Research
Hydrogen Water
26 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Hydrogen Water: Extra Healthy or a Hoax?-A Systematic Review.
Systematic review evaluating the potential benefits of hydrogen-rich water (HRW) on various health aspects, including exercise capacity, physical endurance, liver function, cardiovascular disease, mental health, COVID-19, oxidative stress, and anti-aging. Preliminary results are encouraging, but further research with larger sample sizes and rigorous methodologies is needed.
The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial.
This randomized controlled trial investigated the effect of hydrogen-rich water (HRW) on premenstrual symptoms and quality of life in women with PMS. Participants in the intervention group consumed HRW daily and showed significantly lower premenstrual symptoms and improved physical and psychological quality of life compared to the control group.
Hydrogen-rich water supplementation attenuates oxidative stress and inflammation in chronic high-altitude disease patients: A double-blind randomized placebo-controlled study.
Double-blind randomized placebo-controlled study of hydrogen-rich water (HRW) supplementation in 43 chronic high-altitude disease patients. HRW treatment showed a non-significant downward trend in oxidative stress and inflammation, suggesting a potential protective role in CHAD.
The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial.
RCT of 36 obese men and women evaluating the effects of hydrogen-rich water consumption on appetite, body composition, sleep quality, and circulating glucagon-like peptide-1. Hydrogen-rich water significantly mitigated cravings, improved subjective sleep quality, reduced total and LDL cholesterol, and increased plasma glucagon-like peptide-1 levels compared to control.
The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial.
RCT assessing the impact of hydrogen-rich water (HRW) on exercise-related biomarkers in untrained adults over 50 following resistance training. HRW improved muscle performance, increased serum free testosterone and cortisol, reduced cholesterol levels, and decreased biomarkers of muscular damage. HRW also tended to improve sleep quality.
The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial.
This randomized, single-blind, placebo-controlled trial investigated the effects of hydrogen-rich water on Long-COVID patients over 14 days. The study found that hydrogen-rich water significantly alleviated fatigue, improved cardiorespiratory endurance, musculoskeletal function, and sleep quality, but did not ameliorate dyspnea.
The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease
Clinical trial studying the effect of hydrogen-rich water on coenzyme Q10 levels and platelet mitochondrial bioenergetics in NAFLD patients. The H2 group showed increased CoQ10 in platelets, decreased plasma TBARS, and improved OXPHOS efficiency after 8 weeks, suggesting potential benefits for mitochondrial health.
EFFECT OF ACUTE HYDROGEN-RICH WATER INTAKE ON INTRAOCULAR PRESSURE IN HEALTHY SUBJECTS.
This randomized, double-blind, crossover study assessed the effect of acute ingestion of hydrogen-rich water (HRW) on intraocular pressure (IOP) in 24 healthy subjects. Both HRW and placebo caused a significant increase in IOP, with HRW showing a more clinically significant increase in most subjects. Central corneal thickness did not change significantly.
Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal aerobic speed in trained track and field runners: A randomized, double-blind, placebo-controlled crossover study.
This randomized, double-blind, placebo-controlled crossover study investigated the effects of acute, pre-exercise hydrogen rich water ingestion on running time to exhaustion at maximal aerobic speed in 24 trained track and field runners. The study found no significant ergogenic effect of hydrogen rich water on running performance.
Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players.
This randomized, double-blinded, placebo-controlled crossover study assessed the effect of pre-exercise hydrogen-rich water (HRW) consumption on repeated sprint performance in 16 professional male soccer players. HRW consumption resulted in significantly faster sprint times at 15 m and 30 m during the later stages of repeated sprints, indicating an antifatigue effect.
The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial.
This randomized controlled pilot trial investigated the effects of a 6-month intake of hydrogen-rich water on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over. The study found significant improvements in telomere length, DNA methylation, brain choline and NAA levels, and chair stand performance in the hydrogen-rich water group compared to the control group, suggesting potential anti-aging benefits.
Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study.
Pilot study of 18 Parkinson's disease patients receiving daily photobiomodulation and hydrogen water therapy for 2 weeks. UPDRS scores significantly decreased from the first week, with no adverse events recorded. Improvement persisted after therapy cessation, suggesting safety and efficacy of the combined treatment.
Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training.
