Research
Inulin
110 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Evaluation of antenatal prebiotic intake in infants at risk of atopy: the double-blind PREGRALL randomized clinical trial.
The PREGRALL randomized clinical trial evaluated the effect of antenatal prebiotic intake (GOS/inulin) on preventing atopic dermatitis in infants at high risk of atopy. The study included 376 pregnant women with a history of atopy, randomized to receive prebiotics or placebo. Results showed no significant effect of prebiotic supplementation on preventing atopic dermatitis or reducing its severity in children at 1 year of age.
Inulin Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Levels to Inhibit Colon Tumorigenesis in Rat Models: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of inulin on colorectal cancer in animal models. Inulin supplementation significantly reduced aberrant crypt foci count, increased cecal weight, enhanced colonic lactobacillus counts, decreased coliform bacteria, and elevated colonic short-chain fatty acids levels, demonstrating its chemopreventive effects against CRC.
Three-arm clinical trial of improved flour targeting intestinal microbiota (MALINEA).
Three-arm RCT comparing fortified blended flour (FBF) alone, FBF with azithromycin, and FBF with inulin/fructo-oligosaccharides in children with moderate acute malnutrition. No significant difference in nutritional recovery at 12 weeks, but exploratory endpoint showed higher success with antibiotics or prebiotics.
Prebiotics improve frailty status in community-dwelling older individuals in a double-blind, randomized, controlled trial.
A double-blind, randomized, placebo-controlled trial examined the effects of a prebiotic blend of inulin and oligofructose on frailty in older individuals. The intervention improved frailty status, renal function, protein levels, body fat percentage, walking speed, and grip strength, while also enhancing gut probiotic count and altering microbial metabolite expression.
The Prebiotic Potential of Inulin-Type Fructans: A Systematic Review.
Systematic review of human clinical trials on inulin-type fructans (ITF) as prebiotics. ITF promote beneficial gut microbiota and have positive effects on intestinal barrier function, insulin sensitivity, lipid profile, mineral absorption, and satiety. Evidence suggests chain length may influence effects, but more research is needed.
Assessing the effects of inulin‐type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta‐analysis of randomized controlled trials
Systematic review and meta-analysis of 33 RCTs assessing inulin-type fructan intake on metabolic syndrome features. ITF significantly decreased blood glucose, total cholesterol, and triglycerides in diabetics, but not in other groups. ITF may benefit diabetics by lowering these markers, though mechanisms remain unclear.
Effect of Prebiotic Supplementation With and Without Physiotherapy on Pain and Pain Sensitivity in People with Knee Osteoarthritis.
A 2 × 2 factorial RCT with 117 adults with knee osteoarthritis evaluated the effects of inulin supplementation with and without physiotherapy-supported exercise (PSE) on pain and pain sensitivity. Inulin improved pain, grip strength, pressure pain thresholds, and temporal summation compared to placebo, and increased SCFA butyrate and GLP-1 levels. PSE improved pain, TUG, and 30-CST scores. Inulin had higher retention rates compared to PSE.
Inulin supplementation modulates gut microbiota derived metabolites related to brain function in children with obesity.
RCT assessing the effects of inulin supplementation on gut-brain axis-related amino acids and bioactive molecules in children with obesity. Inulin supplementation led to significant increases in putrescine, spermine, and tyrosine, suggesting enhanced gut-brain communication and potential benefits for obesity management.
Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-blind clinical trial.
This randomized, double-blind clinical trial studied the effects of inulin and fructooligosaccharides (FOS) on glycemic metabolism and gut microbiota in 131 overweight/obese and healthy adults. Inulin significantly improved glycemic outcomes and reduced homocysteine levels in overweight/obese individuals, while FOS decreased homocysteine but did not improve glycemic metrics. Inulin also altered gut microbiota composition, reducing Ruminococcus abundance and propionate levels.
Enhancement of carbohydrate metabolism by probiotic and prebiotic intake promotes short-chain fatty acid production in the gut microbiome: a randomized, double-blind, placebo-controlled crossover trial.
A randomized, double-blind, placebo-controlled crossover trial with 120 participants investigated the effect of Bifidobacterium animalis subsp. lactis GCL2505 and inulin on fecal SCFAs and gut microbial composition. The intake significantly increased acetate, propionate, and butyrate concentrations and Bifidobacterium abundance compared to placebo, suggesting enhanced SCFA production capacity.
The anti-inflammatory effects of three different dietary supplement interventions.
This study examined the impact of six-week supplementation with inulin, omega-3, or a synbiotic on inflammatory markers. All interventions significantly reduced inflammation compared to control, with the synbiotic showing the broadest and strongest effects.
Standardized Hibiscus-Inulin Shot Lowers Lipid-Glucose Indices in Adults with Overweight and Obesity: 8-Week Randomized Trial.
An 8-week randomized, double-blind, placebo-controlled trial assessed the effects of a Hibiscus-inulin shot on lipid-glucose indices in adults with overweight and obesity. The study found significant improvements in Atherogenic and triglyceride-glucose indices compared to placebo, with no significant changes in mean arterial pressure or pulse pressure.
