Research
Lavender (Silexan / Lavandula angustifolia)
106 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Comparative analysis of the effectiveness of pharmacological and non-pharmacological interventions on arteriovenous fistula cannulation-related pain in patients receiving hemodialysis: A systematic review and network meta-analysis.
Systematic review and network meta-analysis of 24 RCTs involving 1704 participants to evaluate interventions for arteriovenous fistula cannulation pain in hemodialysis patients. Non-pharmacological interventions like cryotherapy with visual distraction, visual distraction alone, and lavender inhalation aromatherapy were found effective in reducing pain.
The Sleep-Enhancing Effect of Lavender Essential Oil in Adults: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the sleep-enhancing effect of lavender essential oil in adults, incorporating 11 RCTs with a total of 628 participants. The analysis found a significant sleep-enhancing effect of lavender essential oil, though further high-quality studies are needed to confirm these findings.
Inhalation Aromatherapy With Lavender for Postoperative Pain Management: A Systematic Review of Randomized Controlled Trials.
Systematic review of randomized controlled trials investigating inhaled lavender aromatherapy for postoperative pain relief. Lavender aromatherapy significantly reduced postoperative pain, but evidence on reducing analgesic consumption is insufficient.
A systematic review and meta-analysis of clinical trials on lavender for sleep disorders in older adults.
This systematic review and meta-analysis evaluated clinical trials on the effect of lavender on sleep disorders in older adults. Out of 84 articles, 10 were fully reviewed, and 9 studies showed significant improvement in sleep disorders with lavender, primarily using the Pittsburgh Sleep Quality Index. The meta-analysis indicated a significant improvement in sleep quality scores.
Effects of aromatherapy on sleep quality in older adults: A meta-analysis.
Meta-analysis of randomized controlled trials examining the effects of aromatherapy on sleep quality in older adults. Aromatherapy, particularly with lavender, improved sleep quality and alleviated depression, with non-inhaled methods and durations under 4 weeks being most effective.
Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.
Meta-analysis of 5 randomized, placebo-controlled trials with 1213 adult out-patients assessing Silexan for anxiety disorders. Silexan was significantly superior to placebo in reducing anxiety scores and improving health-related quality of life, with favorable tolerability and safety.
Effect of Lavender Oil on Preoperative Anxiety: Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 20 studies investigating the impact of lavender oil on preoperative anxiety. Lavender oil application significantly reduced anxiety levels in patients scheduled for surgical procedures compared to control.
Effectiveness of aromatherapy in reducing duration of labour: a systematic review.
Systematic review of 22 clinical trials involving 3234 women using various aromatherapies. Lavender was found to be almost effective in reducing the duration of labour, suggesting aromatherapy as a potentially effective and holistic method.
The effect of lavender on stress in individuals: A systematic review and meta-analysis.
Systematic review and meta-analysis of 21 studies with 1595 participants assessing the effect of lavender on stress. Lavender significantly reduced stress scores in the intervention group compared to the control group, with the highest effect observed in L. angustifolia species and student groups.
A systematic review of the effect of lavender on cancer complications.
Systematic review of 13 studies with 838 patients examining the effects of lavender on cancer complications. Lavender, often used as inhalation aromatherapy, was significantly effective in reducing anxiety and pain, and improving sleep quality and vital signs.
Clinical Efficacy and Safety of Massage for the Treatment of Restless Leg Syndrome in Hemodialysis Patients: A Meta-Analysis of 5 Randomized Controlled Trials.
Meta-analysis of 5 RCTs involving 369 hemodialysis patients with restless leg syndrome (RLS) evaluating the efficacy and safety of massage. Massage, particularly with lavender oil, significantly reduced RLS scores compared to routine care without increasing adverse events.
Effects of aromatherapy and music therapy on patients' anxiety during MRI examinations: a randomized controlled trial.
This randomized controlled trial investigated the effects of aromatherapy and music therapy on anxiety during MRI examinations. Aromatherapy was conducted through inhalation of lavender oil. The study found that the combination of aromatherapy and music therapy significantly reduced anxiety and improved comfort levels compared to single interventions or routine care.
Essential oils for healing and/or preventing infection of surgical wounds: a systematic review.
Systematic review analyzing the use of essential oils for healing and preventing infection in surgical wounds. Most studies used lavender oil, with some showing improvement in healing, particularly in episiotomies. Infection was not assessed as a primary outcome.
Beneficial effects of Silexan on co-occurring depressive symptoms in patients with subthreshold anxiety and anxiety disorders: randomized, placebo-controlled trials revisited.