This randomized, double-blinded placebo-controlled cross-over study assessed the effects of hydrogen rich water (HRW) on resistance training in 12 men. HRW improved muscle function, reduced lactate response, and alleviated delayed onset of muscle soreness compared to placebo.
Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial.
Randomized, double-blind, placebo-controlled trial of 38 healthy adults consuming 1.5 L/d of hydrogen-rich water for 4 weeks. The study found increased antioxidant capacity and reduced inflammatory responses in the hydrogen-water group, with significant down-regulation of transcriptional networks related to inflammation and NF-κB signaling.
Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans.
This study assessed the heat-retention effects of hydrogen-rich water baths using thermographic clinical trials with 24 healthy subjects. The hydrogen-rich water bath showed more marked heat-retention effects than normal water baths for several body parts and suggested promotive effects on blood circulation.
Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial.
This randomized non-inferiority pilot trial compared the effects of hydrogen-rich water (HRW) hydrotherapy to the RICE protocol in professional athletes with acute ankle sprain. HRW was found to be equivalent to RICE in reducing ankle swelling, improving range of motion, and enhancing single-leg balance, supporting its use in acute ankle sprain management.
Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.
The study assessed the effects of drinking H2-water on oxidative stress model mice and subjects with mild cognitive impairment (MCI). In mice, H2-water decreased oxidative stress markers and improved memory impairment and neurodegeneration. In MCI subjects, no significant difference was found in ADAS-cog scores between H2 and control groups after 1 year, but APOE4 carriers in the H2-group showed significant improvement.
A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics.
This randomized double-blind placebo-controlled multi-center trial aims to confirm whether drinking hydrogen water can improve Parkinson's disease symptoms. Changes in the total UPDRS scores from baseline to various time points will be evaluated, with the primary endpoint being the change from baseline to the 72nd week.
Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.
RCT investigating the effects of hydrogen-rich water (HRW) on oxidative stress, liver function, and HBV DNA in 60 patients with chronic hepatitis B. HRW significantly attenuated oxidative stress and improved liver function, with a marked reduction in HBV DNA levels.
Acute ingestion of hydrogen-rich water does not improve incremental treadmill running performance in endurance-trained athletes.
This randomized controlled trial examined the effects of hydrogen-rich water ingestion on exercise performance during incremental treadmill running in 14 endurance-trained male runners. The study found no significant differences in physiological responses or exercise performance between hydrogen-rich water and placebo trials.
Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.
This randomized controlled pilot trial studied the effects of 28-day hydrogen-rich water intake on liver fat deposition and liver enzyme profiles in overweight patients with mild-to-moderate NAFLD. Hydrogen-rich water significantly reduced liver fat accumulation and serum aspartate transaminase levels compared to placebo, suggesting potential as an adjuvant treatment for NAFLD.
Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise.
This randomized, double-blinded placebo-controlled crossover study assessed the effects of hydrogen rich water (HRW) on physiological and perceptual responses during exercise in 12 healthy males. HRW reduced blood lactate levels, improved exercise-induced perception of effort, and enhanced ventilatory efficiency at higher exercise intensities compared to placebo.
Randomized, double-blind, multicenter trial of hydrogen water for Parkinson's disease.
Randomized, double-blind, multicenter trial investigating the effects of hydrogen water on Parkinson's disease. No abstract available to provide specific findings.
Effects of hydrogen rich water on prolonged intermittent exercise.
This study investigated the effects of 2 weeks of hydrogen rich water (HRW) intake on repeated sprint performance and acid-base status during prolonged intermittent cycling exercise in 8 trained male cyclists. The HRW group maintained peak power output (PPO) during sprints, while the placebo group showed a significant decrease in PPO during later sprints.
Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.
RCT investigating the efficacy of hydrogen-rich water for treating interstitial cystitis/painful bladder syndrome in 30 patients. The study found no significant difference in symptom improvement between hydrogen-rich water and placebo, although 11% of patients experienced significant improvement in bladder pain scores.
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
Randomized, double-blind, placebo-controlled, crossover study in 36 patients with type 2 diabetes or impaired glucose tolerance. Hydrogen-rich water intake was associated with significant decreases in modified LDL cholesterol, small dense LDL, and urinary 8-isoprostanes, and showed trends of decreased oxidized LDL and free fatty acids, and increased adiponectin and extracellular-superoxide dismutase. In 4 of 6 patients with impaired glucose tolerance, hydrogen-rich water normalized the oral glucose tolerance test.