Research
Hoodia gordonii (Authenticated)
37 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effect of two weeks ingestion of a bitter tastant mixture on energy intake in overweight females.
Randomized, double-blind study of 60 slightly overweight women consuming capsules with a bitter tastant mixture (including Hoodia gordonii) or placebo for 14 days. No significant effect on energy intake was observed between the treatment and placebo groups.
Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial.
RCT assessing the safety and efficacy of 15-day consumption of Hoodia gordonii purified extract (HgPE) in healthy, overweight women. HgPE was less well tolerated than placebo, with no significant effects on energy intake or body weight, but associated with adverse changes in some vital signs and laboratory parameters.
Cultivation practices and manufacturing processes to produce Hoodia gordonii extract for weight management products.
The paper discusses the cultivation practices and manufacturing processes for producing Hoodia gordonii extract for weight management products. It highlights the development of a commercial agronomy program and a food-grade manufacturing process to produce a consistent extract composition for use as a functional food ingredient.
Chemical characterisation of Hoodia gordonii extract.
The paper characterizes the chemical composition of a solvent extract of Hoodia gordonii using chromatographic and analytical techniques. The extract contains steroid glycosides, fatty acids, plant sterols, and polar organic material, with the composition remaining stable for 19 months under specified storage conditions.
Synthesis of Hoodigogenin A, aglycone of natural appetite suppressant glycosteroids extracted from Hoodia gordonii.
The paper reports the synthesis of Hoodigogenin A, the aglycone of natural 14β-hydroxy pregnane glycosides extracted from Hoodia gordonii, which are suggested to have appetite suppressant properties. The synthesis addresses the limited availability of these glycosteroids due to the protected status of H. gordonii and low extraction yields.
Quantification of steroid glycosides from Hoodia gordonii in porcine plasma using high performance liquid chromatography-mass spectrometry.
An HPLC-ESI-MS/MS method was developed for quantifying eight Hoodia gordonii steroid glycosides and their metabolites in porcine plasma. The method was validated and applied to a porcine pharmacokinetics study, allowing monitoring of concentration-time profiles after feeding H. gordonii.
NMR fingerprinting for analysis of hoodia species and hoodia dietary products.
The study applied NMR fingerprinting and multivariate analysis to identify, discriminate, and analyze the quality of Hoodia plant materials and commercial products. It investigated four Hoodia species and assessed ten Hoodia products for chemical composition and quality, demonstrating the potential of NMR fingerprinting for botanical authentication.
A validated bioanalytical method in mouse, rat, rabbit and human plasma for the quantification of one of the steroid glycosides found in Hoodia gordonii extract.
The study describes the validation of a bioanalytical method for quantifying a steroid glycoside, H.g.-12, from Hoodia gordonii extract in mouse, rat, rabbit, and human plasma. The method involves liquid-liquid extraction and chromatographic separation, demonstrating assay sensitivity, linearity, accuracy, precision, and selectivity across various plasma types.
Pregnane glycosides from Hoodia gordonii.
Phytochemical study of Hoodia gordonii's aerial parts led to the isolation of seven pregnane glycosides. Their structures were elucidated using chemical degradation and spectroscopic methods.
Chemical fingerprint of Hoodia species, dietary supplements, and related genera by using HPTLC.
The study developed an HPTLC method for chemical fingerprint analysis of Hoodia species, dietary supplements claiming to contain Hoodia gordonii, and related genera. The method was validated for specificity, stability, repeatability, and robustness, and verified by LC-UV-MS.
Quantification of appetite suppressing steroid glycosides from Hoodia gordonii in dried plant material, purified extracts and food products using HPLC-UV and HPLC-MS methods.
The paper describes the development of HPLC-UV and HPLC-MS methods for quantifying steroid glycosides from Hoodia gordonii in dried plant material, purified extracts, and food products. The methods show high repeatability and recovery rates, with detection limits below 2 microg g(-1).
Identification and structural characterization of steroidal glycosides in Hoodia gordonii by ion-trap tandem mass spectrometry and liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.
The study used electrospray ion-trap tandem mass spectrometry and high-performance liquid chromatography to identify and characterize eight C-21 steroidal glycosides in Hoodia gordonii. It proposed a generalized fragmentation pathway and classified the glycosides into two major core groups: hoodigenin A and calogenin.
Steroidal glycosides from Hoodia gordonii.
The paper reports the isolation of ten new C21-steroidal derivatives, gordonosides A-L, from a chloroform extract of Hoodia gordonii. These compounds are characterized using HR-MS spectrometry and NMR techniques.
