Research
Krill Oil
93 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Krill oil for knee osteoarthritis: A meta-analysis of randomized controlled trials.
Meta-analysis of five randomized controlled trials involving 730 participants assessing krill oil for knee osteoarthritis. Krill oil showed significant benefits in terms of pain, stiffness, and functional outcomes based on WOMAC assessments, but no significant improvement on the visual analog scale or blood markers. Safety profiles were similar between krill oil and usual care groups.
Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.
Systematic review and meta-analysis of five trials with 700 patients assessing krill oil for knee pain. Krill oil showed no significant difference from placebo for knee pain, stiffness, or lipid profiles, but demonstrated a small improvement in knee physical function.
Narcissism Is Not Associated With Success in U.S. Army Soldier Training.
The RRIPP-3 study was a double-blind, placebo-controlled dietary supplement intervention trial involving 555 U.S. Army officers. Participants consumed omega-3 (krill oil) or macadamia nut oil over 20 weeks. The study assessed if narcissistic personality traits predicted success in the Army Ranger Course, finding no significant association between narcissism and trainee success.
The Preventive and Interventional Mechanisms of Omega-3 Polyunsaturated Fatty Acids in Krill Oil for Metabolic Diseases
A 24-month randomized, double-blind, placebo-controlled clinical trial with 300 participants assessed the effects of krill oil on metabolic diseases. The study found significant improvements in blood glucose levels, blood pressure, lipid profiles, and inflammatory markers in the krill oil groups compared to the control group, with more pronounced effects in the high-dose group.
Krill Oil for Knee Osteoarthritis: A Randomized Clinical Trial.
A multicenter, randomized, double-blind, placebo-controlled clinical trial evaluated the efficacy of 2 g/d krill oil supplementation on knee pain in 262 participants with knee osteoarthritis. The study found that krill oil did not improve knee pain compared with placebo over 24 weeks.
Clinical effectiveness of krill oil supplementation on cardiovascular health in humans: An updated systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of krill oil supplementation on cardiovascular disease risk factors. It included 14 trials with 1458 participants and found that krill oil had beneficial effects on lipid profiles, specifically total cholesterol, low-density lipoprotein cholesterol, and triglycerides. No effects were observed on blood pressure, glycemic control, body composition, or inflammatory markers.
Effectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial.
This study pooled results from two randomized, double-blind, placebo-controlled trials to assess the efficacy and safety of a krill oil-derived omega-3 formulation (CaPre) in reducing triglyceride levels in patients with severe hypertriglyceridemia. The omega-3 group showed a significant reduction in triglyceride levels compared to placebo, with effects persisting at 26 weeks. The formulation was well tolerated with a safety profile similar to placebo.
Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
A 6-month multicenter, randomized, double-blind, placebo-controlled trial investigated the effects of krill oil on knee pain in adults with mild to moderate knee osteoarthritis. Krill oil supplementation resulted in modest improvements in knee pain, stiffness, and physical function compared to placebo, with an increased Omega-3 Index.
Impact of Fatty Acid Supplementation on Cognitive Performance among United States (US) Military Officers: The Ranger Resilience and Improved Performance on Phospholipid-Bound Omega-3's (RRIPP-3) Study.
This double-blind, placebo-controlled trial examined the effects of omega-3 supplementation from krill oil on cognition, resilience, and mood among 555 young military officers. No statistically significant treatment effects were found, potentially due to poor compliance and lower than expected omega-3 elevations in the treatment group.
Lipid-modifying effects of krill oil vs fish oil: a network meta-analysis.
Network meta-analysis comparing the lipid-modifying effects of krill oil and fish oil. Krill oil was associated with significantly lower triglyceride levels than control supplements, but no significant differences were found between krill oil and fish oil in terms of triglycerides, LDL cholesterol, HDL cholesterol, and total cholesterol. The reduction in triglycerides depends on the dose of n-3 fatty acids consumed.
Lipid-modifying effects of krill oil in humans: systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 7 RCTs with 662 participants assessing the effect of krill oil on plasma lipids. Krill oil supplementation significantly reduced low-density lipoprotein cholesterol and triglycerides, and increased high-density lipoprotein cholesterol, but did not significantly affect total cholesterol.
Do the effects of krill oil supplementation on skeletal muscle function and size in older adults differ by sex, age or BMI: A secondary analysis of a randomised controlled trial.
This secondary analysis of a randomized controlled trial examined the effects of krill oil supplementation on muscle function and size in older adults. The study found that krill oil improved muscle strength and size regardless of age, sex, and BMI, with neuromuscular effects on membrane excitability being more pronounced in men.