A phase 2 randomized, placebo-controlled trial of inulin for the prevention of gut pathogen colonization and infection among patients admitted to the intensive care unit for sepsis.
A phase 2 randomized, placebo-controlled trial of inulin in ICU patients with sepsis to assess its effect on gut pathogen colonization and infection risk. Inulin did not affect SCFA-producer levels, microbiome diversity, or rates of gut colonization with pathogenic bacteria, nor did it improve clinical outcomes.
Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial.
Randomized, placebo-controlled, double-blind crossover study of inulin supplementation in 21 young adults and 40 older adults. Inulin increased short-chain fatty acid production, with a 44% increase in butyrate production and a 50%-60% increase in fecal acetate, propionate, and butyrate in older adults.
Inulin supplementation improves some inflammatory indices, clinical outcomes, and quality of life in rheumatoid arthritis patients.
Randomized, triple-blind, parallel clinical trial of 60 rheumatoid arthritis patients receiving 10 g of inulin or maltodextrin daily for 8 weeks. Inulin supplementation improved inflammatory indices, disease activity, and clinical outcomes, including reduced CRP levels, improved hand grip, morning stiffness, and quality of life, but did not significantly change pain intensity.
Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
A randomized, double-blind, placebo-controlled study with 50 AUD patients supplemented with inulin or maltodextrin for 17 days. Inulin supplementation led to specific changes in plasma and fecal metabolome, with some metabolites correlated with liver function and gut microbiota.
Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity.
RCT of inulin supplementation in children with obesity, showing significant increases in gut bacterial diversity and enhancement of beneficial bacteria. Inulin improved gut microbiota dysbiosis and modulated functional pathways, suggesting potential benefits for childhood obesity.
The effects of synbiotics on the liver steatosis, inflammation, and gut microbiome of metabolic dysfunction-associated liver disease patients-randomized trial.
A double-blind, placebo-controlled study involving 84 MASLD patients examined the effects of synbiotics on liver steatosis, inflammation, and gut microbiome. Synbiotics significantly decreased liver steatosis and high-sensitive C-reactive protein levels, enriched the gut microbiome, and shortened gut transition time.
Pomegranate Juice Supplemented with Inulin Modulates Gut Microbiota and Promotes the Production of Microbiota-Associated Metabolites in Overweight/Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial.
A randomized, double-blind, placebo-controlled trial with 68 overweight/obese individuals assessed the effects of pomegranate juice (PJ) and PJ supplemented with inulin on gut microbiota. PJ+inulin treatment significantly altered gut microbiota composition and promoted the production of microbiota-associated metabolites, suggesting potential beneficial effects.
The effect of prebiotic supplementation on serum levels of tryptophan and kynurenine in obese women with major depressive disorder: a double-blinded placebo-controlled randomized clinical trial.
Double-blind placebo-controlled RCT examining the effect of inulin supplementation on serum levels of tryptophan, kynurenine, and Trp/Kyn ratio in 51 obese women with mild major depressive disorder. Inulin supplementation did not significantly influence these serum levels or depression scores after 8 weeks.
Exploring the Fecal Metabolome in Infants With Cow's Milk Allergy: The Distinct Impacts of Cow's Milk Protein Tolerance Acquisition and of Synbiotic Supplementation.
The study assessed the effect of synbiotic supplementation on the fecal metabolome in infants with IgE-mediated cow's milk allergy. Synbiotic supplementation significantly modified the fecal metabolome after 6 months, altering purine, bile acid, and unsaturated fatty acid levels, and increasing metabolites of infant-type Bifidobacterium species.
Effect of Continuous Ingestion of Bifidobacteria and Inulin on Reducing Body Fat: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study.
This randomized, double-blind, placebo-controlled study investigated the effects of consuming bifidobacteria GCL2505 and inulin on reducing abdominal fat. Participants consumed a test beverage containing GCL2505 and inulin for 12 weeks, resulting in significant reductions in visceral fat area and total fat area. The intervention also increased the total number of bifidobacteria and affected lipid markers, suggesting improvements in the intestinal environment and reductions in abdominal fat.
Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial.
This randomized, double-blind, placebo-controlled trial studied the effects of continuous ingestion of Bifidobacteria subsp. GCL2505 and inulin on cognitive function. Participants consumed test drinks containing GCL2505 and inulin for 12 weeks, resulting in significant improvements in cognitive function scores and increased fecal bifidobacteria, suggesting benefits for brain health and inflammation.
Effect of daily ingestion of Bifidobacterium and dietary fiber on vascular endothelial function: a randomized, double-blind, placebo-controlled, parallel-group comparison study.
This randomized, double-blind, placebo-controlled study examined the effects of inulin and Bifidobacterium animalis subsp. lactis GCL2505 on vascular endothelial function in 60 healthy subjects. The test drink improved flow-mediated dilation and showed trends in improving low-density lipoprotein cholesterol and plasminogen activator inhibitor-1.