Meta-analysis of five placebo-controlled clinical trials assessing the effect of Silexan on depressive symptoms in patients with subthreshold anxiety and anxiety disorders. Silexan showed significant improvements in depressed mood and depression scale scores compared to placebo, with more pronounced effects in patients with severe symptoms.
Effects of aromatherapy on agitation and aggression in cognitive impairment: A meta-analysis.
Meta-analysis of 15 studies with 693 participants evaluating the effectiveness of aromatherapy on agitation and aggression in cognitive impairment. Lavender oil was found to significantly improve agitation and aggression, with short-term aromatherapy showing better effects.
A systematic literature review and meta-analysis of the clinical effects of aroma inhalation therapy on sleep problems.
Systematic review and meta-analysis of 34 studies on inhalation aromatherapy for sleep problems. Aromatherapy, particularly lavender inhalation, was highly effective in improving sleep problems such as insomnia. Subgroup analysis showed significant effects on stress, depression, anxiety, and fatigue.
Lavender aromatherapy: A systematic review from essential oil quality and administration methods to cognitive enhancing effects.
Systematic review of lavender essential oil inhalation effects on arousal, attention, and memory in healthy subjects. Lavender EO decreased arousal and increased sustained attention, with mixed results on memory. Lack of EO quality assessment and protocol heterogeneity were noted.
Effectiveness of aromatherapy inhalation on anxiety and haemodynamic variables for patients with cardiovascular disease: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effectiveness of aromatherapy on anxiety and haemodynamic variables in patients with cardiovascular disease. Lavender aromatherapy inhalation was most used, showing significant effects on anxiety, systolic blood pressure, and heart rate, with moderate effects on breathing rate.
The antidepressant effects of lavender (Lavandula angustifolia Mill.): A systematic review and meta-analysis of randomized controlled clinical trials.
This systematic review and meta-analysis evaluated the efficacy of lavender on depression severity. It included 17 articles and found significant efficacy of lavender in decreasing depression scores compared to control groups. The oral route was identified as the most effective administration method.
Effects of Lavender on Anxiety, Depression, and Physiological Parameters: Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of randomized controlled trials assessing lavender's efficacy on anxiety, depression, and physiological parameters. Lavender was found to significantly reduce anxiety, depression, and systolic blood pressure compared to placebo or no treatment. The study suggests that increasing sessions of administration enhances anxiolytic effects.
Does aromatherapy with lavender affect physical and psychological symptoms of menopausal women? A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effectiveness of lavender aromatherapy on physical and psychological symptoms in menopausal women. The analysis included 16 studies with 1092 participants, showing significant improvements in menopausal symptoms, sleep quality, sexual function, self-esteem, anxiety, and hot flashes, but negative effects on triglyceride and high-density lipoprotein levels.
The effect of Lavender on pain and healing of episiotomy: A systematic review.
Systematic review of six trials involving 415 participants investigating the effect of Lavender on pain and wound healing of episiotomy. Lavender significantly reduced pain and improved healing compared to placebo, though high heterogeneity was observed in pain outcomes.
Efficacy of aromatherapy on dental anxiety: A systematic review of randomised and quasi-randomised controlled trials.
Systematic review of RCTs and CCTs evaluating aromatherapy's efficacy on dental anxiety. Lavender and orange fragrances were most commonly used. Aromatherapy reduced anxiety-related parameters compared to no treatment, with effects comparable to music. Evidence quality was low to very low.
Effects of lavender on anxiety: A systematic review and meta-analysis.
Systematic review and meta-analysis assessing the efficacy of lavender in various forms on anxiety. The review included 65 RCTs and 25 NRSs, with significant results favoring lavender for anxiety reduction. Lavender inhalation and oral Silexan showed significant anxiety reduction, while massage with lavender oil also appeared effective. The review highlights the need for higher quality RCTs due to study heterogeneity and bias.
The effect of inhalation aromatherapy in patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 9 RCTs with 656 patients undergoing cardiac surgery. Inhalation aromatherapy, especially with lavender, significantly reduced anxiety, pain, and heart rate, but showed no significant effect on systolic and diastolic blood pressure.
Efficacy and safety of lavender essential oil (Silexan) capsules among patients suffering from anxiety disorders: A network meta-analysis.
A network meta-analysis evaluated the anxiolytic effect of lavender essential oil (Silexan) capsules compared to placebo, paroxetine, and lorazepam. The analysis included five studies with 645 participants. Silexan 160 mg showed a significant decline in Hamilton Anxiety Scale scores compared to other treatments, indicating its efficacy in reducing anxiety.
