Research
L-Isoleucine
4 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
L-isoleucine-supplemented oral rehydration solution in the treatment of acute diarrhoea in children: a randomized controlled trial.
This double-blind randomized controlled trial examined the effects of L-isoleucine-supplemented oral rehydration solution on acute diarrhoea in children. The study found a significant reduction in stool output and ORS intake in the L-isoleucine group, although the duration of diarrhoea and antimicrobial peptide induction were not significantly different.
Effects of L-isoleucine and L-valine on hot flushes and serum homocysteine: a randomized controlled trial.
RCT of 100 postmenopausal women testing L-isoleucine and L-valine for hot flushes and serum homocysteine levels. L-isoleucine showed no significant effect on hot flushes, and neither amino acid affected fasting serum homocysteine levels.
Which of the branched-chain amino acids increases cerebral blood flow in hepatic encephalopathy? A double-blind randomized trial.
Double-blind randomized trial comparing leucine and isoleucine supplementation in 27 subjects with cirrhosis and hepatic encephalopathy. Isoleucine increased brain perfusion and improved hepatic encephalopathy at 8 and 12 months, while leucine did not show significant effects.
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.
The study investigates the distinct metabolic effects of the branched-chain amino acids isoleucine, valine, and leucine. It finds that reducing dietary isoleucine and valine improves metabolic health in diet-induced obese mice by increasing hepatic insulin sensitivity and energy expenditure. The study suggests reducing dietary isoleucine as a potential approach to treating and preventing obesity and diabetes.