Research
Holy Basil (Tulsi)
43 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Efficacy of the holy basil in the treatment of oral submucous fibrosis: a systematic review and meta-analysis
Systematic review and meta-analysis evaluating the efficacy of holy basil in managing oral submucous fibrosis. The analysis included 7 studies and found significant improvements in maximal mouth opening and reduction in burning sensation in patients receiving holy basil-based treatments.
A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress
A randomized, double-blind, placebo-controlled trial investigated the effects of Ocimum tenuiflorum extract (HolixerTM) on stress, mood, and sleep in 100 adults experiencing stress. The study found that supplementation improved stress and sleep quality measures, reduced hair cortisol levels, and buffered stress responses compared to placebo.
Ancomparative clinical and radiographic evaluation of a mixture of zinc oxide-extract, zinc oxide-ozonated oil, and zinc oxide-eugenol as obturating materials in primary molars.
RCT comparing zinc oxide-Ocimum sanctum extract, zinc oxide-ozonated oil, and zinc oxide-eugenol as obturating materials in primary molars. The clinical success rates were 88%, 95.7%, and 90.9% for Groups A, B, and C, respectively, with radiographic success rates of 80%, 91.3%, and 86.4%. Zinc oxide-ozonated oil showed the highest success rate.
Antibacterial efficacy of manuka honey, ocimum sanctum, curcuma longa and 0.2% chlorhexidine mouthwash on the level of streptococcus mutans and lactobacillus acidophilus - A randomized controlled trial.
RCT conducted on dental students to assess the antibacterial efficacy of Manuka honey, Ocimum sanctum, Curcuma longa, and 0.2% chlorhexidine mouthwash on Streptococcus mutans and Lactobacillus acidophilus levels. All groups showed a reduction in oral hygiene index scores and substantial percentage reduction in bacterial counts.
The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature
Systematic review of 24 human studies on tulsi (holy basil) reporting therapeutic effects on metabolic disorders, cardiovascular disease, immunity, and neurocognition. All studies reported favorable clinical outcomes with no significant adverse events, suggesting tulsi is effective for lifestyle-related chronic diseases.
Benefits of basil tea for patients with differentiated thyroid cancer during radioiodine therapy: A randomized controlled trial
RCT of 44 DTC patients comparing basil tea to distilled water during RAIT. Basil tea significantly reduced anxiety and protected against oral mucosal conditions and salivary gland disorders, suggesting benefits for patient QOL during RAIT.
Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study.
RCT evaluating the effect of 300mg Ocimum sanctum (Holy basil) leaf extract on cognition and stress in healthy adults over 30 days. Significant improvements were observed in cognitive parameters such as reaction time and error rate in cognitive tests, and P300 latency in the Ocimum sanctum group compared to placebo.
Effects of flaxseed, sardines, pearl millet, and holy basil leaves on production traits of layers and fatty acid composition of egg yolks.
The study investigated the effects of flaxseed, sardines, pearl millet, and holy basil leaf meal on layer hen production traits and egg yolk fatty acid composition. Flaxseed oil and sardine oil increased n-3 polyunsaturated fatty acid levels in egg yolks. Holy basil leaf meal also contributed to elevating yolk n-3 polyunsaturated fatty acid levels, particularly C18:3, without affecting egg production.
Authentication of holy basil using markers relating to a toxicology-relevant compound
The paper discusses the authentication of Holy Basil (Ocimum tenuiflorum) using DNA barcoding to differentiate it from other Ocimum species and identify chemotypes that accumulate the carcinogen methyleugenol. A multiplex PCR approach is proposed to improve differentiation and identification in dried material.
Evaluation of holy basil mouthwash as an adjunctive plaque control agent in a four day plaque regrowth model
The study evaluated the antibacterial efficacy of holy basil mouthwash against periodontopathogens and its antiplaque effect in vivo. Thirty periodontally healthy volunteers were divided into three groups using chlorhexidine, holy basil, or placebo mouthwash. Holy basil showed inhibition of P. intermedia and F. nucleatum in vitro and had a significant antiplaque effect compared to placebo.
Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders.
RCT of Ocimum sanctum leaf extract in 35 subjects with generalized anxiety disorder. The extract significantly attenuated anxiety, stress, and depression, and improved willingness to adjust and attention.
Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus.
Randomized, placebo-controlled, crossover single blind trial studying the effects of holy basil leaves on fasting and postprandial blood glucose and serum cholesterol levels in humans. Significant decreases in fasting and postprandial blood glucose levels were observed during treatment with holy basil leaves compared to placebo.
Inhibition of Intestinal Cholesterol Absorption by Ocimum sanctum L. Flower Aqueous Extract via Changing Physicochemical Properties of Cholesterol Micelles
The study investigated the effects of Ocimum sanctum L. flower aqueous extract (OSLY) on cholesterol absorption. OSLY inhibited cholesterol micelle uptake in Caco-2 cells and reduced intestinal cholesterol absorption in rat jejunal epithelial cells, suggesting a lipid-lowering effect through altering cholesterol micelle properties.
Comparative Molecular Docking Analysis of Ocimum sanctum Compounds and Anti-Allergic Drugs Against Allergic Rhinitis Targets
Molecular docking analysis comparing bioactive compounds from Ocimum sanctum (holy basil) to anti-allergic drugs for inhibiting allergic rhinitis targets. Isoaromadendrene epoxide from O. sanctum showed superior binding affinity compared to Levocetirizine, suggesting potential as a natural therapeutic lead.
