Research
Horse Chestnut Seed Extract (Aescin)
35 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The role of Aescin versus Prednisolone in the management of symptomatic lower ureteral calculi: A comparative study.
Prospective comparative study evaluating the efficacy and safety of aescin versus prednisolone in managing symptomatic distal ureteral stones. The study involved 360 patients randomized into three groups: aescin, prednisolone, and placebo. Aescin and prednisolone showed significantly better outcomes than placebo, with aescin being more effective than prednisolone. Aescin was effective as a medical expulsive therapy with fewer side effects compared to prednisolone.
Rutosides for treatment of post-thrombotic syndrome.
Meta-analysis of three studies with 233 participants assessing the effectiveness and safety of rutosides for post-thrombotic syndrome (PTS) treatment. The review found no clear evidence that rutosides were superior to placebo or elastic compression stockings, with limited low-quality evidence supporting their use in reducing PTS symptoms.
Rutosides for treatment of post-thrombotic syndrome.
Meta-analysis of three studies with 233 participants assessing the effectiveness and safety of rutosides for treating post-thrombotic syndrome (PTS) compared to placebo, elastic compression stockings (ECS), or other treatments. The evidence was of low or very low quality, with no significant improvement in PTS symptoms with rutosides compared to other treatments. Mild adverse effects were noted in one study.
Rutosides for treatment of post-thrombotic syndrome.
Meta-analysis of three studies with 233 participants assessing the effectiveness and safety of rutosides for treating post-thrombotic syndrome (PTS) in patients with deep venous thrombosis. The analysis found no significant evidence that rutosides were superior to placebo or elastic compression stockings in reducing PTS symptoms. Mild adverse effects were noted in one study.
Horse chestnut seed extract for chronic venous insufficiency.
This meta-analysis reviews the efficacy and safety of oral horse chestnut seed extract (HCSE) for chronic venous insufficiency (CVI) compared to placebo or reference therapy. The analysis suggests improvement in CVI-related signs and symptoms, including leg pain and leg volume, with HCSE. Adverse events were mild and infrequent, indicating HCSE as a potentially efficacious and safe short-term treatment for CVI.
Horse chestnut seed extract for chronic venous insufficiency.
Meta-analysis reviewing the efficacy and safety of oral horse chestnut seed extract (HCSE) for chronic venous insufficiency (CVI). The analysis suggests improvement in CVI-related signs and symptoms, including significant reduction in leg pain and leg volume compared to placebo. HCSE may be as effective as compression stockings, with mild and infrequent adverse events.
Horse chestnut seed extract for chronic venous insufficiency.
Systematic review of RCTs assessing the efficacy and safety of oral horse chestnut seed extract (HCSE) for chronic venous insufficiency (CVI). The review found that HCSE improved CVI-related signs and symptoms, including significant reductions in leg pain and leg volume compared to placebo. Adverse events were mild and infrequent.
Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studies.
Meta-analysis of 13 RCTs and 3 observational studies evaluating horse chestnut seed extract (HCSE) for chronic venous insufficiency (CVI). HCSE improved symptoms such as leg volume, pain, edema, and itching compared to placebo, with no severe adverse events reported. Observational studies confirmed effectiveness for pain, edema, and leg fatigue/heaviness.
Horse chestnut seed extract for chronic venous insufficiency.
Systematic review of randomized controlled trials assessing the efficacy and safety of oral horse chestnut seed extract (HCSE) for chronic venous insufficiency (CVI). The review suggests HCSE improves CVI-related signs and symptoms, including leg pain and leg volume, compared to placebo. HCSE may be as effective as compression stockings, with mild and infrequent adverse effects.
Comparison of the efficacy of aescin and diclofenac sodium in the management of postoperative sequelae and their effect on salivary Prostaglandin E2 and serum C-reactive protein levels after surgical removal of impacted mandibular third molar: a randomized, double-blind, controlled clinical trial.
This randomized, double-blind, controlled clinical trial compares the efficacy of aescin and diclofenac sodium in managing postoperative discomfort after the surgical removal of impacted mandibular third molars. The study evaluates their effects on salivary Prostaglandin E2 and serum C-reactive protein levels, as well as their effectiveness in managing pain, swelling, and mouth opening.
Rutosides for prevention of post-thrombotic syndrome.
