Research
L-Arginine
208 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Arginine therapy in sickle cell disease: A systematic review and meta-analysis of clinical outcomes.
This meta-analysis evaluated the efficacy of l-arginine on clinical outcomes in sickle cell disease patients experiencing vaso-occlusive crises. It included eight RCTs with 830 patients and found no statistically significant benefit of arginine on pain scores, opioid consumption, time to crisis resolution, or length of hospital stay. The study concluded that l-arginine is not recommended for routine clinical use due to the lack of proven efficacy and a potential safety signal regarding hospital readmissions.
Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial
A 2-year randomized controlled trial with 6000 children aged 10 to 14 years compared the efficacy of dentifrices containing 8.0% arginine, 1.5% arginine, and 0.32% sodium fluoride in preventing dental caries. The 8.0% arginine dentifrice significantly reduced caries incidence compared to the sodium fluoride control, while the 1.5% arginine dentifrice showed no statistical difference from the control.
L-Arginine and L-Citrulline for Prevention and Treatment of Pre-Eclampsia: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis evaluating the effects of L-arginine and L-citrulline on pre-eclampsia prevention and treatment. L-arginine was associated with reduced risk of pre-eclampsia and severe pre-eclampsia in prevention trials, and may reduce systolic blood pressure and fetal growth restriction in treatment trials. L-citrulline showed no effect in the single study examined.
Impact of chronic pain on acute pain trajectories in sickle cell disease: Insights from the sickle cell disease treatment with arginine therapy (STArT) randomized controlled trial
The STArT trial was a phase-3 double-blind, randomized placebo-controlled trial of intravenous arginine therapy in 271 participants aged 3-21 years with sickle cell disease and vasoocclusive episode pain. The study compared pain trajectories in participants with and without chronic pain, finding that those with chronic pain experienced a smaller magnitude of change in pain score and a slower decline in pain during hospitalization.
Synergistic effects of Bacillus subtilis QST 713 and L-arginine supplementation during late gestation on reproductive performance in Landrace × Yorkshire sows: A randomized controlled trial
A randomized controlled trial on 247 Landrace × Yorkshire sows evaluated the effects of Bacillus subtilis QST 713 and L-arginine supplementation during late gestation on reproductive performance. Co-supplementation significantly increased individual and total birth weights, the proportion of large piglets, and reduced runt piglet incidence, while neither supplement alone produced significant improvements.
Comparative efficacy of different single drugs to prevent necrotizing enterocolitis in preterm infants: an update systematic review and network meta-analysis.
Systematic review and network meta-analysis of 89 RCTs with 26,861 preterm infants comparing the efficacy of lactoferrin, probiotics, prebiotics, glutamine, arginine, and EPO in preventing necrotizing enterocolitis (NEC). Arginine was found to be the most effective in reducing NEC incidence, with probiotics as the next most effective. Lactoferrin was most effective for reducing NEC-associated sepsis.
Nutraceutical interventions for erectile dysfunction: a systematic review and network meta-analysis.
Systematic review and network meta-analysis of 15 RCTs involving 1000 men with erectile dysfunction. The combination of propionyl L-carnitine, acetyl L-carnitine, and Sildenafil showed the highest efficacy in improving erectile function scores, followed by L-Arginine + Tadalafil. L-Arginine and the mix PLC + ALC were particularly useful in combination with PDE5i for organic ED.
Prognostic implications of the arginine metabolism in patients at nutritional risk: A secondary analysis of the randomized EFFORT trial.
Secondary analysis of the EFFORT trial assessing arginine levels and metabolites in 231 polymorbid medical inpatients at nutritional risk. Low arginine levels were associated with higher all-cause mortality at 30 days and 5 years, suggesting worse clinical outcomes.
L-arginine impact on inflammatory and cardiac markers in patients undergoing coronary artery bypass graft: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs examining the impact of L-arginine on inflammatory and cardiac markers in patients undergoing coronary artery bypass grafting. L-arginine significantly reduced troponin T and interleukin-6 levels, suggesting benefits in reducing inflammatory reactions and myocardial ischemia.
A systematic review and meta-analysis of nitric oxide-associated arginine metabolites in schizophrenia.
Systematic review and meta-analysis of arginine metabolites in schizophrenia, focusing on their role in nitric oxide regulation. Patients with schizophrenia had higher levels of ADMA, dimethylamine, and ornithine, suggesting dysregulation of DDAH1 and arginase enzymes.
Sickle Cell Disease Treatment with Arginine Therapy (STArT): study protocol for a phase 3 randomized controlled trial
The STArT Trial is a phase 3, double-blind, placebo-controlled, randomized trial investigating the efficacy of intravenous arginine therapy for acute vaso-occlusive episodes in children, adolescents, and young adults with sickle cell disease. The primary outcome is time to pain crisis resolution, with secondary outcomes including total opioid use and patient-reported outcomes.
The effect of a lozenge combining prebiotic arginine and probiotics on caries increment in children during 10-12 months, a randomized clinical trial.
