Research
Lactoferrin
82 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Impacts of Milk Protein Supplementation on Lipid Profile, Blood Pressure, Oxidative Stress, and Liver Enzymes: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis of 65 RCTs investigated the effects of milk protein supplementation on lipid profiles, blood pressure, oxidative stress, and liver enzymes in adults. Milk protein supplementation significantly reduced total cholesterol, systolic blood pressure, and triglycerides, but had no substantial impact on other measured outcomes.
Evaluation of Bovine Lactoferrin for Prevention of Late-Onset Sepsis in Low-Birth-Weight Infants: A Double-Blind Randomized Controlled Trial.
A double-blind, randomized controlled trial evaluated the effectiveness of bovine lactoferrin supplementation in preventing late-onset sepsis and necrotizing enterocolitis in preterm and low birth weight neonates in Pakistan. The study found no significant prevention of late-onset sepsis or NEC with bovine lactoferrin supplementation compared to placebo.
Efficacy of lactoferrin in preventing recurrent urinary tract infections in pregnant Egyptian women: a randomized controlled trial.
RCT of 220 pregnant women with a history of recurrent UTIs, comparing daily 200 mg lactoferrin supplementation to control. Lactoferrin significantly reduced episodes of asymptomatic bacteriuria and acute cystitis, suggesting a preventive role against UTIs during pregnancy.
Vaccine response was higher in formula-fed infants compared to breastfed but not affected by lactoferrin or iron in a randomised controlled trial.
RCT examining the effect of reduced iron content and added bovine lactoferrin in infant formula on antibody response following routine immunisation in 180 formula-fed and 72 breastfed infants. At 12 months, low iron formula-fed infants showed higher Hib IgG levels compared to control formula-fed infants, but lactoferrin did not affect vaccine IgG response. Breastfed infants had lower IgG levels compared to formula-fed infants.
Effects of supplementation with milk protein on glycemic parameters: a GRADE-assessed systematic review and dose-response meta-analysis.
This systematic review and dose-response meta-analysis assessed the impact of milk protein supplementation on glycemic parameters in adults. The analysis of 36 RCTs with 1851 participants showed that milk protein supplementation effectively reduced fasting blood glucose, fasting insulin, and HOMA-IR levels, though it did not significantly change HbA1c values overall. Sub-group analyses indicated significant HbA1c reduction in participants with normal BMI.
Effect of Lactoferrin on Clinical Outcomes of Hospitalized Patients with COVID-19: The LAC Randomized Clinical Trial.
The LAC randomized double-blind placebo-controlled trial evaluated the clinical efficacy and safety of 800 mg/die oral bovine lactoferrin in 218 hospitalized adult patients with moderate-to-severe COVID-19. No significant differences were observed in primary outcomes between lactoferrin and placebo groups, though lactoferrin was found to be safe and tolerable.
What is the effect of lactoferrin on oral and jawbone tissue repair? A systematic review.
Systematic review of 11 studies on the effect of lactoferrin (LTF) on jawbone repair, including in vitro, in vivo, and one clinical trial. Findings suggest LTF may promote wound repair and inhibit bone resorption, with mixed results on healing rates.
Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review.
Systematic review of 11 studies, including 10 RCTs, evaluating lactoferrin as a treatment for iron-deficiency anemia in children. Lactoferrin improved serum ferritin and hemoglobin levels compared to iron or placebo, with fewer adverse effects such as constipation.
Role of lactoferrin in preventing preterm birth and pregnancy complications: a systematic review and meta-analysis.
Systematic review and meta-analysis of six studies involving 333 pregnancies to assess the role of lactoferrin supplementation in preventing preterm birth in women at risk. Lactoferrin supplementation was associated with a lower risk of preterm birth before 37 weeks and a higher gestational age at delivery.
Bovine lactoferrin for the prevention of COVID-19 infection in health care personnel: a double-blinded randomized clinical trial (LF-COVID).
A double-blinded randomized clinical trial was conducted to assess the effect of 600 mg daily bovine lactoferrin supplementation on the prevention of SARS-CoV-2 infection in health care personnel. The study found no significant differences in infection rates or secondary outcomes between the lactoferrin and placebo groups.
Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials.
This meta-analysis compares the effects of lactoferrin and ferrous sulfate supplementation on iron-deficiency anemia. Lactoferrin showed better effects on serum iron, ferritin, and hemoglobin levels, but reduced fractional iron absorption and IL-6 levels compared to ferrous sulfate. The study suggests lactoferrin as a superior supplement due to its anti-inflammatory effects.
Lactoferrin reduces the risk of respiratory tract infections: A meta-analysis of randomized controlled trials.
Meta-analysis of nine RCTs, with six included, assessing lactoferrin's effect on respiratory tract infections. The analysis showed a significantly reduced odds of developing respiratory infections with lactoferrin use, suggesting its efficacy in reducing RTI risk and potential use in COVID-19 management.
Effects of Milk Protein in Resistance Training-Induced Lean Mass Gains for Older Adults Aged ≥ 60 y: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of milk-based protein supplementation on resistance training-induced gains in lean body mass and muscle strength for older adults aged 60 and above. Milk protein was found to be superior to whey protein in enhancing lean body mass gains, with improvements in muscle strength observed only at higher protein doses.
The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review.
Systematic review of 27 records on the effects of orally administered lactoferrin against viral infections. The findings were heterogeneous with some weak positive results on symptom severity and viral load reduction, but overall effects were inconsistent. High risk of bias and small sample sizes were noted.
Fecal Lactoferrin and Other Putative Fecal Biomarkers in Crohn's Disease: Do They Still Have a Potential Clinical Role?
Systematic review evaluating fecal biomarkers in Crohn's disease, focusing on lactoferrin among others. Lactoferrin shows good performance with endoscopic scores and may be useful for predicting therapy response and endoscopic relapse, but more investigation is needed.
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.
Meta-analysis of 12 RCTs evaluating enteral lactoferrin supplementation in preterm neonates. Lactoferrin decreased late-onset sepsis and length of hospital stay, but had no effect on NEC stage II or III, all-cause mortality, or neurodevelopmental outcomes at 24 months. Supplementation with probiotics showed additional benefits in reducing sepsis and NEC.
The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial.
This multicentre, double-blind, randomised controlled trial assessed the effect of lactoferrin supplementation on very low birthweight infants. The study found no significant improvement in death or major morbidity, but a meta-analysis indicated lactoferrin might reduce late-onset sepsis.
Fecal Lactoferrin for Assessment of Inflammatory Bowel Disease Activity: A Systematic Review and Meta-Analysis.
This meta-analysis evaluated the diagnostic accuracy of fecal lactoferrin (FL) in assessing inflammatory bowel disease (IBD) activity. It included 10 studies with 773 IBD patients, finding that FL is a useful screening marker with high sensitivity and modest specificity, particularly effective for ulcerative colitis (UC) compared to Crohn's disease (CD).
Evidence from systematic reviews of randomized trials on enteral lactoferrin supplementation in preterm neonates.
Systematic review and meta-analysis of 12 randomized controlled trials on enteral lactoferrin supplementation in preterm neonates. The analysis suggests clinical benefits in decreasing late-onset sepsis, late-onset fungal sepsis, length of stay in the hospital, and urinary tract infections, with no adverse effects. No significant decrease in necrotizing enterocolitis, mortality, or neurodevelopmental impairment was observed.
Lactoferrin Concentration in Human Tears and Ocular Diseases: A Meta-Analysis.
Meta-analysis evaluating lactoferrin as a diagnostic biomarker for ocular diseases. The study found pooled mean differences in lactoferrin concentrations between healthy subjects and those with dry eye, Sjögren syndrome, and diabetic retinopathy. Lactoferrin level in tears is suggested as a good candidate for dry eye syndrome diagnostic biomarker.
Impact of lactoferrin on bone regenerative processes and its possible implementation in oral surgery - a systematic review of novel studies with metanalysis and metaregression.