Systematic review aimed to determine the effectiveness and safety of rutosides for prevention of post-thrombotic syndrome (PTS) in patients with deep vein thrombosis (DVT). No studies were identified comparing rutosides versus any alternative in the prevention of PTS, indicating insufficient evidence to support their use as a preventative therapy.
Rutosides for prevention of post-thrombotic syndrome.
Systematic review assessing the effectiveness and safety of rutosides for prevention of post-thrombotic syndrome (PTS) in patients with deep venous thrombosis (DVT). No studies were identified comparing rutosides versus any alternative in the prevention of PTS, indicating insufficient evidence for their use as a preventative therapy.
Rutosides for prevention of post-thrombotic syndrome.
Systematic review aimed to determine the effectiveness and safety of rutosides for prevention of post-thrombotic syndrome (PTS) in patients with deep venous thrombosis (DVT). No studies were identified comparing rutosides versus any alternative in the prevention of PTS, highlighting the need for high quality randomised controlled trials.
Escin improves sperm quality in male patients with varicocele-associated infertility.
RCT evaluating the efficacy of escin in improving sperm quality in 219 Chinese male patients with varicocele-associated infertility. The escin group showed significant improvements in sperm density and motility compared to the control group, with higher improvement rates in mild and moderate varicocele severity subgroups.
Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies.
Meta-analysis of 5 clinical studies evaluating horse chestnut seed extract (HCSE) for chronic venous insufficiency. HCSE demonstrated effectiveness in reducing lower leg edema and alleviating symptoms like leg pain, heaviness, and itching. Aesculaforce, a fresh plant HCSE, is safe, well tolerated, and offers an alternative treatment for mild to moderate venous insufficiency.
Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy.
The study tested the effects of Aescin gel formulations with and without heparin and phosphatidylcholine (PDC) on patients with chronic venous insufficiency and diabetic microangiopathy. Aescin improved microcirculation and skin perfusion, with heparin and PDC serving as enhancers without independent effects. Improved perfusion and nutrition of the skin were observed, potentially reducing ulceration incidence.
Pilot postoperative ileus study of escin in cancer patients after colorectal surgery.
Pilot study of escin's effect on gastrointestinal motility in 72 postoperative colorectal cancer patients. Patients were randomized into four groups receiving different doses of escin or placebo. Escin treatment groups showed a reduction in time to recovery of passage of gas, gastrointestinal sounds, and bowel movements compared to placebo, indicating improved recovery of gastrointestinal motility.
Aescin and troxerutin as a successful combination for the treatment of inner ear perfusion disturbances.
RCT comparing aescin and troxerutin combination to pentoxyfyllin in 68 patients with inner ear perfusion disturbances. Hearing significantly improved in 23 of 34 patients treated with aescin and troxerutin, with a threshold change of more than 10dB. Both treatments were well tolerated with no major adverse effects.
Medical expulsive treatment of distal-ureteral stones using tamsulosin: a single-center experience.
RCT of 96 patients with symptomatic distal-ureteral calculi comparing diclofenac plus aescin to the same therapy with added tamsulosin. The group with tamsulosin had a higher expulsion rate, shorter expulsion time, lower analgesic use, and fewer hospitalizations.
Efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension.
RCT assessing the efficacy of aescin and essential phospholipids gel on skin perfusion in subjects with chronic venous insufficiency and venous hypertension. After 2 weeks, transcutaneous PO(2) values increased and PCO(2) values decreased, indicating improved skin perfusion and nutrition.
Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension: new clinical observations.
RCT evaluating the efficacy of aescin + essential phospholipids (AEPL) topical gel on microcirculation in subjects with chronic venous insufficiency and venous hypertension. After 2 weeks of treatment, significant improvements in microcirculation were observed, with a decrease in skin flux indicating reduced venous microangiopathy.
Escin/diethylammonium salicylate/heparin combination gels for the topical treatment of acute impact injuries: a randomised, double blind, placebo controlled, multicentre study.
RCT investigating the efficacy and safety of escin-containing gels for treating blunt impact injuries in athletes. The gels with 1% and 2% escin were significantly more effective than placebo in reducing tenderness and providing rapid pain relief. The safety and tolerability were excellent.
Efficacy and tolerability of escin/diethylamine salicylate combination gels in patients with blunt injuries of the extremities.
