Research
Lion's Mane
60 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Unveiling the role of erinacines in the neuroprotective effects of Hericium erinaceus: a systematic review in preclinical models
Systematic review of preclinical studies on Hericium erinaceus (lion's mane) and its erinacines, highlighting their neuroprotective effects in animal models. Erinacines A and C were found to induce antioxidant responses, enhance neurogenesis, and improve cognitive and behavioral outcomes, suggesting potential benefits for neurodegenerative conditions.
Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
This systematic review investigates the clinical use of Hericium erinaceus (Lion's Mane mushroom), highlighting its neuroprotective, anti-tumor, antioxidant, and anti-inflammatory effects. The review includes results from RCTs and laboratory studies, showing cognitive improvements, increased gut microbiota diversity, and reduced symptoms of depression and anxiety. Potential side effects include stomach discomfort, headache, and allergic reactions.
Use of Hericium erinaceus as a potential therapeutic of mental disorders: a systematic review
Systematic review of Hericium erinaceus (Lion's Mane) for mental disorders, including cognitive decline and Alzheimer's disease. Three Japanese RCTs showed HE can be useful for cognitive impairment but not effective for depression/anxiety symptoms. More studies are needed for conclusive evidence.
Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study
This double-blind, randomized, placebo-controlled cross-over study investigated the acute effects of Hericium erinaceus (Lion's Mane mushroom) extract on cognition and mood in 18 healthy young adults. The study found no significant overall improvement in cognitive performance and mood, although there was improved performance on the pegboard test at 90 minutes post-consumption.
Effect of Adding Lion’s Mane (Hericium erinaceus) and Reishi Mushroom (Ganoderma Lucidum) to Broiler Diets on the Productive Performance
The study investigated the effects of supplementing broiler diets with Lion’s mane (Hericium erinaceus) and Reishi Mushroom (Ganoderma lucidum) on productive performance. Treatments with Lion’s mane and Reishi Mushroom showed significant improvements in body weight, feed consumption ratio, and feed conversion ratio compared to the control group.
The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study.
This pilot study investigated the acute and chronic effects of Lion's Mane mushroom supplementation on cognitive function and mood in 41 healthy young adults. Results showed improved performance speed on the Stroop task after a single dose and a trend towards reduced subjective stress after 28 days, though findings were tentative due to the small sample size.
Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition.
A single-blind, placebo-controlled study evaluated the effects of Hericium erinaceus supplementation on metabolic flexibility and cognition in 24 participants. The study found no significant effects from ingesting 10 g of Hericium erinaceus per day for 4 weeks on these markers.
Improvement of cognitive functions by oral intake of Hericium erinaceus.
RCT evaluating the cognitive function improvement by taking supplements containing Hericium erinaceus for 12 weeks. The study found that oral intake of H. erinaceus significantly improved cognitive functions as measured by the Mini Mental State Examination (MMSE).
The Lignicolous Fungus Hericium erinaceus (Lion's Mane Mushroom): A Promising Natural Source of Antiradical and DPPH Inhibitory Agents
The study evaluates the nutraceutical and pharmaceutical properties of Hericium erinaceus (Lion's Mane Mushroom) using enriched agricultural waste. It assesses the mineral and mycochemical content of mushroom samples, highlighting the highest phenol and flavonoid contents from specific substrate combinations.
Functional and Nutritional Properties of Lion’s Mane Mushrooms in Oat-Based Desserts for Dysphagia and Healthy Ageing
The study investigated the use of Lion’s Mane mushroom as a functional ingredient in oat milk-based desserts for individuals with dysphagia. Incorporation of Lion’s Mane powder improved nutritional composition and maintained texture and sensory characteristics, supporting healthy ageing and offering potential neuroprotective benefits.
Lion’s Mane (Hericium erinaceus (Bull.) Pers.) as a functional component for wheat bread production: influence on physicochemical, antioxidant, and sensory properties
The study evaluated the use of Lion’s Mane for fortifying wheat bread, analyzing its impact on dough properties, bread quality, and sensory attributes. Lion’s Mane addition improved dough stability and nutritional profile, particularly increasing polyphenol content and antioxidant activity, suggesting its potential for bakery product enhancement.