Chemical fingerprinting of Hoodia species and related genera: chemical analysis of oxypregnane glycosides using high-performance liquid chromatography with UV detection in Hoodia gordonii.
The paper describes the development of a high-performance liquid chromatographic (HPLC) method with UV detection for analyzing 11 oxypregnane glycosides in Hoodia gordonii. The method was applied to identify these glycosides in 3 different species of Hoodia and 23 related genera.
New calogenin glycosides from Hoodia gordonii.
The paper reports the isolation of ten new pregnane glycosides from Hoodia gordonii, an herbal supplement sold as an appetite suppressant. The structures were established using chemical degradation and spectroscopic techniques.
Determination of the appetite suppressant P57 in Hoodia gordonii plant extracts and dietary supplements by liquid chromatography/electrospray ionization mass spectrometry (LC-MSD-TOF) and LC-UV methods.
The paper describes the development of liquid chromatography/mass spectrometry (LC/MS) and LC-UV methods for the quantitative determination of P57, an appetite suppressant constituent in Hoodia gordonii. The methods were validated for linearity, repeatability, and limits of detection and quantification, and applied to plant samples and dietary supplements.
In vitro anti-HIV and antioxidant activity of Hoodia gordonii (Apocynaceae), a commercial plant product.
In vitro study of Hoodia gordonii extracts showing inhibition against HIV-1 enzymes and antioxidant activity. The extracts demonstrated good inhibition against HIV reverse transcriptase and protease, as well as antioxidant properties, suggesting potential new uses for this commercial plant.
Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder.
The study investigates the molecular interaction between Hoodia gordonii and GPR119, a receptor involved in glucose-stimulated insulin secretion. Gordonoside F, a compound from H. gordonii, activates GPR119, promoting insulin secretion and reducing food intake in mice. The effects are mediated by GPR119, as knockout mice did not show these effects.
Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system.
The study investigated the antidepressant-like effects of Hoodia gordonii extract in mice using a forced swimming test. Acute administration decreased immobility, suggesting an antidepressant-like effect, and increased 5-HT levels in the striatum. Chronic treatment elevated 5-HT, norepinephrine, and dopamine levels, indicating involvement of the monoaminergic system.
Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects.
The study investigated the sympathomimetic activity of a Hoodia gordonii product, which is used as an appetite suppressant. Experiments on rat uterine rings showed a smooth muscle relaxant effect mediated through β-adrenergic receptors, suggesting a possible mechanism for the cardiovascular side effects such as increased blood pressure and elevated pulse rate.
Safety profile of Hoodia gordonii extract: mouse prenatal developmental toxicity study.
Animal study on the safety profile of Hoodia gordonii extract in prenatal development. Female CD-1 mice were administered varying doses of the extract from gestation days 5-17. At 50mg/kg/day, there was a marked reduction in feed intake and body weight gain, with fetal development delays observed. The no-observed-adverse-effect level was determined to be 5mg/kg/day.
In vitro transport of the steroidal glycoside P57 from Hoodia gordonii across excised porcine intestinal and buccal tissue.
The study investigated the in vitro transport of the steroidal glycoside P57 from Hoodia gordonii across excised porcine intestinal and buccal tissue using a Sweetana-Grass diffusion apparatus. Results showed that P57 transport was higher in the secretory direction across intestinal tissue, indicating efflux by membrane transporters. Transport was higher when P57 was applied as a crude extract, suggesting inhibition of efflux. No transport was observed for pure P57 across buccal tissue, but higher transport was noted with the crude extract.
Genotoxicity testing of a Hoodia gordonii extract.
Hoodia gordonii extract was assessed for genotoxicity in two in vitro assays: a bacterial mutation assay and a gene mutation assay using mouse lymphoma cells. Additionally, a bone marrow micronucleus assay in mice was conducted. The extract showed no evidence of genotoxic activity in any of these assays.
The steroid glycoside H.g.-12 from Hoodia gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu-80 cells.
The study investigates the steroid glycoside H.g.-12 from Hoodia gordonii, which activates human bitter receptors TAS2R14 and induces CCK release from HuTu-80 cells. This suggests a mechanism by which Hoodia components might influence appetite control through bitter taste-sensing mechanisms coupled to hormone release in the intestine.
Bioavailability, pharmacokinetics, and tissue distribution of the oxypregnane steroidal glycoside P57AS3 (P57) from Hoodia gordonii in mouse model.