RCT of 126 patients with blunt injuries of the extremities comparing escin/diethylamine salicylate combination gels to placebo. The active gels were significantly superior to placebo in reducing pain, with good tolerability and no adverse events.
Horse-chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review.
Systematic review assessing horse-chestnut seed extract (HCSE) for chronic venous insufficiency (CVI). HCSE is suggested to be superior to placebo and as effective as reference medications in reducing lower-leg volume, leg circumference, and symptoms like leg pain and pruritus. Adverse effects are mild and infrequent.
Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency.
RCT comparing the efficacy and safety of compression stockings and horse chestnut seed extract (HCSE) in 240 patients with chronic venous insufficiency. Both treatments significantly reduced lower leg volume compared to placebo, with HCSE showing a decrease of 43.8 mL and compression therapy 46.7 mL. Both therapies were well tolerated and considered equivalent in efficacy.
Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures.
RCT comparing Betesil® plaster to aescin 10% cream in 40 patients after facial rejuvenation procedures. Betesil® significantly improved swelling, edema, and inflammation scores compared to aescin cream, though no significant difference was found in ecchymosis/hematoma scores. Patient satisfaction was higher with Betesil®.
The use of tamsulosin in the medical treatment of ureteral calculi: where do we stand?
Prospective randomized study evaluating the effects of adding tamsulosin to standard therapy with diclofenac and aescin for ureteral stones. Group B, receiving tamsulosin, showed a higher stone expulsion rate and shorter expulsion time compared to Group A. Tamsulosin was effective in treating distal ureteral stones.
Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial.
This multicenter, randomized, open-label, controlled, four-period crossover trial examined the efficacy of escin in delaying indinavir crystallization time in the urine of HIV-1-infected patients. The study found that escin increased the mean crystallization time by 5.5 minutes, suggesting a potential method to prevent indinavir-associated nephrolithiasis. No significant adverse effects were reported.
Variations in plasma free radicals with topical aescin + essential phospholipids gel in venous hypertension: new clinical data.
RCT evaluating the effects of topical Aescin + essential phospholipids (AEPL) gel on plasma free radicals in 10 patients with venous hypertension. Treatment with AEPL gel decreased plasma free radical values by over 30%, indicating improved skin perfusion and protection against deterioration.
Efficacy of topical treatment with aescin + essential phospholipids gel on capillary fragility.
Efficacy study evaluating the effect of topical treatment with aescin and essential phospholipids gel on capillary fragility in patients with chronic venous hypertension. The study used a vacuum suction chamber to assess local capillary fragility in the perimalleolar region of 10 patients.
Bioavailability of beta-aescin from horse chestnut seed extract: comparative clinical studies of two Galenic formulations.
Two randomized crossover clinical trials evaluated the bioavailability of beta-aescin from horse chestnut seed extract in 18 healthy volunteers each. The studies compared a nonretarded test medication with a retarded reference formulation, finding no significant difference in absorption rates. Bioequivalence was established for both formulations.
Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency.
RCT comparing the efficacy and tolerability of oxerutins and horse chestnut extract in 137 female, postmenopausal patients with chronic venous insufficiency. HR (1000 mg/d) was found to be equivalent or better in reducing leg volume compared to HR (1000 mg/d and 500 mg/d) and HCE-treatment. Both compounds showed a substantial carry-over effect.
Report of the results of a double-blind, randomized, single-dose trial of a topical 2% escin gel versus placebo in the acute treatment of experimentally-induced hematoma in volunteers.
A double-blind, randomized single-dose trial tested the efficiency of topically applied 2% escin gel versus placebo in reducing tenderness to pressure on experimentally induced hematoma in healthy volunteers.
Medical edema protection--clinical benefit in patients with chronic deep vein incompetence. A placebo controlled double blind study.
A randomized placebo-controlled double-blind study on 40 patients with venous edema due to chronic deep vein incompetence demonstrated that horse chestnut seed extract significantly reduced edema compared to placebo. Measurements confirmed the clinical efficacy of the extract in various conditions, suggesting it as a useful adjunct to compression therapy.
Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine
This narrative review discusses the phytochemical, ethanomedicinal, and pharmacological applications of escin, a bioactive compound from Aesculus hippocastanum (horse chestnut). It highlights the potential use of horse chestnut extracts and escin in the prevention and treatment of various disorders such as venous congestion, arthritis, and rheumatism.