histological scores. It exerted effects through antioxidant, anti-inflammatory, immunomodulatory, and barrier-protective mechanisms, though it had no significant impact on the α-diversity of the intestinal microbiota.
Molecular mechanisms and therapeutic perspectives of luteolin on diabetes and its complications.
Systematic review evaluating luteolin's antidiabetic potential and its effects on diabetic complications such as cardiomyopathy, nephropathy, and osteopathy. Luteolin shows strong antidiabetic properties by regulating intestinal homeostasis, lipogenesis, carbohydrate absorption, and reducing inflammation, oxidative stress, apoptosis, and autophagy.
Effects of luteolin on sepsis: A comprehensive systematic review.
Systematic review of 33 articles on luteolin's effects on sepsis. Luteolin was found to reduce inflammation and oxidative stress, control immune response, and prevent organ damage through various pathways. Large-scale in vivo experiments are recommended to further explore its potential impacts on sepsis.
Nano-scale drug delivery systems for luteolin: advancements and applications.
Systematic review of nano-scale drug delivery systems for luteolin, focusing on advancements and applications. Discusses the use of nanocarriers to enhance solubility, prolong circulation time, and improve targeting ability of luteolin, addressing its limitations such as poor water solubility and low bioavailability.
Role of microRNAs in the anticancer effects of the flavonoid luteolin: a systematic review.
This systematic review discusses the role of microRNAs in the anticancer effects of the flavonoid luteolin. Luteolin exhibits anticancer properties through mechanisms such as cell apoptosis induction and inhibition of invasion and proliferation. The review highlights the potential of miRNAs as therapeutic targets in cancer treatment.
A Randomized Comparative Study of Luteolin-Based Herbal Unani FormulationsNitrofurantoin in Women with Uncomplicated Urinary Tract Infections.
A randomized, standard-controlled study comparing a luteolin-based Unani herbal formulation to nitrofurantoin in 66 women with uncomplicated urinary tract infections. Both groups showed significant improvement in UTISA scores and HRQoL, with no adverse effects reported. The herbal formulation was as effective as nitrofurantoin, suggesting luteolin's antimicrobial potential.
Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives.
This paper provides a comprehensive review of analytical methods developed for the quantitative determination of luteolin and its derivatives, including orientin, isoorientin, and luteolin 7-O-glucoside. It covers various chromatographic techniques such as TLC, HPTLC, LC, HPLC, GC, and CCC used in analyzing luteolin in plant material.
Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations.
The study examined the effects of co-ultramicronized PEALut in a murine model of delirium and in elderly hip fractured patients. In mice, co-ultraPEALut improved cognitive dysfunctions, reduced inflammation and apoptosis, and stimulated antioxidant response. In the clinical study, Glialia administration prevented the onset of postoperative delirium and reduced symptom intensity and duration in surgical patients.
An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders.
Open-label pilot study of a dietary supplement containing luteolin, quercetin, and rutin in 50 children with autism spectrum disorders over 26 weeks. Significant improvements were observed in adaptive functioning and overall behavior, with transient increased irritability in some participants.
Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men.
RCT with 12 physically active men testing the effects of mangiferin and luteolin supplementation on exercise performance. Both acute and prolonged supplementation enhanced performance, muscle oxygen extraction, and brain oxygenation during sprint exercise at both high and low doses.
Molecular Mechanisms ofExtract in Breast Cancer: Targeting EGFR/TP53 and PI3K-AKT-mTOR Signaling via ROS-Mediated Apoptosis.
The study investigates the anticancer mechanisms of Lamium extract (LNE) in breast cancer. LNE induces ROS-dependent mitochondrial apoptosis in MDA-MB-231 cells by suppressing EGFR/PI3K/AKT signaling and activating TP53-mediated apoptosis. In vivo, LNE suppressed tumor growth and lung metastasis in a 4T1 orthotopic model in BALB/c mice.