Research
L-Histidine
10 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Histidine: A Systematic Review on Metabolism and Physiological Effects in Human and Different Animal Species.
Systematic review of histidine metabolism and physiological effects in humans and various animal species. In humans, dietary histidine may improve metabolic syndrome and affect ion absorption, but excess can cause eating and memory disorders. In animals, histidine influences food intake, neuroprotection, carnosine synthesis, cataract prevention, and milk protein synthesis, with excess causing growth retardation and metabolic dysfunction.
Essential amino acid supplementation for pressure ulcers: pathophysiological rationale and results from a pilot study.
Pilot clinical trial assessing the effect of Pellicar-F, a proprietary food composition containing histidine in the form of carnosine, plus tryptophan and threonine on pressure ulcer control. Patients receiving the supplement showed a statistically significant reduction in pressure ulcer area after six weeks compared to controls.
Tolerance to graded dosages of histidine supplementation in healthy human adults.
RCT assessing tolerance to graded dosages of histidine supplementation in healthy adults. No changes in vitals or body composition were observed, but plasma histidine and blood urea nitrogen increased with higher dosages. Ferritin concentrations decreased at 12 g/d, and serum zinc decreased at 16 g/d. The no-observed adverse effect level was determined to be 8 g/d.
Effects of Histidine Supplementation on Global Serum and UrineH NMR-based Metabolomics and Serum Amino Acid Profiles in Obese Women from a Randomized Controlled Study.
RCT investigating the metabolic changes associated with histidine supplementation in obese women with metabolic syndrome. Histidine supplementation led to changes in serum and urine metabolomics and amino acid profiles, including increased histidine, glutamine, and glycine, and decreased cholesterol and triglycerides.
Antidiarrheal effects of L-histidine-supplemented rice-based oral rehydration solution in the treatment of male adults with severe cholera in Bangladesh: a double-blind, randomized trial.
Double-blind RCT of 126 adult male cholera patients comparing rice-based ORS with and without L-histidine. L-histidine supplementation significantly reduced stool output frequency and volume, required less unscheduled intravenous fluid, and shortened illness duration, with no adverse effects.
Effect of L-histidine in vivo on human platelet function and arachidonic acid metabolism.
The study investigated the effect of l-histidine on human platelet function and arachidonic acid metabolism in 18 healthy subjects with increased spontaneous platelet aggregation. L-histidine intake reduced spontaneous platelet aggregation and inhibited platelet TXB2 generation, while PGE2 synthesis was unaffected. Plasma l-histidine levels increased significantly during the study.
Failure of oral L-histidine to influence appetite or affect zinc metabolism in man: a double-blind study.
Double-blind, balanced, crossover study of oral L-histidine (4 g/day) in 8 normal volunteers for 2 weeks. L-Histidine had no significant effect on appetite, taste and smell perception, food intake, body weight, or zinc metabolism, though serum histidine concentrations increased.
Histidine supplementation for treatment of anaemia of uraemia.
Randomized double-blind controlled study assessing the effects of supplemental histidine on anaemia in 16 chronically uraemic patients and 26 patients undergoing maintenance dialysis. Haemoglobin and packed cell volume increased slightly in both placebo and histidine groups, but the change was statistically significant only in the placebo group. Plasma histidine rose significantly in histidine-treated patients undergoing dialysis. Supplementary L-histidine did not improve anaemia.
L-Histidine: failure to affect the sleep-waking cycle in man.
L-Histidine was administered to patients with narcolepsy, normal volunteers, and a patient with systemic sclerosis. No effect was observed on nocturnal EEG sleep patterns or narcolepsy symptoms, failing to support the hypothesis that histamine is a waking factor.
Benefits and Adverse Effects of Histidine Supplementation.
This narrative review examines the benefits and adverse effects of histidine supplementation. Histidine intake is associated with decreased BMI, adiposity, and markers of glucose homeostasis, inflammation, and oxidative stress. It may also improve cognitive function and stress responses. However, high intakes can lead to adverse effects such as decreased serum zinc and cognitive impairment. The review highlights gaps in knowledge regarding histidine supplementation.