Research
Lactobacillus plantarum
49 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Efficacy and safety of Lactobacillus plantarum P 17630 strain soft vaginal capsule in vaginal candidiasis: a randomized non-inferiority clinical trial.
RCT comparing Lactobacillus plantarum P17630 soft vaginal capsules to miconazole nitrate in 200 women with vulvovaginal candidiasis. Both treatments reduced vaginitis symptoms and IL-6 levels without significant differences. L. plantarum was effective and safe, potentially reducing recurrence risk.
Effects of Lactobacillus plantarum supplementation on glucose and lipid metabolism in type 2 diabetes mellitus and prediabetes: A systematic review and meta-analysis of randomized controlled trials.
A systematic review and meta-analysis of RCTs assessed the effects of Lactobacillus plantarum supplementation on glucose and lipid metabolism in type 2 diabetes mellitus and prediabetes. The supplementation reduced fasting plasma glucose and hemoglobin A1c levels, with non-significant trends towards improvements in insulin resistance and lipid profiles.
Clostridioides difficile Infection in Patients with Chronic Kidney Disease: A Systematic Review.
Systematic review on prevention and treatment of Clostridioides difficile infection (CDI) in chronic kidney disease (CKD) patients. Lactobacillus plantarum (LP299v) was found to be more effective than disinfection measures in preventing CDI, leading to higher cure rates and fewer recurrent episodes.
Effect of Lactobacillusplantarum containing probiotics on blood pressure: A systematic review and meta-analysis.
This systematic review and meta-analysis investigated the role of Lactobacillus plantarum as an anti-hypertensive agent. Seven studies with 653 participants were included, showing significant effects of Lactobacillus plantarum supplementation on lowering systolic and diastolic blood pressure. The findings support its use for blood pressure management, though the clinical significance is limited.
A randomized synbiotic trial to prevent sepsis among infants in rural India.
RCT of an oral synbiotic preparation (Lactobacillus plantarum plus fructooligosaccharide) in 4,556 rural Indian newborns. The treatment significantly reduced the primary outcome of sepsis and death, as well as culture-positive and culture-negative sepsis and lower respiratory tract infections.
Probiotic modulation of gut microbiota with Bifidobacterium animalis subsp. lactis XLTG11 and Lactobacillus plantarum CCFM8661 mitigates recurrent respiratory infections in children: a randomised-controlled trial.
RCT of 120 children with recurrent respiratory tract infections comparing daily probiotic supplementation with Bifidobacterium animalis subsp. lactis XLTG11 and Lactobacillus plantarum CCFM8661 to placebo for 3 months. Probiotics improved clinical efficacy, reduced respiratory episodes, and modulated gut microbiota and immune function without adverse events.
Efficacy and safety of Lactobacillus plantarum GCWB1001 for respiratory health in a double blind randomized placebo controlled trial.
Double-blind, randomized, placebo-controlled trial assessing Lactobacillus plantarum GCWB1001 for respiratory symptoms post-COVID-19 in 126 participants. No significant difference in primary outcome (BCSS score) between groups, though numerical improvements in secondary endpoints were noted. No serious adverse events reported, indicating safety.
Impact of probiotic Lactobacillus plantarum GKM3 on gastrointestinal health in overweight and obese individuals: A randomized clinical trial.
RCT investigating the effects of Lactobacillus plantarum strain GKM3 on gastrointestinal health in overweight and obese individuals. The probiotic group showed increased bowel movement frequency and alleviated gastrointestinal symptoms, with changes in gut microbiota composition.
Distinct Microbial Taxa Are Associated with LDL-Cholesterol Reduction after 12 Weeks of Lactobacillus plantarum Intake in Mild Hypercholesterolemia: Results of a Randomized Controlled Study.
RCT with 86 participants assessing the effect of Lactobacillus plantarum strains on serum lipids and gut microbiota in mild hypercholesterolemia. LDL-C decreased significantly in the LP group compared to placebo, with no effects on HDL, TG, or cardiovascular parameters.
Effect of Lactobacillus plantarum LMT1-48 on Body Fat in Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial.