RCT of 343 children aged 5-9 years comparing a lozenge containing arginine and probiotics to placebo over 10-12 months. The intervention group showed a statistically significant reduction in caries increment but no effect on plaque or gingivitis occurrence.
The efficacy of combined arginine and probiotics as an add-on to 1450 ppm fluoride toothpaste to prevent and control dental caries in children - A randomized controlled trial.
RCT examining the effect of a lozenge combining arginine and probiotics on dental caries in children over 10-12 months. The intervention group showed a marked, though not statistically significant, reduction in caries progression and active lesions compared to the placebo group.
Efficacy of L-arginine and Pycnogenol ® in the treatment of male erectile dysfunction: a systematic review and meta-analysis.
This meta-analysis reviewed clinical trials of the combination of Pycnogenol and L-arginine (PAL) in treating erectile dysfunction in men. The results showed significant improvements in various sexual function scores, though no significant difference in testosterone levels was observed. The study suggests PAL may improve sexual function in patients with mild to moderate ED.
Circulating arginine metabolites in Alzheimer's disease and vascular dementia: A systematic review and meta-analysis.
Systematic review and meta-analysis of circulating arginine metabolites linked to NO synthesis in Alzheimer's disease and vascular dementia. Found significantly higher ADMA, SDMA, and citrulline concentrations in dementia patients compared to controls, suggesting potential biomarkers for dementia pathophysiology.
The influence of arginine supplementation on IGF-1: A systematic review and meta-analysis.
This systematic review and meta-analysis investigated the efficacy of acute and chronic arginine supplementation on IGF-1 levels. The analysis included nine studies and found that neither acute nor chronic arginine supplementation significantly affected IGF-1 levels.
Efficacy and safety of pharmacological interventions for managing sickle cell disease complications in children and adolescents: Systematic review with network meta-analysis.
Systematic review with network meta-analysis of 18 RCTs evaluating disease-modifying agents for managing sickle cell disease in children and adolescents. Hydroxyurea and immunotherapy/monoclonal antibodies were more effective for preventing vaso-occlusive crisis, acute chest syndrome, and transfusions, while l-arginine and placebo were more prone to these events. Therapies were generally safe, though antiplatelets and sulfates may lead to severe adverse events.
l-Arginine in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes: A Systematic Review.
Systematic review of 37 articles assessing the safety and efficacy of l-arginine in managing stroke-like episodes in patients with mitochondrial disease. The review found no demonstrable clinical benefit of IV or oral l-arginine in acute or prophylactic treatment, with moderate adverse events reported and 12% mortality during follow-up.
l-arginine supplementation improved neonatal outcomes in pregnancies with hypertensive disorder or intrauterine growth restriction: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs examining l-arginine supplementation in pregnancies with hypertensive disorder or intrauterine growth restriction. Findings indicate l-arginine increases plasma nitric oxide, reduces preeclampsia risk, elevates birth weights, and reduces small for gestational age risk in complicated pregnancies.
Oral L-arginine supplementation for fracture healing: a systematic review of preclinical studies.
Systematic review of preclinical studies on oral L-arginine supplementation for fracture healing. The review included 3 animal studies and 1 in vitro study, showing increased angiogenesis, reduced defect area, higher osteoblasts and osteoclasts, and higher rate of bone formation with L-arginine supplementation.
Effect of l-Arginine Supplementation on Blood Pressure in Adults: A Systematic Review and Dose-Response Meta-analysis of Randomized Clinical Trials.
Systematic review and dose-response meta-analysis of 22 RCTs examining the impact of l-arginine supplementation on blood pressure in adults. The analysis found significant decreases in systolic and diastolic blood pressure after l-arginine supplementation, with variations based on dosage, duration, and participant characteristics.
Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women.
This systematic review evaluates the efficacy and safety of l-arginine alone or in combination for treating women with hypoactive sexual desire disorder and related conditions. It includes five randomized controlled trials and two nonrandomized studies, with most studies reporting improvements in sexual function scores. Combination products containing l-arginine, such as ArginMax or Lady Prelox, may be beneficial for these conditions.
The effect of L-arginine supplementation on maximal oxygen uptake: A systematic review and meta-analysis.
This systematic review and meta-analysis investigated the effect of L-arginine supplementation on maximal oxygen uptake (VO2 max) in healthy people. The results of 11 randomized clinical trials indicated that L-arginine supplementation increased VO2 max compared to the control group.
Effects of L-arginine supplementation on biomarkers of glycemic control: a systematic review and meta-analysis of randomised clinical trials.
This meta-analysis of twelve randomised clinical trials assessed the effectiveness of L-arginine supplementation on biomarkers of glycemic control in adults. The study found that L-arginine had no significant effect on serum fasting blood sugar, serum insulin, glycated haemoglobin A1c, or insulin resistance.
Asymmetric dimethylarginine predicts perioperative cardiovascular complications in patients undergoing medium-to-high risk non-cardiac surgery.
Prospective RCT of 269 patients undergoing major abdominal and/or thoracic surgery, assessing L-arginine/L-citrulline supplementation's effect on perioperative cardiovascular risk. L-arginine/L-citrulline increased plasma L-arginine levels and improved the L-arginine/ADMA ratio, with a non-significant trend towards fewer cardiovascular events in patients with high pre-operative ADMA.
