Research
Licorice Root
66 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Licorice and liver function in patients with primary liver disease: A systematic review and meta-analysis of RCTs.
This systematic review and meta-analysis evaluated the efficacy of licorice formulations on liver function enzymes in patients with primary liver disease. Analysis of 15 RCTs with 1367 participants showed that licorice significantly reduced ALT and AST levels compared to controls, with purified glycyrrhizic acid compounds being particularly effective. The safety profile was consistent with known mild side effects.
Effects of Licorice Functional Components Intakes on Blood Pressure: A Systematic Review with Meta-Analysis and NETWORK Toxicology.
Systematic review and meta-analysis of 8 RCTs with 541 participants investigating the effects of licorice functional components on blood pressure. Glycyrrhizic acid (GA) increased systolic and diastolic blood pressure, while licorice flavonoids (LF) had no significant effect. The hypertensive mechanism of GA may involve modulation of specific genes affecting nitrogen metabolism pathways.
COMPARATIVE EFFICACY OF THERAPEUTIC INTERVENTIONS FOR THE MANAGEMENT OF RECURRENT APHTHOUS ULCERS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.
Systematic review and network meta-analysis of 38 trials involving 2773 patients to assess the efficacy of interventions for recurrent aphthous ulcers. Diode laser and acacia nilotica with licorice formulation were among the most effective for reducing ulcer diameter. Most trials reported no adverse effects.
Topical Licorice for Aphthous: A Systematic Review of Clinical Trials.
Systematic review of clinical trials on the therapeutic effect of topical licorice for recurrent aphthous stomatitis (RAS). Six studies with 314 subjects showed licorice significantly reduces RAS pain, ulcer size, and healing time due to its anti-inflammatory, antioxidant, and antibacterial properties. Licorice was used in various forms, including paste, patch, and mouthwash, with no adverse effects reported.
Preclinical studies of licorice in ulcerative colitis: A systematic review with meta-analysis and network pharmacology.
This systematic review with meta-analysis and network pharmacology investigates the effects of licorice on ulcerative colitis in preclinical studies. Licorice extract and its active compounds showed strong therapeutic effects, including reduced histological scores, reversed colonic shortness, and decreased TNF-α levels, indicating anti-inflammatory, anti-oxidative stress, immunomodulatory effects, and microbiota homeostasis.
Comparative Efficacy of 6 Topical Pharmacological Agents for Preventive Interventions of Postoperative Sore Throat After Tracheal Intubation: A Systematic Review and Network Meta-analysis.
Systematic review and network meta-analysis of 62 RCTs comparing the efficacy of 6 topical pharmacological agents, including Glycyrrhiza, for preventing postoperative sore throat after tracheal intubation. Glycyrrhiza, along with corticosteroids, NSAIDs, and NMDA receptor antagonists, was associated with reduced postoperative pharyngeal pain across various time intervals.
Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data.
Systematic review of classical Chinese medicine and RCTs on licorice and jujube formula (LJF) for menopausal symptoms. LJF is historically used for menopause-like symptoms, with evidence suggesting potential improvements in sleep symptoms, but insufficient evidence for clinical recommendations.
Efficacy of Licorice Lollipops in Reducing Dental Caries in a Paediatric Population: A Systematic Review.
Systematic review assessing the efficacy of licorice lollipops in reducing dental caries in children. Licorice lollipops showed a promising effect in reducing caries by decreasing Streptococcus mutans counts in saliva. Further research with RCT designs and larger sample sizes is recommended.
Effectiveness of licorice in preventing dental caries in children: A systematic review.
Systematic review assessing the effectiveness of licorice in reducing Streptococcus mutans count and preventing dental caries in children. Licorice extracts are effective as an antimicrobial agent, reducing SM count and preventing an acidic environment that increases the risk of dental caries.
Topical application of licorice for prevention of postoperative sore throat in adults: A systematic review and meta-analysis.
Systematic review and meta-analysis of five RCTs involving 609 patients assessing the efficacy and safety of topical licorice for preventing postoperative sore throat in adults undergoing tracheal intubation. Topical licorice significantly reduced the incidence and severity of postoperative sore throat compared to non-analgesic control, with no significant adverse events reported.