An Adapted Cardioprotective Diet with or Without Phytosterol and/or Krill Oil Supplementation in Familial Hypercholesterolemia: Results of a Pilot Randomized Clinical Trial.
This pilot RCT evaluated the effects of a cardioprotective diet with or without phytosterol and/or krill oil supplementation on lipid parameters in Brazilian adults with familial hypercholesterolemia. No significant differences between groups were found for LDL-c or Lp(a), but a significant reduction in Lp(a) concentrations was observed following the diet intervention. The study supports the feasibility of a larger trial and highlights the potential of dietary interventions in managing familial hypercholesterolemia.
The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial.
RCT comparing krill oil and fish oil interventions on clinical symptoms and cardiometabolic risk factors in 57 adults with major depressive disorder. Both krill oil and fish oil significantly improved depression scores and increased HDL-c levels compared to placebo, with no apparent superiority between the two oils.
Krill oil supplementation improves transepidermal water loss, hydration and elasticity of the skin in healthy adults: Results from two randomized, double-blind, placebo-controlled, dose-finding pilot studies.
Two randomized, double-blind, placebo-controlled pilot studies investigated the effects of krill oil supplementation on skin health in healthy adults. Krill oil significantly improved transepidermal water loss, hydration, and elasticity of the skin compared to placebo, with dose-dependent effects correlating with changes in the omega-3 index.
Correction of omega-3 fatty acid deficiency and improvement in disease activity in patients with systemic lupus erythematosus treated with krill oil concentrate: a multicentre, randomised, double-blind, placebo-controlled trial.
A multicentre, randomised, double-blind, placebo-controlled trial investigated the effect of krill oil concentrate (KOC) on omega-3 levels and disease activity in patients with systemic lupus erythematosus (SLE). KOC supplementation significantly increased the Omega-3 Index and decreased disease activity in patients with high baseline disease activity. KOC was well-tolerated with no significant safety concerns.
A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis.
A 12-week, randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of a krill oil, astaxanthin, and hyaluronic acid complex (FP-MD) on joint health in 100 participants with mild osteoarthritis. The FP-MD group showed significant improvements in joint pain and function compared to placebo, with fewer adverse events reported.
Krill oil supplementation's effect on school grades in typically developing adolescents.
A double-blind randomized placebo-controlled trial investigated the effect of krill oil supplementation on school grades in adolescents with a low Omega-3 Index at baseline. The study found no significant effect of krill oil supplementation on subject grades or standardized mathematics test performance after 12 months, although there was a small significant increase in the mean Omega-3 Index.
The effect of krill oil supplementation on skeletal muscle function and size in older adults: A randomised controlled trial.
RCT of krill oil supplementation in 102 older adults over 6 months. Krill oil increased knee extensor maximal torque, grip strength, and vastus lateralis muscle thickness compared to control. Significant increases in erythrocyte fatty acid profile were also observed.
Effect of one year krill oil supplementation on depressive symptoms and self-esteem of Dutch adolescents: A randomized controlled trial.
A one-year double-blind, randomized, placebo-controlled trial of krill oil supplementation in Dutch adolescents. The study found no significant effects on depressive symptoms or self-esteem, though results should be interpreted with caution due to adherence and drop-out issues.
Effect of 1 Year Krill Oil Supplementation on Cognitive Achievement of Dutch Adolescents: A Double-Blind Randomized Controlled Trial.
A double-blind, randomized controlled trial investigated the effect of one year of krill oil supplementation on cognitive performance in Dutch adolescents with a low Omega-3 Index. Despite a small increase in Omega-3 Index, there was no significant effect on neurocognitive test scores, likely due to non-compliance and insufficient increase in Omega-3 Index.
A protocol for a randomised controlled trial investigating the effect of increasing Omega-3 index with krill oil supplementation on learning, cognition, behaviour and visual processing in typically developing adolescents.
This protocol outlines a double-blind, randomised, placebo-controlled trial investigating the effect of krill oil supplementation on cognitive functioning, academic achievement, and mental well-being in typically developing adolescents. The study involves 264 adolescents receiving either 400mg or 800mg of EPA+DHA or a placebo for 52 weeks, with the Omega-3 Index monitored and adjusted to reach 8-11%.
Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels.
Double-blind, randomized, placebo-controlled study of 300 adults with borderline high or high triglyceride levels, testing the effects of krill oil supplementation over 12 weeks. Krill oil significantly reduced serum triglyceride levels by 10.2% without increasing LDL-C levels, suggesting a positive effect on cardiovascular risk factors.
Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized Trial.
Randomized trial investigating krill oil supplementation during alternate-day fasting in adults with overweight. The krill oil group showed no change in fat-free mass and handgrip strength, while the placebo group experienced reductions. Krill oil supplementation attenuated the decline in muscle strength and fat-free mass during weight loss.
Krill Oil Supplementation Does Not Change Waist Circumference and Sagittal Abdominal Diameter in Overweight Women: A Pilot Balanced, Double-Blind, and Placebo-Controlled Clinical Trial.
This pilot, balanced, double-blind, and placebo-controlled clinical trial evaluated the effects of krill oil supplementation on waist circumference and sagittal abdominal diameter in 26 overweight women. The study found no significant changes in anthropometric measurements or handgrip strength after eight weeks of supplementation, though there were differences in carbohydrate and polyunsaturated fatty acid intake between groups.
Enrichment of n-3 containing ether phospholipids in plasma after 30 days of krill oil compared with fish oil supplementation.
Randomized crossover study comparing krill oil and fish oil supplementation in 11 healthy women over 30 days. Krill oil led to a greater enrichment of n-3 PUFA in plasma phospholipids, particularly in choline and ethanolamine ether-phospholipids, compared to fish oil.
Krill-Oil-Dependent Increases in HS-Omega-3 Index, Plasma Choline and Antioxidant Capacity in Well-Conditioned Power Training Athletes.
RCT of 35 power training athletes comparing 2.5 g/day of Neptune krill oil to olive oil placebo for 12 weeks. The krill oil group showed significant increases in HS-Omega-3 Index, improved choline recovery, and reduced oxidative stress post-exercise.
Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study.
Randomized crossover study in 11 healthy women comparing the effects of krill oil and fish oil supplementation on the plasma lipidome over 30 days. Krill oil resulted in a significantly greater relative area under the curve for plasma EPA and affected more lipid molecular species compared to fish oil.
A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease.
RCT assessing the efficacy of krill oil and fish oil omega-3 supplements for treating dry eye disease in 60 participants. Both supplements reduced tear osmolarity and improved tear stability. Krill oil showed additional benefits in reducing DED symptoms and interleukin 17A levels compared to placebo.
Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial.
RCT of 50 adults with mild knee pain comparing 2 g/day krill oil to placebo for 30 days. Krill oil significantly improved knee pain and stiffness, as well as range of motion, compared to placebo. Plasma EPA levels and EPA/AA ratio increased with krill oil administration.
Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study.
This randomized double-blind study compared the bioavailability of EPA and DHA from fish oil-EE, fish oil-TG, and krill oil in 66 healthy adults over four weeks. No significant differences in plasma or RBC levels of EPA + DHA were observed between the groups, indicating comparable bioavailability.
Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers.
RCT comparing the effects of krill oil and fish oil on serum lipids and markers of oxidative stress and inflammation in 113 subjects. Both krill oil and fish oil increased plasma EPA, DHA, and DPA levels, with no significant differences between the two oils in terms of serum lipids or markers of oxidative stress and inflammation.
Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women.
RCT of 76 overweight and obese men and women comparing krill oil, menhaden oil, and control oil supplementation for 4 weeks. Krill oil significantly increased plasma EPA and DHA concentrations without adverse effects on safety parameters.
Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia.
A multi-center, three-month RCT evaluated the effects of krill oil on blood lipids in 120 patients with hyperlipidemia. Krill oil significantly reduced total cholesterol, LDL, triglycerides, and glucose levels, and increased HDL levels compared to fish oil and placebo.
Stability of probiotic microcapsules produced through complex coacervation based on whey protein-gum arabic coupled with double emulsification: Role of krill oil in middle oil phase.
The study developed a microcapsule system using double emulsification and complex coacervation to encapsulate probiotics, evaluating the effect of krill oil in the middle oil layer on microcapsule structure and probiotic stability. Krill oil enhanced the coacervate's compactness, improving probiotic survival rates after freeze-drying and providing better protection under environmental stress.
Krill oil supplementation in vivo promotes increased fuel metabolism and protein synthesis in cultured human skeletal muscle cells
The study investigated the effects of krill oil supplementation on energy metabolism and substrate turnover in human skeletal muscle cells. Krill oil increased oleic acid oxidation and leucine accumulation in vivo, and enhanced glucose and oleic acid metabolism in vitro, suggesting improved fuel metabolism and protein synthesis.