The study investigated the bioavailability, pharmacokinetics, and tissue distribution of P57, an oxypregnane steroidal glycoside from Hoodia gordonii, in CD1 female mice. P57 showed moderate bioavailability and was rapidly eliminated, with the highest tissue distribution in the kidney followed by liver and brain.
Characterization of in vitro pharmacokinetic properties of hoodigogenin A from Hoodia gordonii.
In vitro study predicting pharmacokinetic properties of hoodigogenin A from Hoodia gordonii. Hoodigogenin A showed stability in gastric and intestinal fluids, efficient passive diffusion across cell monolayers, metabolic instability in liver microsomes, and strong inhibition of CYP3A4, suggesting potential drug-herb interactions.
Effect of Hoodia gordonii meal supplementation at finisher stage on productivity and carcass characteristics of Ross 308 broiler chickens.
Two experiments evaluated Hoodia gordonii meal supplementation at the finisher stage on Ross 308 broiler chickens. Supplementation had no effect on diet intake, growth rate, feed conversion ratio, or live weight, but reduced fat pad weights by 40% and 18% in different setups.
In vitro metabolic stability and intestinal transport of P57AS3 (P57) from Hoodia gordonii and its interaction with drug metabolizing enzymes.
The study investigated the metabolic stability and intestinal transport of P57AS3 (P57) from Hoodia gordonii, focusing on its interaction with drug metabolizing enzymes. P57 was metabolically stable in human liver microsomes and inhibited CYP3A4 activity. In the Caco-2 cell model, P57 showed higher transport in the secretory direction, mediated by P-gp and MRP transporters.
An appetite suppressant from Hoodia species.
The study identified extracts from Hoodia species, particularly Hoodia pilifera and Hoodia gordonii, as having appetite suppressing properties. Two pregnane glycosides were isolated and tested for appetite suppressant properties in rats, showing a decrease in food consumption and body mass compared to controls.
New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii.
The study isolated eleven new oxypregnane glycosides and a previously reported glycoside from Hoodia gordonii. The structures were determined using chemical evidence and spectroscopic methods. Cytotoxicity and antioxidant activities were tested in cell-based assays, where the compounds were found to be inactive.
Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside.
The study investigates the anorectic mechanism of a steroidal glycoside, P57AS3, isolated from Hoodia gordonii. Intracerebroventricular injections of P57AS3 in animals increased ATP content in hypothalamic neurons and reduced food intake, suggesting a central mechanism of action related to energy sensing and satiety.
Hoodia gordonii extract targets both adipose and muscle tissue to achieve weight loss in rats.
Animal study on lean and obese male Wistar rats supplemented with Hoodia gordonii extract. All supplemented rats exhibited significant weight loss, attributed to decreases in both adipose cell size and skeletal muscle fibre size.
Hoodia gordonii: to eat, or not to eat.
The paper reviews peer-reviewed studies on the physiological effects of Hoodia gordonii, known for its claimed appetite suppression. It discusses the role of pregnane glycoside P57 and highlights potential adverse effects associated with high doses required for therapeutic effects. An in vivo rodent study is included to assess the benefit-to-risk ratio.
Safety profile of Hoodia gordonii extract: rabbit prenatal developmental toxicity study.
Hoodia gordonii extract was administered to female New Zealand white rabbits to assess prenatal developmental toxicity. Doses of 6 or 12 mg/kg/day reduced feed intake and bodyweight gain, but reproductive indices and fetal development were unaffected. The no-observed-effect level for developmental effects was 12 mg/kg/day, and the maternal NOEL was 3 mg/kg/day.
Hoodia gordonii: an up-to-date review of a commercially important anti-obesity plant.
This narrative review provides an overview of Hoodia gordonii, a plant consumed for its purported anti-obesity effects. It discusses the plant's traditional use, commercialisation issues, quality control challenges, and the focus on the pregnane glycoside P57 as the active ingredient. The review highlights the lack of sufficient scientific studies on its biopharmaceutics, biological activity, clinical efficacy, and safety.
Hoodia gordonii: a natural appetite suppressant.
This narrative review summarizes the botany, ethnopharmacology, and phytochemistry of Hoodia gordonii, a plant that has become an important commercial appetite-suppressant herbal. The review highlights the historical use of Hoodia species as food plants and thirst quenchers, and discusses the structures of steroid glycosides isolated from Hoodia gordonii.
Indigenous use of Hoodia gordonii and appetite suppression.
Narrative review discussing the indigenous use of Hoodia gordonii for appetite suppression.