Metabolic changes after licorice consumption: A systematic review with meta-analysis and trial sequential analysis of clinical trials.
Systematic review and meta-analysis of 26 clinical trials with 985 patients on licorice consumption. Licorice significantly reduces body weight and BMI but increases diastolic blood pressure, suggesting it should be avoided by hypertensive patients.
The association between consistent licorice ingestion, hypertension and hypokalaemia: a systematic review and meta-analysis.
Systematic review and meta-analysis of 18 studies (n=337) evaluating the effects of chronic licorice ingestion on blood pressure and plasma potassium. Chronic ingestion of licorice significantly increased systolic and diastolic blood pressure and decreased plasma potassium, renin activity, and aldosterone levels. A dose-response relationship was observed for blood pressure changes.
Effectiveness of Taiwanese traditional herbal diet for pain management in terminal cancer patients.
RCT involving 2,466 terminal cancer patients comparing a Taiwanese traditional herbal diet (TTHD) with analgesic herbs to a regular hospital diet and a control diet. The TTHD group reported enhanced pain relief compared to the other groups, suggesting potential benefits of combining Eastern and Western medicine for pain management.
Efficacy and immunomodulatory effects of licorice nasal spray in allergic rhinitis: A clinical study comparing with conventional steroid treatment.
RCT comparing licorice nasal spray (LNS) to steroid nasal spray (SNS) in 60 patients with allergic rhinitis. LNS significantly reduced nasal blockage, postnasal drip, rhinorrhea, itchy nose, and improved sleep quality. LNS also showed significant reductions in cytokine levels and improved mucociliary function, indicating immunomodulatory effects.
Therapeutic potential of(licorice) in modulating metabolic and inflammatory parameters in women with PCOS.
This study evaluated the therapeutic efficacy of Glycyrrhizaglabra (licorice) supplementation in women with polycystic ovarian syndrome (PCOS) by assessing its impact on metabolic and inflammatory markers.
Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit.
Triple-blind clinical trial comparing the effects of licorice and chlorhexidine mouthwash on the oral health of 120 intubated patients in an ICU. Both mouthwashes improved oral health significantly, with no significant difference between them post-intervention. Chlorhexidine showed a greater impact on reducing dental plaque and thinning saliva.
Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial.
This randomized, double-blind, placebo-controlled trial studied the effects of licorice extract combined with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in 66 overweight/obese women with PCOS. Licorice supplementation led to significant improvements in body weight, BMI, body fat, lipid profiles, fasting blood sugar, insulin levels, HOMA-IR, and HOMA-B compared to placebo.
Efficacy and safety of licorice (Glycyrrhiza glabra) in moderately ill patients with COVID-19: a randomized controlled trial.
RCT evaluating the efficacy and safety of licorice (glycyrrhizin) in 60 patients with moderate COVID-19. Licorice showed no significant effect on SO, body temperature, or respiratory rate, but CRP and ALT improved toward baseline. Licorice demonstrated a safe profile of adverse events.
Impact of licorice root on the burn healing process: A double-blinded randomized controlled clinical trial.
Double-blinded randomized controlled trial investigating the effect of hydroalcoholic extract of licorice root on second-degree burn healing. The licorice hydrogel group showed significantly lower inflammation, redness, pain, and burning, with a faster healing process compared to the control group.
Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double-blind clinical trial.
This randomized double-blind, placebo-controlled trial evaluated the effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in 60 women with nonalcoholic fatty liver disease. Licorice root supplementation led to significant improvements in liver enzymes, insulin levels, insulin resistance, oxidative stress markers, and liver steatosis compared to placebo.
Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial.
A randomized double-blind placebo-controlled trial involving 54 primary care patients with aphthous ulcers tested the effects of licorice gargle juice. The intervention group showed significantly reduced pain levels compared to the placebo group at both day 1 and day 2, indicating that licorice gargle juice can rapidly reduce pain and healing time.
Nasal irrigation with Glycyrrhiza glabra extract for treatment of allergic rhinitis - A study of in vitro, in vivo and clinical trial.
