Research
Inositol Hexaphosphate (IP6)
19 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of Myo-inositol Hexaphosphate (SNF472) on Bone Mineral Density in Patients Receiving Hemodialysis: An Analysis of the Randomized, Placebo-Controlled CaLIPSO Study.
The CaLIPSO study assessed the effects of SNF472 on bone mineral density in patients receiving hemodialysis. Patients were randomized to receive placebo, 300 mg SNF472, or 600 mg SNF472. Bone mineral density decreased modestly in all groups over 1 year, with a more pronounced reduction in the 600 mg SNF472 group. Fractures were infrequent across all groups.
Effect of phytate on hypercalciuria secondary to bone resorption in patients with urinary stones: pilot study.
This controlled randomized study evaluated the effect of phytate supplements on calciuria in patients with urinary stones and elevated bone resorption. Patients in the phytate group received a 380 mg capsule of calcium-magnesium InsP6 daily for 3 months. Phytate significantly reduced calciuria and ß-CrossLaps levels compared to the control group, indicating a positive effect on bone health.
Slowing Progression of Cardiovascular Calcification With SNF472 in Patients on Hemodialysis: Results of a Randomized Phase 2b Study.
This double-blind, placebo-controlled phase 2b trial studied the effect of SNF472 (myo-inositol hexaphosphate) on cardiovascular calcification in patients with end-stage kidney disease on hemodialysis. SNF472 significantly attenuated the progression of coronary artery calcium and aortic valve calcification compared to placebo over 52 weeks.
Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial.
Randomized crossover trial investigating the impact of daily InsP6 consumption on serum adiponectin levels in 39 patients with type 2 diabetes. InsP6 supplementation increased adiponectin levels and decreased HbA1c, with no changes in TNF-alpha, IL-6, and IL-1beta.
Effects of a sodium fluoride- and phytate-containing dentifrice on remineralisation of enamel erosive lesions-an in situ randomised clinical study.
This in situ randomised clinical study evaluated the effects of a dentifrice containing sodium fluoride and phytate on the remineralisation of enamel erosive lesions. The study found that the addition of phytate or pyrophosphate to a fluoride dentifrice inhibited the remineralising effect of fluoride, although both formulations still delivered fluoride to the enamel and inhibited demineralisation.
Effects of Mediterranean diets with low and high proportions of phytate-rich foods on the urinary phytate excretion.
This study examined the effects of Mediterranean diets with varying proportions of phytate-rich foods on urinary phytate excretion. Participants in the high phytate group had significantly higher phytate consumption and urinary excretion compared to the low phytate group.
Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women.
Double-blind, 6-week RCT in 55 postmenopausal women assessing the effects of soy protein components isoflavones and phytate on CVD risk factors. Soy protein with native phytate significantly reduced tHcy, transferrin saturation, and ferritin, while soy protein with native isoflavones had no effect.
Effect of Inositol Hexaphosphate (IP) on Serum Uric Acid in Hyperuricemic Subjects: a Randomized, Double-Blind, Placebo-Controlled, Crossover Study.
This randomized double-blind placebo-controlled crossover study investigated the effect of inositol hexaphosphate (IP) on fasting serum uric acid levels in 31 hyperuricemic subjects. The study found that a 2-week supplementation of 600 mg IP twice daily significantly lowered fasting SUA levels compared to placebo, although the urinary uric acid to creatinine ratio did not change.
Phytate Decreases Formation of Advanced Glycation End-Products in Patients with Type II Diabetes: Randomized Crossover Trial.
Randomized crossover trial investigating the impact of daily IP6 supplementation on protein glycation in 33 patients with type 2 diabetes mellitus. IP6 supplementation for 3 months resulted in lower levels of circulating AGEs and HbA1c, suggesting potential benefits in preventing diabetes-related complications.
Inositol hexaphosphate (InsP6) as an effective topical treatment for patients receiving adjuvant chemotherapy after breast surgery.
