Research
Lactobacillus rhamnosus (LGG)
44 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Unlocking the potential of probiotic administration in caries management: a systematic review.
Systematic review assessing the potential of probiotics, particularly Lacticaseibacillus rhamnosus, in the prevention and management of dental caries. The review included 14 articles and found that probiotic supplemented milk showed beneficial effects on caries outcomes, though more well-designed studies are needed.
Next-Gen biotherapeutics: A systematic review and network meta-analysis on postbiotics as treatment for pediatric atopic dermatitis.
This systematic review and network meta-analysis evaluated the efficacy and safety of postbiotic strains in treating pediatric atopic dermatitis. Lactobacillus rhamnosus IDCC 3201 showed significant benefits in reducing symptoms of atopic dermatitis, while Lactobacillus paracasei GM080 ranked highest in safety but did not significantly reduce symptoms.
Pathogen-Specific Effects of Probiotics in Children With Acute Gastroenteritis Seeking Emergency Care: A Randomized Trial.
RCT analyzing the effects of probiotics (Lactobacillus rhamnosus and Lactobacillus helveticus) on children with acute gastroenteritis. No significant differences were found in disease severity or diarrhea duration between probiotic and placebo groups, except fewer diarrheal episodes in adenovirus-infected children receiving L. rhamnosus R0011/L. helveticus R0052.
Probiotic peanut oral immunotherapy versus oral immunotherapy and placebo in children with peanut allergy in Australia (PPOIT-003): a multicentre, randomised, phase 2b trial.
This multicentre, randomised, phase 2b trial investigated the addition of a probiotic adjuvant, Lactobacillus rhamnosus, to peanut oral immunotherapy (OIT) in children with peanut allergy. The study found that both probiotic and peanut oral immunotherapy (PPOIT) and OIT were effective at inducing sustained unresponsiveness, but the addition of the probiotic did not improve efficacy. However, it might offer a safety benefit compared to OIT alone, particularly in preschool children.
Lactobacillus rhamnosus Used in the Perinatal Period for the Prevention of Atopic Dermatitis in Infants: A Systematic Review and Meta-Analysis of Randomized Trials.
Systematic review and meta-analysis of randomized controlled trials examining the effect of Lactobacillus rhamnosus on atopic eczema in infants. The meta-analysis found statistically significant reductions in atopic eczema incidence up to 7 years with L. rhamnosus use, though high attrition rates temper these findings.
Association Between Diarrhea Duration and Severity and Probiotic Efficacy in Children With Acute Gastroenteritis.
Secondary analysis of two RCTs in children 3-48 months with acute gastroenteritis, evaluating the efficacy of Lactobacillus rhamnosus GG and a combination probiotic. No significant difference in moderate-to-severe gastroenteritis symptoms, diarrhea duration, or healthcare visits between probiotic and placebo groups.
A randomized trial evaluating virus-specific effects of a combination probiotic in children with acute gastroenteritis.
A multi-center, double-blind RCT of 816 children with acute gastroenteritis comparing a probiotic containing Lactobacillus rhamnosus and Lactobacillus helveticus to placebo. The study found no virus-specific beneficial effects of the probiotic on reducing clinical symptoms or viral nucleic acid clearance.
Meta-analysis: the effect and adverse events of Lactobacilli versus placebo in maintenance therapy for Crohn disease.
Meta-analysis of six RCTs with 359 participants comparing Lactobacilli to placebo in Crohn disease maintenance therapy. L. rhamnosus strain GG may increase relapse rates, while L. johnsonii is inefficacious in reducing relapse incidence.
Effects of a novel synbiotic intervention on abdominal visceral fat reductions and gut microbiota in overweight and obese adults: A randomized, double-blind, placebo-controlled trial.
RCT of a novel synbiotic formulation in 112 overweight and obese adults over 12 weeks. The synbiotic significantly reduced visceral adipose tissue area compared to placebo, with more pronounced effects in men and individuals with BMI 24-28. Microbiota analysis showed transient enrichment of specific probiotic strains.
Impact of Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 supplementation on the gut microbiota and metabolic health of alcohol-consuming individuals: a randomised, double-blind, placebo-controlled trial.
RCT assessing the impact of a probiotic complex containing BLa80 and LRa05 on gut microbiota and metabolic indicators in alcohol-consuming individuals. The intervention maintained gut microbiota composition, increased beneficial genera, and improved serum uric acid levels, suggesting benefits for gut health and metabolic function.
Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial.