RCT of 100 overweight volunteers comparing Lactobacillus plantarum LMT1-48 to placebo for 12 weeks. The LMT1-48 group showed significant decreases in body weight, abdominal visceral fat area, insulin resistance, and leptin levels, suggesting anti-obesogenic potential.
Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on Overweight and the Gut Microbiota in Humans: Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
A randomized, double-blind, placebo-controlled study on 72 overweight individuals examined the effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 supplementation. The probiotic group showed reductions in body weight, visceral fat mass, and waist circumference, and an increase in adiponectin, compared to placebo. The probiotics also modulated gut microbiota by increasing Bifidobacteriaceae and Akkermansiaceae and decreasing Prevotellaceae and Selenomonadaceae.
Effect of a new Lactobacillus plantarum product, LRCC5310, on clinical symptoms and virus reduction in children with rotaviral enteritis.
RCT comparing Lactobacillus plantarum (LRCC5310) to control in children with rotaviral enteritis. LRCC5310 improved clinical symptoms, including diarrhea and Vesikari score, and inhibited viral proliferation without significant side effects.
Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition.
The study investigated the effects of Lactobacillus plantarum HY7714 on skin health through its impact on intestinal condition and immune responses. HY7714 consumption altered gut bacterial abundances, reduced inflammation markers, and regulated gene expression related to gut barrier integrity, suggesting benefits for skin health.
Inflammatory cytokines and lipid profile in children and adolescents with nephrotic syndrome receiving L. Plantarum: a randomized, controlled feasibility trial.
This randomized, double-blind, placebo-controlled trial evaluated the efficacy of Lactobacillus Plantarum as an immunomodulatory and hypolipidemic agent in dyslipidemic nephrotic children and adolescents. The probiotic group showed a tendency to reduce TNF-α levels, increase IL-10 levels, and decrease serum triglyceride and total cholesterol levels compared to controls.
Probiotic supplementation with Lactobacillus plantarum and Pediococcus acidilactici for Helicobacter pylori therapy: A randomized, double-blind, placebo-controlled trial.
RCT evaluating the safety, tolerability, and efficacy of probiotic supplementation with Lactobacillus plantarum and Pediococcus acidilactici for Helicobacter pylori eradication therapy. No differences were observed in side effects, compliance, or eradication rates between the probiotic and placebo groups.
Effects of race distance and probiotics intervention on kidney, muscle, and gut injury and inflammation biomarker responses during running.
This randomized, double-blind, placebo-controlled study assessed the impact of trail race running on kidney and muscle injury and gut inflammation biomarkers, and the potential mitigating effects of Lp299v supplementation. Running increased kidney injury markers and gut inflammation, especially in ultradistance races. Lp299v supplementation showed a protective effect against gut inflammation.
Consumption of a new developed synbiotic yogurt improves oxidative stress status in adults with metabolic syndrome: a randomized controlled clinical trial.
RCT of 44 adults with metabolic syndrome comparing synbiotic yogurt containing Lactobacillus plantarum, Lactobacillus pentosus, and Chloromyces marcosianos yeast to regular yogurt for 12 weeks. The synbiotic yogurt group showed significant improvements in oxidative stress markers, including glutathione peroxidase and total oxidant status.
The effect of a new developed synbiotic yogurt consumption on metabolic syndrome components in adults with metabolic syndrome: a randomized controlled clinical trial.
RCT of 44 adults with metabolic syndrome comparing synbiotic yogurt containing L. plantarum, L. pentosus, and C. marcosianos yeast to regular yogurt for 12 weeks. The synbiotic yogurt group showed significant improvements in fasting blood glucose, fasting insulin, HOMA-IR index, waist to hip ratio, and systolic blood pressure.
A tangible prospect for the treatment of gingivitis using a potentially probiotic strain Lactobacillus plantarum MK06 isolated from traditional dairy products: a triple blind randomized clinical trial.
A triple-blind randomized clinical trial investigated the effect of Lactobacillus plantarum MK06 on gingivitis treatment. Patients used either placebo or probiotic suspensions for four weeks. The experimental group showed a higher reduction in gingival indices, with a significant difference in gingival index by the fourth week.