Systematic review and meta-analysis of studies on lactoferrin's impact on bone regeneration in oral surgery. Lactoferrin use increases new bone growth and shortens graft resorption time, with a dose-dependent effect on bone formation. Further clinical studies are recommended.
Lactoferrin Supplementation to Prevent Late-Onset Sepsis in Preterm Infants: A Meta-Analysis.
Meta-analysis of 10 RCTs involving 3,679 preterm infants to assess lactoferrin supplementation's role in preventing late-onset sepsis (LOS). Lactoferrin supplementation, with or without probiotics, significantly decreased LOS. It did not significantly reduce necrotizing enterocolitis, all-cause mortality, bronchopulmonary dysplasia, or retinopathy of prematurity.
Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial.
This large randomised controlled trial investigated the effect of enteral bovine lactoferrin supplementation on late-onset infection in very preterm infants. The study found that lactoferrin did not significantly reduce the risk of late-onset infection compared to the control group, suggesting it should not be routinely used for this purpose.
Is Lactoferrin More Effective in Reducing Late-Onset Sepsis in Preterm Neonates Fed Formula Than in Those Receiving Mother's Own Milk? Secondary Analyses of Two Multicenter Randomized Controlled Trials.
This study is a post hoc subgroup analysis and meta-analysis of two RCTs evaluating the effect of bovine lactoferrin (BLF) supplementation on late-onset sepsis (LOS) in preterm neonates. The analysis found that BLF reduced the risk of LOS in infants not exclusively fed mother's own milk, with a relative risk reduction of 18%. The study suggests further research to determine if BLF is more effective in infants fed formula or donor milk compared to those fed mother's own milk.
Prophylactic lactoferrin for preventing late-onset sepsis and necrotizing enterocolitis in preterm infants: A PRISMA-compliant systematic review and meta-analysis.
Systematic review and meta-analysis of 9 RCTs involving 1834 preterm infants. Prophylactic lactoferrin significantly reduced the incidence of late-onset sepsis and necrotizing enterocolitis, decreased hospital-acquired infection and infection-related mortality, and shortened time to full enteral feeding without significant adverse effects.
Protocol for the Lactoferrin Infant Feeding Trial (LIFT): a randomised trial of adding lactoferrin to the feeds of very-low birthweight babies prior to hospital discharge.
This is a multicentre, two-arm, randomised trial testing whether adding bovine lactoferrin to feeds in very-low birthweight infants improves survival to hospital discharge free from brain injury, late-onset sepsis, NEC, and treated retinopathy of prematurity. The trial also evaluates the effect of lactoferrin on survival and developmental outcomes at 24 to 36 months corrected gestational age.
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.
Meta-analysis of six RCTs evaluating oral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis (NEC) in preterm neonates. Lactoferrin decreased late-onset sepsis and NEC stage II or III without adverse effects, but did not affect all-cause mortality. Evidence quality is low, and further trials are needed to improve evidence quality and clarify dosing regimens.
Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials.
This meta-analysis evaluated the efficacy of daily oral bovine lactoferrin versus ferrous iron preparations for treating iron deficiency anemia in pregnant women. The analysis included 4 trials with 600 women, showing that lactoferrin improved hematological parameters with fewer gastrointestinal side effects compared to ferrous sulfate.
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants.
Meta-analysis of four RCTs evaluating oral lactoferrin supplementation in preterm neonates. Lactoferrin decreased late-onset sepsis, NEC stage II or greater, and all-cause mortality without adverse effects. Evidence quality ranged from moderate to low.
Longitudinal changes in lactoferrin concentrations in human milk: a global systematic review.
Systematic review of 52 studies evaluating longitudinal changes in lactoferrin concentrations in human milk from 2724 women. Lactoferrin levels were highest during early lactation and declined to stable levels from 1 month to 2 years. The review highlights regional data disparities and a lack of data on preterm milk.
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants.
Systematic review assessing oral lactoferrin for preventing sepsis and necrotizing enterocolitis (NEC) in preterm neonates. One trial with 472 infants showed lactoferrin reduced late-onset sepsis, especially in infants under 1000 g. Lactoferrin alone did not reduce NEC incidence, but a combination with Lactobacillus rhamnosus GG did.