Effects of inulin supplementation on body composition and metabolic outcomes in children with obesity
A randomized, double-blinded placebo-controlled study in obese Thai children aged 7–15 years assessed the effects of inulin supplementation on body composition and metabolic outcomes. The inulin group showed a significant increase in fat-free mass index, but no significant differences in metabolic profiles or adiposity compared to other groups.
Effects of enriched seafood sticks (heat-inactivated B. animalis subsp. lactis CECT 8145, inulin, omega-3) on cardiometabolic risk factors and gut microbiota in abdominally obese subjects: randomized controlled trial.
RCT of 120 abdominally obese individuals consuming enriched seafood sticks with omega-3, inulin, and heat-inactivated B. animalis subsp. lactis CECT 8145. The study found reductions in insulin, HOMA-IR, and pulse pressure, with changes in gut microbiota composition. The enriched seafood sticks also reduced postprandial triglyceride levels.
Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals.
A multicenter randomized placebo-controlled trial tested the effect of inulin supplementation combined with physical activity on metabolic improvements in obese individuals. The study found that increased physical activity during inulin supplementation led to reduced BMI, decreased liver enzymes, and improved glucose tolerance. The regulation of gut microbiota by inulin was significant only with increased physical activity.
Effects of inulin-type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.
RCT of 75 women with PCOS comparing 10g/day of high-performance inulin or oligofructose-enriched inulin to placebo for 12 weeks. High-sensitive C-reactive protein decreased significantly in the high-performance inulin group compared to placebo, indicating a positive effect on inflammation. Other markers like nitric oxide and endothelin-1 showed changes but were not significant compared to placebo.
Overall Structural Alteration of Gut Microbiota and Relationships with Risk Factors in Patients with Metabolic Syndrome Treated with Inulin Alone and with Other Agents: An Open-Label Pilot Study.
This open-label pilot study investigated the effects of inulin alone and in combination with traditional Chinese medicine or metformin on gut microbiota in 60 patients with metabolic syndrome. Inulin alone resulted in a higher proportion of Bacteroides, while combinations showed more Romboutsia, Streptococcus, and Holdemanella. The study identified relationships between gut microbiota and clinical parameters like lipids, uric acid, and glucose.
Liver alterations are not improved by inulin supplementation in alcohol use disorder patients during alcohol withdrawal: A pilot randomized, double-blind, placebo-controlled study.
This pilot randomized, double-blind, placebo-controlled study evaluated the effects of inulin supplementation on liver parameters in 50 alcohol use disorder patients during a 3-week detoxification program. Inulin supplementation led to specific changes in the gut microbiota but did not alleviate liver damage, with higher AST and ALT levels observed in the inulin group compared to placebo.
Tolerance development in cow's milk-allergic infants receiving amino acid-based formula: A randomized controlled trial.
This randomized controlled trial evaluated tolerance development to cow's milk and the safety of an amino acid-based formula including synbiotics in infants with IgE-mediated cow's milk allergy. After 12 and 24 months, cow's milk tolerance did not differ significantly between groups, but fewer subjects receiving the synbiotic formula required hospitalization due to infections.
The effects of co-administration of probiotics and prebiotics on chronic inflammation, and depression symptoms in patients with coronary artery diseases: a randomized clinical trial.
This randomized clinical trial studied the effects of Lactobacillus Rhamnosus GG and inulin co-supplementation on chronic inflammation and depression symptoms in 96 patients with coronary artery disease. The co-supplementation significantly improved depression, anxiety, and inflammatory biomarkers compared to placebo.
Diet Therapeutics Interventions for Obesity: A Systematic Review and Network Meta-Analysis.
Systematic review and network meta-analysis comparing diet therapeutic interventions for obesity. The study identified several effective treatments for weight loss, including catechin-rich green tea with inulin and other dietary interventions.
Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial.
A randomized, placebo-controlled trial in 150 obese patients tested the impact of 16g/day native inulin on gut microbiota-related outcomes. The inulin group showed greater weight loss, decreased diastolic blood pressure, AST, and insulinemia compared to placebo. Metformin treatment compromised gut microbiota changes and metabolic improvements linked to inulin.
Effect of chicory inulin-type fructan-containing snack bars on the human gut microbiota in low dietary fiber consumers in a randomized crossover trial.
Randomized crossover trial in 50 healthy adults with low dietary fiber intake, testing snack bars containing chicory root inulin-type fructans. Moderate-dose bars increased Bifidobacterium abundance significantly, suggesting a positive effect on gut microbiota. Fiber intake increased with both low- and moderate-dose bars.
The effects of inulin on gut microbial composition: a systematic review of evidence from human studies.
Systematic review of human studies assessing the effects of inulin on gut microbiome composition. The review found consistent increases in Bifidobacterium and other beneficial bacteria, but no associated increase in short-chain fatty acids levels.
Effect of phytosterols and inulin-enriched soymilk on LDL-cholesterol in Thai subjects: a double-blinded randomized controlled trial.