Combining Deep Learning and Structural Modeling to Identify Potential Acetylcholinesterase Inhibitors from Hericium erinaceus
The study uses a computational approach combining deep learning and structural modeling to identify potential acetylcholinesterase inhibitors from Hericium erinaceus. Two compounds, erinacerin A and hericenone B, were identified as promising candidates for further research into Alzheimer's disease symptom alleviation.
Bioactive compounds and antioxidant activity of Lion’s Mane mushroom (Hericium erinaceus) from different growth periods
The study investigated the bioactive compounds and antioxidant activity of Lion’s Mane mushroom (Hericium erinaceus) at different growth periods. The 14-days sample had the highest concentrations of bioactive compounds, while the 21-days sample showed the highest antioxidant activity. The findings suggest that growth periods affect the bioactive content and antioxidant properties of the mushroom.
A comparative study of conventional and supercritical carbon dioxide extraction methods for the recovery of bioactive compound from Lion’s Mane mushroom (Hericium erinaceus)
The study compares conventional solvent extraction and supercritical fluid extraction using carbon dioxide for recovering bioactive compounds from Lion’s Mane mushroom. SCFE-CO2 methods showed higher recovery of ergosterol and hericenone C, with significant antioxidant activity at higher extraction conditions.
Mycochemical Profiling and Antioxidant Activity of Two Different Tea Preparations from Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).
The study compared two tea preparations, infusion and decoction, from Hericium erinaceus, a medicinal mushroom. Both teas were rich in bioactive mycochemicals and exhibited antioxidant properties, with the infusion showing better results than the decoction.
Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.
RCT of 30 females assessing the effects of Hericium erinaceus intake on menopause, depression, sleep quality, and indefinite complaints. The HE group showed significant reductions in depression and anxiety scores compared to placebo, suggesting potential benefits for mood and stress.
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.
A double-blind, placebo-controlled trial on 30 Japanese men and women with mild cognitive impairment tested the efficacy of Yamabushitake (Hericium erinaceus) for cognitive improvement. The Yamabushitake group showed significantly increased cognitive function scores compared to placebo, with improvements correlating with the duration of intake. No adverse effects were observed.
EFFECT OF ADDING A MIXTURE OF LION’S MANE HERICIUM ERINACEUS AND REISHI MUSHROOM GANODERMA LUCIDUM TO BROILER DIETS ON THE PRODUCTIVE PERFORMANCE
The study investigated the effect of adding a mixture of Lion’s Mane (Hericium erinaceus) and Reishi Mushroom (Ganoderma lucidum) to broiler diets on productive performance. 120 Ross 308 broiler chicks were used, with treatments including different proportions of the mushrooms. Results showed significant improvements in body weight, feed conversion ratio, and carcass weight in certain treatment groups compared to the control.
Metabolites of Culinary-medicinal Mushroom Hericium erinaceus Showed Anti-neuroinflammatory Activity in BV2 Cells and Anti-H2O2-induced Oxidative Stress Activity in SH-SY5Y Cells
In vitro study of compounds isolated from Hericium erinaceus showing anti-neuroinflammatory activity in BV2 cells and protection against H2O2-induced oxidative stress in SH-SY5Y cells. Compounds 3 and 7 inhibited nitric oxide production and regulated apoptosis-related proteins, suggesting potential therapeutic effects for oxidative stress-associated diseases.
Identification and Reconstitution of the First Two Enzymatic Steps for the Biosynthesis of Bioactive Meroterpenoids from Hericium erinaceus (Lion’s Mane Mushroom)
The study identifies and reconstitutes the first two steps of the biosynthetic pathway of hericenones from Hericium erinaceus using heterologous expression in Aspergillus oryzae. This research aims to enable large-scale production of hericenones, which are associated with brain health benefits.