Prenatal Amino Acid Supplementation to Improve Fetal Growth: A Systematic Review and Meta-Analysis
Systematic review and meta-analysis of human and animal studies on prenatal amino acid supplementation for fetal growth. Arginine and N-Carbamyl glutamate showed beneficial effects on fetal/birth weight, while BCAA and methyl donor supplementation did not. Arginine family supplementation, particularly arginine and NCG, improves fetal growth in complicated pregnancies.
Effects of l-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials.
This meta-analysis assessed the effects of l-arginine supplementation on glycemic control indices in RCTs. L-arginine significantly decreased fasting blood glucose and serum insulin levels, but had no significant effects on HOMA-IR and HbA1c. Subgroup analysis showed significant decreases in serum insulin levels under specific conditions.
Effects of tree nut and groundnut consumption compared with those of l-arginine supplementation on fasting and postprandial flow-mediated vasodilation: Meta-analysis of human randomized controlled trials.
Meta-analysis comparing effects of tree nut and groundnut consumption with l-arginine supplementation on fasting and postprandial endothelial function, assessed by flow-mediated vasodilation (FMD). Both tree nuts/groundnuts and l-arginine improved fasting FMD, but only l-arginine improved postprandial FMD. Effects between treatments were not statistically different.
The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis.
Systematic review and meta-analysis of 10 randomized controlled trials assessing arginine supplements for erectile dysfunction (ED) in 540 patients. Arginine significantly improved ED outcomes compared to placebo or no treatment, with improvements in IIEF subdomain scores. Adverse effects were mild and occurred at a rate of 8.3% in the arginine group.
L-arginine effect on inflammatory mediators: A systematic review of randomized controlled clinical trials.
Systematic review of randomized controlled trials assessing L-arginine's effect on inflammatory mediators in 387 human adults. L-arginine generally did not reduce inflammatory mediators, except in one study where it decreased IL-6 among cardiopathic nondiabetic patients after 6 months.
l-arginine and l-NMMA for assessing cerebral endothelial dysfunction in ischaemic cerebrovascular disease: A systematic review.
Systematic review evaluating the use of l-arginine and l-NMMA for assessing cerebral endothelial dysfunction in ischaemic cerebrovascular disease. Seven studies with 315 subjects were included, investigating cerebrovascular response to these substances in various conditions. Results showed inconsistent effects on endothelium-dependent vasodilatation, likely due to methodological and population differences.
Effect of L-arginine on immune function: a meta-analysis.
Meta-analysis of 11 trials involving 321 patients assessing L-arginine supplementation on immune function. L-arginine supplementation significantly increased CD4+ T-cell proliferation and reduced the incidence of infectious complications compared to control.
Arginine supplementation in prevention of necrotizing enterocolitis in the premature infant: an updated systematic review.
Systematic review of RCTs assessing L-arginine supplementation in preterm infants for prevention of necrotizing enterocolitis (NEC). L-arginine supplementation showed a 59% reduction in stage II and III NEC incidence compared to placebo, with no significant impact on neurodevelopmental outcomes at 36 months.
Arginine supplementation for improving maternal and neonatal outcomes in hypertensive disorder of pregnancy: a systematic review.
This meta-analysis assessed the effects of L-arginine supplementation on hypertensive disorders in pregnancy, involving data from seven RCTs with 916 patients. L-arginine was found to reduce the incidence of preeclampsia or eclampsia and prolong pregnancy weeks compared to placebo. It lowered diastolic pressure but had an unbalanced effect on systolic pressure and did not significantly increase neonatal weight.
The role of L-arginine in the prevention and treatment of pre-eclampsia: a systematic review of randomised trials.
Systematic review of randomised trials assessing L-arginine for prevention and treatment of pre-eclampsia in pregnant women. L-arginine was associated with a reduction in pre-eclampsia and preterm birth risk, suggesting a potential preventative role in pregnancy-related hypertensive diseases.
Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials.
Meta-analysis of 11 randomized, double-blind, placebo-controlled trials involving 387 participants. Oral L-arginine supplementation significantly lowered systolic BP by 5.39 mm Hg and diastolic BP by 2.66 mm Hg compared to placebo.
Oral L-arginine supplementation in acute myocardial infarction therapy: a meta-analysis of randomized controlled trials.
Meta-analysis of randomized controlled trials assessing oral L-arginine supplementation on clinical outcomes in acute myocardial infarction patients. The analysis included 2 trials with 927 participants and found no significant effect on mortality or clinical outcomes.
Home-use agents in the treatment of dentin hypersensitivity: clinical effectiveness evaluation with different measurement methods.
RCT evaluating the effectiveness of home-use desensitizing agents for dentin hypersensitivity over 8 weeks. CPP-ACP showed the greatest reduction in hypersensitivity symptoms compared to baseline, with significant improvements in DHEQ-15, VAS, and SSS scores.
L-arginine role for stone lower ureter: A randomized controlled trial.
