Research
Hyaluronic Acid
283 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Efficacy and Safety of Amino Acid-Enriched Hyaluronic Acid in Facial Rejuvenation: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis evaluating the efficacy and safety of an injectable formulation combining hyaluronic acid and amino acids for facial rejuvenation. The treatment significantly reduced wrinkle severity, increased dermal thickness, and improved cell viability, enhancing overall skin aesthetics.
Conservative Treatments May Show No Significant Differences for Partial-Thickness Rotator Cuff Tears: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.
Systematic review and network meta-analysis of randomized controlled trials evaluating conservative treatments for partial-thickness rotator cuff tears. PRP was the most frequently reported treatment, but no conservative therapies showed statistically significant improvements in pain relief or functional recovery compared to normal saline.
Quantitative analysis of the efficacy and associated factors of intra-articular hyaluronic acid with respect to osteoarthritis symptoms: A systematic review of randomized trials and model-based meta-analysis.
Systematic review and meta-analysis of 168 studies with 24,101 participants evaluating the efficacy of hyaluronic acid (HA) for osteoarthritis. HA combined with corticosteroids or platelet-rich plasma showed the best efficacy. Younger, overweight patients with severe symptoms and lower KL grade benefited more.
The Clinical Efficacy of Traditional Chinese Medicine Topical Therapy Combined with Sodium Hyaluronate Intra-articular Injection in the Treatment of Patellar Chondromalacia: a systematic review and meta-analysis.
Meta-analysis of 11 RCTs involving 1,279 patients with chondromalacia patellae. The study found that combining traditional Chinese medicine topical therapy with sodium hyaluronate intra-articular injection significantly enhanced clinical efficacy, reduced pain, and had a quicker onset compared to sodium hyaluronate injection alone.
A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA).
This meta-analysis of 11 RCTs involving 1023 KOA patients found that PRP combined with hyaluronic acid (PRP + HA) is more effective than PRP alone in reducing pain and improving function, with a low risk of adverse events.
Effectiveness of treatments for temporomandibular joint osteoarthritis: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating minimally invasive interventions versus conservative therapies for TMJ OA. Arthrocentesis with adjuvants like PRP, i-PRF, corticosteroids, or NSAIDs significantly improved pain and MMO. Intra-articular hyaluronic acid, with or without glucosamine, showed clinical benefit, but its superiority over conservative care was inconsistent.
Intra-articular injections of platelet-rich plasma combined with hyaluronic acid versus platelet-rich plasma alone in the treatment of knee osteoarthritis: a systematic review and meta-analysis.
Systematic review and meta-analysis comparing intra-articular injections of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) versus PRP alone in knee osteoarthritis treatment. PRP+HA improved WOMAC physical function and total scores compared to PRP alone, though differences were below the minimal clinically important difference. Adverse events were more frequent in the PRP group.
Hyaluronic Acid for Sinonasal Surgery: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of hyaluronic acid in sinonasal surgery, particularly functional endoscopic sinus surgery (FESS). The analysis of 15 RCTs with 789 participants found that hyaluronic acid significantly reduced synechiae formation, improved epithelialization, and decreased post-operative edema compared to routine post-operative care.
The Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effectiveness of hyaluronic acid injections on skin aging. The meta-analysis showed that HA injections improved skin hydration and radiance but did not significantly affect skin elasticity or melanin index.
Adjunctive use of hyaluronic acid in non-surgical periodontal therapy: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the clinical effects of topical hyaluronic acid as an adjunct to non-surgical periodontal treatment in periodontitis patients. The analysis included 23 studies, with 12 in the meta-analysis, showing improvements in probing depth reduction, clinical attachment level gain, and bleeding on probing reduction. However, due to study heterogeneity and moderate quality of evidence, further research is needed to confirm these findings.
Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysis.
Systematic review and meta-analysis assessing the efficacy of hyaluronic acid in root coverage procedures for gingival recessions. The analysis showed no significant difference between hyaluronic acid and control groups in terms of mean root coverage, suggesting slight benefits in certain parameters but not significant over connective tissue graft.
Transforming TMJ pain relief: Hyaluronic acid's efficacy in focus - a comprehensive systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis assessed the impact of hyaluronic acid (HA) on temporomandibular joint (TMJ) disorders. HA was found to be a safe and effective injectable material for reducing TMJ pain and enhancing maximum mouth opening, showing superior long-term results compared to platelet-rich plasma.
Comparison of hyaluronic acid and platelet-rich plasma in knee osteoarthritis: a systematic review.
Systematic review and meta-analysis comparing the effectiveness and safety of hyaluronic acid (HA) and platelet-rich plasma (PRP) for knee osteoarthritis. PRP resulted in lower VAS and WOMAC scores compared to HA, indicating superior effectiveness, though with a higher incidence of mild adverse events.
Hyaluronic acid and urology: a systematic review and meta-analysis.