Carbon monoxide (CO) correlates with symptom severity, autoimmunity, and responses to probiotics treatment in a cohort of children with autism spectrum disorder (ASD): a post-hoc analysis of a randomized controlled trial.
Post-hoc analysis of a randomized controlled trial involving 35 children with autism spectrum disorder (ASD) to explore the effects of Lactobacillus plantarum probiotic supplementation. The study found correlations between ASD severity and various biomarkers, suggesting that probiotic treatment may influence gut microbiome and inflammatory markers, potentially improving ASD symptoms.
Lactobacillus plantarum HAC01 Supplementation Improves Glycemic Control in Prediabetic Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial
RCT of 40 prediabetic subjects comparing Lactobacillus plantarum HAC01 supplementation to placebo over eight weeks. The supplemented group showed significant reductions in 2h-PPG and HbA1c levels, indicating improved glycemic control.
Effects of 4 weeks of Lactobacillus plantarum 299v supplementation on nutritional status, enteral nutrition tolerance, and quality of life in cancer patients receiving home enteral nutrition - a double-blind, randomized, and placebo-controlled trial.
Double-blind, randomized, placebo-controlled trial of 35 cancer patients receiving home enteral nutrition, comparing Lactobacillus plantarum 299v to placebo for 4 weeks. Lp299v group showed a significant increase in serum albumin concentration and reduced gastrointestinal symptoms, but no significant impact on overall nutritional status or quality of life compared to placebo.
Beneficial effect of Lactobacillus plantarum IS-10506 supplementation in adults with atopic dermatitis: a randomized controlled trial
A randomized double-blind placebo-controlled trial assessed the effects of Lactobacillus plantarum IS-10506 supplementation in 30 adults with mild and moderate atopic dermatitis. The probiotic group showed significantly lower SCORAD scores and IL-4 and IL-17 levels, and higher IFN-γ and Foxp3+ levels compared to the placebo group, indicating improved AD symptoms due to immunomodulatory effects.
Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study.
RCT evaluating the impact of Probi Defendum (Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2) on common cold symptoms in 131 children attending day care. The probiotic significantly reduced nasal congestion severity and concomitant medication use, with projected data favoring reduced absence from day care and symptom severity.
Probiotics modulate the gut microbiota composition and immune responses in patients with atopic dermatitis: a pilot study.
Pilot RCT with 109 AD patients divided into placebo, oligosaccharides, Bifidobacterium bifidum CCFM16, and Lactobacillus plantarum CCFM8610 groups. CCFM8610 significantly decreased SCORAD index, increased serum IL-10 levels, and influenced gut microbiota composition, suggesting strain-specific amelioration effects on AD.
New evidence on oral L. plantarum P17630 product in women with history of recurrent vulvovaginal candidiasis (RVVC): a randomized double-blind placebo-controlled study.
RCT evaluating the oral probiotic Lactobacillus plantarum P17630 in 93 women with recurrent vulvovaginal candidiasis. The probiotic significantly improved lactobacilli colonization and clinical signs such as redness, swelling, and discharge compared to placebo.
The effects of synbiotic supplementation on insulin resistance/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus: A randomized double blind placebo controlled clinical trial.
RCT of 90 pregnant women with gestational diabetes mellitus assessing synbiotic supplementation effects on insulin resistance, lipid profile, and antioxidative status. No significant changes in insulin resistance/sensitivity, lipid profile, and TAC indices were observed compared to placebo. Significant within-group increases for HDL-C and TAC levels in the synbiotic group were noted. Synbiotic supplementation significantly reduced systolic and diastolic blood pressure compared to placebo.
Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals.
A randomized, double-blind, placebo-controlled study on 66 overweight individuals evaluated the effects of Lactobacillus curvatus and Lactobacillus plantarum supplementation on body fat and metabolic intermediates. Probiotic supplementation significantly increased medium-chain acylcarnitines and was associated with reductions in body weight, body fat percentage, body fat mass, and subcutaneous fat area.
Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia.