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants.
Systematic review assessing the safety and effectiveness of oral lactoferrin in preventing sepsis and necrotizing enterocolitis (NEC) in preterm neonates. One trial with 472 infants showed a significant reduction in late-onset sepsis with lactoferrin, especially in infants weighing less than 1000 g. Lactoferrin alone did not reduce NEC incidence, but a combination with Lactobacillus rhamnosus GG did.
Meta-analysis: the effect of supplementation with lactoferrin on eradication rates and adverse events during Helicobacter pylori eradication therapy.
Meta-analysis of nine randomized trials with 1343 participants evaluating lactoferrin supplementation during H. pylori eradication therapy. Lactoferrin increased eradication rates and reduced side-effects, particularly nausea, compared to placebo or no treatment.
Preventing Sepsis in Preterm Infants with Bovine Lactoferrin: A Randomized Trial Exploring Immune and Antioxidant Effects.
This randomized, double-blind, placebo-controlled trial evaluated the effects of early enteral bovine lactoferrin (bLf) supplementation in 103 very low birth weight infants. The study found that bLf reduced late-onset neonatal sepsis and supported immunologic, antioxidant, and hematologic stability, with significant effects on cytokine levels and hemoglobin in non-transfused infants.
Supporting respiratory epithelia and lowering inflammation to effectively treat common cold symptoms: A randomized controlled trial.
This double-blind randomized placebo-controlled trial involved 157 participants to test a throat spray containing a mucosal immune complex (lysozyme, lactoferrin, aloe) and anti-inflammatory salicylates. The study found significant reductions in sore throat pain and other cold symptoms, suggesting that supporting respiratory epithelia and reducing inflammation can effectively treat common cold symptoms.
Lactoferrin: A Promising New Player in Treatment of Iron Deficiency Anemia in Patients on Regular Hemodialysis: A Randomized Controlled Trial.
RCT comparing 100 mg of 20%-30% iron-saturated lactoferrin (BLF) to 576 mg of ferrous glycine sulfate in 140 patients on regular hemodialysis with iron deficiency anemia. BLF significantly decreased serum hepcidin levels and increased hemoglobin concentration and transferrin saturation more than ferrous glycine sulfate, suggesting BLF as a promising treatment for iron deficiency anemia in these patients.
A Randomized, Double-Blind, Controlled Trial to Assess the Effects of Lactoferrin at Two Doses vs. Active Control on Immunological and Safety Parameters in Healthy Adults.
A randomized, double-blind, controlled trial assessed the effects of recombinant human lactoferrin (rhLF) at two doses versus bovine lactoferrin (bLF) on immunological parameters in 66 healthy adults over 28 days. The study found no increased anti-hLF antibodies or adverse events following ingestion of rhLF, indicating no evidence of alloimmunization.
Influence of bovine lactoferrin on feeding intolerance and intestinal permeability in preterm infants: a randomized controlled trial.
RCT assessing the effects of oral bovine lactoferrin supplementation on feeding intolerance and intestinal permeability in 60 preterm infants. The lactoferrin group achieved full enteral feeding significantly faster and had lower serum zonulin concentrations compared to the control group, indicating improved feeding intolerance and decreased intestinal permeability.
Effect of in vitro food oral coating and lubricity on satiety: A randomized controlled trial using milk protein beverages.
RCT investigating the effects of milk protein-rich beverages with varying oral coating properties on appetite ratings and food intake. High coating beverages increased fullness ratings after 20 minutes, with a correlation between protein concentration in saliva and reduced desire to eat. No effect on energy intake and gut peptides was observed.
Improved Neurodevelopmental Outcomes at 5.5 Years of Age in Children Who Received Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula Through 12 Months: A Randomized Controlled Trial.
RCT evaluating neurodevelopmental outcomes in children at 5.5 years who received infant formula with added bovine milk fat globule membrane and lactoferrin through 12 months. Children in the supplemented group showed improved cognitive outcomes, including higher intelligence and executive function scores, compared to the control group.