Systematic review and meta-analysis of 33 studies on hyaluronic acid use in urology, focusing on conditions like Peyronie disease and premature ejaculation. Most studies reported positive results, with increases in intravaginal ejaculatory latency, penile girth, glans circumference, and International Index of Erectile Function. Complications were rare, but study quality varied.
Platelet-Rich Plasma, Bone Marrow Aspirate Concentrate, and Hyaluronic Acid Injections Outperform Corticosteroids in Pain and Function Scores at a Minimum of 6 Months as Intra-Articular Injections for Knee Osteoarthritis: A Systematic Review and Network Meta-analysis.
Systematic review and network meta-analysis comparing intra-articular injections for knee osteoarthritis. PRP, BMAC, and HA showed significant improvements in pain and function scores compared to placebo, with PRP having the highest likelihood of improvement.
Effects and safety of hyaluronic acid gel on intrauterine adhesion and fertility after intrauterine surgery: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.
Systematic review and meta-analysis of 16 RCTs involving 2359 patients assessing hyaluronic acid gel for preventing intrauterine adhesions and improving fertility after intrauterine surgery. Hyaluronic acid reduced intrauterine adhesion incidence and improved pregnancy rates, with a protective effect observed after 6 to 12 weeks.
Efficacy and safety of platelet-rich plasma and hyaluronic acid combination therapy for knee osteoarthritis: a systematic review and meta-analysis.
Systematic review and meta-analysis of 10 RCTs involving 943 patients comparing platelet-rich plasma (PRP) and hyaluronic acid (HA) combination therapy to PRP or HA alone for knee osteoarthritis. The combination therapy showed more pronounced pain and functional improvement than HA alone and had a lower incidence of adverse events compared to both HA and PRP monotherapies.
Efficacy and safety of different hyaluronic acid fillers on cheek volume augmentation: systematic review and network meta-analysis.
Systematic review and network meta-analysis of six RCTs with 579 patients evaluating different hyaluronic acid fillers for cheek volume augmentation. Giselleligne demonstrated superior safety compared to other fillers, though no significant differences in efficacy were observed.
Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis.
Meta-analysis comparing intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis. The study found no significant difference in pain control between the two treatments over 4 to 6 months of follow-up.
A Multicenter, Randomized, Evaluator-Blinded Study to Examine the Safety and Effectiveness of Hyaluronic Acid Filler in the Correction of Infraorbital Hollows.
This multicenter, randomized, evaluator-blinded study examined the safety and effectiveness of Restylane Eyelight hyaluronic acid injections for correcting infraorbital hollows. The study found a significantly higher responder rate for hyaluronic acid treatment compared to control, with sustained efficacy through Month 12 and Month 18 after retreatment. Safety outcomes were generally mild.
Adjunctive use of hyaluronic acid in the treatment of gingival recessions: a systematic review and meta-analysis.
Systematic review and meta-analysis exploring the efficacy of hyaluronic acid as an adjunctive treatment for gingival recessions. Analysis of 3 randomized studies showed a weighted mean difference in favor of hyaluronic acid, but statistical significance was not reached. High heterogeneity was noted, and further well-designed RCTs are needed.
Comparison of outcomes with intra-articular hyaluronic acid vs corticosteroids after TMJ arthrocentesis: a systematic review and meta-analysis.
Systematic review and meta-analysis comparing intra-articular hyaluronic acid vs corticosteroids after TMJ arthrocentesis. No significant difference in pain scores at 1 week, 1 month, and 6 months, but pain scores were lower in the hyaluronic acid group at 3 months. No significant difference in maximal mouth opening between the groups.
Hyaluronic Acid Combined with Ozone in Dental Practice
Systematic review of 28 studies examining the combination of topical hyaluronic acid and ozone therapy in dental practice. The combination was found to be effective in promoting post-operative healing and providing positive outcomes for chronic gingivitis, periodontal inflammation, and oral ulcers.
Comparison of Effectiveness of Intraarticular Hyaluronate and Corticosteroid injections in Adhesive Capsulitis: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis comparing intraarticular hyaluronic acid (HA) and corticosteroid (CS) injections for adhesive capsulitis. CS injections showed superior short-term pain reduction and functional improvement at 2-4 weeks, but similar outcomes were observed at 6 and 12 weeks for both HA and CS injections.
Development and application of hydroxyapatite-based scaffolds for bone tissue regeneration: A systematic literature review.
Systematic literature review on hydroxyapatite-based scaffolds for bone tissue regeneration. Highlights HA's biocompatibility and osteoconductive properties, and discusses enhancements through ion incorporation for improved mechanical strength. Reviews applications in bone defect repair and tissue engineering.
Hyaluronic Acid in Bone Regeneration: Systematic Review and Meta-Analysis
Systematic review and meta-analysis assessed the effect of hyaluronic acid (HA) mixed with graft materials on bone regeneration. The analysis included three randomized controlled trials and found no statistically significant effect of HA on new bone formation or remaining graft particles.