The Influence of Polysaccharide Fractions of the Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) on the Immunomodulatory and Antioxidant Activity of Neutrophils Exposed to Stress of Different Durations.
Polysaccharide fractions from the mycelium of lion's mane mushroom were tested for their effects on neutrophils under cold stress. The fraction grown on rye showed high phagocytic, bactericidal, and antioxidant activity, suggesting immunomodulatory and antioxidant benefits.
Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages
The study evaluated the antioxidative and neuroprotective activities of micronized mycelium of Hericium erinaceus (HEM) in mice treated with MPTP. HEM improved dopamine levels and reduced oxidative damage markers in the liver and brain, while enhancing antioxidant enzyme activities.
Effects of Dietary Supplementation with In Vitro-Cultivated Arboreal Medicinal Mushrooms on Long-Term Memory and Anxiety-Like Behavior of Male Mice.
Animal study comparing dietary supplementation with Lion's mane, agarikon, or pink oyster mushrooms on long-term memory and anxiety-like behavior in male mice. Only Lion's mane improved long-term memory, with no effect on anxiety-like behavior. Weight gain correlated with lower expression of Gsk3β and Mtor in hippocampi.
Optimization of vegetative growth conditions for submerged cultivation of edible medicinal mushroom Hericium erinaceus through resonance surface methodology
The study aimed to optimize vegetative growth conditions for the edible medicinal mushroom Hericium erinaceus, known as Lion's mane. Using the Box Behnken Design, 17 trial runs were conducted to assess the effects of pH, temperature, and agitation on biomass production in submerged conditions. The optimal conditions for maximum biomass production were identified as 24.4°C, pH 6.4, and 147.4 rpm agitation.
Antibiofilm activity and bioactive phenolic compounds of ethanol extract from the Hericium erinaceus basidiome
The study investigated the antibiofilm activity of Hericium erinaceus (lion's mane mushroom) against biofilm-forming pathogenic bacteria, identifying its phenolic compound profile. P. mirabilis was the most susceptible bacteria to HE, and protocatechuic acid and p-coumaric acid were the most abundant phenolic compounds.
Ameliorating Effect of the Edible Mushroom Hericium erinaceus on Depressive-Like Behavior in Ovariectomized Rats.
The study investigated the effect of Hericium erinaceus (Lion's Mane mushroom) on depressive-like behavior in ovariectomized rats, a model for postmenopausal symptoms. The administration of HE reduced depressive-like behavior in the forced swim test, suggesting its potential for treating menopausal depression without the risk of carcinogenesis associated with ERα activation.
Lion’s Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model
This study assessed the effects of Hericium erinaceus (Lion's mane) on cognitive and non-cognitive behaviors in a mouse model of Alzheimer's disease with tau pathology. Mice given H. erinaceus showed anxiolytic effects, such as shorter latencies to enter the center of the open field and more time spent in the open arms of the elevated zero maze, but no improvements in spatial memory or activities of daily living.
Prospecting medicinal properties of Lion's mane mushroom.
The study investigated the bioactive components of Hericium erinaceus (Lion's mane mushroom) extracts using two solvents, evaluating their antioxidant, antimicrobial, and antiproliferative efficacy in vitro. The extracts showed significant antioxidant activity, antibacterial effects, and cytotoxicity towards lung adenocarcinoma cells, suggesting potential therapeutic benefits.
Evaluation of In Vitro Antioxidant and Antihyperglycemic Activities of Extracts from the Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).
In vitro study evaluating antioxidant and antihyperglycemic activities of Hericium erinaceus extracts. Ethyl acetate fraction showed strong inhibitory effects on α-amylase and α-glucosidase, while chloroform fraction had high radical scavenging abilities. Results suggest potential antihyperglycemic and antioxidant effects.
Screening and Comparison of Anti-Intestinal Inflammatory Activities of Three Polysaccharides from the Mycelium of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).