RCT evaluating nasal irrigation with Glycyrrhiza glabra extract for allergic rhinitis treatment. The study involved 60 participants and compared licorice nasal irrigation (LNI) to corticosteroid and saline nasal irrigation. LNI showed superior effects on nasal blockage, rhinorrhea, and other symptoms, with improved nasal resistance and turbinate hypertrophy, and no side effects.
Comparative Study of the Effect of Licorice Muco-adhesive Film on Radiotherapy Induced Oral Mucositis, A Randomized Controlled Clinical Trial.
RCT of 60 head and neck cancer patients undergoing radiotherapy, comparing licorice mucoadhesive film to placebo for oral mucositis. Licorice film significantly reduced pain and mucositis scores in weeks 3 and 4.
Efficacy of Licorice on SalivaryLevels vs Chlorhexidine Mouthwash in High Caries Risk Patients: A Randomized Clinical Trial.
RCT comparing the efficacy of licorice mouthwash to chlorhexidine mouthwash in 52 high caries risk patients. Licorice mouthwash stimulated salivary flow and increased salivary pH, but chlorhexidine showed better results in reducing plaque index. No significant difference in bacterial count was observed between the two mouthwashes.
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule.
Pharmacokinetic study of Glycyrrhiza uralensis (Gancao) compounds in LianhuaQingwen capsule, focusing on their metabolism and potential to induce pseudoaldosteronism by inhibiting renal 11β-HSD2. Major constituents glycyrrhizin and licorice saponin G2 were metabolically activated to pseudoaldosterogenic compounds glycyrrhetic acid and 24-hydroxyglycyrrhetic acid.
The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial.
Double-blind randomized clinical trial comparing diphenhydramine solution (DS) and diphenhydramine-containing glycyrrhiza glabra (DSG) for recurrent aphthous stomatitis. DSG significantly reduced pain scores and wound healing duration compared to DS, with no adverse effects observed.
The effectiveness of a traditional Persian medicine preparation in the treatment of chronic cough: A randomized, double-blinded, placebo-controlled clinical trial.
RCT evaluating the effect of licorice pastille on chronic cough in 70 participants. The licorice group showed a significant decrease in cough severity score compared to placebo, with no major side effects reported.
Caries Preventive and Antibacterial Effects of Two Natural Mouthwashes vs Chlorhexidine in High Caries-risk Patients: A Randomized Clinical Trial.
RCT comparing the caries preventive and antibacterial effects of Gum Arabic and Licorice mouthwashes versus chlorhexidine in 63 high caries-risk patients. After 12 months, Gum Arabic and Licorice showed significantly lower DMF scores and reduced bacterial counts compared to chlorhexidine, which showed increased bacterial resistance and oral side effects.
A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao).
This systematic review summarizes the anticancer properties and mechanisms of compounds isolated from licorice, including triterpene saponins and flavonoids. It highlights the inhibition of proliferation, induction of cell cycle arrest, apoptosis, and other anticancer effects, as well as the enhancement of chemotherapy effects and reduction of side effects.
A randomized, double-blind comparison of licorice versus sugar-water gargle for prevention of postoperative sore throat and postextubation coughing.
RCT comparing licorice gargle to sugar-water gargle in 236 patients undergoing elective thoracic surgery with double-lumen intubation. Licorice gargling significantly reduced the incidence of postoperative sore throat and postextubation coughing compared to sugar-water.
A Comparative evaluation of locally delivered licorice gel and tetracycline gel as an adjunct to non-surgical therapy in the treatment of controlled type -2 diabetic patients with periodontitis stage II and grade B - A split mouth randomized clinical trial.
This randomized, double-blind clinical trial evaluated the effectiveness of licorice gel compared to tetracycline gel as adjuncts to non-surgical periodontal therapy in 20 patients with Type-II diabetes and stage II periodontitis. Licorice gel showed statistically significant improvements in probing pocket depth and clinical attachment level, with better healing outcomes compared to tetracycline gel.
A low dose of daily licorice intake affects renin, aldosterone, and home blood pressure in a randomized crossover trial.
A randomized crossover trial with 28 healthy volunteers examined the effects of daily licorice intake containing 100 mg glycyrrhizic acid on home blood pressure. The study found that licorice intake significantly increased systolic blood pressure and suppressed renin and aldosterone levels, suggesting that the safe limit of licorice intake might need reconsideration.