RCT evaluating L-arginine 1000 mg once daily as a medical expulsive therapy for lower ureteral stones in 153 patients. L-arginine showed higher spontaneous stone expulsion rates and reduced expulsion time compared to placebo and tamsulosin, with better pain control.
Impact of L-arginine and liposomal vitamin C supplementation on quality of life and daily life activities in patients with COPD: a randomized, multicenter, single blind, placebo-controlled trial (ILDA study).
Randomized, multicenter, single blind, placebo-controlled trial assessing the impact of L-arginine and liposomal vitamin C supplementation on COPD patients. L-arginine supplementation significantly improved dyspnea and activities of daily living compared to placebo.
Assessment of the effectiveness and safety of two-month oral supplementation with L-arginine depending on the type of lipid metabolism disorder in patients with atherosclerotic lower limb ischemia.
Randomized study of 100 patients with atherosclerotic lower limb ischemia assessing the efficacy and safety of oral L-arginine supplementation. Significant increases in nitric oxide and total antioxidant status levels, as well as extended pain-free walking distance, were observed in the L-arginine group compared to controls. No significant effects on ankle-brachial index or lipid concentrations were noted.
L-arginine vs. L-glutamine oral suspensions for radiation-induced oral mucositis: a triple-blind randomized trial.
Triple-blind RCT comparing L-arginine and L-glutamine oral suspensions to maltodextrin in 69 head and neck cancer patients with radiation-induced oral mucositis. Both amino acids reduced mucositis severity, pain, and weight loss, and improved quality of life compared to maltodextrin. L-arginine showed a potential late advantage in complete healing by week 7.
Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial.
RCT of 50 children with sickle cell disease and elevated tricuspid regurgitant jet velocity, comparing L-arginine treatment to control. L-arginine significantly reduced TRJV levels and NT-proBNP, and improved NO biomarkers, suggesting potential benefits for reducing pulmonary hypertension risk.
Impact of Immunonutrition on Nutritional Status in Patients Undergoing Colorectal Cancer Surgery: A Randomized Controlled Clinical Trial
RCT comparing perioperative vs preoperative immunonutrition in 50 colorectal cancer surgery patients. Perioperative immunonutrition improved anthropometric and biochemical parameters compared to preoperative immunonutrition, with no difference in hospital stay or postoperative complications.
Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial.
RCT investigating the effects of L-arginine on sexual function and mood in women with major depressive disorder. L-arginine supplementation improved sexual function, particularly lubrication and orgasm, and mood, with minimal side effects. However, changes were not statistically significant compared to placebo.
Glutargin Versus Arginine for Hyperammonemia in Chronic Liver Diseases: A Randomized Controlled Trial
RCT comparing glutargin and arginine for hyperammonemia in 80 patients with chronic liver diseases. Both substances showed similar efficacy in lowering blood ammonia levels, but glutargin improved symptoms and signs more than arginine.
Effects of l-Arginine Plus Vitamin C Supplementation on l-Arginine Metabolism in Adults with Long COVID: Secondary Analysis of a Randomized Clinical Trial.
This study investigated the effects of l-arginine plus vitamin C supplementation on l-arginine metabolism in adults with long COVID. After 28 days, serum l-arginine concentrations and markers of nitric oxide bioavailability increased significantly compared to placebo, suggesting potential benefits for immune and vascular function.
Long-term high-dose L-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial.
This randomized, double-blind, placebo-controlled clinical trial studied the effects of high-dose L-arginine supplementation (6 g/day) for 3 months on erectile function in 98 patients with vasculogenic erectile dysfunction. L-arginine significantly improved IIEF-6 scores and peak systolic flow velocity in patients with mild-moderate ED, and improved IIEF-6 scores in patients with severe ED, suggesting it as an alternative treatment for mild-moderate ED.
Evaluation of a Supervised Adapted Physical Activity Program Associated or Not with Oral Supplementation with Arginine and Leucine in Subjects with Obesity and Metabolic Syndrome: A Randomized Controlled Trial.
RCT evaluating the effects of a supervised adapted physical activity program with or without oral supplementation of arginine and leucine in 79 patients with obesity and metabolic syndrome. The study found no significant changes in body weight, body composition, or metabolic markers, but improvements in cardiorespiratory parameters were observed in groups undergoing physical activity.
L-Arginine is a feasible supplement to heal chronic anal fissure via reducing internal anal sphincter pressure: a randomized clinical trial study.
This randomized, double-blind, placebo-controlled trial assessed the effect of oral L-arginine on chronic anal fissures in 76 patients. The study found that L-arginine significantly decreased bleeding, fissure size, and pain, and improved quality of life by reducing internal anal sphincter pressure.
The effect of l-arginine supplementation on amelioration of oxygen support in severe COVID-19 pneumonia.
A triple-blinded RCT was conducted on 74 patients with severe COVID-19 pneumonia to assess the effect of l-arginine supplementation on reducing respiratory support. Patients received either 3g of oral l-arginine or placebo daily. The study found no significant differences between the groups in terms of cessation of oxygen support, duration of hospitalization, or incidence of adverse thrombotic events.