Double-blinded RCT with 240 Thai subjects comparing phytosterols and inulin-enriched soymilk to standard soymilk. The enriched soymilk significantly reduced LDL-c and TC levels compared to control, with no effect on TG and HDL-c levels. Both products were comparably safe.
Safety and efficacy of inulin and oligofructose supplementation in infant formula: results from a randomized clinical trial.
RCT of 252 formula-fed infants comparing a control formula to one supplemented with 0.8 g/dL oligofructose-enriched inulin (SYN1) over the first 4 months of life. SYN1 infants showed a gut microbiota composition closer to breastfed infants, with higher Bifidobacterium counts, softer stools, and higher stool frequency. No differences in anthropometry, adverse events, water balance, or blood parameters were observed.
Effects of inulin and enzyme complex, individually or in combination, on growth performance, intestinal microflora, cecal fermentation characteristics, and jejunal histomorphology in broiler chickens fed a wheat- and barley-based diet.
The study examined the effects of inulin, alone or with an enzyme complex, on growth performance and intestinal health in broiler chickens fed a wheat- and barley-based diet. Inulin improved final body weight gain and positively affected bifidobacteria and lactobacilli counts in ileal and cecal contents, as well as altered cecal fermentation patterns. Enzyme supplementation had limited effects.
Efficacy of inulin supplementation in metabolic control and Akkermansia muciniphila levels in subjects with type 1 diabetes: a pilot study.
Pilot RCT of 49 subjects with type 1 diabetes comparing inulin supplementation plus insulin to insulin alone over 3 months. Inulin was associated with a slight decrease in body weight and insulin need, but did not increase Akkermansia muciniphila levels.
Inulin-induced improvements on bowel habit and gut microbiota in adults with functional constipation: findings of a randomized, double-blind, placebo-controlled study.
This randomized, double-blind, placebo-controlled, cross-over trial investigated the effect of daily 12g chicory inulin intake in 39 individuals with functional constipation. Inulin intake improved stool frequency, abdominal symptoms, and quality of life, and modulated gut microbiota towards higher abundances of butyrate-producing genera.
A randomized trial of inulin for bowel symptoms, depression and quality of life in constipation predominant IBS.
This randomized, single-blind, placebo-controlled trial evaluated the effect of inulin on bowel symptoms, depression, and quality of life in 34 individuals with constipation-predominant IBS. The prebiotic group showed significant improvements in IBS-QoL and IBS-SSS scores, as well as in constipation status and psychological state.
The Role of Fermentable Fibre on Endurance Exercise Capacity: A Randomised Crossover Trial of Inulin Supplementation.
Randomised controlled cross-over trial with 21 healthy males to investigate the effect of 15g of inulin on exercise performance during a 15km cycle time trial. Inulin did not affect time to completion, plasma acetate concentration, or muscle oxygenation compared to placebo, though markers of inulin fermentation were higher.
Effect of Intake of Bifidobacteria and Dietary Fiber on Resting Energy Expenditure: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparison Study.
RCT evaluating the effects of Bifidobacteria subsp. GCL2505 and inulin on resting energy expenditure (REE) in overweight or mildly obese Japanese adults. Participants ingested GCL2505 and inulin daily for 4 weeks, resulting in a significantly higher REE score and increased fecal bifidobacteria counts compared to placebo.
Black Tea drinks with inulin and dextrin reduced postprandial plasma glucose fluctuations in patients with type 2 diabetes: an acute, randomized, placebo-controlled, single-blind crossover study.
An acute, randomized, placebo-controlled, single-blind crossover study on 32 patients with type 2 diabetes mellitus evaluated the effects of black tea drinks with inulin and dextrin on postprandial plasma glucose. The study found that the drink significantly reduced postprandial glucose fluctuations and insulin secretion compared to placebo, suggesting improved insulin sensitivity.
Faecal microbial transfer and complex carbohydrates mediate protection against COPD.
The study investigated the role of the gut microbiome in COPD pathogenesis using a mouse model and a pilot study in 16 COPD patients. Faecal microbial transfer and inulin supplementation improved COPD features, suggesting therapeutic potential of targeting the gut microbiome.
Effect of inulin on breath hydrogen, postprandial glycemia, gut hormone release, and appetite perception in RYGB patients: a prospective, randomized, cross-over pilot study.
Prospective, randomized, cross-over pilot study in 8 RYGB patients assessing the effects of inulin vs. maltodextrin on breath hydrogen, glycemia, gut hormones, and appetite. Inulin accelerated intestinal fermentation post-surgery and potentiated glucose-lowering and appetite-suppressive effects, though no effect on plasma SCFAs or gut hormones was observed.
Chronic consumption of a blend of inulin and arabinoxylan reduces energy intake in an ad libitum meal but does not influence perceptions of appetite and satiety: a randomised control-controlled crossover trial.
A double-blind randomised crossover trial in 20 healthy adult men tested the effects of a prebiotic blend of inulin and arabinoxylan (I + AX) consumed for 21 days. The intervention reduced energy intake in an ad libitum meal and increased faecal SCFA concentration and beneficial gut microbiota, but did not affect perceived satiety and appetite.