Chinese medicine Yangmo decoction ameliorates intrauterine adhesion prognosis following hysteroscopic adhesiolysis.
This retrospective, non-randomized controlled study assessed the effects of Yangmo decoction after hysteroscopic adhesiolysis (HA) in patients with moderate or severe intrauterine adhesions. The Yangmo decoction group showed a better surgical success rate, significant reduction in AFS score, improved density of endometrial glands, and higher fertility rate compared to the estrogen and progesterone group.
Lollipop containing Glycyrrhiza uralensis extract reduces Streptococcus mutans colonization and maintains oral microbial diversity in Chinese preschool children.
RCT testing the efficacy of herbal lollipops containing Glycyrrhiza uralensis extract in reducing salivary Streptococcus mutans levels in high caries-risk children aged 3-6. The study found that daily use of 2 licorice-containing lollipops for 3 weeks significantly reduced S. mutans levels without affecting the biodiversity of the oral microbiome.
Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial
RCT of 64 overweight and obese subjects comparing 1.5 g/day of licorice extract plus a low-calorie diet to placebo over 8 weeks. Licorice supplementation significantly decreased waist circumference, fat mass, serum vaspin, zinc-α2 glycoprotein, insulin, and HOMA-IR, but only the reduction in serum vaspin levels was significant compared to placebo.
Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: A randomized controlled study.
RCT conducted in three dialysis centers in Northern Taiwan with 122 hemodialysis patients. Patients were assigned to pure water mouthwash, licorice mouthwash, or no mouthwash. Licorice mouthwash significantly improved unstimulated salivary flow rates and reduced xerostomia scores, while pure water mouthwash improved salivary flow rates but not xerostomia scores.
To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori.
RCT evaluating the effect of adding licorice to a clarithromycin-based regimen for H. pylori eradication in 120 patients with dyspepsia. The study group receiving licorice showed a significantly higher eradication rate (83.3%) compared to the control group (62.5%).
[Adjunctive treatment of axial undifferentiated spondyloarthritis by Qiangji Recipe: a clinical study].
RCT evaluating the efficacy and safety of Qiangji Recipe (QR) as an adjunctive treatment for axial undifferentiated spondyloarthritis. QR combined with Celecoxib showed better improvement in BASDAI, BASFI, ASQoL, and CRP compared to Celecoxib alone, with 76.92% of the treatment group achieving ASAS 20 response at week 4.
Comparison of triamcinolone acetonide mucoadhesive film with licorice mucoadhesive film on radiotherapy-induced oral mucositis: A randomized double-blinded clinical trial.
This randomized double-blind clinical trial compared the efficacy and safety of triamcinolone acetonide and licorice mucoadhesive films on radiotherapy-induced oral mucositis in 60 patients. Both treatments were effective in reducing pain, with no significant difference between the two groups, although a trend towards reduced oral discomfort was observed in the licorice group.
Effect of preoperative licorice lozenges on incidence of postextubation cough and sore throat in smokers undergoing general anesthesia and endotracheal intubation.
RCT of 100 smokers undergoing surgery with general anesthesia and endotracheal intubation, comparing licorice lozenges to sugar candy for reducing postextubation cough and sore throat. Licorice lozenges significantly reduced the incidence of postextubation cough and showed efficacy in reducing sore throat severity at 12 and 24 hours post-extubation.
Evaluation of contextual and demographic factors on licorice effects on reducing hot flashes in postmenopause women.
RCT comparing the effects of licorice (1140 mg/day) to hormone replacement therapy (HRT) on hot flash symptoms in 60 menopausal women over 90 days. Licorice was not very different from HRT in reducing the number and duration of hot flashes, but HRT reduced severity more effectively. Licorice was more effective than HRT in improving hot flash duration.
The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial.
This double-blind randomized clinical trial investigated the effects of licorice root extract on non-alcoholic fatty liver disease (NAFLD) in 66 patients. The case group received 2g of licorice root extract daily for 2 months, resulting in a statistically significant decrease in liver transaminase levels (ALT and AST), while the control group showed no significant changes.
Association of emblica, licorice and belides as an alternative to hydroquinone in the clinical treatment of melasma.