Efficacy of Silexan in subthreshold anxiety: meta-analysis of randomised, placebo-controlled trials.
Meta-analysis of three randomised, placebo-controlled trials assessing the anxiolytic effect of Silexan in patients with subthreshold anxiety. Silexan was superior to placebo in reducing anxiety scores and had a beneficial effect on sleep and quality of life without causing sedation.
Relaxing Environment Lowers Anxiety During Chemodenervation: a Randomized Trial.
Single-center randomized trial of women receiving intradetrusor chemodenervation for overactive bladder, comparing a relaxing environment with lavender aromatherapy, calming music, and dim lighting to a typical office environment. The relaxing environment significantly reduced patient anxiety before the procedure.
The effect of lavender herbal tea on the mental health of individuals with misophonia: A randomized controlled trial.
A single-center, single-blind RCT with 60 participants diagnosed with misophonia evaluated the effects of lavender tea on mental health. The experimental group consumed 2g of lavender tea twice daily for 14 days. Positive changes were observed in misophonia and related psychological symptoms, suggesting potential benefits of lavender tea for anxiety, depression, and anger.
The effect of aromatherapy and music therapy on blood pressure and heart rate of nursing students before taking the exam.
Quasi-experimental study on 169 nursing students examining the effects of aromatherapy with lavender and damask rose, and music therapy on blood pressure and heart rate before exams. Aromatherapy and music therapy significantly reduced systolic and diastolic blood pressure and pulse rate, indicating a decrease in stress-related physiological responses.
The impact of aromatherapy with Citrus bergamia- Lavandula angustifolia essential oil and/or mindfulness-based therapy on postmenopausal health: A factorial randomized controlled trial.
This factorial RCT studied the effects of lavender and bergamot essential oil aromatherapy and mindfulness-based therapy on menopausal symptoms, sleep quality, and serum cortisol in 132 postmenopausal women. Aromatherapy improved menopausal symptoms and sleep quality, while the combination with mindfulness-based therapy showed no additional benefits.
The efficacy of lavender oil on fatigue and sleep quality in patients with hematological malignancy receiving chemotherapy: a single-blind randomized controlled trial.
Single-blind RCT evaluating the effect of lavender oil aromatherapy on fatigue and sleep quality in 100 patients with hematological malignancies undergoing chemotherapy. The experimental group showed significantly higher sleep quality and lower fatigue scores compared to the control group.
Effect of aromatherapy massage with lavender essential oil on sleep quality, pain, and mental and psychiatric disorders among breast cancer patients undergoing chemotherapy: a randomized controlled trial.
RCT assessing the effects of lavender aromatherapy massage on sleep quality, anxiety, and pain in breast cancer patients undergoing chemotherapy. Significant improvements were observed in sleep quality, anxiety, and pain response in the intervention group compared to the placebo group.
The effect of lavender oil on anxiety before endoscopy in children: A randomized controlled trial.
RCT investigating the effect of lavender oil on anxiety before endoscopy in children aged 9-12 years. Lavender oil inhalation significantly reduced state anxiety scores compared to placebo and control groups.
Evaluating the impact of lavender aromatherapy and music therapy on reducing stress, anxiety, and depression in female nurses during the COVID-19 pandemic.
Quasi-experimental study evaluating the impact of lavender aromatherapy and music therapy on stress, anxiety, and depression in 60 female nurses during the COVID-19 pandemic. Both interventions significantly reduced physiological and psychological stress indicators, with combined therapy showing greater and lasting benefits.
Evaluating efficacy, safety, and innovation in skin care applications of essential oils: a systematic review.
Systematic review of 70 studies evaluating the efficacy and safety of essential oils in skin care applications. Tea tree oil was effective for acne treatment, while lavender and rosemary oils showed promising anti-inflammatory and anti-aging properties. Various formulations improved skin hydration, elasticity, and appearance.
Aromatherapy Using Lavender Oil Effectiveness on Pain and Anxiety After C-Section: A Randomized Controlled Trial.
RCT of 100 women undergoing c-sections comparing inhaled lavender essential oil to placebo for managing pain and anxiety. The aromatherapy group showed significantly lower pain and anxiety levels post-intervention without adverse effects.
The efficacy of oral Lavandula angustifolia Mill. essential oil on menopausal symptoms, serum lipid profile, and cortisol concentration in postmenopausal women: A triple-blind, randomized, controlled trial.
Triple-blind RCT of 72 postmenopausal women assessing the effect of oral Lavandula angustifolia Mill. essential oil on menopausal symptoms, serum cortisol, and lipid profile. LEO significantly improved sexual dysfunction compared to placebo, but did not affect lipid profile or cortisol levels.