Effect of 8% arginine toothpaste on Streptococcus mutans in patients undergoing fixed orthodontic treatment: randomized controlled trial
A randomized controlled trial assessed the effect of 8% arginine toothpaste on Streptococcus mutans in dental plaque around orthodontic brackets compared to regular fluoride toothpaste. The arginine group showed a significant decrease in the relative number of bacteria after 30 days, suggesting arginine's role as a prebiotic agent in maintaining healthy oral biofilms and preventing dental caries during orthodontic treatment.
L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults.
RCT of 72 frail hypertensive elderly patients comparing 4-weeks oral supplementation of L-Arginine to placebo. L-Arginine significantly improved cognitive function as measured by the MoCA test and attenuated Angiotensin II-induced mitochondrial oxidative stress in human endothelial cells.
Arginine Therapy and Cardiopulmonary Hemodynamics in Hospitalized Children with Sickle Cell Anemia: A Prospective Double-Blinded Randomized Placebo-Controlled Trial.
A prospective double-blinded randomized placebo-controlled trial evaluated the effects of oral arginine supplementation on cardiopulmonary hemodynamics in children with sickle cell anemia experiencing pain. The study found that arginine supplementation led to a greater reduction in tricuspid-regurgitation-jet-velocity and improved multiple indices of cardiopulmonary hemodynamics compared to placebo.
Effect of Arginine and nano-hydroxyapatite application on the hypersensitivity and color change of bleached enamel: A randomized controlled clinical trial
This randomized controlled trial evaluated the effect of 2.5% Arginine and nano-hydroxyapatite (nHA) on post-bleaching hypersensitivity and color change in bleached enamel. Sixty-four participants were divided into four groups, with desensitizing agents applied after bleaching. Results showed no significant hypersensitivity differences between groups after day-2, and both Arginine and nHA groups exhibited higher color change compared to the UltraEZ group.
Nitric-Oxide-Inducing Factors on Vitamin D Changes in Older People Susceptible to Suffer from Sarcopenia.
RCT with 61 older adults susceptible to sarcopenia, assessing the effects of NO precursors (L-arginine, L-citrulline, and beetroot extract) on circulating levels of calcium, magnesium, vitamin D, and steroid hormones. Higher circulating vitamin D levels were observed in the L-arginine- and beetroot-supplemented groups, suggesting vasodilators may improve muscular function by increasing vitamin D levels.
Randomized Clinical and Biochemical Study Comparing the Effect of L-arginine and Sildenafil in Beta Thalassemia Major Children With High Tricuspid Regurgitant Jet Velocity.
RCT comparing the effects of L-arginine and sildenafil in 60 beta thalassemia major children with pulmonary hypertension. Both treatments reduced tricuspid regurgitant jet velocity and increased nitric oxide levels. L-arginine also reduced ADMA levels, showing superiority to sildenafil on some biochemical markers.
Postprandial Glucose and Gastrointestinal Hormone Responses of Healthy Subjects to Wheat Biscuits Enriched with L-Arginine or Branched-Chain Amino Acids of Plant Origin.
The study investigates the effects of wheat biscuits enriched with L-arginine or branched-chain amino acids on postprandial glucose response in healthy subjects. The enriched biscuits elicited lower glucose iAUC compared to a glucose solution, with BCAAsB showing lower insulin iAUC and ArgB showing higher GLP-1 and glicentin responses. Both enriched biscuits increased amino acid concentrations and satiety compared to conventional biscuits.
Adjuvant daily therapy with L-arginine 2,500 mg and tadalafil 5 mg increases efficacy and duration of benefits of low-intensity extracorporeal shock wave therapy for erectile dysfunction: A prospective, randomized, single-blinded study with 1-year follow-up.
Prospective, randomized, single-blinded study investigating the combination of low-intensity extracorporeal shock wave therapy (Li-ESWT), tadalafil, and L-arginine for erectile dysfunction. Group A received adjuvant oral therapy with tadalafil 5 mg and L-arginine 2,500 mg, showing improved IIEF-EF and EHS scores over 12 months compared to control.
Effect of L-Arginine supplementation in pregnant women with chronic hypertension and previous placenta vascular disorders receiving Aspirin prophylaxis: a randomized control trial.
RCT evaluating the effects of L-Arginine supplementation (3g) with Magnesium and Salicylate on maternal blood pressure, uterine artery doppler PI, and neonatal outcomes in pregnant women with chronic hypertension and previous placenta vascular disorders. The L-Arginine group showed significant improvements in blood pressure and uterine artery PI compared to the aspirin-only group, with a lower need for new antihypertensive drugs.
Effect of l-arginine on cardiac reverse remodeling and quality of life in patients with heart failure.
This double-blind randomized controlled trial investigated the effect of 3 gr/d l-arginine supplementation for 10 weeks on cardiac outcomes and quality of life in 50 patients with ischemic heart failure. Significant improvements were observed in ejection fraction, left ventricular function, diastolic dysfunction, and quality of life scores in the l-arginine group compared to placebo.