Effects of inulin supplementation on inflammatory biomarkers and clinical symptoms of women with obesity and depression on a calorie-restricted diet: a randomised controlled clinical trial.
This double-blind randomized controlled trial investigated the effects of inulin supplementation on psychological outcomes and biomarkers of gut permeability, endotoxemia, inflammation, and BDNF in 45 women with obesity and depression on a calorie-restricted diet. The study found no significant beneficial effects of inulin on depressive symptoms, gut permeability, or inflammatory biomarkers compared to the control group.
Daily Intake of a Functional Synbiotic Yogurt Increases Calcium Absorption in Young Adult Women.
A 3-week crossover RCT in 30 young adult women tested the effect of daily consumption of a synbiotic yogurt containing inulin and Lactobacillus rhamnosus GG on calcium absorption. The synbiotic yogurt enhanced calcium absorption compared to a control yogurt, with a significant SYN/CON tracer ratio in the 0-36-hour urine pool.
Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial.
Pilot RCT assessing inulin supplementation (10 g/day) versus placebo in adults at risk for type 2 diabetes over six weeks. Inulin reduced fasting insulin concentrations and HOMA-IR, but did not improve peripheral insulin sensitivity. Findings suggest further investigation is needed.
Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial
RCT of 24 obese patients comparing 16 g/d inulin intake to placebo over 3 months. Inulin intake increased Bifidobacterium and reduced fecal calprotectin, a marker of gut inflammation, suggesting improved gut health.
Acute and short-term effects of Lactobacillus paracasei subsp. paracasei 431 and inulin intake on appetite control and dietary intake: A two-phases randomized, double blind, placebo-controlled study.
This study examined the acute and short-term effects of prebiotics, probiotics, and their combination on appetite, energy intake, and satiety-related hormones in healthy men. The first phase showed that energy intake was lowest with the prebiotic drink, followed by probiotic, synbiotic, and control drinks. The second phase found no significant differences in hunger-satiety scores or hormone concentrations after 21 days of synbiotic consumption.
Effect of Dietary Inulin Supplementation on the Gut Microbiota Composition and Derived Metabolites of Individuals Undergoing Hemodialysis: A Pilot Study.
This pilot study assessed the impact of a 4-week inulin supplementation on gut microbiota composition and metabolites in 12 hemodialysis patients. Inulin increased the relative abundance of certain gut bacteria but did not lead to major shifts in fecal microbiota or metabolites. Larger studies are needed to determine the effects of prebiotic fibers in this population.
Pre-meal high-performance inulin supplementation reduce post-prandial glycaemic response in healthy subjects: A repeated single-arm clinical trial.
A repeated single-arm clinical trial with 8 healthy adults consuming 20g of high-performance inulin before meals. The study found that pre-meal inulin supplementation could suppress post-prandial glycaemic response.
Sensory Acceptance, Appetite Control and Gastrointestinal Tolerance of Yogurts Containing Coffee-Cascara Extract and Inulin.
A blind cross-over nutritional trial with 45 healthy adults tested yogurts containing coffee-cascara extract and varying concentrations of inulin. Inulin addition increased yogurt's firmness and consistency, with Y13 achieving higher acceptance scores. Y3 showed similar gastrointestinal tolerance to Y0, while Y7 and Y13 caused significant bloating and flatulence. Appetite ratings were not significantly affected.
Microbiota Stability and Gastrointestinal Tolerance in Response to a High-Protein Diet with and without a Prebiotic, Probiotic, and Synbiotic: A Randomized, Double-Blind, Placebo-Controlled Trial in Older Women.
This 18-week, double-blind, placebo-controlled, crossover study examined the effects of a high-protein diet with and without a probiotic, prebiotic (inulin), and synbiotic on gut microbiota and wellness in 26 older women. The microbiota profile showed relative stability, with some changes in bacterial representation. Fat-free mass increased, but there was a minimal increase in gastrointestinal distress with inulin.
Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial.
RCT evaluating the prebiotic effect of inulin-type fructans on faecal microbiota and SCFA in 25 patients with type 2 diabetes. Inulin-type fructans induced moderate changes in microbiota composition, increased SCFA concentrations, and had a significant bifidogenic effect.
Calorie restriction in combination with prebiotic supplementation in obese women with depression: effects on metabolic and clinical response
This 8-week double-blind placebo-controlled RCT assessed the effects of prebiotics (10g/day Inulin) combined with calorie restriction on metabolic and clinical response in 62 obese women with MDD. While both groups showed decreased weight, waist and hip circumferences, and HDRS scores, fat mass and total cholesterol declined only in the prebiotic group. No significant between-group differences were found for MDD symptoms post-intervention.
Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study.
RCT assessing the efficacy of the prebiotic UG1601 in adults with mild constipation. The prebiotic group showed greater improvement in symptoms and significant decreases in serum CD14 and LPS concentrations, indicating potential benefits for gut health.