Mechanisms affecting the gut of preterm infants in enteral feeding trials: a nested cohort within a randomised controlled trial of lactoferrin.
Cohort study nested within an RCT to determine the impact of supplemental bovine lactoferrin on the gut microbiome and metabolome of preterm infants. The study found minimal impacts of lactoferrin on gut microbiome diversity and composition, with hospital site and postnatal age having larger effects.
Lactoferrin for iron-deficiency anemia in children with inflammatory bowel disease: a clinical trial.
RCT comparing lactoferrin to oral ferrous sulfate for treating iron-deficiency anemia in 80 children with inflammatory bowel disease. Lactoferrin significantly increased hemoglobin, serum iron, transferrin saturation, and serum ferritin compared to ferrous sulfate, and decreased IL-6 and hepcidin levels, suggesting it is an effective treatment with fewer side effects.
Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 25 studies on lactoferrin supplementation in humans, examining effects on inflammation, immune function, and respiratory tract infections. Findings suggest lactoferrin reduces systemic inflammation and improves immune function, with mixed results on respiratory tract infection outcomes.
Effects of a Novel High-Quality Protein Infant Formula on Energetic Efficiency and Tolerance: A Randomized Trial.
This randomized, double-blind trial evaluated a novel infant formula containing alpha-lactalbumin, lactoferrin, partially hydrolyzed whey, and whole milk on growth and tolerance compared to a commercial formula and human milk. The study found improved gastrointestinal tolerance and more efficient growth with less daily formula and protein intake in infants consuming the study formula.
The effect of milk and rapeseed protein on growth factors in 7-8 year-old healthy children - A randomized controlled trial.
This randomized controlled trial assessed the effect of combinations of milk and rapeseed protein versus milk protein alone on growth factors in 129 healthy 7-8 year-old children. The study found no differences in changes of plasma IGF-1, IGFBP-3, IGF-1/IGFBP-3 ratio, or insulin between groups after 1 or 4 weeks. Growth factors increased within groups, but no significant differences were observed between the intervention groups.
Lactoferrin versus iron hydroxide polymaltose complex for the treatment of iron deficiency anemia in children with cerebral palsy: a randomized controlled trial.
RCT comparing lactoferrin (Lf) and iron hydroxide polymaltose complex (IPC) for treating iron deficiency anemia in 66 children with cerebral palsy. Both groups showed significant improvements in hemoglobin and other blood parameters, but Lf was more effective and had fewer side effects than IPC.
Reducing Iron Content in Infant Formula from 8 to 2 mg/L Does Not Increase the Risk of Iron Deficiency at 4 or 6 Months of Age: A Randomized Controlled Trial.
RCT of 180 Swedish healthy full-term formula-fed infants comparing low-iron formula with and without bovine lactoferrin to standard formula. Iron status indicators were unaffected by lactoferrin, and reducing iron content to 2 mg/L did not increase the risk of iron deficiency at 4 or 6 months.
Cytokine responses to symbiotic and lactoferrin combination in very low birth weight neonates: a randomized control trial.
RCT investigating cytokine response to a combination of probiotics, oligosaccharides, and lactoferrin in very low birth weight neonates. The study found a decrease in IL-10 levels in the study group, but no change in other cytokines.
Circulating Insulin-Like Growth Factor-1 Is Positively Associated with Growth and Cognition in 6- to 9-Year-Old Schoolchildren from Ghana.
Secondary analysis of a randomized, double-blind, controlled trial in 6-9-year-old children from rural Ghana. The study assessed the effect of milk protein supplementation on circulating IGF-1 and its correlation with growth and cognition. Milk protein intake increased IGF-1 levels, which were associated with improvements in cognitive test performance and growth metrics.
Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial.
RCT evaluating neurodevelopment, growth, and health outcomes in infants receiving formula with bovine milk fat globule membrane and lactoferrin. Infants in the MFGM + LF group showed improved cognitive, language, and motor scores at day 365, with fewer respiratory and diarrhea-related adverse events through day 545.