Viscosupplementation with High Molecular Weight Hyaluronic Acid for Hip Osteoarthritis: a Systematic Review and Meta-Analysis of Randomised Control Trials of the Efficacy on Pain, Functional Disability, and the Occurrence of Adverse Events.
Systematic review and meta-analysis of randomized control trials assessing the efficacy of high molecular weight hyaluronic acid (HMWHA) for hip osteoarthritis. The analysis found no statistically significant differences in pain relief or functional outcomes compared to control treatments, and no increased risk of adverse events.
Modified Mesenchymal stem cell, platelet-rich plasma, and hyaluronic acid intervention in early stage osteoarthritis: A systematic review, meta-analysis, and meta-regression of arthroscopic-guided intra-articular approaches.
This systematic review and meta-analysis evaluated the combination of mesenchymal stem cells, platelet-rich plasma, and hyaluronic acid for treating early-stage osteoarthritis. The analysis showed significant improvements in clinical outcomes such as Lysholm score, VAS score, KSS, and WOMAC score, indicating effective cartilage regeneration.
Efficacy and safety of corticosteroids, hyaluronic acid, and PRP and combination therapy for knee osteoarthritis: a systematic review and network meta-analysis.
Systematic review and network meta-analysis of 35 studies with 3104 participants comparing the efficacy and safety of corticosteroids, platelet-rich plasma (PRP), hyaluronic acid (HA), and combination therapy for knee osteoarthritis. PRP and PRP+HA were most effective in improving function and alleviating pain at 3, 6, and 12 months follow-up, with no increase in treatment-related adverse events.
The Efficacy and Safety of Hyaluronic Acid Injection in Tear Trough Deformity: A Systematic Review and Meta-analysis.
This meta-analysis synthesized quantitative data on the aesthetic outcomes and adverse effects of tear trough deformity correction with hyaluronic acid injection. It included 31 reports with 2556 participants, showing a pooled overall satisfaction rate of 91.0% and various complication rates, such as swelling/edema at 19.2% and bruising/ecchymosis at 18.4%.
Efficacy and safety of sodium hyaluronate combined with celecoxib for knee osteoarthritis: A systematic review and meta-analysis.
Systematic review and meta-analysis of 9 RCTs involving 2339 participants evaluating the efficacy and safety of sodium hyaluronate combined with celecoxib for knee osteoarthritis. The combination treatment reduced VAS scores, improved Lysholm knee scores and clinical efficiency, and had fewer adverse effects compared to the control group.
Dressings and topical agents containing hyaluronic acid for chronic wound healing.
Systematic review evaluating the effects of hyaluronic acid on chronic wound healing, including pressure ulcers, diabetic foot ulcers, and leg ulcers. The review included 12 trials with 1108 participants. Evidence suggests hyaluronic acid may improve complete ulcer healing and slightly decrease pain compared to neutral vehicle, but overall certainty of evidence is very low.
Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials
Systematic review and meta-analysis of preclinical and clinical trials assessing hyaluronic acid application in tooth extraction. Hyaluronic acid may reduce pain after surgical removal of lower third molars but does not significantly affect other complications or enhance bone formation according to meta-analysis.
Efficacy of intra-articular injections of hyaluronic acid in patients with glenohumeral joint osteoarthritis: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the efficacy of intra-articular hyaluronic acid (HA) injections for pain relief in patients with glenohumeral joint osteoarthritis. The analysis included 15 randomized controlled trials with a total of 1023 subjects, showing significant improvements in pain relief compared to baseline and corticosteroid injections.
Efficacy and safety of arthroscopic surgery combined with hyaluronic acid for meniscal injuries: A systematic review and meta-analysis of randomized controlled studies.
Meta-analysis of 11 RCTs with 955 patients comparing arthroscopic surgery combined with hyaluronic acid to surgery alone for meniscal injuries. The combined treatment improved treatment efficiency, joint pain relief, and joint function without increasing complications.
Topical non-steroidal agents for the prevention of radiation dermatitis: a systematic review and meta-analysis.
Systematic review and meta-analysis of six RCTs with 627 patients on the use of topical non-steroidal agents for preventing radiation dermatitis. Biafine was significant in preventing grade 3+ RD in breast cancer patients, while trolamine and hyaluronic acid did not significantly prevent RD.
Comparative effectiveness of hyaluronic acid, platelet-rich plasma, and platelet-rich fibrin in treating temporomandibular disorders: a systematic review and network meta-analysis.
Systematic review and network meta-analysis comparing the efficacy of hyaluronic acid, platelet-rich plasma, and platelet-rich fibrin for treating temporomandibular disorders. PRF showed better analgesic effects than PRP or HA after 1 and 3 months, while PRP was more effective after 6 months. PRF was recommended for long-term efficacy in treating TMD.
Effects of ozone combined with articular injection of sodium hyaluronate on patients with knee osteoarthritis and their inflammatory factors and hemorheological indices.
RCT of 292 KOA patients comparing ozone combined with articular injection of sodium hyaluronate to glucosamine hydrochloride tablets and sodium hyaluronate. The combination treatment improved VAS and HSS scores, reduced inflammatory factors, and improved hemorheological indices more than the control.
Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy
Multicenter randomized clinical trial of 260 prostate cancer patients assessing the effect of hyaluronic acid rectal spacer on acute grade 2 or higher gastrointestinal toxic effects before hypofractionated radiation therapy. The spacer group had a 2.9% rate of toxic effects compared to 13.8% in the control group.
[Efficacy of esophagus protection in complex treatment of erosive gastroesophageal reflux disease: a systematic review and meta-analysis of controlled trials].
Systematic review and meta-analysis of controlled trials assessing the efficacy of a fixed combination of hyaluronic acid and chondroitin sulfate as an esophagus protective agent in patients with erosive GERD. Combination therapy with PPIs and the esophagus protective agent was more effective than PPI monotherapy for complete epithelialization of esophageal erosions at 28 days, but not for complete resolution of heartburn.
Could Hyaluronic Acid Be Considered as a Senomorphic Agent in Knee Osteoarthritis? A Systematic Review
Systematic review investigating the potential role of intra-articular hyaluronic acid (IAHA) as a senomorphic agent in knee osteoarthritis (KOA). The review highlights IAHA's therapeutic efficacy, anti-inflammatory properties, and low risk of side effects, suggesting it may provide pain relief, improve joint function, and slow joint degeneration.
Efficacy of Injectable Laryngoplasty With Hyaluronic Acid and/or Calcium Hydroxyapatite in the Treatment of Glottic Incompetence. Systematic Review and Meta-analysis.
Systematic review and meta-analysis evaluating the effectiveness of injectable laryngoplasty with hyaluronic acid and calcium hydroxyapatite for treating glottic incompetence. The study found evidence of effectiveness, but highlighted the need for more comparative studies.
Intra-articular Hyaluronic Acid Treatments for Knee Osteoarthritis: A Systematic Review of Product Properties
This systematic review evaluates differences in intra-articular hyaluronic acid (IA-HA) products for knee osteoarthritis, focusing on molecular weight, source, and structure. High molecular weight (HMW) HA is found to provide superior pain relief compared to low molecular weight (LMW) HA, with avian-derived and cross-linked products potentially increasing inflammatory events.
Intra-articular injection of platelet-rich plasma vs hyaluronic acid as an adjunct to TMJ arthrocentesis: A systematic review and meta-analysis.
Systematic review and meta-analysis comparing intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) after temporomandibular joint arthrocentesis. The analysis found no significant difference in maximum mouth opening or pain scores between PRP and HA groups at 1, 3, and 6 months, with high inter-study heterogeneity.
Clinical efficacy of hyaluronic acid in the treatment of periodontal intrabony defect: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of hyaluronic acid (HA) in the treatment of periodontal intrabony defects. The study found that HA combined with open flap debridement (OFD) significantly improved clinical attachment level gain and probing depth reduction at 6 months compared to OFD alone. However, no additional benefits were observed when HA was combined with bone substitutes at 12 months.
Time to Total Knee Arthroplasty after Intra-Articular Hyaluronic Acid or Platelet-Rich Plasma Injections: A Systematic Literature Review and Meta-Analysis
Systematic literature review and meta-analysis of intra-articular hyaluronic acid (HA) and platelet-rich plasma (PRP) injections for knee osteoarthritis. HA injections were associated with a 9.8-month delay in time to total knee arthroplasty (TKA) compared to standard care. Data were insufficient to conclude any effect of PRP injections on TKA delay.
The effect of hyaluronic acid in embryo transfer media in donor oocyte cycles and autologous oocyte cycles: a systematic review and meta-analysis.
Systematic review and meta-analysis of 15 studies with 4686 participants examining the effect of hyaluronic acid in embryo transfer media on pregnancy outcomes. In autologous oocyte cycles, HA increased live birth, clinical pregnancy, and multiple pregnancy rates. In donor oocyte cycles, HA showed little effect on live birth and clinical pregnancy rates.
The Role of Hyaluronic Acid for Soft Tissue Indications: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of hyaluronic acid (HA) for soft tissue indications across 19 RCTs with 1629 patients. HA demonstrated benefits in short-term and mid-term pain relief for conditions like rotator cuff disease, elbow pain, and tendinopathies compared to placebo and active comparators.
The selection of hyaluronic acid when treating with the nasolabial fold: A meta-analysis.
This meta-analysis compared the efficacy and safety of monophasic and biphasic hyaluronic acid (HA) in treating nasolabial folds. Monophasic HA showed greater improvement in wrinkle severity and higher patient satisfaction compared to biphasic HA, with no significant difference in adverse event rates.
Effect of hyaluronic acid on radiotherapy-induced mucocutaneous side effects: a meta-analysis of randomized controlled trials.
Meta-analysis of 15 RCTs with 1131 patients assessing the effects of hyaluronic acid on radiotherapy-induced mucocutaneous side effects in cancer patients. The HA group showed significant improvements in skin pain scores, decreased pain frequency, lower incidence of desquamation, and reduced mucosal problems compared to controls.