Milk Powder Co-Supplemented with Inulin and Resistant Dextrin Improves Glycemic Control and Insulin Resistance in Elderly Type 2 Diabetes Mellitus: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial.
A 12-week randomized, double-blind, placebo-controlled trial evaluated the effects of milk powder co-supplemented with inulin and resistant dextrin on elderly patients with type 2 diabetes mellitus. The MPCIR group showed significant improvements in glycemic control, insulin resistance, and blood pressure compared to the placebo group.
Effect of Butyrate and Inulin Supplementation on Glycemic Status, Lipid Profile and Glucagon-Like Peptide 1 Level in Patients with Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Trial.
RCT evaluating the effects of sodium butyrate and inulin supplementation on glycemic status, lipid profile, and glucagon-like peptide 1 level in 60 adults with type 2 diabetes. Supplementation significantly reduced diastolic blood pressure, fasting blood sugar, and waist to hip ratio, with increased glucagon-like peptide 1 concentration in certain groups.
Prebiotic inulin-type fructans induce specific changes in the human gut microbiota.
Double-blind, randomised, cross-over intervention study assessing the effect of inulin consumption on stool frequency in healthy adults with mild constipation. Inulin consumption led to modest changes in global microbiota composition and specific changes in relative abundances of certain genera, associated with softer stools and improved constipation-specific quality-of-life measures.
Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial.
RCT investigating the efficacy of synbiotic (Bifidobacterium lactis B94 with inulin), probiotic (B. lactis B94), and prebiotic (inulin) treatments for IBS in children. Synbiotic and probiotic treatments significantly improved symptoms like belching-abdominal fullness, bloating, and constipation, with the synbiotic group showing a higher percentage of full recovery compared to the prebiotic group.
Randomised clinical study: inulin short‐chain fatty acid esters for targeted delivery of short‐chain fatty acids to the human colon
Randomised clinical study investigating inulin short‐chain fatty acid esters for targeted delivery of short‐chain fatty acids to the human colon. The study focuses on the metabolic effects associated with SCFA produced through fermentation by the gut microbiota.
A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial.
RCT of 52 women with type 2 diabetes comparing 10g/d oligofructose-enriched inulin to placebo for 8 weeks. The inulin group showed significant improvements in total antioxidant capacity, fasting plasma glucose, HbA1c, total cholesterol, LDL-c, and malondialdehyd levels compared to placebo.
Effects of inulin and di-D-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens.
In vitro and in vivo experiments evaluated the effects of di-D-fructose dianhydride-enriched caramels and inulin on intestinal microbiota and performance in broiler chickens. Inulin and FC improved gut microbiota composition and nutrient digestibility, with FC also increasing final body weight compared to controls.
The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: a randomized clinical trial in obese Mexican women.
RCT in 144 obese Mexican women evaluating partial meal replacement with and without inulin on weight reduction, blood lipids, and micronutrient intake. PMR with and without inulin reduced triglycerides and improved micronutrient intake, but had no additional effect on weight reduction compared to a low-calorie diet alone.
Microbiota benefits after inulin and partially hydrolized guar gum supplementation: a randomized clinical trial in constipated women.
RCT in 60 constipated female health workers comparing 15 g/d inulin/partially hydrolyzed guar gum mixture (I-PHGG) to placebo for 3 weeks. Both groups showed increased bowel movements and satisfaction, but I-PHGG decreased Clostridium sp levels, indicating protective effects on gut microbiota.
[Fructooligo- and fructopoly-saccharides in correction and prevention of intestinal microbiocenosis disorders in patients with bronchopulmonary pathology receiving antibacterial therapy].
RCT evaluating the efficacy of 'Stimbifid', containing inulin, oligofructose, vitamins, and minerals, in correcting microbiota disorders in 50 patients with bronchopulmonary pathology receiving antibiotic therapy. The study found high efficiency in correcting microbiota.
Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients.
RCT investigating the effects of a synbiotic containing inulin enriched with oligofructose and probiotics on immune functions in colon cancer and polypectomised patients. The synbiotic had minor stimulatory effects on systemic immune parameters, with increased IL-2 secretion in the polyp group and increased IFN-gamma production in the cancer group.
The effect of probiotic fermented milk and inulin on the functions and microecology of the intestine.
Double-blinded RCT with 66 healthy adults comparing the effects of probiotic fermented milk with and without inulin on gastrointestinal function and microecology. Both probiotic products increased faecal lactobacilli and bifidobacteria. Inulin increased gastrointestinal symptoms, especially flatulence.
Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial
A 7-day randomised, double-blind, three-way cross-over trial in 17 adults with asthma tested the effects of soluble fibre (inulin) supplementation, with and without a probiotic, on plasma SCFA, airway inflammation, asthma control, and gut microbiome. Inulin supplementation improved asthma control, reduced sputum eosinophils, and altered gut microbiome composition, though it did not change SCFA levels.
Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.