Extraction of high-quality Antarctic krill (Euphausia Superba) oil using low-temperature continuous phase-transition extraction equipment.
The study explores a processing method for efficient extraction of high-quality krill oil using low-temperature continuous phase-transition extraction equipment. Compared to other methods, this method had the highest lipid yield, bioactive substances, and the lowest oxidative deterioration, making it suitable for long-term storage and transportation.
Characterisation of a casein-/whey protein concentrate–Antarctic krill oil emulsion system and improvement of its storage stability
The study developed Antarctic krill oil emulsions with casein and whey protein concentrate, examining their physicochemical properties and storage stability. The emulsions showed promising characteristics with predicted shelf lives at various temperatures, indicating potential as a new krill oil supplement.
Improved colloidal and oxidative stability of krill oil using natural biopolymers via spray drying microencapsulation
The study aimed to improve the colloidal and oxidative stability of krill oil via microencapsulation using spray drying with various biopolymers. WPI+MD microcapsules showed the highest encapsulation efficiency and improved oxidative stability, enhancing krill oil's potential applications in the food industry.
Analysis of Phospholipids in Digestion Using Hybrid IDA and SWATH Acquisition: An Example for Krill Oil
The study established a model-assisted LC-MS method to analyze phosphatidylcholine (PC) and lyso-phosphatidylcholine (LPC) species in krill oil before and after digestion. It found differences in PC and LPC compositions among different krill oils and identified newly generated LPC species in the digestive products.
Two-Step Enzymolysis of Antarctic Krill for Simultaneous Preparation of Value-Added Oil and Enzymolysate
The study developed a two-step enzymolysis-assisted extraction method for Antarctic krill to produce value-added oil and enzymolysate. The method increased lipid yield and improved the content of phospholipids, EPA, DHA, and astaxanthin in the oil, while the enzymolysate was rich in functional nutrients like proteins and amino acids. Both products showed high antioxidant capacity.
Detection and Quantification of Adulteration in Krill Oil with Raman and Infrared Spectroscopic Methods
The study evaluates the use of Raman and infrared spectroscopy to detect and quantify adulterants in krill oil. It uses principal component analysis and support vector machines for classification, and partial least squares regression for quantification, showing Raman spectroscopy's superior performance over IR spectroscopy.
Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging
The study investigates the effects of krill oil on healthy aging using C. elegans and human cells. Krill oil was found to protect dopaminergic neurons from age-related degeneration, decrease alpha-synuclein aggregation, and improve dopamine-dependent behavior and cognition. It rewires gene expression to attenuate aging hallmarks such as oxidative stress and mitochondrial dysfunction, promoting healthy aging.
Evaluation of OM3-PL/FFA Pharmacokinetics After Single and Multiple Oral Doses in Healthy Volunteers.
Phase I, open-label, randomized study evaluating the pharmacokinetics of OM3-PL/FFA, a krill oil mixture, in 42 healthy volunteers. The study assessed single and multiple oral doses of 1, 2, and 4 g/d over 14 days, finding dose proportionality and no significant effect of meal fat content on bioavailability.
Differential plasma postprandial lipidomic responses to krill oil and fish oil supplementations in women: A randomized crossover study.
Randomized crossover study in 10 healthy women comparing postprandial plasma lipidomic responses to krill oil versus fish oil supplementation. Krill oil resulted in significantly greater concentrations in 5 out of 34 lipid classes or subclasses compared to fish oil, with differences in the partitioning of eicosapentaenoic acid and docosahexaenoic acid.
Postprandial long-chain n-3 polyunsaturated fatty acid response to krill oil and fish oil consumption in healthy women: a randomised controlled, single-dose, crossover study.
RCT comparing postprandial incorporation of long-chain n-3 polyunsaturated fatty acids into plasma lipids after consumption of krill oil, fish oil, and olive oil in 10 healthy women. Significant increases in plasma EPA concentrations were observed after krill oil and fish oil consumption, with similar increases despite a lower dose of EPA in krill oil.
Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men.
Randomized, double-blind, controlled crossover trial in 47 overweight men assessing the effects of krill and salmon oil supplementation on insulin sensitivity. The study found that insulin sensitivity was 14% lower with the krill and salmon oil blend compared to control, suggesting potential increased metabolic risk.
The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function.
RCT with 37 participants examining the effects of 6 weeks of krill oil supplementation on exercise performance and immune function. Krill oil increased PBMC IL-2 production and NK cell cytotoxic activity 3h post-exercise but did not modify exercise performance.