Alleviating effect of lavender (Lavandula angustifolia) and its major components on postherpetic pain: a randomized blinded controlled trial.
RCT evaluating the effects of inhalation of lavender oil and its components (linalool and linalyl acetate) on postherpetic neuralgia pain in 58 patients. The study found significant reductions in sensory and affective pain, as well as pain severity and intensity, in the lavender oil, linalool, and linalyl acetate groups compared to the control group.
The effect of lavender and bergamot oil applied via inhalation on the anxiety level and sleep quality of surgical intensive care unit patients.
RCT involving 54 surgical intensive care unit patients to assess the effect of lavender and bergamot oil inhalation on anxiety and sleep quality. Both lavender and bergamot groups showed significant reductions in anxiety and improvements in sleep quality compared to the control group.
The Effect of Aromatherapy with Lavender Essential Oil on the Sleep and Fatigue Level of Patients with Multiple Sclerosis in Turkey: A Randomized Controlled Trial.
RCT conducted in Turkey examining the effects of lavender oil aromatherapy on sleep and fatigue in MS patients. Significant improvements were observed in fatigue severity and sleep quality scores in the experimental group compared to controls.
Effectiveness of cold application and lavender oil on pain during drain removal: A randomized clinical trial.
RCT of 121 patients evaluating the effectiveness of lavender aromatherapy and cold application in controlling pain during drain removal. Lavender aromatherapy and cold application were found to be effective in reducing pain.
Effectiveness of Aromatherapy in Early Palliative Care for Oncology Patients: Blind Controlled Study.
RCT assessing the effectiveness of massage, aromatherapy massage, and combined aromatherapy inhalation on cancer patients in palliative care. Combined aromatherapy showed significant improvements in physical and psychological symptoms and activities compared to control.
Does addition of aromatherapy and music help to reduce pain and anxiety during shockwave lithotripsy compared to standard analgesia alone? A randomised controlled trial.
RCT assessing the effect of aromatherapy with lavender oil, alone and with music, on pain and anxiety during shockwave lithotripsy for kidney stones. Both aromatherapy groups showed a trend towards lower pain scores compared to control, but differences were not statistically significant. No significant difference in anxiety scores was observed.
Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial.
Randomized, double-blind clinical trial of 68 PCOS patients comparing lavender (250 mg twice daily) to metformin (500 mg three times a day) for 90 days. Both treatments increased progesterone levels and regulated menstrual cycles, with lavender showing similar effects to metformin.
Restless Legs Syndrome in Chronic Kidney Disease- a Systematic Review.
Systematic review of restless legs syndrome in chronic kidney disease, focusing on epidemiology, correlating factors, and treatment options. Non-pharmacological treatments include exercise and massage with lavender oil, while pharmacological treatments involve dopaminergic drugs and calcium channel blockers.
Effects of lavender oil on odor elimination, ostomy adjustment and quality of life in patients with permanent colostomy: A randomized controlled trial.
RCT assessing the impact of lavender oil on odor elimination, ostomy adjustment, and quality of life in patients with permanent colostomy. The experimental group receiving lavender oil showed significant improvements in odor reduction, workplace performance, body image, stoma functionality, financial concerns, acceptance, anxiety, social involvement, and irritability compared to the control group.
Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824).
Randomized clinical trial comparing the analgesic effects of inhaled lavender essential oil (LEO) and vanilla essential oil (VEO) during neonatal frenotomy. Both groups showed similar NIPS scores and crying times, with no significant differences in heart rate or oxygen saturation changes. No side effects were observed.
Determining the effect of inhalation and lavender essential oil massage therapy on the severity of perceived labor pain in primiparous women: A randomized controlled trial.
RCT investigating the effect of lavender essence inhalation and massage therapy on labor pain in primiparous women. Lavender oil inhalation and massage therapy reduced perceived labor pain compared to control, with inhalation being most effective in the latent phase and massage in the active and transition phases.
Effects of Iranian Polyherbal Syrup (Zufa syrup) on oxygen saturation and clinical symptoms in suspected patients with COVID-19: a triple-blinded, randomized, placebo-controlled trial.
Triple-blind RCT of Zufa syrup in 116 patients with mild to moderate COVID-19 symptoms. No significant difference in symptom improvement or oxygen saturation between Zufa syrup and placebo over 10 days.
Efficacy of Auricular Acupuncture and Lavender Oil Aromatherapy in Reducing Preinterventional Anxiety in Cardiovascular Patients: A Randomized Single-Blind Placebo-Controlled Trial.