Randomised cross-over trial with 12 non-diabetic adults with overweight and obesity receiving inulin-propionate ester (IPE), inulin, and cellulose. Both IPE and inulin improved insulin resistance compared to cellulose. IPE decreased proinflammatory interleukin-8 levels, while inulin altered gut bacterial populations.
Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial
This randomized, double-blind, placebo-controlled trial investigated the effect of chicory-derived inulin on bowel function in 44 healthy subjects with constipation. Consumption of Orafti Inulin significantly increased stool frequency and softened stools compared to placebo, indicating improved bowel function.
Replacement of glycaemic carbohydrates by inulin-type fructans from chicory (oligofructose, inulin) reduces the postprandial blood glucose and insulin response to foods: report of two double-blind, randomized, controlled trials.
Two double-blind, randomized, controlled trials investigated the glycaemic and insulinaemic responses to foods where sucrose was partially replaced by inulin or oligofructose from chicory. The studies found that replacing sugars with inulin-type fructans significantly reduced postprandial blood glucose and insulin responses.
Influence of Synbiotics on Selected Oxidative Stress Parameters.
RCT assessing the influence of synbiotics with inulin on oxidative stress parameters in 32 healthy volunteers. Synbiotic supplementation significantly decreased MDA, HO, and GSSG concentrations and increased GSHt, GSH, and -SH group content compared to control, indicating a positive effect on oxidative stress markers.
The effect of enriched chicory inulin on liver enzymes, calcium homeostasis and hematological parameters in patients with type 2 diabetes mellitus: A randomized placebo-controlled trial.
RCT of 46 female patients with type 2 diabetes mellitus evaluating the effects of enriched chicory inulin supplementation. Significant reductions in fasting serum glucose, Hb A1C, AST, ALP, and blood pressure were observed in the chicory-treated group. Serum calcium increased significantly, while hematocrit and mean corpuscular volume values were reduced.
The acute effects of inulin and resistant starch on postprandial serum short-chain fatty acids and second-meal glycemic response in lean and overweight humans.
Randomized crossover study of 25 participants comparing the effects of inulin and resistant starch on postprandial serum short-chain fatty acids and second-meal glycemic response. Inulin increased serum SCFA but had no effect on glucose and insulin responses, while resistant starch reduced FFA rebound and second-meal glucose and insulin responses.
A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes
RCT of 44 subjects with prediabetes comparing inulin to cellulose supplementation over 18 weeks. The inulin group lost significantly more weight between weeks 9 and 18 and had lower hepatic and soleus muscle fat content at 18 weeks compared to control. Inulin may promote weight loss and reduce ectopic fat independent of weight loss.
Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial.
RCT involving 38 women with gynecological cancer receiving abdominal radiotherapy. The study compared prebiotics (inulin and fructo-oligosaccharide) to placebo, finding that prebiotics improved stool consistency and potentially quality-of-life during treatment.
Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial.
RCT of 30 overweight or obese individuals testing a gastrointestinal microbiome modulator containing inulin, β-glucan, blueberry anthocyanins, and blueberry polyphenols. The study found improved blood glucose tolerance and increased satiety after four weeks of consumption.
Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial.
RCT evaluating the effects of inulin supplementation on inflammatory indices and metabolic endotoxemia in 49 women with type 2 diabetes. Inulin significantly decreased FBS, HbA1c, fasting insulin, HOMA-IR, hs-CRP, TNF-α, and LPS compared to the maltodextrin group.
Effects of intervention with sulindac and inulin/VSL#3 on mucosal and luminal factors in the pouch of patients with familial adenomatous polyposis.
A 4-week intervention study on 17 patients with familial adenomatous polyposis comparing sulindac, inulin/VSL#3, and their combination. The study measured cell proliferation and GST enzyme activity in pouch mucosa, and SCFA content, pH, and cytotoxicity in fecal water. Results showed non-significant changes in cell proliferation and detoxification capacity with sulindac or VSL#3/inulin, but no additional effect with the combination.
A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects.
A double-blind, cross-over study in 32 healthy adults assessed the impact of very-long-chain inulin (VLCI) from globe artichoke on gut microbiota. VLCI significantly increased faecal bifidobacteria and lactobacilli compared to placebo, indicating a pronounced prebiotic effect. Mild and moderate bloating increased with VLCI ingestion, but it was well tolerated overall.
Gastrointestinal tolerance of chicory inulin products.
RCT assessing gastrointestinal tolerance of two inulin fibers, oligofructose and native inulin, at 5- and 10-g doses in 26 healthy adults. The study found that doses up to 10 g/day of native inulin and up to 5 g/day of oligofructose were well-tolerated, though the 10-g dose of oligofructose increased GI symptoms compared to control.
Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii.
RCT examining the effect of inulin on gut microbiota in 12 human volunteers over 16 days. Inulin consumption significantly increased the prevalence of Faecalibacterium prausnitzii and Bifidobacterium adolescentis, indicating a positive impact on gut health.
Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers.