Supplementation of krill oil with high phospholipid content increases sum of EPA and DHA in erythrocytes compared with low phospholipid krill oil.
A semi-randomized crossover single-blind study with 20 healthy participants compared the effects of low phospholipid (LPL) and high phospholipid (HPL) krill oil on the bioavailability of EPA and DHA. HPL krill oil increased RBC concentrations of EPA, DPA, and total n-3 PUFA more than LPL, and decreased the n-6:n-3 ratio. HPL also elevated plasma total and LDL cholesterol compared to control, while LPL did not.
Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study.
Pilot study of krill oil supplementation in 17 healthy young adults over 28 days. Krill oil reduced plasma triacylglycerol levels, improved lipoprotein particle concentration, fatty acid composition, and redox status, suggesting potential cardiovascular benefits.
Bioavailability of fatty acids from krill oil, krill meal and fish oil in healthy subjects--a randomized, single-dose, cross-over trial.
A randomized, single-dose, cross-over trial in 15 healthy subjects compared the bioavailability of EPA and DHA from krill oil, krill meal, and fish oil. Krill oil showed higher 72-hour bioavailability of EPA and DHA in plasma phospholipid fatty acids than krill meal or fish oil. No difference in bioavailability was found between krill meal and fish oil.
Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers.
RCT in 45 healthy elderly males comparing krill oil, sardine oil, and medium-chain triglycerides over 12 weeks. Krill oil, rich in n-3 PUFAs in phosphatidylcholine, significantly improved cognitive function, as measured by changes in oxyhemoglobin concentrations and P300 latency during memory tasks, compared to placebo.
Efficacy of food supplement to improve metabolic syndrome parameters in patients affected by moderate to severe psoriasis during anti-TNFα treatment.
Open-label RCT evaluating a nutraceutical containing Q10 coenzyme, Krill-oil, lipoic acid, resveratrol, Vitis vinifera seed oil, vitamin E, and selenium in addition to etanercept therapy in 40 psoriasis patients with metabolic syndrome. The nutraceutical group showed significant improvements in HDL cholesterol and triglycerides after 3 months.
Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil.
Double-blinded, randomized, placebo-controlled crossover trial with 24 healthy volunteers comparing krill oil, fish oil, and placebo. Krill oil increased plasma and RBC n-3 PUFA concentrations and improved the omega-3 index more effectively than fish oil. Total and LDL cholesterol concentrations increased with both krill and fish oil compared to control.
Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil.
A double-blinded crossover trial comparing the bioavailability of EPA and DHA from fish oil (rTAG, EE) and krill oil in 12 healthy young men. Krill oil showed the highest incorporation of EPA+DHA into plasma phospholipids, followed by fish oil rTAG and EE. No significant differences were found due to high standard deviation, but trends were observed for EPA bioavailability.
Effects of combination of krill oil with curcumin and/or silymarin on mouse non-alcoholic fatty liver disease.
Animal study investigating the effects of a combination of krill oil, curcumin, and silymarin on high-fat diet-induced non-alcoholic fatty liver disease in mice. The mixture inhibited disease progression by regulating gene transcription related to triglyceride synthesis, fatty acid metabolism, inflammation, and antioxidant capacity.
Analysis of Fatty Acid Compositions and Acid Values of Krill Oil Supplementary Products from the Korean Market
The study analyzed the fatty acid compositions and acid values of 20 commercially available krill oil supplements from the Korean market. It determined the levels of omega-3 PUFAs such as DHA and EPA, and found variations in fatty acid composition among the samples, providing a reference for evaluating the chemical and nutritional properties of krill oil supplements.
Krill Oil Ameliorates Liver Injury in Diabetic Mice by Activating Antioxidant Capacity and Inhibiting Ferroptosis.
The study investigated the effect of krill oil supplementation on diabetic liver injury in a mouse model of type 2 diabetes mellitus. Krill oil ameliorated liver injury by activating antioxidant capacity and inhibiting ferroptosis, reducing oxidative gene expression, lipid peroxidation, and ROS production.
Antarctic Krill Euphausia superba Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice
The study investigated the effects of Antarctic krill oil supplementation on diet-induced obese mice. Krill oil was found to mitigate high-fat diet-induced oxidative stress, fat accumulation, and hypercholesterolemia by improving metabolic parameters and molecular pathways related to cholesterol metabolism.