Double-blind RCT of 20 patients comparing 4% topical inositol hexaphosphate (InsP6) to a hyaluronic acid gel in women receiving chemotherapy after breast surgery. InsP6 significantly improved quality of life and functional status, reducing side effects and showing differences in white blood cells and platelets count compared to control.
Dietary phytate intake inhibits the bioavailability of iron and calcium in the diets of pregnant women in rural Bangladesh: a cross-sectional study
Cross-sectional study assessing dietary phytate intake and its inhibitory effect on the bioavailability of calcium, iron, and zinc in 717 pregnant women in rural Bangladesh. Phytate was found to inhibit iron absorption in all women and calcium absorption in 52% of women, with significant predictors of mineral absorption identified.
Regular Consumption of a High-Phytate Diet Reduces the Inhibitory Effect of Phytate on Nonheme-Iron Absorption in Women with Suboptimal Iron Stores.
RCT with 28 nonanemic females with suboptimal iron stores, comparing high-phytate (HP) and low-phytate (LP) diets over 8 weeks. The HP group showed a 41% increase in serum iron response postintervention, while the LP group showed no significant change. Habitual HP diet consumption reduced phytate's negative effect on nonheme-iron absorption.
Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical study.
Prospective, randomized pilot clinical study evaluating the effects of IP6 + Inositol in breast cancer patients undergoing chemotherapy. Patients taking IP6 + Inositol showed significantly better quality of life and functional status compared to placebo, without changes in blood cell counts or tumor markers.
Anticalculus effect of a triclosan mouthwash containing phytate: a double-blind, randomized, three-period crossover trial.
A randomized, double-blind, three-period crossover trial with 25 volunteers assessed the efficacy of a phytate-containing mouthwash in preventing dental calculus formation. The study found a statistically significant decrease in total calcium, magnesium, and phosphorus in the phytate-treatment period compared to control and placebo, indicating the efficacy of phytate in reducing dental calculus formation.
Fecal phytate excretion varies with dietary phytate and age in women.
The study investigated fecal excretion of dietary phytate and phosphorus in young and elderly women consuming high and low phytate diets. Results showed that dietary phytate level impacts phytate excretion in young subjects but not in elderly subjects. Phosphorus excretion and absorption were affected by dietary phytate level but not by age.
Protective effect of myo-inositol hexaphosphate (phytate) on bone mass loss in postmenopausal women.
The study evaluated the relationship between urinary concentrations of myo-inositol hexaphosphate (phytate) and bone mass loss in 157 postmenopausal women. Women with high urinary phytate levels had significantly less bone mass loss in the lumbar spine and a lower 10-year fracture probability compared to those with low phytate levels, suggesting that increased phytate consumption can prevent osteoporosis.
Phytate levels and bone parameters: a retrospective pilot clinical trial.
Cross-sectional study of 180 postmenopausal women evaluating the relationship between urinary phytate levels and bone mineral density. Higher urinary phytate levels correlated with higher bone mineral density in the lumbar spine and femoral neck, suggesting potential use of phytate in treating bone-related diseases.
Dietary Phytic Acid, Dephytinization, and Phytase Supplementation Alter Trace Element Bioavailability—A Narrative Review of Human Interventions
Narrative review of human intervention studies on the interactions between phytic acid, phytase, and micronutrient bioavailability. Most studies showed that phytase supplementation or food dephytinization improved iron and zinc bioavailability, while phytic acid-rich diets compromised it.
Improvement in wound healing, pain, and quality of life after 12 weeks of SNF472 treatment: a phase 2 open-label study of patients with calciphylaxis.
Open-label, single-arm study of SNF472 (myo-inositol hexaphosphate) in 14 calciphylaxis patients on hemodialysis. Improvements in wound healing, pain, and quality of life were observed over 12 weeks. SNF472 was well tolerated with no serious treatment-related adverse events.