The study isolated three polysaccharides from the mycelium of Hericium erinaceus and assessed their chemical properties and anti-inflammatory activities. wHEP-1 showed the best anti-inflammatory activity in LPS-induced Caco-2 cells and a rat model, suggesting potential for alternative therapies.
Liver and Brain Protective Effect of Sulfated Polysaccharides from Residue of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), on D-Galactose-Induced Aging Mice.
The study investigates the antioxidant and antiaging effects of sulfated polysaccharides from Hericium erinaceus on D-galactose-induced aging mice. SHRPs were found to alleviate aging properties by scavenging radicals, elevating enzyme activities, and reducing malondialdehyde content, improving serum biochemical indices, and enhancing immunological activity. Liver and brain injuries in mice were remitted by SHRP interventions.
Impact of different additives on spawn production of different strains of lion’s mane mushroom (Hericium Spp.)
The study investigated the effect of organic and inorganic additives on the mycelium growth of Lion’s Mane Mushroom (Hericium Spp.). Organic additives like pigeon pea flour and rice flour, and inorganic additive MgSO4 were tested for spawn production. Maximum mycelial growth was observed in strain He-02 with these supplements.
Effect of the methanol extract of the Lion's Mane mushroom, Hericium erinaceus, on bone metabolism in ovariectomized rats
Animal study investigating the effect of Hericium erinaceus (Lion's Mane mushroom) on bone metabolism in ovariectomized rats. The study found that H. erinaceus does not prevent but rather accelerates bone loss in these rats.
Characterization of α-glucosidase inhibitory constituents of the fruiting body of lion's mane mushroom (Hericium erinaceus).
The study characterized α-glucosidase inhibitory constituents of lion's mane mushroom (Hericium erinaceus), identifying ten compounds including four new ones. Several compounds demonstrated strong inhibition of α-glucosidase activity, supporting the traditional use of H. erinaceus for treating diabetes and metabolic diseases.
Effects of Extraction Conditions on Crude Polysaccharides and Antioxidant Activities of the Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).
The study investigates the influence of extraction conditions on the polysaccharide content and antioxidant activities of Hericium erinaceus using response surface methodology. It finds that extraction temperature is the dominant factor affecting polysaccharide content and antioxidant activities, with different extraction conditions yielding components with diverse antioxidant mechanisms.
Morphology, anticancer and neurological activities of Hericium erinaceus.
Narrative review of Hericium erinaceus (Lion's Mane) examining its bioactive compounds and therapeutic capabilities, focusing on antiproliferative and neuroprotective effects. The review highlights its antimicrobial, anti-hypertensive, anti-diabetic, wound-healing, anti-cancer, immunomodulatory, hypolipidemic, antioxidant, and neuroprotective properties.
The Usage of Lion’s Mane in Sports and Its Metabolic Impact – a literature review
This literature review explores the potential applications of lion's mane (Hericium erinaceus) in sports and metabolic health, highlighting its antioxidant, anti-inflammatory, and cognitive-enhancing properties. The review identifies promising findings in cognitive function, oxidative stress reduction, and glucose metabolism, but notes limited direct evidence on athletic metrics such as endurance, strength, or recovery times.
Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review
Narrative review of Hericium erinaceus (lion's mane mushroom) highlighting its antioxidant, anti-inflammatory, and antimicrobial activities. The review discusses its potential in neuroprotection and managing neurodegenerative diseases, as well as its bioactive compounds and future research directions.
Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A Narrative Review.
Narrative review investigating Hericium erinaceus (HE) as a potential therapeutic treatment for Alzheimer's disease. The review includes 3 human clinical trials and 13 animal-model studies, highlighting HE's neurotrophic and neuroprotective properties and its potential to improve cognitive function. Erinacine A enriched HE shows the highest bioactive potency.
Unlocking the potential of Lion’s Mane Mushroom (Hericium erinaceus)
This narrative review explores the potential of Lion's Mane mushroom (Hericium erinaceus) in cognitive health, mood disorders, and immune system support. It highlights the neuroprotective properties and bioactive compounds of the mushroom, suggesting its role in addressing neurodegenerative conditions, mood disorders, and chronic diseases.