New Insights on the Effects of Krill Oil Supplementation, a High-Fat Diet, and Aging on Hippocampal-Dependent Memory, Neuroinflammation, Synaptic Density, and Neurogenesis
Animal study investigating the effects of krill oil supplementation on hippocampal-dependent memory, neuroinflammation, synaptic density, and neurogenesis in aged rats on a high-fat diet. Krill oil supplementation did not produce significant changes in the measured parameters, suggesting no benefit to hippocampal or cortical functions in this aging model.
Phospholipid-rich krill oil promotes intestinal health by strengthening beneficial gut microbial interactions in an infectious colitis model.
The study used a multi-omics approach to investigate how krill oil (KO) affects gut microbial interactions and promotes epithelial healing in an infectious colitis model. KO reversed infection-induced intestinal hyperplasia, reduced inflammation, enriched butyrate-producing bacteria, and enhanced mucosal barrier function, demonstrating its protective role in infectious colitis.
Microfluidization outperforms homogenization: Optimizing stability and bioaccessibility in krill oil emulsions
Comparative analysis of high‐pressure homogenization and microfluidization for krill oil emulsions, focusing on oxidative stability and bioaccessibility. Microfluidization showed superior oxidative stability and bioaccessibility, with enhanced retention of EPA, DHA, and astaxanthin, and improved digestion and absorption due to smaller droplet size.
Krill Oil’s Protective Benefits against Ultraviolet B-Induced Skin Photoaging in Hairless Mice and In Vitro Experiments
The study investigated krill oil's effects on skin health, focusing on its antioxidant, anti-inflammatory, anti-wrinkle, and moisturizing properties in vitro and in hairless mice. Krill oil showed dose-dependent inhibition of oxidative stress-induced inflammatory photoaging-related skin changes and increased collagen and hyaluronic synthesis, suggesting potential benefits against UVB-induced skin photoaging.
Long-Term Krill Oil Administration Alleviated Early Mild Cognitive Impairment in APP/PS1 Mice.
The study investigates the effects of long-term krill oil administration on early cognitive impairment in APP/PS1 mice. Results show that krill oil improves learning and memory abilities, reduces amyloid β concentration, inhibits neuro-inflammation, and enhances gut barrier integrity. The findings suggest krill oil may prevent cognitive impairment through the microbiota-gut-brain axis.
Evaluation of the Role of Soybean Lecithin, Egg Yolk Lecithin, and Krill Oil in Promoting Ovarian Development in the Female Redclaw Crayfish Cherax quadricarinatus
The study evaluated the effects of soybean lecithin, egg yolk lecithin, and krill oil supplementation on ovarian development in female redclaw crayfish. Krill oil was found to be the most effective in promoting ovarian development, increasing the gonadosomatic index, and enhancing antioxidant capacity compared to other supplements.
Development and evaluation of novel krill oil-based clomiphene microemulsion as a therapeutic strategy for PCOS treatment
The study developed a krill oil-based clomiphene microemulsion to treat PCOS. In vivo tests on letrozole-induced PCOS rats showed the formulation reversed effects on body weight and estrus cycle, reduced insulin resistance, cholesterol, and serum testosterone levels, and improved follicle development.
Antarctic Krill Oil from Euphausia superba Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model
The study investigated the antithrombotic effects of Antarctic krill oil (FJH-KO) in carrageenan-induced thrombosis mouse models and human endothelial cells. FJH-KO attenuated thrombus formation, prolonged tail bleeding, and modulated various plasma levels and signaling pathways, suggesting its potential as an antithrombotic agent.
Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice
The study used a chronic unpredictable mild stress (CUMS) model in mice to evaluate the effect of krill oil on depression-like behaviors. Krill oil supplementation ameliorated CUMS-induced depression-like behaviors and disrupted lipid metabolism, suggesting a potential strategy for depression prevention and treatment.
Anti-Osteoarthritic Effects of Antarctic Krill Oil in Primary Chondrocytes and a Surgical Rat Model of Knee Osteoarthritis
The study investigated the anti-osteoarthritic effects of krill oil in primary chondrocytes and a surgical rat model of knee osteoarthritis. Oral administration of krill oil improved joint swelling, mobility, bone mineral density, and compressive strength in cartilage, while upregulating chondrogenic genes and inhibiting inflammation markers and ECM-degrading enzymes.
Krill Oil attenuates doxorubicin induced cognitive impairment by inhibiting oxidative stress markers in the brains of wistar rats
The study evaluated krill oil's neuroprotective and memory-improving benefits against doxorubicin-induced cognitive and neurobiological defects in female Wistar rats. Krill oil significantly protected against memory impairment and reduced oxidative and inflammatory markers in the brain.