RCT of 128 non-diabetic subjects with hypertriglyceridemia evaluating the effect of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 supplementation. The probiotic group showed an 18.3% reduction in triglycerides and increases in apolipoprotein A-V and LDL particle size compared to placebo.
Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study.
RCT of 110 volunteers aged 41 to 59 with dry skin and wrinkles, testing Lactobacillus plantarum HY7714 against placebo for 12 weeks. The probiotic group showed significant improvements in skin hydration, wrinkle depth, skin gloss, and elasticity, confirming the anti-aging benefits of HY7714.
The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects.
A randomized, double-blind, placebo-controlled study on 92 participants with hypertriglyceridemia evaluated the triglyceride-lowering effects of dual probiotic strains Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032. The probiotic group showed a 20% reduction in serum triglycerides and a 25% increase in apolipoprotein A-V after 12 weeks.
Impact of probiotic Lactobacillus plantarum TENSIA in different dairy products on anthropometric and blood biochemical indices of healthy adults.
Two double-blinded randomised placebo-controlled exploratory trials assessed the effects of probiotic Lactobacillus plantarum TENSIA in cheese or yoghurt on healthy adults over three weeks. The probiotic lowered systolic and diastolic blood pressure, regardless of food matrix or baseline values, suggesting a potential to decrease CVD risk.
Effect of Lactobacillus plantarum on diarrhea and intestinal barrier function of young piglets challenged with enterotoxigenic Escherichia coli K88.
RCT investigating the effect of Lactobacillus plantarum on diarrhea and intestinal barrier function in young piglets challenged with enterotoxigenic Escherichia coli K88. L. plantarum improved growth performance and prevented ETEC K88-induced diarrhea by enhancing intestinal barrier function and morphology.
Evaluation of paraprobiotic applicability of Lactobacillus plantarum in improving the immune response and disease protection in giant freshwater prawn, Macrobrachium rosenbergii (de Man, 1879).
A 90-day feeding trial evaluated the paraprobiotic effect of heat-killed Lactobacillus plantarum on giant freshwater prawn Macrobrachium rosenbergii. While growth and feed utilization parameters showed marginal improvement, immune parameters and disease resistance significantly improved with higher concentrations of the paraprobiotic.
Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics.
RCT examining the effect of Lactobacillus plantarum intake on gastrointestinal symptoms in antibiotic-treated patients. The study found a significantly lower risk of developing loose or watery stools and nausea among those receiving L. plantarum, though diarrhea was unaffected.
Bacteriotherapy with Lactobacillus plantarum in burns.
Exploratory RCT comparing topical Lactobacillus plantarum to silver sulphadiazine (SD-Ag) in 80 burn patients. L. plantarum showed similar or better outcomes in reducing bacterial load, promoting granulation tissue, and healing compared to SD-Ag, suggesting it as a potential alternative for burn treatment.
Improvement of constipation and liver function by plant-derived lactic acid bacteria: a double-blind, randomized trial.
Double-blind RCT with 68 healthy adults evaluating the effects of yogurts made by different types of LAB on gastrointestinal health, serum lipid contents, and liver function. Type A and B yogurts improved defecation frequency in constipated subjects, while type B yogurt also improved serum lipid contents and liver function.
Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomised controlled open pilot study.
RCT comparing the probiotic Lactobacillus plantarum 299 (Lp299) to chlorhexidine (CHX) for reducing pathogenic bacteria in the oropharynx of intubated, mechanically ventilated patients. No significant difference was found between Lp299 and CHX in reducing bacterial colonisation.
Benefits of a synbiotic formula (Synbiotic 2000Forte) in critically Ill trauma patients: early results of a randomized controlled trial.
RCT of 65 critically ill, mechanically ventilated, multiple trauma patients comparing a synbiotic formula (Synbiotic 2000Forte) to placebo. Synbiotic-treated patients showed significantly reduced rates of infections, SIRS, severe sepsis, and mortality, as well as reduced ICU stay and days under mechanical ventilation.
Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients.