Mono-blind clinical study comparing the efficacy and safety of a cream containing Belides, Emblica, and Licorice to Hydroquinone 2% in treating melasma in 56 women. Both groups showed significant depigmentation with no statistical differences between them, but the Emblica, Licorice, and Belides group had fewer skin adverse events.
A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers.
Randomized, double-blind clinical trial of an intraoral adhesive patch containing glycyrrhiza root extract for treatment of recurrent aphthous ulcers. By the eighth day, the ulcer size for the active treatment group was significantly lower, and by the fourth day, the active treatment group reported significantly less pre-stimulus pain compared to placebo and no-treatment groups.
[Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood].
RCT comparing integrative Chinese and Western medicine using Kangqian Decoction and levocetirizine hydrochloride in treating chronic urticaria. The treatment group showed a higher effective rate and significant changes in IL-10 and IL-8 levels, indicating improved immune function and anti-inflammatory effects.
The effect of an endogenous antioxidant glabridin on oxidized LDL.
RCT investigating the effect of glabridin, a polyphenolic isoflavone antioxidant from licorice root, on LDL oxidation. Oral administration of a glycyrrhizin-free licorice-root methanol extract containing glabridin to healthy subjects for 6 months reduced oxidative stress and plasma LDL oxidation by 20%.
Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial.
RCT assessing the efficacy and safety of the herbal preparation STW 5-II for functional dyspepsia in 120 patients. The herbal preparation significantly improved gastrointestinal symptoms compared to placebo, with 43.3% of patients on active treatment reporting complete relief after 8 weeks.
The treatment of atopic dermatitis with licorice gel.
Double-blind clinical trial evaluating the effect of licorice extract topical gel on atopic dermatitis in 60 patients. Two percent licorice gel was more effective than 1% in reducing erythema, oedema, and itching over two weeks.
Investigation of the potential of Glycyrrhiza glabra as a bioavailability enhancer of Vitamin B12
The study investigated the potential of Glycyrrhiza glabra (licorice) extract to enhance the bioavailability of Vitamin B12. In vitro, ex vivo, and in vivo assays showed that the extract significantly increased the permeation and pharmacokinetic parameters of Vitamin B12, suggesting its capability as a bioavailability enhancer.
Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract.
The study assessed the anti-inflammatory properties of a topical herbal composition VEL-091604 containing gentian root, licorice root, and willow bark extract in a randomized, placebo-controlled UV-erythema test with 42 healthy volunteers. The cream significantly reduced inflammation compared to placebo and was as effective as 1% hydrocortisone acetate. An open-label study in 10 subjects with atopic dermatitis showed a significant reduction in SCORAD severity score.
Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomized double blinded clinical trial.
This double-blinded RCT assessed the efficacy of oral licorice as an adjunct therapy in 39 Parkinson's disease patients. Licorice intake significantly improved total UPDRS, daily activities, tremor, motor test, and rigidity scores without serious adverse events.
Maternal prenatal licorice consumption alters hypothalamic-pituitary-adrenocortical axis function in children.
Observational study examining the association between maternal glycyrrhizin consumption in licorice during pregnancy and hypothalamic-pituitary-adrenocortical axis function in children. High exposure to glycyrrhizin was linked to increased salivary cortisol levels in children, suggesting prenatal programming effects.
Effect of glycyrrhizin on the activity of CYP3A enzyme in humans.
RCT investigating the effects of repeated glycyrrhizin ingestion on the oral pharmacokinetics of midazolam, a probe drug for CYP3A activity, in 16 healthy adult males. Glycyrrhizin administration resulted in a modest induction of CYP3A, affecting midazolam pharmacokinetics.
An evaluation of the efficacy of licorice gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study.
Prospective, randomized, single-blind study evaluating the efficacy of licorice gargle in attenuating postoperative sore throat (POST) in 40 adults undergoing elective lumbar laminectomy. Licorice gargle reduced the incidence and severity of POST compared to water, with no difference in side effects.
The efficacy of the bioadhesive patches containing licorice extract in the management of recurrent aphthous stomatitis.