RCT assessing the effect of 4-week consumption of Lacticaseibacillus rhamnosus CNCM I-3690 on the gut microbiome in students under academic stress. The probiotic group showed lower changes in gut microbiota diversity and a potential beneficial effect on stress response, with increased abundance of F. prausnitzii associated with lowered anxiety levels.
Lacticaseibacillus rhamnosus attenuates uremic toxins in patients with nondialysis chronic kidney disease through the anti-inflammatory molecules.
RCT and in vitro study of Lacticaseibacillus rhamnosus L34 and LGG in patients with non-dialysis chronic kidney disease. L34 administration reduced gut-derived uremic toxins and attenuated systemic inflammation and gut dysbiosis compared to placebo.
Effect of the Food Matrix on the Survival to the Gastrointestinal Transit of Lacticaseibacillus rhamnosus CRL1505: A Randomized, Controlled, Crossover Study.
RCT investigating the survival of Lacticaseibacillus rhamnosus CRL1505 through gastrointestinal transit in healthy volunteers. The probiotic's survival was higher when administered as oat- and milk-fermented drinks, highlighting the importance of food matrix selection for probiotic viability.
Effects of synbiotics on necrotizing enterocolitis and full enteral feeding in very low birth weight infants: A double-blind, randomized controlled trial.
A double-blind, randomized controlled trial assessed the efficacy of PediLact, a multi-strain synbiotic, on necrotizing enterocolitis (NEC) and nutritional parameters in very low birth weight infants. The synbiotic group showed a significant decrease in NEC incidence, improved feeding tolerance, and greater weight gain compared to placebo. Hospitalization duration and time to full enteral feeding were also reduced.
A Randomized Clinical Trial to Evaluate the Efficacy of an Oral Probiotic in Acne Vulgaris.
A 12-week randomized, double-blind, placebo-controlled trial evaluated the efficacy of a probiotic capsule containing Lacticaseibacillus rhamnosus and Arthrospira platensis in patients with acne vulgaris. The probiotic group showed significant improvement in the Acne Global Severity Scale and a reduction in non-inflammatory acne lesions compared to placebo. The probiotic was effective and well tolerated.
Efficacy of an adjuvant Lactobacillus rhamnosus formula in improving skin lesions as assessed by PASI in patients with plaque psoriasis from a university-affiliated, tertiary-referral hospital in São Paulo (Brazil): a parallel, double-blind, randomized clinical trial.
This randomized, double-blind, placebo-controlled trial assessed the efficacy of Lactobacillus rhamnosus as an adjuvant treatment for plaque psoriasis in 103 patients. The study found no significant improvement in skin lesions or quality of life in the experimental group compared to controls, suggesting no clinical benefit from the probiotic intervention.
Evaluation of the effects of the FODMAP diet and probiotics on irritable bowel syndrome (IBS) symptoms, quality of life and depression in women with IBS.
RCT evaluating the effects of a low-FODMAP diet and probiotics on IBS symptoms, quality of life, and depression in 52 women with IBS. Both groups showed significant improvements in IBS symptoms, anxiety, depression, and quality of life, but no significant difference was found between the groups.
Safety and functional enrichment of gut microbiome in healthy subjects consuming a multi-strain fermented milk product: a randomised controlled trial.
RCT assessing the safety and gut microbiota response to a multi-strain fermented milk product in 96 healthy adults over 4 weeks. No significant safety differences were found between test and control groups. Probiotic strains were detected only during consumption, with no alteration in gut microbiota structure.
A randomized trial of Lactobacillus rhamnosus IDCC 3201 tyndallizate (RHT3201) for treating atopic dermatitis.
RCT evaluating the therapeutic effect and safety of tyndallized Lactobacillus rhamnosus (RHT3201) in children with moderate atopic dermatitis. The RHT3201 group showed a significantly greater reduction in SCORAD scores compared to the control group, with a tendency for decreased levels of eosinophil cationic protein and interleukin-31. No significant differences in safety parameters were observed.
Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis.
RCT involving 886 children with gastroenteritis to test a combination probiotic containing Lactobacillus rhamnosus and L. helveticus. The probiotic did not prevent moderate-to-severe gastroenteritis or reduce the duration of diarrhea and vomiting compared to placebo.
Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature.
The paper presents a clinical case of infective endocarditis caused by Lactobacillus rhamnosus in a patient with hereditary hemorrhagic telangiectasia (HHT) and reviews literature on similar cases. It highlights the potential risk of serious infections from probiotics in patients with predisposing factors like HHT.
A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial.
Double-blind, randomized placebo-controlled trial of 474 infants at risk of allergic disease. Lactobacillus rhamnosus supplementation significantly reduced the risk of eczema by 2 years, while Bifidobacterium animalis subsp lactis did not. Neither probiotic had a significant effect on atopy.