RCT evaluating the efficacy of auricular acupuncture and lavender oil aromatherapy in reducing preinterventional anxiety in cardiovascular patients. The verum group showed significantly decreased anxiety on the STAI compared to the placebo group, with more patients reporting subjective treatment success.
The Effect of Inhalation Aromatherapy on Sedation Level, Analgesic Dosage, and Bispectral Index Values during Donor Site Dressing in Patients with Burns: A Randomized Clinical Trial.
RCT on 62 burn patients comparing inhalation of damask rose and lavender essential oils to routine protocol during donor site dressing. The intervention group required significantly lower doses of sedatives and analgesics, and had lower BIS values and heart rates.
The Effects of Aromatherapy on Anxiety and Depression in People With Cancer: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 17 studies on aromatherapy's effects on anxiety and depression in cancer patients. Aromatherapy, particularly with lavender essential oils, was effective in relieving anxiety but showed no beneficial effect on depression or psychological wellbeing.
The Effects of Lavender and Citrus aurantium on Anxiety and Agitation of the Conscious Patients in Intensive Care Units: A Parallel Randomized Placebo-Controlled Trial.
A randomized parallel placebo-controlled trial with 150 ICU patients comparing the effects of lavender and Citrus aurantium essential oils on anxiety and agitation. Both aromatherapies significantly reduced anxiety compared to placebo, with no significant difference between the two essential oils. Agitation decreased in all groups, but no significant difference was found between them.
Effects of lavender and Citrus aurantium on pain of conscious intensive care unit patients: A parallel randomized placebo-controlled trial.
Parallel randomized placebo-controlled trial comparing aromatherapy with lavender and Citrus aurantium essential oils against placebo for reducing pain in conscious ICU patients. Lavender significantly reduced pain scores compared to placebo, while Citrus aurantium did not show a significant effect.
An overview of the comparison of inhalation aromatherapy on emotional distress of female and male patients in preoperative period.
RCT comparing the effect of inhalation aromatherapy with lavender and spring orange on emotional distress in male and female preoperative patients. Lavender reduced anxiety in both genders, while spring orange reduced anxiety in women but not as effectively as lavender.
Effect of inhaler and topical lavender oil on pain management of arteriovenous fistula cannulation.
RCT of 90 hemodialysis patients with AVFs comparing the effects of inhaler and topical application of 100% lavender essential oil on pain management during arterial needle insertion. Both applications significantly reduced pain severity compared to control.
The effects of lavender, rosemary and orange essential oils on memory problems and medication adherence among patients undergoing hemodialysis: A parallel randomized controlled trial.
Parallel RCT of 86 hemodialysis patients comparing the effects of Lavender, Rosemary, and Orange essential oils on memory problems and medication adherence. Lavender and Rosemary reduced retrospective memory problems, but no significant effects were found on prospective memory or medication adherence.
Lavender Aromatherapy for Anxiety and Pain During Multichannel Urodynamics: A Randomized Controlled Pilot Trial.
RCT of 78 women undergoing urodynamic testing comparing lavender aromatherapy to placebo. Lavender significantly reduced anxiety from baseline to catheter placement and post-procedure, with no differences in pain.
Essential oil therapy in rheumatic diseases: A systematic review.
Systematic review of 13 articles evaluating essential oil therapy in rheumatic diseases, including osteoarthritis, rheumatoid arthritis, and fibromyalgia. Lavender essential oil was the most used, followed by ginger oil, rosemary oil, and Rosmarinus officinalis. Most studies demonstrated the efficacy of aromatherapy.
Can lavender oil inhalation help to overcome dental anxiety and pain in children? A randomized clinical trial.
RCT evaluating the effects of lavender oil inhalation on dental anxiety and pain in 126 children undergoing tooth extraction. The lavender group showed significantly lower anxiety and pain scores, as well as reduced blood pressure and pulse rate after inhalation compared to the control group.
Effects of Aromatherapy with Lavender and Peppermint Essential Oils on the Sleep Quality of Cancer Patients: A Randomized Controlled Trial
RCT comparing inhalation aromatherapy with lavender and peppermint essential oils on sleep quality in 120 cancer patients. Both lavender and peppermint groups showed improved sleep quality compared to control, as measured by the Pittsburgh Sleep Quality Inventory.
The Effect of Aromatherapy Massage With Lavender and Citrus Aurantium Essential Oil on Quality of Life of Patients on Chronic Hemodialysis: A Parallel Randomized Clinical Trial Study.
