Research
Kaempferol
13 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Kaempferol as a multi-targeted phytotherapeutic for arthritis: systematic review and meta-analysis of preclinical models.
Systematic review and meta-analysis of preclinical models assessing kaempferol's anti-arthritic effects. Kaempferol significantly reduced arthritis scores, inflammatory cytokines, and oxidative stress markers, while improving cartilage degradation markers. Results suggest strong anti-arthritic potential, warranting further in vivo validation and clinical trials.
The Neuroprotective Mechanisms of Kaempferol in Experimental Ischemic Stroke: A Preclinical Systematic Review.
Systematic review of preclinical studies investigating the neuroprotective properties of kaempferol in ischemic stroke. Kaempferol shows significant neuroprotective potential through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms, suggesting its promise as a therapeutic agent for ischemic stroke.
Bibliometric and visual analysis of global publications on kaempferol.
The paper provides a bibliometric and visual analysis of global publications on kaempferol, highlighting its health benefits such as anti-inflammatory, antioxidant, antiviral, anticancer, cardioprotective, and neuroprotective effects. It maps the evolution of research frontiers and hotspots in the field, noting significant contributions from countries like China, the USA, and India.
Network pharmacological mechanism analysis and evidence-based medical validation of Dahuang Mudan Decoction in the treatment of acute pancreatitis.
The study used a network pharmacological approach and meta-analysis to investigate the active ingredients and potential targets of Dahuang Mudan Decoction in treating acute pancreatitis. It identified kaempferol, quercetin, and eupatin as main components targeting proteins like AKT1 and TNF-a. The meta-analysis showed improved treatment efficacy and reduced inflammation compared to control.
Kaempferol, a potential neuroprotective agent in neurodegenerative diseases: From chemistry to medicine.
Systematic review of kaempferol and its derivatives as neuroprotective agents in neurodegenerative diseases. The review summarizes mechanisms by which kaempferol may benefit conditions like Alzheimer's, Parkinson's, Huntington's, and ALS, including preventing amyloid fibril deposition, inhibiting microglia activation, and reducing oxidative stress.
Kaempferol as a therapeutic agent in Alzheimer's disease: Evidence from preclinical studies.
Systematic review of preclinical studies on kaempferol (KMP) as a therapeutic agent in Alzheimer's disease (AD). The review confirms the neuroprotective effects of KMP in AD models, highlighting its antioxidant, anti-inflammatory, anti-apoptotic, and anti-acetylcholinesterase mechanisms.
Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases.
Systematic review of kaempferol's pharmacological mechanisms and potential value in treating liver diseases such as ALD, NASH, liver fibrosis, and HCC. Kaempferol shows promise in protecting liver cells through antioxidant and anti-apoptotic mechanisms, reducing immune inflammatory responses, and inhibiting tumor growth.
Acute kaempferol ingestion lowers oxygen uptake during submaximal exercise and improves high-intensity exercise capacity in well-trained male athletes.
This randomized, double-blind, placebo-controlled crossover study assessed the effect of a single 10 mg kaempferol intake on cardiopulmonary response and exercise performance in 16 well-trained male athletes. Kaempferol significantly reduced oxygen uptake during submaximal exercise and increased exercise duration at maximal intensity.
Antioxidant and Anti-Inflammatory Benefits of Gymnema inodorum Leaf Extract in Human Umbilical Vein Endothelial Cells Under Peroxynitrite Stress
The study investigated the antioxidant and anti-inflammatory effects of Gymnema inodorum leaf extract on human umbilical vein endothelial cells under peroxynitrite-induced stress. The extract, particularly its flavonoid constituents kaempferol and quercetin, enhanced antioxidant defenses and suppressed inflammation, suggesting potential benefits for managing endothelial dysfunction and oxidative stress-related complications in diabetes.
An investigation into the mechanism for Kaempferol improving melanocyte death based on network Pharmacology and experimental verification
The study investigates the effect of kaempferol on melanocyte death in vitiligo through network pharmacology and experimental verification. Kaempferol was found to ameliorate RSL3-induced ferroptosis in human primary epidermal melanocytes by alleviating mitochondrial damage, decreasing ROS and iron ion levels, and up-regulating GPX4 and antioxidants. Silencing GPX4 attenuated kaempferol's protective effects, suggesting its mechanism involves the ferroptosis pathway.
Identification of Kaempferol as Viral Entry Inhibitor and DL-Arginine as Viral Replication Inhibitor from Selected Plants of Indian Traditional Medicine against COVID-19: AnGuided in vitro Approach.
The study identifies kaempferol as a viral entry inhibitor and DL-arginine as a viral replication inhibitor against SARS-CoV-2 using molecular docking and in vitro assays. Kaempferol showed significant interaction energy with spike glycoprotein binding domains, and DL-arginine showed comparable results with remdesivir against the RdRp binding domain.
Mechanism and Experimental Verification of the Use of Rhodiola crenulata to Cytokine Storm Based on Network Pharmacology and Molecular Docking
The study investigates the mechanisms by which Rhodiola crenulata treats cytokine storm using network pharmacology, molecular docking, and experimental verification in a rat model. Kaempferol, an active component of Rhodiola crenulata, was found to down-regulate inflammatory factors and protect against systemic inflammatory response and organ damage.
Hyaluronic Acid Modified Nanostructured Lipid Carrier for Targeting Delivery of Kaempferol to NSCLC: Preparation, Optimization, Characterization, and Performance Evaluation In Vitro
The study prepared hyaluronic acid-modified kaempferol-loaded nanostructured lipid carriers (HA-KA-NLCs) and evaluated their antitumor effects on A549 cells. The HA-KA-NLCs showed predominant in vitro antitumor effects, inhibiting proliferation, migration, and invasion, promoting apoptosis, and increasing cellular uptake of A549 cells.