Research
Lactobacillus helveticus
17 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
A randomized controlled trial to evaluate the effect of influenza vaccination and probiotic supplementation on immune response and incidence of influenza-like illness in an elderly population in Indonesia.
RCT in 554 elderly subjects evaluating the effect of influenza vaccination and probiotic supplementation on immune response and ILI incidence. The influenza vaccine increased seroprotection and seroconversion rates, while probiotics did not alter influenza antibody titers or ILI incidence.
The effects of next generation probiotics on metabolic dysfunction-associated steatotic liver disease: a parallel, double-blind, randomized, placebo-controlled trial.
RCT of 110 patients with MASLD evaluating the effects of probiotics (Lactobacillus delbrueckii subsp. Lactis, L. helveticus, and Pediococcus pentosaceus) on liver function and stool microbiome. LL001 improved liver enzyme levels, LH001 reduced body weight, and PPKID7 reduced cholesterol levels. Probiotics altered gut microbiota composition.
Effects of supplementation with two probiotic strains (Lactobacillus helveticus and Bifidobacterium longum) on hormonal status, oxidative stress, and clinical symptoms in women with polycystic ovary syndrome: a randomized clinical trial.
This randomized clinical trial investigated the effects of 8-week supplementation with Lactobacillus helveticus and Bifidobacterium longum on hormonal status, oxidative stress, and clinical symptoms in 90 women with PCOS. The probiotic supplementation significantly increased sex hormone binding globulin, total antioxidant capacity, and superoxide dismutase activity, while decreasing free androgen index, C-reactive protein, and malondialdehyde levels. Clinical symptoms such as acne, alopecia, and hirsutism showed no significant changes.
The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Iranian overweight and obese elderly: a randomized, double-blind, placebo-controlled clinical trial.
This randomized, double-blind, placebo-controlled clinical trial investigated the effects of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in 67 overweight and obese elderly individuals. The study found a significant improvement in depression scores with probiotic-fortified kefir, but no significant effects on appetite, inflammation, and oxidative stress parameters, except for total antioxidant capacity.
Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome.
RCT of 163 patients with constipation-predominant IBS comparing sterilized probiotic containing Lactobacillus helveticus with and without polydextrose. Both groups showed reduced intestinal transit time and fecal pH, and improved constipation-related symptoms. The addition of polydextrose did not confer additional benefits.
Modulatory effect of three probiotic strains on infants' gut microbial composition and immunological parameters on a placebo-controlled, double-blind, randomised study.
RCT analyzing the effect of three probiotic strains on gut microbial composition and immunological parameters in infants aged 3 to 12 months. The probiotic groups showed a microbiome profile resembling younger infants and an anti-inflammatory effect, while the placebo group exhibited a pro-inflammatory profile.
A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression.
This double-blind, randomized, placebo-controlled trial investigated the effects of a probiotic preparation containing Lactobacillus helveticus and Bifidobacterium longum on mood, stress, and anxiety in participants with low mood. No significant differences were found between the probiotic and placebo groups on psychological outcomes or blood-based biomarkers. The study found no evidence that the probiotic formulation is effective in treating low mood.
Effectiveness of Lactobacillus helveticus and Lactobacillus rhamnosus for the management of antibiotic-associated diarrhoea in healthy adults: a randomised, double-blind, placebo-controlled trial.
This 10-week randomised, double-blind, placebo-controlled trial investigated the effect of Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011 on antibiotic-associated diarrhoea in healthy adults. While primary outcomes showed no significant difference, a post hoc analysis revealed that probiotic intervention reduced the duration of diarrhoea-like defecations by 1 day compared to placebo.
Emergency Department Treatment of Children With Diarrhea Who Attend Day Care: A Randomized Multidose Trial of a Lactobacillus helveticus and Lactobacillus rhamnosus Combination Probiotic.
RCT of children aged 4 to 48 months with gastroenteritis receiving placebo or probiotic (Lactobacillus helveticus and Lactobacillus rhamnosus) for 5 days. The probiotic did not significantly reduce day care absenteeism or unscheduled health care visits compared to placebo.
The antihypertensive effect of fermented milk in individuals with prehypertension or borderline hypertension.
Randomised, double-blind placebo-controlled study of the antihypertensive effect of Lactobacillus helveticus fermented milk in 94 prehypertensive and borderline hypertensive subjects. No statistically significant differences in blood pressure were found between groups, although the group receiving 300ml FM showed reduced BP in several readings, suggesting a minor effect.
Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects.
The study investigated the anxiolytic-like activity of a probiotic formulation containing Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 in rats and humans. In rats, the formulation reduced anxiety-like behavior, while in humans, it alleviated psychological distress, reducing scores on anxiety, depression, and stress scales.
Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement.
RCT of 94 hypertensive patients comparing Lactobacillus helveticus LBK-16H fermented milk with high tripeptide doses to a control product for 10 weeks. The L. helveticus group showed significant reductions in systolic and diastolic blood pressure compared to the control group, with no difference in adverse events.
Effect of powdered fermented milk with Lactobacillus helveticus on subjects with high-normal blood pressure or mild hypertension.
RCT evaluating the effect of powdered fermented milk with Lactobacillus helveticus CM4 on subjects with high-normal blood pressure or mild hypertension. Significant decrease in diastolic blood pressure was observed in the high-normal group, and a significant decrease in systolic blood pressure in the mild hypertension group, with no adverse effects.
Effects of 12 weeks of treatment with fermented milk on blood pressure, glucose metabolism and markers of cardiovascular risk in patients with type 2 diabetes: a randomised double-blind placebo-controlled study.
RCT of 41 patients with type 2 diabetes comparing 300 ml milk fermented with Lactobacillus helveticus to placebo for 12 weeks. The fermented milk did not significantly reduce blood pressure but did lower heart rates and fasting plasma glucose levels compared to placebo.
The effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly subjects.
Prospective, randomized, double-blind, placebo-controlled crossover study of 29 healthy elderly subjects examining the effects of Lactobacillus helveticus fermented milk on sleep and health perception. Significant improvements in sleep efficiency and number of wakening episodes were observed with fermented milk, though no significant changes were noted in quality of life scores.
The effect of Lactobacillus helveticus fermented milk on acute changes in calcium metabolism in postmenopausal women.
Randomised double-blind crossover study of 20 postmenopausal women examining the effect of Lactobacillus helveticus fermented milk on calcium metabolism. The fermented milk reduced serum PTH and increased serum calcium compared to control milk, indicating a positive acute effect on calcium metabolism.
A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects.
A placebo-controlled study tested the effect of Calpis sour milk, fermented with Lactobacillus helveticus and Saccharomyces cerevisiae, on blood pressure in 30 elderly hypertensive patients. The sour-milk group showed significant decreases in systolic and diastolic blood pressure after 4 and 8 weeks, with no significant changes in the placebo group.