Parallel RCT assessing the effect of aromatherapy massage with Lavender and Citrus Aurantium essential oils on the quality of life of 105 hemodialysis patients. Both essential oils significantly improved quality of life compared to the control group, but no significant difference was found between the two essential oil groups.
The Effect of Lavender Oil on Sleep Quality and Vital Signs in Palliative Care: A Randomized Clinical Trial.
RCT examining the effect of lavender oil on sleep quality and vital signs in 68 palliative care patients. Lavender oil improved sleep quality, facilitated falling asleep, and reduced awakening frequency, but did not affect vital signs.
The Effectiveness of Aromatherapy in the Management of Labor Pain and Anxiety: A Systematic Review.
Systematic review of 33 studies evaluating aromatherapy for managing labor pain and anxiety. Lavender was the most commonly used essential oil, and most studies confirmed its positive effect in reducing labor pain and anxiety.
Effectiveness of Silexan oral lavender essential oil compared to inhaled lavender essential oil aromatherapy for sleep in adults: a systematic review.
Systematic review aimed to compare the effectiveness of Silexan oral lavender essential oil to inhaled lavender essential oil aromatherapy for sleep and anxiety in adults. No studies meeting the inclusion criteria were found, indicating a lack of evidence on the topic.
Is lavender an anxiolytic drug? A systematic review of randomised clinical trials.
Systematic review of 15 RCTs evaluating lavender for stress/anxiety relief. Seven trials favored lavender over controls for at least one outcome, but methodological issues limit conclusions. Oral lavender supplements may have therapeutic effects, but further studies are needed.
Effects of Aromatherapy on Pain, Stress, and Behaviors of Newborns: A Randomized Controlled Trial.
RCT examining the effects of massage and bathing using lavender oil on pain, stress, and behavior in 45 newborns. Lavender massage reduced pain and stress levels and improved behavioral outcomes more effectively than lavender bath or control.
Effects of lavender essential oil inhalation aromatherapy on depression and sleep quality in stroke patients: A single-blind randomized controlled trial.
Single-blind RCT assessing the effects of inhalation aromatherapy with lavender essential oil on depression and sleep quality in 40 patients with post-stroke depression. The experimental group showed significant improvements in depression and sleep quality compared to the placebo group.
Sex differences in the effects of aromatherapy on anxiety and salivary oxytocin levels.
Randomized open crossover trial with 15 men and 10 women to investigate the effects of aromatherapy with lavender oil on anxiety and salivary oxytocin levels. In women, aromatherapy reduced anxiety and increased oxytocin levels, while in men, anxiety decreased but no significant change in oxytocin levels was observed. The study suggests sex differences in the effects of aromatherapy.
Effect of a lavender essential oil and sleep hygiene protocol on insomnia in postmenopausal women: A pilot randomized clinical trial.
Pilot RCT of 35 postmenopausal women with insomnia comparing lavender essential oil to placebo (sunflower oil) inhaled before bedtime for 29 days. The Aroma group showed significant improvement in overall quality of life and self-assessed sleep patterns, though no differences were observed in hot flashes or daytime sleepiness.
The effect of a combined treatment of foot soak and lavender oil inhalation therapy on the severity of insomnia of patients with cancer: Randomized interventional study.
This randomized intervention study evaluated the effects of foot soak and lavender oil inhalation therapy on insomnia severity in cancer patients. The study found that lavender oil inhalation, both alone and combined with foot soak, significantly reduced insomnia severity compared to baseline, with the combined treatment showing a higher effect size.
"Effects of abdominal massage applied with ginger and lavender oil for elderly with constipation: A randomized controlled trial".
RCT investigating the effect of abdominal massage with ginger and lavender oil on constipation in 40 elderly individuals. The intervention group showed improved stool consistency and reduced constipation severity compared to the control group after 4 weeks.
The Effect of Lavender on Anxiety and Hemodynamic Status Before Septorhinoplasy and Rhinoplasty.
Parallel randomized control trial testing the effect of lavender fragrance on anxiety and hemodynamic status in 34 candidates before septorhinoplasty and rhinoplasty. Lavender group showed significant reduction in anxiety and improved hemodynamic parameters compared to control.
The Effect of Lavender Oil on Perioperative Pain, Anxiety, Depression, and Sleep after Microvascular Breast Reconstruction: A Prospective, Single-Blinded, Randomized, Controlled Trial.
Prospective, single-blinded, randomized, controlled trial of 49 patients undergoing microvascular breast reconstruction to assess lavender oil's effect on perioperative anxiety, depression, sleep, and pain. No significant differences were found between the lavender oil and placebo groups in any measured outcomes.