A review of the effects of mushrooms on mood and neurocognitive health across the lifespan.
This narrative review evaluates epidemiological and clinical studies on the effects of mushrooms, particularly Lion's Mane, on neurocognition and mood. Epidemiological studies showed significant benefits of dietary mushrooms on cognition and mood, while intervention studies had mixed results.
Some Applications of Hericium erinaceus Mushrooms: A Review
This review examines the potential health benefits of Hericium erinaceus, also known as Lion's Mane mushroom, focusing on its therapeutic uses in disease control. It discusses its anti-inflammatory, neuro-protective, anti-oxidant, and immune-modulatory effects, highlighting its potential as a natural remedy for various illnesses.
Neuroprotective and Cognitive Benefits of Hericium erinaceus: A Comprehensive Review of Recent Clinical Studies
This narrative review examines recent clinical studies on Hericium erinaceus (Lion's Mane) supplementation, highlighting its neuroprotective potential and cognitive benefits. The review analyzes studies with interventions lasting from 4 to 49 weeks, showing improvements in cognitive test scores and increased serum levels of brain-derived neurotrophic factor. One study also noted enhanced gut microbiota diversity, suggesting a gut-brain axis mechanism. Adverse effects were rare, with mild gastrointestinal discomfort reported.
Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?
Narrative review summarizing the current state of knowledge on Hericium erinaceus dietary supplementation and its therapeutic potential in clinical settings. The review highlights preclinical studies showing neuroprotective effects in conditions like Alzheimer's, depression, and Parkinson's, and calls for more clinical trials to establish safety and efficacy.
Lion’s Mane Mushroom- From Culinary to Medicine
The article explores Lion's Mane mushroom, highlighting its nutritional composition and potential health benefits, including positive impacts on brain health, mood stabilization, gastric health, heart health, blood sugar regulation, cancer prevention, and immunity enhancement. It emphasizes Lion's Mane as a safe dietary supplement with minimal side effects.
Lion’s Mane (Hericium erinaceus): A Potential Treatment for Neurologic Disorders in Veterinary Medicine
The paper reviews the potential of Lion’s Mane (Hericium erinaceus) in treating neurological disorders in veterinary medicine. It highlights the mushroom's bioactive compounds, such as hericenones and erinacines, which stimulate nerve growth factor and have neuroprotective actions.
ALSUntangled #73: Lion’s Mane
The paper reviews the potential benefits of Lion's Mane (Hericium erinaceus) in neurodegenerative diseases, highlighting its anti-inflammatory, neuroprotective, and neurite growth-promoting properties demonstrated in cell and animal models. A small trial showed temporary cognitive improvement in mild cognitive impairment, but no studies exist for ALS. Lion's Mane is generally safe, though one anaphylactic case was reported.
Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder
The paper reviews the potential of edible medicinal mushrooms as adjunctive treatments for major depressive disorder (MDD), focusing on Lion’s mane, Caterpillar mushroom, and Reishi. Preliminary studies suggest Lion’s mane may influence well-being, while results for Reishi are mixed and studies for Caterpillar mushroom are ongoing. The paper also discusses the role of 5-HTP in serotonergic neurotransmission related to MDD.
Therapeutic potential of Lion's Mane (Hericium erinaceus) in neurological and cognitive disorders - a review of the literature
Narrative review of scientific research on Hericium erinaceus (Lion's Mane) for neurological and cognitive disorders. Studies suggest potential benefits in treating depressive and cognitive disorders, Alzheimer's disease, and post-traumatic brain injury, primarily based on animal model experiments.
Online Survey for Patient Outcomes on Hericium Erinaceous Mushroom
The paper discusses Lion's Mane mushroom, also known as Hericium Erinaceous, and its history of use in traditional Chinese medicine. It is commonly found in over-the-counter health supplements in various forms.
Therapeutic Effect and Potential Mechanisms of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Submerged Culture on Ethanol-Induced Chronic Gastric Injury.