Safety of intravenous arginine therapy in children with sickle cell disease hospitalized for vaso‐occlusive pain: A randomized placebo‐controlled trial in progress
The paper discusses a randomized placebo-controlled trial in progress to assess the safety of intravenous arginine therapy in children with sickle cell disease hospitalized for vaso-occlusive pain.
Effect of a Food for Special Medical Purposes for Muscle Recovery, Consisting of Arginine, Glutamine and Beta-Hydroxy-Beta-Methylbutyrate on Body Composition and Skin Health in Overweight and Obese Class I Sedentary Postmenopausal Women.
This randomized, double-blinded pilot study evaluated the efficacy of a food for special medical purposes consisting of arginine, glutamine, and HMB on body composition and skin health in obese postmenopausal women. The intervention group showed significant improvements in visceral adipose tissue reduction and skin health, including brightness, elasticity, and wrinkle reduction, while maintaining fat-free mass.
Effect of preoperative immunonutrition on outcomes of colon cancer surgery: study protocol for a randomized controlled trial
This randomized controlled trial aims to evaluate the effect of preoperative immunonutrition on outcomes of colon cancer surgery. Patients will receive oral supplementation with arginine and ω-3 fatty acids for 7 days before surgery. The primary endpoint is the rate of infectious complications, with a sample size of 176 patients.
Effect of Enteral Immunonutrition on Immune, Inflammatory Markers and Nutritional Status in Gastric Cancer Patients Undergoing Gastrectomy: A Randomized Double-Blinded Controlled Trial
RCT of 124 gastric cancer patients post-gastrectomy comparing early postoperative enteral immunonutrition (EIN) to standard enteral nutrition (SEN). EIN significantly improved immune function and inflammatory response, with higher CD4+ T-cells, CD3+ T-cells, and immunoglobulin levels, and lower WBC, CRP, and TNF-α levels. No significant differences in nutritional markers were observed.
Comparison of the clinical efficacy of daily use of L-arginine, tadalafil and combined L-arginine with tadalafil in the treatment of elderly patients with erectile dysfunction.
Single-blind placebo-controlled clinical trial on 120 elderly male patients with erectile dysfunction, comparing daily oral administration of L-arginine, tadalafil, and their combination. The combined L-arginine with tadalafil group showed the highest SHIM scores and total testosterone levels, indicating significant improvement in sexual health.
Beneficial effect of l-arginine in women using assisted reproductive technologies: a small-scale randomized controlled trial.
This small-scale randomized controlled trial examined the effect of l-arginine supplementation on hCG-positive rate and clinical pregnancy rate in women undergoing assisted reproductive technology. The study involved 120 patients divided into groups receiving different doses of l-arginine and a control group. Results showed increased hCG-positive rates and clinical pregnancy rates in the l-arginine groups, particularly in women undergoing ART due to male infertility.
Factors effective in the prevention of Preeclampsia:A systematic review.
Systematic review of 29 interventional studies, mostly RCTs, examining factors effective in preventing preeclampsia. Substances like L-arginine, folic acid, vitamin D, and others were found to prevent preeclampsia alone or combined with calcium.
The effect of l-arginine supplementation on lipid profile: a systematic review and meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of randomized controlled trials examining the effect of l-arginine supplementation on lipid profile. The analysis found that l-arginine significantly reduces serum TAG levels but does not significantly change total cholesterol, LDL, or HDL concentrations.
Effect of L-Arginine supplementation on lipid profiles and inflammatory markers: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs examining the effect of L-Arginine supplementation on lipid profiles and inflammatory markers. L-Arginine significantly reduces triglyceride levels but has no significant effect on LDL-c, total cholesterol, HDL-c, CRP, and TNFα indices.
The effect of L-arginine supplementation on obesity-related indices: A systematic review and meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of RCTs evaluating L-arginine supplementation on obesity-related indices. L-arginine significantly reduced waist circumference but had no significant effect on BMI and body weight. Longer-term interventions showed positive effects on body weight and BMI.
Effect of l-arginine supplementation on C-reactive protein and other inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs assessing the effect of L-arginine on inflammatory biomarkers. L-arginine supplementation had no significant effect on inflammatory biomarkers overall, but increased CRP levels in older adults, those with high baseline CRP, cancer patients, and when used in enteral formula.
Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of l-arginine supplementation effects on endothelial function markers in patients with cardiovascular or metabolic disorders. No significant improvements were found in flow-mediated dilation, NOx, or ADMA responses compared to placebo.
The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome.
Systematic review of 111 patients with hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, detailing clinical, biochemical, and genetic profiles. Management includes protein-restricted diet supplemented with citrulline/arginine and ammonia scavengers. Prognosis varies from severe to milder forms.
Difference in effectiveness between strontium acetate and arginine-based toothpastes to relieve dentin hypersensitivity. A systematic review.
Systematic review comparing the effectiveness of strontium acetate and arginine-based toothpastes in relieving dentin hypersensitivity. The majority of studies found arginine/calcium carbonate to be more effective than strontium acetate, with only one study showing superior efficacy of strontium acetate for tactile stimuli after 8 weeks.
The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF).
RCT comparing the efficacy of a dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride to a control dentifrice with 1450 ppm fluoride alone in arresting and reversing buccal caries lesions in children. The arginine-containing dentifrice showed statistically significantly superior efficacy in improving caries lesions after 6 months.