Krill oil inhibited adipogenic differentiation by inducing the nuclear Nrf2 expression and the AMPK activity
The study investigated the antiadipogenic mechanism of krill oil in 3T3‐L1 adipocytes. Krill oil reduced lipid accumulation by 54% and downregulated adipogenic transcription factors, suggesting it could be a potential natural antiobesity ingredient.
Effect of Krill Oil Supplementation and Stocking Density on Growth Performance, Proximate Composition, and Organo-somatic Indices of Cyprinus carpio
The study investigated the effects of krill oil supplementation on growth performance, proximate composition, and organo-somatic indices of Cyprinus carpio in a recirculating aquaculture system at different stocking densities. Krill oil supplementation improved growth performance in low-density groups without affecting the proximate composition of meat. Significant differences were observed in organo-somatic indices between experimental variants.
Krill Oil Inhibits NLRP3 Inflammasome Activation in the Prevention of the Pathological Injuries of Diabetic Cardiomyopathy
The study investigates the effect of krill oil on preventing diabetic cardiomyopathy (DCM) in a mouse model induced by streptozotocin and a high-fat diet. Krill oil prevented pathological features such as cardiac fibrosis, apoptosis, and inflammatory cell infiltration, and inhibited NLRP3 inflammasome activation, suggesting its potential in clinical prevention of DCM.
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
The study investigated the preventive effect of krill oil on diabetic nephropathy using a type 2 diabetes mouse model. Krill oil significantly prevented albuminuria, mesangial matrix accumulation, glomerular hypertrophy, and fibrosis formation, primarily by modulating TGF-β1 signaling, but did not improve hyperglycemia and glucose intolerance.
The Complex of Phycobiliproteins, Fucoxanthin, and Krill Oil Ameliorates Obesity through Modulation of Lipid Metabolism and Antioxidants in Obese Rats
The study prepared a complex of phycobiliproteins, fucoxanthin, and krill oil (PFK) and assessed its anti-obesity, lipid-lowering, and antioxidant activities in high-fat diet rats. The complex significantly reduced body weight gain and regulated serum biochemical parameters, suggesting potent anti-obesity and hypolipidemic effects.
Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice
The study investigated the effects of local application of krill oil on wound healing in type 2 diabetic mice. Krill oil reversed delayed wound healing, excessive inflammation, impaired collagen deposition, and depressed neovascularization in diabetic mice, suggesting its potential in managing diabetic wounds.
Lipidome reveals the alleviation of acrylamide-induced impairment by krill oil.
The study investigated the effects of krill oil on acrylamide-induced impairment in C. elegans. Krill oil supplementation improved locomotion by enhancing head thrashes and body bends, and reversed gene expressions related to neuron status, antioxidants, and energy metabolism. Lipidomics analysis showed krill oil restored metabolic changes induced by acrylamide.
Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet
Animal study investigating the effects of krill oil and coconut oil on dyslipidemia and lipid metabolism in rats on a high-fat diet. Both oils reduced serum lipids and improved lipid metabolism, with krill oil showing additional benefits in reducing hepatic triglyceride content and adipogenic gene expression.
Krill oil prevents lipopolysaccharide-evoked acute liver injury in mice through inhibition of oxidative stress and inflammation.
The study investigated the protective effect of krill oil on lipopolysaccharide-evoked acute liver injury in mice. Krill oil pretreatment significantly ameliorated hepatic dysfunction, reduced oxidative stress, and inhibited inflammation, showing superior hepatoprotective effects compared to fish oil.
Krill Oil Inhibits Cholesterol Synthesis and Stimulated Cholesterol Excretion in Hypercholesterolemic Rats
Animal study investigating the effects of krill oil supplementation on hypercholesterolemic rats. Krill oil suppressed triglycerides, total cholesterol, and LDL-cholesterol levels, and stimulated cholesterol excretion, suggesting its potential in reducing LDL-cholesterol and preventing atherosclerosis.
Krill Oil Attenuates Inflammation in Monosodium Iodoacetate-Induced Osteoarthritic Rats, SW982 Synovial Cell Line, and Primary Chondrocytes
The study investigated the effects of krill oil (FJH-KO) in MIA-induced osteoarthritis in rat models and treated primary chondrocytes and SW982 synovial cell line. Krill oil supplementation improved physical performance in osteoarthritic rats and prevented cell death and matrix degradation in treated cell lines, suggesting potential benefits in preventing osteoarthritis progression.
Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway
The study investigated the protective effect of krill oil on methamphetamine-induced memory deficits in mice. Krill oil treatment significantly improved memory impairment, potentially through the MAPK signaling pathway and dopaminergic synapse pathways. The study used a combination of bioinformatics analysis and experimental validation to explore the molecular mechanisms.
Krill Oil Mitigates Cisplatin-Induced Ovarian Toxicity via Attenuation of Oxidative Stress and Inflammatory Pathways
Animal study investigating the protective effects of krill oil against cisplatin-induced ovarian damage in rats. Krill oil supplementation improved follicle counts, reduced fibrosis, and restored biochemical markers, suggesting significant antioxidant and anti-inflammatory effects.
Krill oil: nutraceutical potential in skin health and disease
This narrative review explores the nutraceutical potential of krill oil in skin health and disease. It highlights krill oil's antioxidative and anti-inflammatory effects, suggesting its potential in skin care applications, particularly for anti-aging and enhancing overall skin health.
Why is Antactic krill (Euphasia superba) oil on the spotlight? A review
This review outlines the chemical composition, extraction methods, and health advantages of Antarctic krill oil, highlighting its distinctive fat profile rich in phospholipids, EPA, and DHA. It discusses the potential health benefits, including cardiovascular disease prevention, anti-inflammatory effects, support for women's physiology, anticancer activities, and neuroprotection.
Krill Oil and Its Bioactive Components as a Potential Therapy for Inflammatory Bowel Disease: Insights from In Vivo and In Vitro Studies
This narrative review discusses the potential therapeutic benefits of krill oil in preventing and treating inflammatory bowel disease (IBD). It highlights krill oil's anti-inflammatory and antioxidant properties, its role in maintaining intestinal barrier functions, and its effects on gut microbiota.
The Effects of Krill Oil Content on Asthma
The paper reviews several studies on the effects of antioxidant compounds in krill oil on asthma, suggesting that these compounds can reduce inflammation and exacerbations of asthma. It highlights the need for further biomolecular research to determine the levels of antioxidant compounds in krill oil.
The comparative anti-cancer effects of krill oil and oxaliplatin in an orthotopic mouse model of colorectal cancer
The study compared the anti-cancer effects of krill oil (KO) with oxaliplatin in a mouse model of colorectal cancer. Mice treated with KO and KO plus a half dose of oxaliplatin showed significant reductions in tumour weight and volume, similar to oxaliplatin-treated mice. KO increased the expression of cytochrome c, cleaved caspase-9 and -3, and DNA damage, while decreasing PD-L1, PD-L2, and HSP-70 expression in tumour tissues.
Krill oil supplementation reduces the growth of CT-26 orthotopic tumours in Balb/c mice
Animal study investigating the effects of krill oil supplementation on colorectal cancer tumour growth in Balb/c mice. Krill oil reduced tumour growth, cell proliferation, and microvessel density in a dose-dependent manner, with the highest dose showing the most significant effects. The study also found krill oil to have pro-apoptotic effects and to downregulate the EGFR signalling pathway.
Preventive and Therapeutic Effects of Krill Oil on Obesity and Obesity-Induced Metabolic Syndromes in High-Fat Diet-Fed Mice
The study examined the effects of krill oil on obesity and metabolic syndromes in high-fat diet-fed mice. Krill oil treatments significantly reduced weight gain, fat deposition, and improved blood parameters related to NAFLD, type 2 diabetes, and renal dysfunction. It also showed hepatic antioxidant activities and glucose-lowering effects, suggesting its potential in inhibiting obesity and metabolic syndromes.
Advances in Technologies for Highly Active Omega-3 Fatty Acids from Krill Oil: Clinical Applications
This review provides an overview of the chemical composition, bioavailability, and bioaccessibility of krill oil, as well as its mechanisms of action, extraction techniques, health benefits, and current applications. Krill oil is noted for its metabolic, anti-inflammatory, neuroprotective, and chemopreventive effects in preclinical studies, and metabolic, vascular, and ergogenic actions in clinical trials.
Krill oil extract suppresses cell growth and induces apoptosis of human colorectal cancer cells
In vitro study assessing the efficacy of krill oil extract on human colorectal cancer cell lines. Krill oil extract inhibited cell proliferation and induced apoptosis, with EPA being a significant bioactive component. The study suggests krill oil extract may be an effective chemotherapeutic agent.
Krill Products: An Overview of Animal Studies
This narrative review summarizes findings from animal studies on krill oil, krill powder, and krill protein concentrate. It discusses their mechanisms of action, effects on obesity, depression, myocardial infarction, and inflammation, and compares the tissue uptake of EPA and DHA in different forms.