RCT comparing early enteral nutrition with fiber and living Lactobacillus plantarum 299 to selective bowel decontamination in 95 liver transplant recipients. The group receiving living lactobacilli and fiber developed significantly fewer bacterial infections compared to the SBD group. The mean duration of antibiotic therapy, total hospital stay, and ICU stay were shorter in the living Lactobacillus group, though not statistically significant.
Probiotic Soy Milk Consumption and Renal Function Among Type 2 Diabetic Patients with Nephropathy: a Randomized Controlled Clinical Trial.
RCT of 48 type 2 diabetic nephropathy patients comparing 200 mL/day probiotic soy milk to soy milk for 8 weeks. Probiotic soy milk significantly reduced Cys-C and PGRN levels, indicating potential benefits for renal function.
Kidney Function Improvement by Soy Milk Containing Lactobacillus plantarum A7 in Type 2 Diabetic Patients With Nephropathy: a Double-Blinded Randomized Controlled Trial.
Double-blinded RCT of 44 type 2 diabetic patients with nephropathy comparing probiotic soy milk containing Lactobacillus plantarum A7 to conventional soy milk for 8 weeks. Probiotic soy milk significantly reduced albuminuria, serum creatinine, interleukin-18, and sialic acid, and improved estimated glomerular filtration rate.
The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial.
RCT investigating the effects of three Lactobacillus plantarum strains on small intestinal barrier function and mucosal gene transcription in 10 healthy volunteers. L. plantarum TIFN101 modulated gene transcription pathways related to cell-cell adhesion, with specific effects on tight- and adhesion junction protein synthesis and degradation, while the lactulose-rhamnose ratio was not significantly affected by the bacterial interventions.
Citrus juice fermented with Lactobacillus plantarum YIT 0132 alleviates symptoms of perennial allergic rhinitis in a double-blind, placebo-controlled trial.
Double-blind, placebo-controlled trial examining the effects of citrus juice fermented with Lactobacillus plantarum YIT 0132 on perennial allergic rhinitis. The LP0132 group showed significant reductions in nasal symptoms and improvements in immune markers compared to the placebo group.
Effect of probiotic L. plantarum IS-10506 and zinc supplementation on humoral immune response and zinc status of Indonesian pre-school children.
A 90-day randomized, double-blind, placebo-controlled trial in Indonesian children aged 12-24 months tested the effects of Lactobacillus plantarum IS-10506 and zinc supplementation. The probiotic and combination groups showed significant increases in fecal sIgA, and the combination group had the highest elevation in serum zinc concentrations, indicating improved humoral immune response and zinc status.
Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients--a randomized double-blind placebo-controlled pilot study.
This randomized, double-blind, placebo-controlled pilot study tested a hypocaloric diet supplemented with probiotic cheese containing Lactobacillus plantarum TENSIA in obese hypertensive patients. The probiotic cheese group showed significant reductions in BMI and arterial blood pressure, indicating potential benefits for metabolic syndrome symptoms.
Long-term colonization of a Lactobacillus plantarum synbiotic preparation in the neonatal gut.
This randomized, double-masked, controlled trial studied the colonizing ability and impact of a synbiotic supplement containing Lactobacillus plantarum and fructooligosaccharides in neonates. The synbiotic preparation quickly colonized the gut, increased bacterial diversity, and reduced gram-negative bacterial load, with infants remaining colonized for several months post-therapy.
Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis.
RCT of 45 patients with acute pancreatitis comparing live L. plantarum 299 with heat-killed L. plantarum 299. The treatment group showed reduced pancreatic sepsis and fewer surgical interventions compared to the control group.
Effect of probiotics Lactobacillus paracasei GKS6, L. plantarum GKM3, and L. rhamnosus GKLC1 on alleviating alcohol-induced alcoholic liver disease in a mouse model
Animal study on the effects of probiotics Lactobacillus paracasei GKS6, L. plantarum GKM3, and L. rhamnosus GKLC1 on alcohol-induced alcoholic liver disease in mice. Probiotics reduced serum ALT, liver TG, and liver TC levels, and inhibited decreasing GSH and CAT levels, suggesting potential benefits in alleviating ALD.