Clinical trial: effectiveness of Lactobacillus rhamnosus (strains E/N, Oxy and Pen) in the prevention of antibiotic-associated diarrhoea in children.
Double-blind, randomized, placebo-controlled trial in children receiving antibiotics to test the efficacy of Lactobacillus rhamnosus (strains E/N, Oxy and Pen) in preventing antibiotic-associated diarrhoea. The probiotic group had a lower incidence of diarrhoea compared to the placebo group, with no adverse events observed.
Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations.
RCT comparing five probiotic preparations for treating acute diarrhoea in children. Lactobacillus rhamnosus strain GG and a mix of four bacterial strains significantly reduced the duration of diarrhoea compared to oral rehydration solution alone. Other preparations did not affect primary outcomes.
The Effect of Probiotic Yogurt Containing Lactobacillus rhamnosus and Bifidobacterium bifidum on Disease Activity and Disability in Patients with Systemic Lupus Erythematosus: A Randomized Controlled Trial.
This triple-blind, randomized controlled trial evaluated the effect of probiotic yogurt containing Lactobacillus rhamnosus and Bifidobacterium bifidum on disease activity and disability in patients with systemic lupus erythematosus (SLE). The study found no significant short-term effect on SLEDAI scores and disability between the probiotic and control groups.
Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double-Blind Randomized Placebo-Controlled Crossover Trial.
A double-blind randomized placebo-controlled crossover trial evaluated the effects of a multi-species probiotic containing Lactobacillus rhamnosus and Bifidobacterium lactis on cognitive and emotional function in healthy older adults. The study found significant improvements in cognitive function, memory, and depressive symptoms after the probiotic intervention.
Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
RCT of 30 subjects with IBS-C comparing 8 weeks of Lacticaseibacillus rhamnosus IDCC 3201 to placebo. The probiotic group showed significant improvement in bowel movements, constipation discomfort, and IBS symptoms. Fecal microbiome analysis indicated increased abundance of beneficial microbes.
A low glycemic index, energy-restricted diet but not Lactobacillus rhamnosus supplementation changes fecal short-chain fatty acid and serum lipid concentrations in women with overweight or obesity and polycystic ovary syndrome.
RCT involving 40 overweight and obese women with PCOS, comparing an energy-restricted diet with and without Lactobacillus rhamnosus supplementation. The diet significantly improved body weight, BMI, fat mass, SCFA levels, and lipid profile, with no additional benefits from the probiotic supplementation.
EFFECTS OF SYNBIOTIC SUPPLEMENTATION ON GUT FUNCTIONING AND SYSTEMIC INFLAMMATION OF COMMUNITY-DWELLING ELDERS - SECONDARY ANALYSES FROM A RANDOMIZED CLINICAL TRIAL.
Secondary analysis from a 24-week RCT evaluating synbiotic supplementation in 49 community-dwelling elders. No significant differences were found in serum inflammatory markers, but subtle beneficial changes were observed in gut functioning and faeces types.
Supplementation of lactobacilli improves growth, regulates microbiota composition and suppresses skeletal anomalies in juvenile pike-perch (Sander lucioperca) reared in recirculating aquaculture system (RAS): A pilot study.
Pilot study testing lactobacilli supplementation in juvenile pike-perch reared in a recirculating aquaculture system. Results showed positive effects on fish growth, microbiota balance, and skeletal development, with enriched Artemia and hydrolyzed OTOHIME improving protein digestibility and reducing pathogen levels.
Pyrosequencing analysis reveals changes in intestinal microbiota of healthy adults who received a daily dose of immunomodulatory probiotic strains.
The study analyzed the fecal microbiota of healthy adults receiving probiotic strains Lactobacillus rhamnosus, Lactobacillus paracasei, or Bifidobacterium breve. Results showed increased Shannon indices and changes in microbiota composition, with a significant increase in the Lactobacillus genus after intervention with L. rhamnosus.
Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-controlled study.
RCT assessing the effectiveness of vaginal probiotic capsules containing Lactobacillus rhamnosus, L acidophilus, and Streptococcus thermophilus for preventing recurrent bacterial vaginosis in 120 women. Probiotic prophylaxis significantly reduced BV recurrence and Gardnerella vaginalis incidence through 11 months.
The effect of early nutritional supplementation with a mixture of probiotic, prebiotic, fiber and micronutrients in infants with acute diarrhea in Indonesia.