Supplementation With Lactoferrin and Lysozyme Ameliorates Environmental Enteric Dysfunction: A Double-Blind, Randomized, Placebo-Controlled Trial.
A double-blind, randomized, placebo-controlled trial in rural Malawi tested the effects of lactoferrin and lysozyme supplementation on environmental enteric dysfunction (EED) in children aged 12-23 months. The study found significant improvements in gut health markers and reduced rates of hospitalization and acute malnutrition in the experimental group.
Enteral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates.
Systematic review assessing the safety and efficacy of oral lactoferrin as an adjunct to antibiotics in treating neonates with suspected or confirmed sepsis or necrotizing enterocolitis. No eligible trials were identified, and there is currently no evidence to support or refute the use of enteral lactoferrin for these conditions.
Lactoferrin reduces mortality in preweaned calves with diarrhea.
Blinded, randomized field trial of 628 preweaned calves with diarrhea comparing oral administration of garlic extract, lactoferrin, or water (control) over 3 days. Lactoferrin significantly reduced mortality and culling compared to control, while garlic extract did not show a significant effect. Neither substance affected disease duration or weight gain over 10 days.
A systematic review of lactoferrin use in dermatology.
Systematic review of clinical evidence for lactoferrin use in dermatology. The review found encouraging evidence for lactoferrin's benefits in acne, psoriasis, and diabetic ulcerations, though further research is needed.
Role of lactoferrin in neonatal care: a systematic review.
Systematic review evaluating the role of lactoferrin in neonatal care, particularly in preterm infants. The review found that lactoferrin reduces late onset sepsis, invasive fungal infection, necrotizing enterocolitis, and mortality in neonates. The role of lactoferrin in preventing bronchopulmonary dysplasia and retinopathy of prematurity remains unclear.
Factors affecting lactoferrin concentration in human milk: how much do we know?
Systematic review investigating factors affecting lactoferrin concentration in breast milk. Colostrum has the highest LF levels, decreasing with days postpartum. No other factor consistently associated with LF concentration. Highlights need for standardized studies to identify significant factors affecting LF expression.
Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial.
RCT evaluating the effect of bovine lactoferrin supplementation from iron-fortified formulas on diarrhea and respiratory tract infections in 260 weaned infants. The lactoferrin-fortified group showed a lower incidence of respiratory-related illnesses and diarrhea compared to the control group.
Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial.
This randomized clinical trial assessed the effect of bovine lactoferrin (BLF), alone or with the probiotic LGG, on the prevention of necrotizing enterocolitis (NEC) in very-low-birth-weight neonates. BLF supplementation significantly reduced the incidence of stage 2 NEC and death-and/or stage 2 NEC compared to placebo, suggesting its potential as a preventive strategy in NICU settings.
Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children.
RCT of 555 children comparing bovine lactoferrin supplementation to placebo for 6 months. While diarrhea incidence was similar between groups, the bLF group had lower longitudinal prevalence, shorter episode duration, and reduced severity of dehydration and liquid stools.
Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates.
Systematic review assessing the safety and efficacy of oral lactoferrin as an adjunct to antibiotics in treating neonates with suspected or confirmed sepsis and/or necrotizing enterocolitis. No eligible neonatal trials were identified, and there is currently no evidence to recommend or refute the use of lactoferrin for these conditions.
Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates.
Systematic review assessing the safety and efficacy of oral lactoferrin as an adjunct to antibiotics in treating neonatal sepsis and necrotizing enterocolitis. No eligible trials were identified, and there is currently no evidence to recommend or refute lactoferrin use in this context.
Milk Protein Glycation Compromises Postprandial Lysine Bioavailability but does not Modulate Postprandial Muscle Protein Synthesis Rates In Vivo in Males: A Double-blind, Randomized Parallel Trial.
This double-blind, randomized parallel trial assessed the impact of milk protein glycation on postprandial plasma amino acid availability and muscle protein synthesis rates in 45 healthy young males. The study found that higher glycation levels in milk protein reduced plasma lysine availability but did not affect postprandial muscle protein synthesis rates during recovery from resistance exercise.