Lavender essential oil on postmenopausal women with insomnia: Double-blind randomized trial.
Double-blind RCT evaluating the effect of Lavandula angustifolia essential oil inhalation on sleep and menopausal symptoms in 35 postmenopausal women with insomnia. No significant differences between groups were found, but the aroma group showed improvements in sleep onset latency, depression levels, hot flashes, and sleep efficiency compared to baseline.
A pilot study on essential oil aroma stimulation for enhancing slow-wave EEG in sleeping brain.
A single-blinded study on the effect of lavender essential oil aroma on sleep quality and EEG in nine healthy participants. The study found that lavender aroma improved subjective sleep quality, increased delta wave activity during slow-wave sleep, and reduced alpha wave activity during wake stages.
Comparing the effects of vestibular rehabilitation with and without lavender oil scents as an olfactory stimulus on balance, fear of falling down and activities of daily living of people with multiple sclerosis: a randomized clinical trial.
RCT evaluating the effect of lavender oil as an olfactory stimulus during vestibular rehabilitation exercises in people with multiple sclerosis. The experimental group showed significant improvements in balance, fear of falling, and psychological aspects compared to the control group.
Comparing the effects of massage and aromatherapy massage with lavender oil on sleep quality of cardiac patients: A randomized controlled trial.
RCT comparing the effects of massage and aromatherapy massage with lavender oil on sleep quality in cardiac patients. Both interventions improved sleep quality, but there was no statistically significant difference between the two intervention groups.
Influence of lavender oil inhalation on vital signs and anxiety: A randomized clinical trial.
RCT investigating the effectiveness of lavender oil inhalation on anxiety, mood, and vital signs in 126 patients undergoing oral surgery. Significant changes in blood pressure were observed in the lavender oil group post-operatively, and the majority of patients reported satisfaction with the experience.
The effect of aromatherapy massage with lavender and chamomile oil on anxiety and sleep quality of patients with burns.
Quasi-experimental study on 105 burn patients assessing the effect of aromatherapy massage with lavender and chamomile oils on anxiety and sleep quality. Significant improvements were observed in anxiety scores and sleep quality in the aromatherapy group compared to control.
Comparing effects of aromatherapy with lavender essential oil and orange essential oil on fatigue of hemodialysis patients: A randomized trial.
RCT comparing aromatherapy with lavender and orange essential oils on fatigue in hemodialysis patients. Both essential oils significantly reduced fatigue compared to control, but no significant difference was found between the two oils.
Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial.
Triple-blind RCT comparing the effects of lavender and bitter orange on anxiety in postmenopausal women. Both substances significantly reduced state and trait anxiety scores compared to the control group after eight weeks of treatment.
Aromatherapy: The Effect of Lavender on Anxiety and Sleep Quality in Patients Treated With Chemotherapy.
This randomized controlled trial examined the effects of lavender oil aromatherapy on anxiety and sleep quality in 70 patients undergoing chemotherapy. Significant improvements in trait anxiety and sleep quality were observed in the lavender group compared to controls.
Subjective assessment of the effects of an herbal supplement containing lavender essential oil on sleep quality: A randomized, double-blind, placebo-controlled crossover study
A randomized, double-blind, placebo-controlled crossover study evaluated the effects of an herbal supplement containing lavender essential oil on sleep quality in 51 adults with insomnia. The supplement improved overall LSEQ scores and several individual sleep parameters compared to placebo, with no significant differences in sleep diary data.
The Effect of Lavender Oil in Patients with Renal Colic: A Prospective Controlled Study Using Objective and Subjective Outcome Measurements.
Prospective controlled study assessing lavender oil as an adjuvant in the treatment of pain due to renal stones in 100 patients. The group receiving aromatherapy with lavender oil in addition to standard medical treatment showed significantly lower pain scores at 30 minutes, particularly in female patients.
Effect of Inhaled Lavender and Sleep Hygiene on Self-Reported Sleep Issues: A Randomized Controlled Trial.
RCT comparing the effectiveness of inhaled lavender and sleep hygiene versus sleep hygiene alone on sleep quality in 79 college students with self-reported sleep issues. The lavender group showed better sleep quality at postintervention and two-week follow-up, with a significant effect on waking feeling refreshed. Sleep quantity did not differ between groups.
Effects of aromatherapy on sleep quality and anxiety of patients.
RCT of 60 coronary ICU patients assessing the effect of 2% lavender essential oil inhalation on sleep quality and anxiety. The intervention group showed significant improvements in sleep quality and reduced anxiety levels compared to the control group.