Efficacy and safety of platelet-rich plasma combined with hyaluronic acid versus platelet-rich plasma alone for knee osteoarthritis: a systematic review and meta-analysis.
Systematic review and meta-analysis comparing platelet-rich plasma (PRP) combined with hyaluronic acid (HA) versus PRP alone for knee osteoarthritis. PRP+HA therapy showed some improvements in scores but did not exceed the minimum clinically important difference. PRP+HA was associated with a greater reduction in adverse events compared to PRP alone.
The Administration of Hyaluronic Acid into the Temporomandibular Joints’ Cavities Increases the Mandible’s Mobility: A Systematic Review and Meta-Analysis
Systematic review and meta-analysis of 16 reports on 20 study groups with 1007 patients assessing the impact of intra-articular administration of hyaluronic acid on mandibular mobility and pain in temporomandibular joint disorders. The mean effectiveness in mandibular abduction was 122% of the initial value over 6 months, and pain levels decreased by an average of 29%. Multiple administrations may reduce analgesic effectiveness.
Efficacy and Safety of Hyaluronic Acid Intra-articular Injection after Arthroscopic Knee Surgery: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 15 studies involving 951 knees to evaluate the efficacy and safety of hyaluronic acid intra-articular injection after arthroscopic knee surgery. The results showed no significant differences in pain relief or functional recovery between the HA group and control group, and no increase in adverse events. The application of HA injection post-surgery is not recommended.
Efficacy of Hyaluronic Acid in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis.
This meta-analysis compares the surgical results of endoscopic dacryocystorhinostomy for chronic dacryocystitis with and without intraoperative hyaluronic acid application. The analysis of seven RCTs involving 739 eyes found that hyaluronic acid significantly enhances the success rate, promotes re-epithelization, and reduces granulation and scar formation.
Heparin and Related Substances for Treating Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of nine randomized studies involving 620 participants to evaluate the efficacy and safety of heparin and heparin-related substances for treating diabetic foot ulcers. The study found that hyaluronic acid may improve complete ulcer healing and shorten healing time, while low molecular weight heparin showed no significant benefits. Both substances were generally well tolerated.
The Effect of Intra-articular Injection of Hyaluronic Acid in Frozen Shoulder: a Systematic Review and Meta-analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 7 RCTs involving 504 patients with frozen shoulder, comparing intra-articular hyaluronic acid (HA) injection to other non-surgical treatments. HA injection showed no superior pain control but facilitated functional recovery in external rotation and improved SPADI scores.
Different changes in the biomarker C-terminal telopeptides of type II collagen (CTX-II) following intra-articular injection of high molecular weight hyaluronic acid and oral non-steroidal anti-inflammatory drugs in patients with knee osteoarthritis: a multi-center randomized controlled study.
A multicenter RCT comparing intra-articular injections of hyaluronic acid (IA-HA) to oral NSAIDs in 200 knee osteoarthritis patients. IA-HA increased urinary CTX-II levels, while NSAIDs reduced them, indicating different molecular effects despite both improving symptoms.
Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation: A Meta-Analysis
This meta-analysis and systematic review investigated the effectiveness of hyaluronic acid (HA) for lip augmentation. The study found that HA is effective in increasing lip fullness, with a responder rate of 91% at 2 months, 74% at 6 months, and 46% at 12 months post-injection. Most adverse effects were mild or moderate, with some serious adverse effects reported.
Monophasic versus biphasic hyaluronic acid filler for correcting nasolabial folds: a systematic review and meta-analysis.
Systematic review and meta-analysis comparing monophasic (MHA) and biphasic (BHA) hyaluronic acid fillers for nasolabial folds correction. MHA filler showed significant improvement in wrinkle severity and global aesthetic improvement scores compared to BHA filler, with no significant difference in pain or adverse events.
Knee Osteoarthritis Pain Management with an Innovative High and Low Molecular Weight Hyaluronic Acid Formulation (HA-HL): A Randomized Clinical Trial
RCT comparing a single intra-articular injection of high and low molecular weight hyaluronic acid formulation (HA-HL) versus placebo in 692 patients with knee osteoarthritis. HA-HL showed significant improvements in pain reduction, functional limitation, and quality of life over 24 weeks compared to placebo.
Clinical therapy of platelet-rich plasma vs hyaluronic acid injections in patients with knee osteoarthritis: A systematic review and meta-analysis of randomized double-blind controlled trials.
Systematic review and meta-analysis comparing platelet-rich plasma (PRP) and hyaluronic acid (HA) injections in patients with knee osteoarthritis. PRP showed superiority over HA in improving knee function and quality of life at long-term follow-up.
Molecular Weight of Hyaluronic Acid Has Major Influence on Its Efficacy and Safety for Viscosupplementation in Hip Osteoarthritis: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared the efficacy and safety of intra-articular hyaluronic acid injections with different molecular weights for treating hip osteoarthritis. The high-molecular-weight HA group showed the best improvement in visual analogue scale and Lequesne index scores, with low rates of systemic adverse effects and similar rates of local adverse effects compared to other groups.