The study investigated the therapeutic effect of Hericium erinaceus mycelia on ethanol-induced chronic gastric injury in mice. HE mycelia showed therapeutic effects by ameliorating inflammation and regulating epidermal differentiation, with involvement of the p53 signaling pathway.
Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia
In vitro study of Hericium erinaceus (Lion's Mane Mushroom) extracts on HT22 hippocampal neurons and BV2 microglia. HE-ETH extract showed neuroprotective activity by increasing neuron viability and reducing oxidative stress markers. It also demonstrated anti-inflammatory effects by reducing nitric oxide levels in microglia.
In Vitro and In Vivo Inhibition of Helicobacter pylori by Ethanolic Extracts of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).
The study investigated the inhibitory effects of Hericium erinaceus (lion's mane mushroom) extracts on Helicobacter pylori. The extracts showed growth inhibition of H. pylori strains and reduced H. pylori adhesion to gastric epithelial cells. In mice, the extract reduced H. pylori colonization in the stomach.
Thirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats.
A 13-week subchronic rodent feeding study evaluated the safety of erinacine A-enriched Hericium erinaceus mycelia in Sprague-Dawley rats. No mortalities or noticeable toxicological effects were observed, and physiological, hematological, and biochemical parameters showed no significant differences between treatment and control groups, suggesting its safe use in food preparation.
The Antihyperlipidemic Effect of Lion’s Mane Mushroom ( Hericium erinaceus ) in Hyperlipidemic Rats Induced by High Fat and Cholesterol Diet
The study investigated the effects of Lion's Mane Mushroom (Hericium erinaceus) on lipid metabolism in hyperlipidemic rats induced by a high-fat and cholesterol diet. Rats fed with the mushroom showed significantly reduced body weight gain, serum total cholesterol, LDL-cholesterol, and atherogenic index compared to the high-fat control group, suggesting a positive effect on lipid metabolism.
Inhibitory Effect on In Vitro LDL Oxidation and HMG Co-A Reductase Activity of the Liquid-Liquid Partitioned Fractions of Hericium erinaceus (Bull.) Persoon (Lion's Mane Mushroom)
In vitro study evaluating the inhibitory effect of Hericium erinaceus fractions on LDL oxidation and HMG Co-A reductase activity. The hexane fraction showed the highest inhibition of LDL oxidation and HMG Co-A reductase activity, suggesting potential therapeutic benefits for preventing oxidative stress-mediated vascular diseases.
Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats
The study investigated the gastroprotective effects of aqueous extract of Hericium erinaceus against ethanol-induced ulcers in Sprague Dawley rats. The extract significantly reduced ulcer area and protected gastric mucosa by preventing antioxidant enzyme depletion and limiting malondialdehyde levels. Immunohistochemistry showed upregulation of HSP70 and downregulation of BAX protein in treated rats.
Therapeutic Potential of Hericium erinaceus for Depressive Disorder
This narrative review examines the potential benefits of Hericium erinaceus (Lion's mane mushroom) for treating depressive disorder. It discusses the bioactive compounds in H. erinaceus that promote neurotrophic factors and suggests its potential as an alternative treatment for depression.
Lion’s mane mushroom; new addition to food and natural bounty for human wellness: A review
This review article provides information on the nutritional and medicinal uses of lion's mane mushroom (Hericium erinaceus), highlighting its dietetic and pharmacological activities. It discusses the mushroom's rich content of proteins, carbohydrates, vitamins, minerals, and polysaccharides, which play roles in regulating and curing various diseases.
Neurological Activity of Lion’s Mane (Hericium erinaceus)
The paper reviews the neurological activity of Hericium erinaceus (lion's mane), highlighting its bioactive compounds with potential neuroprotective and neuroregenerative properties. It discusses the mushroom's anti-inflammatory effects and promotion of nerve growth factor gene expression, suggesting promise for treating Alzheimer's and Parkinson's diseases. The fungus was well tolerated in two clinical studies.