Prevention and treatment of postpartum hypertension.
Meta-analysis assessing interventions for preventing and treating postpartum hypertension. Four trials compared furosemide, nifedipine capsules, or L-arginine with placebo/no therapy for prevention. For treatment, trials compared various antihypertensives, but results were inconsistent. Postnatal furosemide showed a trend towards reduced antihypertensive use in women with antenatal pre-eclampsia.
Arginine-containing toothpastes for dentin hypersensitivity: systematic review and meta-analysis.
Systematic review and meta-analysis of 14 randomized controlled trials evaluating the efficacy of arginine-containing toothpastes for dentin hypersensitivity. Arginine-containing toothpastes showed better effects compared to placebo, potassium salt-containing, and strontium-containing toothpastes. The quality of evidence was moderate compared to placebo and potassium salt-containing toothpastes, and low compared to strontium-containing toothpastes.
Effect of L-arginine supplementation on blood pressure in pregnant women: a meta-analysis of placebo-controlled trials.
Meta-analysis of placebo-controlled trials evaluating L-arginine supplementation on blood pressure in pregnancy. L-arginine significantly lowered diastolic blood pressure and increased gestation age at delivery, but did not reduce systolic blood pressure.
Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent.
RCT evaluating the effects of FERTIMEV (L-arginine, L-carnitine, acetyl-L-carnitine, and ginseng extracts) combined with prulifloxacin on semen quality in 206 patients with Chlamydia trachomatis infection and oligoasthenoteratozoospermia. The combination therapy improved sperm concentration and motility compared to antibiotic therapy alone.
Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis.
Systematic review and meta-analysis examining plasma L-arginine concentrations in sepsis patients. Plasma L-arginine levels were found to be significantly lower in sepsis patients compared to nonseptic controls, particularly in medical sepsis without trauma or surgery.
The effects of in ovo feeding arginine, beta-hydroxy-beta-methyl-butyrate, and protein on jejunal digestive and absorptive activity in embryonic and neonatal turkey poults.
The study investigated the effects of in ovo feeding of arginine, beta-hydroxy-beta-methyl-butyrate, and egg white protein on jejunal digestive and absorptive activity in embryonic and neonatal turkey poults. Results showed significant increases in jejunal sucrase, maltase, and LAP activities, as well as enhanced glucose and alanine uptake in poults fed these nutrients.
Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute ischaemic stroke.
Systematic review assessing the effects of nitric oxide donors, L-arginine, or nitric oxide synthase-inhibitors in people with acute ischaemic stroke. No completed trials were found, and there is currently no evidence from randomised trials on their effects.
Acute effects of combined supplementation of L-arginine and citrulline malate on aerobic, anaerobic, and CrossFit exercise performance.
This randomized, double-blind, placebo-controlled trial investigated the effects of combined L-arginine and citrulline-malate supplementation on aerobic, anaerobic, and CrossFit exercise performance in 46 healthy, trained men. The study found no significant improvement in performance with supplementation compared to placebo, except for a shorter time to reach peak power in the Wingate test.
Acute effects of L-arginine intake on heart rate variability after a submaximal exercise test in healthy men: randomized clinical trial.
Triple-blind, randomized, placebo-controlled, crossover trial assessing the acute effects of 3 g L-arginine supplementation on heart rate variability (HRV) and cardiovascular recovery after submaximal aerobic exercise in 37 healthy men. No significant differences were found between L-arginine and placebo conditions for HRV or hemodynamic outcomes, suggesting limited autonomic effects of L-arginine in populations with high baseline HRV.
Assessing the efficacy of L-arginine and vitamin C supplementation in pediatric Long-COVID: a Randomized Controlled Trial
RCT assessing the effects of L-arginine and vitamin C supplementation in pediatric Long-COVID patients. The study aimed to evaluate improvements in quality of life and respiratory function using the Borg scale. Thirty-six patients were divided into three treatment arms, showing improvement.
L-Arginine Supplementation Did Not Impact the Rapid Recovery of Cardiovascular and Autonomic Function Following Exercise in Physically Active Healthy Males: A Triple-Blind Randomised Placebo-Controlled Crossover Trial.
Triple-blind randomized placebo-controlled crossover trial with 32 healthy males to assess the effects of L-arginine supplementation on post-exercise autonomic and cardiovascular recovery. L-arginine did not significantly alter heart rate recovery, heart rate variability, or blood pressure responses compared to placebo.
An open-label, randomized, controlled trial on the benefit of β-hydroxy-β-methyl butyrate, l-arginine, l-glutamine combination beverages and locomotion training as supportive care for the treatment of unresectable hepatocellular carcinoma using lenvatinib: A pilot study (HELLO study).
RCT of a beta-hydroxy-beta-methyl butyrate/l-arginine/l-glutamine beverage and locomotion training as supportive care in the treatment of unresectable hepatocellular carcinoma with lenvatinib. The intervention did not reduce adverse events but might help maintain skeletal muscle mass.