Clinical Outcomes Of Intra-Articular High Molecular Weight Hyaluronic Acid Injection For Hip Osteoarthritis- A Systematic Review And Meta-Analysis.
Systematic review and meta-analysis of intra-articular high molecular weight hyaluronic acid (HMWHA) injections for hip osteoarthritis. Analyzed efficacy for pain relief and functional improvement, finding mixed results with no severe complications. Results do not favor HMWHA over other treatments.
Bladder instillation for urinary tract infection prevention in neurogenic bladder patients practicing clean intermittent catheterization: A systematic review.
Systematic review assessing the efficacy and safety of bladder instillation agents in neurogenic bladder patients practicing intermittent catheterization. Gentamicin, hyaluronic acid, and other agents were found to decrease urinary tract infections, with gentamicin being the most recommended. No major adverse events were reported.
The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial
RCT comparing intra-articular injections of hyaluronic acid, platelet-rich plasma, plasma rich in growth factors, and ozone in 200 patients with knee osteoarthritis. Ozone showed better short-term results, but PRP and PRGF had superior long-term effects, with improvements persisting for 12 months.
Effectiveness of Sodium Hyaluronate and ADCON-T/N for the Prevention of Adhesions in Hand Flexor Tendon Surgery: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis assessing the effectiveness of sodium hyaluronate and ADCON-T/N for preventing adhesions after hand flexor tendon repair. Repeated administration of sodium hyaluronate showed statistically and clinically significant improvement in postoperative active finger motion in the mid-term.
Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis.
Systematic review and meta-analysis of 7 studies (5 RCTs, 2 cohort studies) with 941 patients on the effects of PRP combined with hyaluronic acid (HA) for knee osteoarthritis. The combination improved WOMAC Function Scores, WOMAC Total Score, VAS ratings, and Lequesne Index scores compared to PRP alone, with no significant difference in adverse events.
Platelet-Rich Plasma Combined With Hyaluronic Acid Improves Pain and Function Compared With Hyaluronic Acid Alone in Knee Osteoarthritis: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis comparing platelet-rich plasma (PRP) combined with hyaluronic acid (HA) injections versus HA alone for knee osteoarthritis. PRP-HA combination showed greater improvements in pain and function at 3, 6, and 12 months compared to HA alone.
Efficacy and Safety of Sodium Hyaluronate/chondroitin Sulfate Preservative-free Ophthalmic Solution in the Treatment of Dry Eye: A Clinical Trial.
This randomized phase IV, multicentric, prospective, double-blind clinical trial evaluated the efficacy of a preservative-free sodium hyaluronate/chondroitin sulfate ophthalmic solution in patients with dry eye disease. The study found significant improvements in goblet cell density, tear break-up time, and OSDI scores, with no significant differences between treatment groups. The solution was found to be as effective, safe, and well-tolerated as comparator treatments.
The Effectiveness of Hyaluronic Acid in Controlling Pain, Edema, and Trismus After Extraction of Third Molars: Systematic Review and Meta-Analysis.
Systematic review and meta-analysis evaluating hyaluronic acid (HA) for controlling pain, edema, and trismus after third molar extraction. HA reduced pain levels on the third and seventh postoperative days but showed no effect on trismus. Meta-analysis for edema was not possible due to measurement heterogeneity.
Efficacy of intra-articular polynucleotides associated with hyaluronic acid vs hyaluronic acid alone in the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized clinical trial.
Systematic review and meta-analysis of randomized clinical trials evaluating the efficacy of intra-articular polynucleotides associated with hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis. Aims to provide comprehensive reference for clinical practice.
Evidence on ankle injections for osteochondral lesions and osteoarthritis: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the safety and effectiveness of intra-articular injective treatments for ankle osteochondral lesions and osteoarthritis. No severe adverse events were reported. Hyaluronic acid showed a significant difference favoring its use over saline for ankle osteoarthritis at six months, but the evidence quality was very low.
An assessment of the effectiveness of hyaluronic acid and polyacrylamide hydrogel in horses with osteoarthritis: Systematic review and network meta-analysis.
Systematic review and network meta-analysis evaluating the efficacy of hyaluronic acid and polyacrylamide hydrogel in reducing lameness in horses with osteoarthritis. Hyaluronic acid showed long-term ineffectiveness when associated with anti-inflammatory drugs, while polyacrylamide hydrogel was found to be an effective alternative therapy with a long period of action.
Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis-A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis evaluating hyaluronic acid injection laryngoplasty as a treatment for unilateral vocal fold paralysis. The analysis showed improvements in glottal closure insufficiency, maximal phonation time, and voice-related quality of life, with varying duration of treatment effects.
Safety of Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized Trials Involving More than 8,000 Patients.