A double-blind, randomized, placebo-controlled study with 45 volunteers tested the effects of Jerusalem artichoke and chicory inulin in snack bars on faecal microbiota. Consumption increased bifidobacteria counts and reduced certain pathogenic bacteria, with slight changes in stool frequency and consistency. Mild flatulence was noted in some subjects.
Inulin and oligofructose do not influence the absorption of cholesterol, or the excretion of cholesterol, Ca, Mg, Zn, Fe, or bile acids but increases energy excretion in ileostomy subjects.
Double-blind cross-over study in ileostomy patients investigating the effects of inulin and oligofructose on cholesterol absorption and mineral excretion. Inulin and oligofructose increased energy excretion but did not affect cholesterol absorption or mineral excretion.
Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study.
Open label single-arm study assessing the effects of synbiotic supplementation (Enterolactis Duo) on non-motor symptoms in 30 patients with stable Parkinson's Disease and constipation. Improvements were observed in neurological and gastroenterological evaluations, including MDS-UPDRS part 1, SCOPA-AUT, TAS-20, HAM-D, DIFt, PAS-A, PAC-SYM score, and bowel movement frequency.
Ternary inulin hydrogel with long-term intestinal retention for simultaneously reversing IBD and its fibrotic complication
The study introduces a probiotic inulin hydrogel loaded with polypyrrole nanozymes and antifibrotic drug pirfenidone for ameliorating IBD and its fibrotic complication. The inulin gel demonstrated significant efficacy in reducing pro-inflammatory cytokine levels and enhancing intestinal barrier repair in mouse models of colitis and intestinal fibrosis.
Inulin diet uncovers complex diet-microbiota-immune cell interactions remodeling the gut epithelium
The study investigates the impact of inulin consumption on the gut microbiota and intestinal stem cell functions in mice. Inulin intake was found to increase the proliferation of intestinal stem cells, leading to deeper crypts and longer colons, an effect dependent on the altered gut microbiota and the presence of γδ T cells and IL-22.
Inulin intervention attenuates hepatic steatosis in rats via modulating gut microbiota and maintaining intestinal barrier function.
Animal study investigating the effects of inulin on high-sucrose diet-induced hepatic steatosis in rats. Inulin ameliorated hepatic steatosis and inflammation, improved liver lipogenesis regulators, restored intestinal barrier integrity, and modulated gut microbiota composition, enhancing SCFA-producers and suppressing opportunistic pathogens.
Dietary Supplementation of Inulin Ameliorates Subclinical Mastitis via Regulation of Rumen Microbial Community and Metabolites in Dairy Cows
The study investigated the effects of dietary inulin supplementation on subclinical mastitis in dairy cows. Inulin improved milk yield, milk protein, and lactose, reduced somatic cell counts, and modulated the rumen microbial community and metabolites, leading to decreased proinflammatory cytokines and increased beneficial bacteria and metabolites.
Corrigendum to "A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota" [Carbohydr. Polym. 247 (2020) 116761].
Corrigendum to a study on a novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
Inulin Exerts Beneficial Effects on Non-Alcoholic Fatty Liver Disease via Modulating gut Microbiome and Suppressing the Lipopolysaccharide-Toll-Like Receptor 4-Mψ-Nuclear Factor-κB-Nod-Like Receptor Protein 3 Pathway via gut-Liver Axis in Mice
Animal study investigating the effects of inulin on non-alcoholic fatty liver disease (NAFLD) in mice. Inulin treatment restored abnormal metabolic and inflammatory indicators, modulated gut microbiota composition, and increased short-chain fatty acids, suggesting a beneficial effect on NAFLD via the gut-liver axis.
Inulin alleviates adverse metabolic syndrome and regulates intestinal microbiota composition in Nile tilapia (Oreochromis niloticus) fed with high-carbohydrate diet
The study investigated the effects of inulin on Nile tilapia fed a high-carbohydrate diet. Inulin improved survival rates against Aeromonas hydrophila, reduced liver lipid accumulation, and altered intestinal microbiota composition, suggesting positive effects on immunity, gut health, and metabolic syndrome alleviation.
Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients
The study investigated the impact of preintervention gut microbiota characteristics on the physiological response to inulin in obese individuals and humanised obese mice. Results showed that different gut microbiota compositions influenced the metabolic outcomes of inulin supplementation, including decreases in adiposity and hepatic steatosis in mice, and BMI reduction in humans.
Effect of in ovo-delivered prebiotics and synbiotics on lymphoid-organs' morphology in chickens.
The study investigated the effects of in ovo administration of prebiotics and synbiotics on the development of lymphoid organs in broilers. Synbiotic treatment, particularly Bi2tos with L. lactis subsp. cremoris, modulated the development of central and peripheral lymphatic organs, enhancing B-cell proliferation and affecting the spleen/bursa of Fabricius ratio.
Effects of dietary inulin on serum lipids.
A randomized, double-blind, crossover trial investigated the effects of consuming inulin-containing foods on serum lipid profiles in hypercholesterolemic men and women. The study found significant reductions in LDL-C and total cholesterol during the inulin phase compared to the control phase, suggesting potential lipid-modulating properties of dietary inulin.