Evaluation and comparison of the effects of a new paste containing 8% L-Arginine and CaCO3 plus KNO3 on dentinal tubules occlusion and dental sensitivity: a randomized, triple blinded clinical trial study.
This randomized, triple-blind clinical trial evaluated a paste containing 8% L-arginine, calcium carbonate, and potassium nitrate for its effects on dentinal tubules occlusion and dental sensitivity. The paste significantly reduced dentin permeability and occluded dentinal tubules, effectively mitigating dentin hypersensitivity to various stimuli.
Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
Double-blind, randomized, crossover study with 15 elite taekwondo athletes examining the effects of nitrate and L-arginine supplementation on performance. NIT*L-ARG supplementation significantly improved anaerobic performance, blood lactate levels, and agility compared to placebo.
Bioactive glass and arginine dentifrices reduce root sensitivity during daily activities following non-surgical periodontal therapy: A randomized clinical trial.
This randomized clinical trial compared the efficacy of calcium sodium phosphosilicate (CSPS) and arginine dentifrices in reducing root sensitivity (RS) during daily activities in patients undergoing non-surgical periodontal therapy. Both dentifrices provided RS relief within 2-4 weeks and remained effective up to 8 weeks.
The effect of 24-hour sleep deprivation and anaerobic exercise on the expression of BAX, BCL2, BMAL1 and CCAR2 genes in peripheral blood mononuclear cells after L-arginine supplementation.
RCT evaluating the effect of eight weeks of L-arginine supplementation on gene expression related to apoptosis in peripheral blood mononuclear cells during sleep deprivation and anaerobic exercise. L-arginine increased the expression of BMAL1 and BCL2 genes and decreased the expression of BAX and CCAR2 genes, suggesting a balancing effect on the apoptotic state.
Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial.
A single-blind randomized controlled trial in adults with long COVID assessed the effects of l-arginine plus vitamin C supplementation on physical performance, endothelial function, and fatigue. The supplement improved the 6 min walk distance, handgrip strength, flow-mediated dilation, and reduced fatigue compared to placebo over 28 days.
Effect of preoperative immunonutrition on fecal microbiota in colon cancer patients: a secondary analysis of a randomized controlled trial
Secondary analysis of an RCT evaluating the effect of preoperative immunonutrition with arginine and ω-3 fatty acids on fecal microbiota composition in colon cancer patients. No significant differences were observed in microbiota composition between the immunonutrition and control groups.
Effects of acute arginine supplementation on neuroendocrine, metabolic, cardiovascular, and mood outcomes in younger men: A double-blind, placebo-controlled trial
Double-blind, placebo-controlled crossover trial in 30 healthy men assessing the effects of 10g arginine supplementation on growth hormone (GH), metabolic parameters, and mood. Arginine increased GH, glucose, and TSH levels, with responders showing higher benzoate metabolites and an unknown gut microbiome-related compound.
New perspectives for investigating muscular perfusion response after dietary supplement intake: an exploratory, randomized, double-blind, placebo-controlled crossover trial in healthy young athletes using contrast-enhanced ultrasound (CEUS).
This exploratory, randomized, double-blind, placebo-controlled crossover trial investigated the effects of 'NO-boosting' supplements, including an amino acid combination (L-arginine and L-citrulline) and green tea extract, on muscular perfusion in 30 young male athletes. No significant differences in biceps perfusion, caliber, or muscle pump were observed between the supplements and placebo. The study demonstrated the feasibility of using contrast-enhanced ultrasound for perfusion quantification.
Supplemental Protein and a Multinutrient Beverage Speed Wound Healing after Acute Sleep Restriction in Healthy Adults.
Single-blind crossover study in 20 healthy young adults assessing the effect of supplemental protein and a multinutrient beverage on wound healing after sleep restriction. The multinutrient group showed shorter skin barrier restoration time compared to placebo.
A Single Dosage of l-Arginine Oral Supplementation Induced Post-Aerobic Exercise Hypotension in Hypertensive Patients.
A double-blind, randomized, placebo-controlled crossover trial investigated the effect of a single dose of l-arginine oral supplementation on post-exercise blood pressure in hypertensive patients. The study found that l-arginine supplementation led to significant post-exercise systolic hypotension compared to placebo.
One-Week L-Arginine Supplementation Had No Effect on 200m Freestyle Swimming Time Trial in Moderately-Trained Male Swimmers.
This randomized, cross-over, double-blind study assessed the effect of one-week L-arginine supplementation on 200-m freestyle swimming performance in 8 moderately-trained male swimmers. The study found no significant difference in swimming time or blood lactate concentration between L-arginine and placebo trials.
Bioactive glass and arginine dentifrices immediately relieved dentine hypersensitivity following non-surgical periodontal therapy: A randomized controlled trial.
A double-blind randomized controlled trial with 45 volunteers assessed the efficacy of dentifrices containing bioactive glass, 5% CSPS, and 8% arginine in relieving dentine hypersensitivity following non-surgical periodontal therapy. The CSPS dentifrice significantly reduced dentine hypersensitivity immediately and continued to decline through week 8, while the arginine group showed reduced sensitivity through week 2.