The muscle protein synthetic response following corn protein ingestion does not differ from milk protein in healthy, young adults.
This randomized, double-blind, parallel-group study compared muscle protein synthesis rates following ingestion of 30 g corn protein, 30 g milk protein, and a 30 g blend of corn plus milk protein in 36 healthy young males. The results showed no significant difference in muscle protein synthesis rates between the different protein sources.
Managing children with frequent respiratory infections and associated wheezing: a preliminary randomized study with a new multicomponent nasal spray.
Preliminary RCT investigating a multicomponent nasal spray containing lactoferrin, dipotassium glycyrrhizinate, carboxymethyl-beta-glucan, and vitamins C and D3 in preschoolers with frequent respiratory infections and wheezing. The treatment group experienced fewer respiratory infections and used fewer beta-2 agonists compared to the control group.
A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men.
This randomized trial investigated muscle protein synthesis responses in older men to a 20g blend of collagen protein hydrolysate and milk protein versus a non-blended milk protein source. Both supplements resulted in equivalent muscle protein synthesis responses, suggesting the collagen blend may be a suitable alternative for maintaining muscle mass in older adults.
Dose-response effects of dietary protein on muscle protein synthesis during recovery from endurance exercise in young men: a double-blind randomized trial.
This double-blind randomized trial studied the effects of graded doses of dietary protein co-ingested with carbohydrate on muscle protein synthesis during recovery from endurance exercise in 48 young, endurance-trained men. The study found that 30 g of protein was sufficient to maximize myofibrillar protein synthesis rates, while mitochondrial protein synthesis increased dose-dependently.
Iron Absorption is Greater from Apo-Lactoferrin and is Similar Between Holo-Lactoferrin and Ferrous Sulfate: Stable Iron Isotope Studies in Kenyan Infants.
Crossover study in Kenyan infants comparing iron absorption from maize-based porridge with ferrous sulfate alone, ferrous sulfate with apo-lactoferrin, and holo-lactoferrin. Iron absorption was significantly higher with apo-lactoferrin compared to ferrous sulfate or holo-lactoferrin, suggesting lactoferrin facilitates iron absorption.
Efficacy of Lactoferrin Oral Administration in the Treatment of Anemia and Anemia of Inflammation in Pregnant and Non-pregnant Women: An Interventional Study.
Interventional study comparing oral administration of lactoferrin to ferrous sulfate in 198 anemic women, including those with minor β-thalassemia and hereditary thrombophilia. Lactoferrin decreased IL-6 and increased total serum iron and hematological parameters more effectively than ferrous sulfate, suggesting it as a promising treatment for anemia and anemia of inflammation.
Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial.
RCT comparing oral lactoferrin plus health education to total dose infusion of low-molecular weight iron dextran for treating iron deficiency anemia in pregnant women. Both groups showed significant clinical improvement of anemia after 4 weeks, with lactoferrin showing better improvement in iron indices.
Milk Powder Added to a School Meal Increases Cognitive Test Scores in Ghanaian Children.
A randomized, double-blind, placebo-controlled clinical trial in Ghanaian children aged 6-9 years compared the effects of 8.8 g milk protein/d with control groups on cognitive function and body composition. The group receiving 8.8 g milk protein/d showed improved executive cognitive function and increased lean body mass, but no differences in linear growth.
Lactoferrin and lysozyme to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for a randomized controlled trial.
This study protocol outlines a randomized controlled trial to assess the effectiveness of lactoferrin and lysozyme supplementation in reducing environmental enteric dysfunction and stunting in Malawian children aged 12-23 months. The trial will measure changes in biomarkers for EED and linear growth over 16 weeks.
A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris.
RCT of 168 subjects with mild to moderate acne vulgaris comparing lactoferrin with vitamin E and zinc to placebo for 3 months. The lactoferrin group showed significant reductions in acne lesions, comedones, and inflammatory lesions, with improvements in sebum scores by week 12. No adverse events were observed.
Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g.
RCT of bovine lactoferrin supplementation in 190 Peruvian neonates with birth weight less than 2500g to prevent late-onset sepsis. The lactoferrin group had a lower cumulative sepsis incidence compared to placebo, though the primary outcome did not reach statistical significance. The study suggests a potential effect warranting further investigation.
Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study.
Prospective, randomized, controlled trial comparing bovine lactoferrin to ferrous sulfate in 100 pregnant women with iron deficiency anemia. Both treatments significantly improved Hb, serum ferritin, and iron levels, with no significant differences between groups. Bovine lactoferrin had fewer gastrointestinal side effects compared to ferrous sulfate.
Randomised clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment.
RCT assessing the efficacy of an oral formulation containing Lactobacillus acidophilus, Lactobacillus rhamnosus, and bovine lactoferrin as adjuvant therapy to clotrimazole in women with recurrent vulvovaginal candidiasis. The intervention group showed significant improvement in symptoms and reduced recurrence rates compared to placebo over a six-month follow-up.
Randomized Control Trial of Human Recombinant Lactoferrin: A Substudy Reveals Effects on the Fecal Microbiome of Very Low Birth Weight Infants.
RCT evaluating the effects of enteral lactoferrin on the fecal microbiome of very low birth weight infants. Lactoferrin modified the fecal microbiome, reducing Enterobacter and Klebsiella, increasing Citrobacter, and decreasing staphylococci. Fewer hospital-acquired infections occurred in infants treated with lactoferrin.
Lactobacilli vaginal colonisation after oral consumption of Respecta(®) complex: a randomised controlled pilot study.
RCT with 40 healthy volunteers consuming Respecta complex (L. acidophilus La-14, L. rhamnosus HN001, and bovine lactoferrin) twice daily for 2 weeks. Vaginal swabs showed increased levels of L. rhamnosus and L. acidophilus, suggesting potential benefits for urogenital tract health.
Bovine lactoferrin and piroxicam as an adjunct treatment for lymphocytic-plasmacytic gingivitis stomatitis in cats.
Randomized double-blinded clinical trial in 13 cats with caudal stomatitis testing a combination of bovine lactoferrin oral spray and oral piroxicam. The combination treatment significantly improved clinical signs, quality of life, and weight gain compared to piroxicam alone, with no detectable influence on liver or kidney function.
Effects of a composition containing lactoferrin and lactoperoxidase on oral malodor and salivary bacteria: a randomized, double-blind, crossover, placebo-controlled clinical trial.
This randomized, double-blind, crossover, placebo-controlled clinical trial studied the effects of tablets containing bovine lactoferrin and lactoperoxidase on oral malodor and salivary bacteria in 15 subjects. The test group showed significantly lower levels of CH(3)SH, a volatile sulfur compound, compared to the placebo group, indicating a suppressive effect on oral malodor. No significant difference in salivary bacteria numbers was detected, although one bacterial fragment showed a lower copy number in the test group.
Diet and faecal flora in the newborn: lactoferrin.
The study investigated the effects of adding bovine lactoferrin to the diet of bottle-fed babies on their faecal flora. It found that lactoferrin had little effect on the faecal microflora and did not make it more similar to that of breastfed babies. The addition of iron to the formula had a more significant impact on the faecal flora.
The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor
In vitro study demonstrating the broad-spectrum antiviral activity of lactoferrin against SARS-CoV-2 and other common human coronaviruses. Bovine lactoferrin was found to be more potent than human lactoferrin, with its mechanism involving binding to heparan sulfate proteoglycans to block viral attachment. Lactoferrin's antiviral activity was synergistic with remdesivir.
Formulation for Oral Delivery of Lactoferrin Based on Bovine Serum Albumin and Tannic Acid Multilayer Microcapsules
The study investigates the use of bovine serum albumin and tannic acid multilayer microcapsules for oral delivery of lactoferrin. The encapsulation system showed high stability in gastric conditions and effectively protected lactoferrin from digestion, allowing higher absorption in the small intestine and accumulation in the liver in mice.