Systematic review and meta-analysis of 35 randomized controlled trials involving 8,078 patients with knee osteoarthritis. The study assessed the safety of intra-articular hyaluronic acid (IAHA) compared to saline. IAHA was associated with an increased risk of nonserious, transient local reactions but showed no significant differences in adverse events, serious adverse events, or study withdrawals compared to saline.
Comparative Effectiveness of Intralesional Therapy for Peyronie's Disease in Controlled Clinical Studies: A Systematic Review and Network Meta-Analysis.
This systematic review and network meta-analysis compared the efficacy of different intralesional therapies for Peyronie's disease, including collagenase Clostridium histolyticum (CCH), hyaluronic acid, verapamil, and interferon alpha-2b. CCH and interferon alpha-2b showed the best outcomes for penile curvature improvement, while hyaluronic acid was most efficient for erectile function improvement.
What is the Role of Hyaluronic Acid Ester in Myringoplasty? Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of hyaluronic acid ester in myringoplasty, analyzing tympanic membrane closure and postoperative hearing outcomes. The study found no significant difference in success rates between hyaluronic acid ester myringoplasty and conventional tympanoplasty, but a higher closure rate compared to fat graft myringoplasty.
Effectiveness and Safety of Hyaluronic Acid Gel with Lidocaine for the Treatment of Nasolabial Folds: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis comparing hyaluronic acid gel with lidocaine (HAL) to hyaluronic acid (HA) alone for nasolabial folds treatment. HAL provided better pain relief shortly after injection, but both had similar effectiveness and safety for long-term correction.
Efficacy of hyaluronic acid after knee arthroscopy: A systematic review and meta-analysis.
Systematic review and meta-analysis of six RCTs involving 310 patients assessing the effect of hyaluronic acid following knee arthroscopy. Hyaluronic acid significantly improved WOMAC scores and reduced pain on motion, but had no substantial influence on pain scores at 2, 6, and 12 weeks.
Viscosupplementation for Hip Osteoarthritis: A Systematic Review and Meta-Analysis of the Efficacy on Pain and Disability, and the Occurrence of Adverse Events.
Systematic review and meta-analysis of 8 RCTs (n=807) assessing the efficacy of hyaluronic acid (HA) for hip osteoarthritis. The study found very low evidence that HA is not superior to placebo for pain at 3 months and high evidence that it is not superior in adverse events. HA showed no significant difference compared to platelet-rich plasma or methylprednisolone for pain relief or adverse events.
Intravesical hyaluronic acid and chondroitin sulfate for recurrent urinary tract infections: systematic review and meta-analysis.
Systematic review and meta-analysis assessing the efficacy of intravesical hyaluronic acid and chondroitin sulfate for recurrent urinary tract infections in adult female patients. HA plus CS decreased the UTI rate per patient-year and increased the time to first UTI recurrence. The quality of evidence is higher for the combination than for HA alone.
Hyaluronic acid for post sinus surgery care: systematic review and meta-analysis.
Systematic review and meta-analysis of 13 studies (501 patients) evaluating hyaluronic acid as an adjunct treatment following endoscopic sinus surgery. The meta-analysis showed a lower risk ratio of adhesion formation in the hyaluronic acid group compared to the control group. Hyaluronic acid was found to be clinically safe and well tolerated.
Exploring reasons for the observed inconsistent trial reports on intra-articular injections with hyaluronic acid in the treatment of osteoarthritis: Meta-regression analyses of randomized trials.
Meta-regression analysis of 99 randomized trials with 14,804 patients assessing the efficacy of intra-articular hyaluronic acid for pain reduction in osteoarthritis. Hyaluronic acid showed a better effect than saline on pain reduction, though publication bias suggests only a small clinical effect.
Comparative safety profile of hyaluronic acid products for knee osteoarthritis: a systematic review and network meta-analysis.
Systematic review and network meta-analysis of 74 studies involving 13,032 participants comparing the safety of intra-articular hyaluronic acid products for knee osteoarthritis. The study found that hyaluronic acid products have a similar safety profile to each other and to intra-articular placebo, with a low incidence of adverse events.
Effectiveness of hyaluronic acid and its derivatives on chronic wounds: a systematic review.
Systematic review of nine RCTs involving 865 participants with chronic wounds, assessing the effectiveness of hyaluronic acid and its derivatives. Limited evidence was found for their effectiveness in promoting wound healing, but some evidence suggests they may reduce pain intensity in mixed arterial and venous ulcers.
Systematic Review and Meta-Analysis of Intravesical Hyaluronic Acid and Hyaluronic Acid/Chondroitin Sulfate Instillation for Interstitial Cystitis/Painful Bladder Syndrome.
Systematic review and meta-analysis assessing the efficacy of intravesical hyaluronic acid and hyaluronic acid/chondroitin sulfate instillation in patients with interstitial cystitis/painful bladder syndrome. Significant improvements were found in pain symptoms, quality of life, and other outcomes.