A randomized double-blind clinical trial in 58 Indonesian infants with acute diarrhea assessed the efficacy of a special infant formula containing Lactobacillus rhamnosus, inulin, dietary fiber, and increased zinc and iron. The study group showed a significantly shorter duration of diarrhea compared to the control group, supporting the formula's efficacy in managing infantile diarrhea.
Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis.
RCT of 54 infants with moderate to severe atopic dermatitis comparing daily Lactobacillus rhamnosus GG to placebo over 8 weeks. No significant differences were found between groups in clinical symptoms, use of topical corticosteroids and antihistamines, immunological parameters, or health-related quality of life.
Nucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic lactobacilli.
A randomized, placebo-controlled trial showed that daily oral intake of Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14 restored lactobacilli-dominant microbiota in subjects with bacterial vaginosis (BV) but not in controls. The study highlights the potential of nucleic acid-based methods for identifying bacteria responsible for BV and suggests the use of probiotics for improved management.
Oral probiotics and the female urinary microbiome: a double-blinded randomized placebo-controlled trial.
Double-blinded randomized controlled trial of oral probiotics (Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14) in healthy pre-menopausal women. The study found no significant effect of probiotics on the uropathogens:Lactobacillus ratio or microbiota diversity in the urinary tract.
Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo- controlled trial with 9-month follow-up
This double-blind, placebo-controlled RCT evaluated the effects of Lactobacillus rhamnosus SP1 probiotics and azithromycin as adjuncts to nonsurgical therapy in chronic periodontitis. All groups, including the placebo, showed improvements in clinical and microbiological parameters, with no significant differences between them.
Postoperative symbiotic in patients with head and neck cancer: a double-blind randomised trial.
Double-blind randomized trial evaluating postoperative use of symbiotics in head and neck cancer surgical patients. Symbiotics did not impact intestinal function or postoperative outcomes compared to placebo.
Vaginal colonisation by probiotic lactobacilli and clinical outcome in women conventionally treated for bacterial vaginosis and yeast infection.
Two pilot open label clinical trials investigated the colonisation by lactobacilli and clinical outcomes in women with bacterial vaginosis (BV) and recurrent vulvovaginal candidiasis (R-VVC) receiving antibiotic or anti-fungal treatment in combination with EcoVag® capsules. The study found that the combination treatment provided long-term cure against BV and R-VVC, with higher cure rates observed in women receiving the probiotic alongside conventional treatments.
The innovative potential of Lactobacillus rhamnosus LR06, Lactobacillus pentosus LPS01, Lactobacillus plantarum LP01, and Lactobacillus delbrueckii Subsp. delbrueckii LDD01 to restore the "gastric barrier effect" in patients chronically treated with PPI: a pilot study.
Pilot study assessing the efficacy of probiotics Lactobacillus rhamnosus, Lactobacillus pentosus, Lactobacillus plantarum, and Lactobacillus delbrueckii in reducing gastric and duodenal bacterial overgrowth in patients on long-term PPI therapy. Probiotics significantly reduced bacterial overgrowth and restored the gastric barrier effect, with a decrease in fecal enterococci, coliforms, E. coli, molds, and yeasts.
Probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM® modifies subpopulations of fecal lactobacilli and Clostridium difficile in the elderly.
This randomized, controlled cross-over clinical trial assessed the effects of a probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM on the intestinal microbiota and fecal immune markers of 31 elderly volunteers. The probiotic cheese increased the number of L. rhamnosus and L. acidophilus in the feces and was associated with a trend towards lower counts of Clostridium difficile, but did not significantly alter major microbial groups or fecal immune markers.
Probiotics and Crohn's disease.
RCT of 45 patients with Crohn's disease comparing Lactobacillus rhamnosus GG to placebo for 12 months. The study found no differences in endoscopic and clinical remission between the two groups.
Encapsulation of Lactobacillus rhamnosus with Hyaluronic Acid-based Hydrogel for Pathogen-targeted Delivery to Ameliorate Enteritis.
The study investigates the encapsulation of Lactobacillus rhamnosus in a hyaluronic acid-based hydrogel for targeted delivery to ameliorate enteritis. The encapsulated probiotics showed enhanced viability and therapeutic effects against Salmonella-induced enteritis compared to free cells, demonstrating the potential of this delivery system for improving probiotic efficacy.
Study of the alleviation effects of a combination of Lactobacillus rhamnosus and inulin on mice with colitis.
Animal study investigating the effects of Lactobacillus rhamnosus 1.0320 combined with inulin on DSS-induced colitis in mice. The combination alleviated colitis, reduced Disease Activity Index scores, decreased myeloperoxidase activity, increased hemoglobin content, and regulated inflammatory cytokines. It also increased the abundance and diversity of intestinal flora.