A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models.
Systematic review of essential oils and their anxiolytic-like effects in animal models. Lavendula angustifolia showed the best profile with positive results in controlled clinical trials. Citrus aurantium also showed significant effects in animal models.
Effects of orally administered lavender essential oil on responses to anxiety-provoking film clips.
RCT of orally administered lavender capsules (placebo, 100, 200 microl) in 97 participants viewing anxiety-provoking film clips. The 200 microl dose showed trends towards reduced state anxiety, GSR, and HR, and increased HRV, particularly in females, suggesting decreased anxiety under low anxiety conditions.
A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder.
A multi-center, double-blind, randomized study comparing the efficacy of silexan, an oral lavender oil capsule, to lorazepam in adults with generalized anxiety disorder (GAD). The study found that silexan effectively ameliorates generalized anxiety comparable to lorazepam, with similar reductions in the Hamilton Anxiety Rating Scale scores and other anxiety measures. Silexan showed no sedative effects and no potential for drug abuse, suggesting it as a well-tolerated alternative to benzodiazepines.
Treatment with lavender aromatherapy in the post-anesthesia care unit reduces opioid requirements of morbidly obese patients undergoing laparoscopic adjustable gastric banding.
A prospective randomized placebo-controlled study on 54 patients undergoing laparoscopic adjustable gastric banding evaluated the effectiveness of lavender aromatherapy in reducing opioid requirements post-surgery. The lavender group required significantly less morphine postoperatively compared to the placebo group, suggesting lavender aromatherapy can reduce opioid demand in the immediate postoperative period.
The Use of Lavender Aromatherapy for Pain After Total Hip and Total Knee Arthroplasty: A Randomized Trial.
RCT with 102 participants undergoing total hip or knee arthroplasty to assess lavender aromatherapy's effect on opioid use post-surgery. While overall opioid use was similar, THA patients using lavender had slightly lower opioid use. Most participants found the lavender inhaler useful for pain management.
The Effect of Aromatherapy on Blood Pressure and Stress Responses by Inhalation and Foot Massage in Patients With Essential Hypertension: Randomized Clinical Trial.
A 3-arm, parallel group, randomized clinical trial examined the effect of aromatherapy with lavender oil through inhalation and foot massage on blood pressure and stress response in patients with essential hypertension. Lavender oil reduced blood pressure, heart rate, serum cortisol, and subjective anxiety in hypertensive patients.
The Effect of Aromatherapy on Sleep and Quality of Life in Menopausal Women with Sleeping Problems: A Non-Randomized, Placebo-Controlled Trial.
Quasi-experimental study with 57 menopausal women, investigating the effects of lavender oil aromatherapy on sleep and quality of life. The intervention group showed significant improvements in sleep quality and quality of life compared to the placebo group.
A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia.
RCT evaluating Lavender and Lemon Balm essential oils for agitated behavior in older people with and without dementia. Lemon Balm was more effective in reducing agitation in residents without dementia, while Lavender was more effective in reducing physical non-aggressive behavior in dementia. No reduction in agitation was observed compared to placebo.
The effect of topical application of lavender essential oil on the intensity of pain caused by the insertion of dialysis needles in hemodialysis patients: A randomized clinical trial.
This randomized clinical trial studied the effect of topical application of lavender essential oil on pain intensity during dialysis needle insertion in 34 hemodialysis patients. The study found that lavender oil significantly reduced pain intensity compared to no intervention and placebo.
The effects of lavender and rosemary essential oils on test-taking anxiety among graduate nursing students.
RCT studying the effects of lavender and rosemary essential oil sachets on test-taking anxiety in graduate nursing students. The use of these essential oils reduced test-taking stress as evidenced by lower scores on test anxiety measures, personal statements, and pulse rates.
Effects of aromatherapy acupressure on hemiplegic shoulder pain and motor power in stroke patients: a pilot study.
RCT of 30 stroke patients with hemiplegic shoulder pain comparing aromatherapy acupressure using lavender, rosemary, and peppermint to acupressure alone. Pain scores were significantly reduced in both groups, with aromatherapy acupressure showing greater reduction. Motor power improved in both groups, but no significant intergroup difference was found.
Relaxation effects of lavender aromatherapy improve coronary flow velocity reserve in healthy men evaluated by transthoracic Doppler echocardiography.
RCT assessing the effect of lavender aromatherapy on coronary circulation in 30 healthy men. Lavender aromatherapy reduced serum cortisol and improved coronary flow velocity reserve, suggesting beneficial acute effects on coronary circulation and stress reduction.