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Network meta-analysis of 137 studies with 33,243 participants comparing pharmacologic interventions for knee osteoarthritis. Hyaluronic acid was the most efficacious for pain relief, outperforming oral placebo and other treatments. Intra-articular treatments were generally superior to nonsteroidal anti-inflammatory drugs.
Intra-articular injections in thumb osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs assessing intra-articular injections of hyaluronic acid and corticosteroids in thumb osteoarthritis. Hyaluronic acid improved functional capacity at week 12, while corticosteroids reduced pain at week 24. No significant differences were found between the two treatments until week 12.
Effectiveness of hyaluronic acid for treating diabetic foot: a systematic review and meta-analysis.
This meta-analysis evaluated the effectiveness of hyaluronic acid (HA) in treating diabetic foot ulcers. It included four studies with a total of 328 patients, showing that HA increased the complete healing rate of diabetic foot ulcers with an overall odds ratio of 1.71.
Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis.
Systematic review and meta-analysis of 89 trials involving 12,667 adults with knee osteoarthritis assessing viscosupplementation with hyaluronic acid. The analysis found a small and clinically irrelevant reduction in pain and an increased risk for serious adverse events.
Effectiveness of intra-articular hyaluronic acid for ankle osteoarthritis treatment: a systematic review and meta-analysis.
Systematic review and meta-analysis of intra-articular hyaluronic acid (HA) for ankle osteoarthritis treatment. The study found that HA administration significantly reduces pain compared to baseline and is likely superior to reference therapies. The analysis suggests that multiple doses with appropriate injection volume maximize effectiveness.
Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis.
Systematic review and meta-analysis comparing intraarticular hyaluronic acid with corticosteroids for knee osteoarthritis. Initially, corticosteroids were more effective for pain, but by week 8 and beyond, hyaluronic acid showed greater efficacy.
Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis.
Systematic review and meta-analysis comparing the effectiveness and safety of intraarticular hylan versus hyaluronic acid in knee osteoarthritis. The pooled effect size slightly favored hylan, but with high heterogeneity. Hylan was associated with an increased risk of local adverse events and flares.
Effectiveness of combined arthrocentesis with platelet-rich plasma, platelet rich-fibrin, hyaluronic acid, corticosteroids and non-steroidal anti-inflammatory drugs in temporomandibular joint osteoarthritis: a systematic review and meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of RCTs evaluating combined arthrocentesis with platelet-rich plasma, fibrin-rich plasma, hyaluronic acid, corticosteroids, and NSAIDs in temporomandibular joint osteoarthritis. The combined treatment showed significant improvements in maximum mouth opening at six and twelve months and in pain at twelve months post-treatment.
Comparison of the short-term effect of intra-articular hyaluronic acid and platelet-rich plasma injections in knee osteoarthritis: a randomized clinical trial.
RCT comparing intra-articular injections of hyaluronic acid (HA) and platelet-rich plasma (PRP) in 90 patients with knee osteoarthritis. The PRP group showed significantly lower knee pain, stiffness, and improved physical function compared to the HA group after five months.
Clinical and Radiographic Evaluation of Intrabony Periodontal Defects Treated with Hyaluronic Acid or Enamel Matrix Proteins: A 6-Month Prospective Study.
This study compared the regenerative effects of cross-linked hyaluronic acid (xHyA) and enamel matrix proteins (EMD) on periodontal intrabony defects in 60 patients. Both treatments showed statistically significant clinical and radiographic improvements after six months, with similar outcomes in clinical attachment level gain and pocket probing depth reduction.
Intravesical Interferon Therapy vs Hyaluronic Acid for Pain Among Female Individuals With Interstitial Cystitis: A Randomized Clinical Trial.
This randomized clinical trial compared intravesical interferon therapy to hyaluronic acid in 52 female patients with interstitial cystitis. The interferon group showed a more significant decrease in visual analog pain scores and symptom indices, suggesting potential benefits of antiviral approaches in IC.
Non-surgical treatment of residual periodontal pockets using sodium hypochlorite/amino acid gel and cross-linked hyaluronic acid-a 9-month pilot randomized controlled clinical trial.
This pilot randomized controlled clinical trial compared the clinical outcomes of subgingival instrumentation with adjunctive sodium hypochlorite/amino acid gel and crosslinked hyaluronic acid versus instrumentation alone in 52 patients with persistent periodontal pockets. The adjunctive treatment group showed significant improvements in pocket depth reduction and clinical attachment level gain over 9 months.
Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial.
Randomized crossover trial investigating the efficacy of an oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C in improving sexual and urinary symptoms in participants with recurrent urinary tract infections. The intervention group showed significant improvements in FSFI and IPSS scores compared to control, with early improvement in sexual and urinary symptoms.
A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.
Randomized controlled study evaluating the efficacy and tolerability of NCTF®135HA, a hyaluronic acid-based solution, on reducing superficial wrinkles and improving skin quality. The study involved 146 subjects and showed significant improvements in wrinkle reduction, skin hydration, and self-esteem compared to a control group using only anti-aging cream.