This study evaluated the efficacy of licorice bioadhesive hydrogel patches in managing recurrent aphthous stomatitis. Significant reductions in pain and the diameter of the inflammatory halo and necrotic center were observed with licorice patches compared to no-treatment and placebo groups.
[Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration].
RCT of 44 patients with refractory PCOS comparing Bushen Houxue method combined with ultrasound-guided follicle aspiration to follicle aspiration alone. The combined treatment significantly reduced the dosage of HMG needed for ovulation and improved pregnancy rates, with fewer cases of OHSS and LUFS.
Treatment of polycystic ovary syndrome with spironolactone plus licorice.
RCT comparing spironolactone alone versus spironolactone plus licorice in 32 women with PCOS. The combination reduced mean blood pressure and symptoms related to volume depletion, with lower activation of the renin-aldosterone system and reduced prevalence of metrorrhagia.
Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application.
RCT evaluating the effect of topical glycyrrhetinic acid cream on thigh fat thickness in 18 healthy women. The treatment significantly reduced the circumference and thickness of the superficial fat layer compared to placebo, likely due to inhibition of 11beta-hydroxysteroid dehydrogenase type 1.
Effect of licorice on the reduction of body fat mass in healthy subjects.
RCT studying the effect of licorice on body fat mass in 15 normal-weight subjects over 2 months. Licorice consumption reduced body fat mass without changing BMI, and suppressed aldosterone. The study suggests licorice may reduce fat by inhibiting 11beta-hydroxysteroid dehydrogenase Type 1 at fat cells.
In vivo 11beta-HSD-2 activity: variability, salt-sensitivity, and effect of licorice.
The study investigated the effect of glycyrrhetinic acid on 11beta-HSD-2 activity and its role in salt-sensitive hypertension. It found that glycyrrhetinic acid increased the (THF+5alpha-THF)/THE ratio, which was more sensitive than UFF/UFE for detecting decreased 11beta-HSD-2 activity, particularly in salt-sensitive subjects.
Evaluating the use of an advance lotion for addressing skin hyperpigmentation
The study examined the efficacy and safety of Advance Lotion, containing licorice, kojic acid, arbutin, and vitamin E, for addressing skin hyperpigmentation. Results showed a significant reduction in skin pigmentation and improvements with continued use, with no cases of skin intolerance reported.
Glycyrrhiza glabra (Licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 cardiomyocytes.
The study investigates the effects of Glycyrrhiza glabra (licorice) root extract on doxorubicin-induced cardiotoxicity in H9c2 cardiomyocytes. The extract was found to reduce oxidative stress, maintain mitochondrial functions, and regulate lipid homeostasis, thereby preserving cardiac health and mitigating the negative effects of doxorubicin.
Effects of prolonged ingestion of graded doses of licorice by healthy volunteers.
RCT administering graded daily doses of dried, aqueous extract of licorice root to 24 healthy volunteers for 4 weeks. No significant effects in lower dose groups, but highest doses led to side effects such as hypertension and hypokalaemia, particularly in individuals with subclinical disease or taking oral contraceptives.
The Power of Licorice (Radix glycyrrhizae) to Improve Oral Health: A Comprehensive Review of Its Pharmacological Properties and Clinical Implications
This narrative review explores the pharmacological properties and clinical implications of licorice (Radix glycyrrhizae) for oral health. It discusses the potential therapeutic benefits of licorice extracts and their bioactive components on oral diseases such as dental caries, periodontitis, halitosis, candidiasis, and recurrent aphthous ulcers, highlighting its anti-inflammatory, antimicrobial, antioxidative, and immunomodulatory effects.
Formulation and evaluation of floating tablets of liquorice extract
The study formulated and evaluated floating tablets containing liquorice extract for the treatment of Helicobacter pylori and gastric ulcers. The tablets were optimized based on buoyancy time and in vitro drug release, with the optimized formulation releasing 98.3% of the drug in 8 hours.
A Review of the Pharmacological Efficacy and Safety of Licorice Root from Corroborative Clinical Trial Findings
This narrative review discusses the pharmacological efficacy and safety of licorice root, highlighting its anti-inflammatory, antioxidative, anti-allergenic, and antimicrobial properties. It also addresses potential adverse effects such as hypokalemia and hypertension due to mineralocorticoid-like activity.