In Vitro Morphogenesis of Tobacco: Modulation of Endogenous Growth Regulators by Tulsi (Holy Basil)
The study investigated the use of Tulsi (Ocimum sanctum) leaf extract to enhance regenerative response in Nicotiana tabacum leaf explants. Tulsi extract improved shoot production and modulated endogenous plant growth regulators, suggesting its potential as a natural supplement for plant regeneration in vitro.
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro
In vitro study identifying sulfoquinovosyl diacylglycerol (SQDG) from Holy Basil as a potent inhibitor of the SARS-CoV-2 main protease and viral replication. SQDG showed no cytotoxicity and inhibited Mpro activity and SARS-CoV-2 replication effectively.
Formulation and evaluation of kiwi herbal syrup using holy basil and apple
The paper discusses the formulation and evaluation of a kiwi herbal syrup using holy basil (Tulsi) and apple. The syrup is designed for therapeutic applications, particularly for its antioxidant properties. The formulation demonstrated stability and superior antioxidant activity compared to other formulations.
Analysis of Antioxidant Capacity Variation among Thai Holy Basil Cultivars (Ocimum tenuiflorum L.) Using Density-Based Clustering Algorithm
The study analyzed the antioxidant capacities of 26 Thai holy basil cultivars using a density-based clustering algorithm. It identified four distinct groups based on terpenoid, flavonoid, phenolic, and anthocyanin content, with significant variability in antioxidant activity among the cultivars.
Effects of Holy Basil (Ocimum Sanctum Linnaeus) On the Modulation Of Stress in Nile Tilapia (Oreochromis Niloticus Linnaeus)
Animal study on the effects of holy basil (Ocimum sanctum) on stress modulation in Nile tilapia. The study found no significant effect of basil on stress parameters when comparing stress and stress-basil treatments, although stress due to cortisol was significant.
The potential role of the novel orodispersible film from rice polymer loaded with silkworm pupae hydrolysate and the combined extract of holy basil and ginger for the management of stroke with stress.
Animal study exploring the neuroprotective effect of an orodispersible film from rice polymer loaded with silkworm pupae hydrolysate and combined extract of holy basil and ginger (JP1) on stroke under stress conditions. JP1 decreased brain infarct volume, oxidative stress, inflammation, and apoptosis, and improved neurological deficits in rats.
Potential of hydroethanolic leaf extract of Ocimum sanctum in ameliorating redox status and lung injury in COPD: an in vivo and in silico study
The study investigates the protective effect of Ocimum sanctum leaf extract (OLE) in a cigarette smoke-induced model of COPD. OLE administration reduced inflammation, decreased oxidant concentration, and increased antioxidant concentration. Molecular docking studies showed strong binding interactions between OLE phytocompounds and antioxidant enzymes, suggesting OLE's potential as a therapeutic option for COPD prevention and treatment.
Hepatoprotective effects of bioactive compounds from traditional herb Tulsi (Ocimum sanctum Linn) against galactosamine-induced hepatotoxicity in rats
The study assessed the hepatoprotective potential of Ocimum sanctum L. (Tulsi) against galactosamine-induced hepatotoxicity in rats. Various extracts of Tulsi were evaluated for their ability to reduce histological damage and serum enzyme changes. The ethyl acetate fraction showed significant hepatoprotective activity, attributed to bioactive compounds like rutin, ellagic acid, and quercetin.
The holy basil administration diminishes the NF‐kB expression and protects alveolar epithelial cells from pneumonia infection through interferon gamma
In vitro study using A549 human alveolar epithelial cells to assess the effects of holy basil extract on pneumonia infection. Holy basil improved cell viability, reduced proinflammatory cytokine response, and enhanced bactericidal capacity and phagocytosis in cells infected with Klebsiella pneumoniae.
The activity of holy basil leaves (Ocimum sanctum, L) to microbia food born disease (Bacillus cereus, Staphylococcus aureus and Escherichia coli)
The study tested the antibacterial activity of ethyl acetate extract of holy basil leaves (Ocimum sanctum) against food-borne bacteria Bacillus cereus, Staphylococcus aureus, and Escherichia coli. The extract showed effective inhibition at various concentrations, with notable bacteriostatic and bacteriocidal effects.
Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses
The study investigates eugenol, a component of holy basil and clove, for its ability to inhibit the interaction between SARS-CoV-2 spike S1 and ACE2. Eugenol was found to suppress the entry of pseudotyped SARS-CoV-2 into human cells and reduce inflammation markers in lung cells. Oral treatment with eugenol improved symptoms in SARS-CoV-2 spike S1-intoxicated mice.
A Novel Supplement Consisting of Rice, Silkworm Pupae and a Mixture of Ginger and Holy Basil Improves Post-Stroke Cognitive Impairment
Animal study assessing the protective effect of an orodispersible film loaded with silkworm pupae hydrolysate and a combined extract of holy basil and ginger (JP1) on post-stroke cognitive impairment. JP1 improved oxidative stress, inflammation, apoptosis, Erk signaling pathway, cholinergic function, and the growth of beneficial gut bacteria, suggesting potential benefits for brain health.
Harnessing the Antibacterial, Anti-Diabetic and Anti-Carcinogenic Properties of Ocimum sanctum Linn (Tulsi)
This narrative review highlights the therapeutic properties of Ocimum sanctum (Tulsi), focusing on its antibacterial, anti-diabetic, anti-carcinogenic, radioprotective, immunomodulatory, anti-inflammatory, cardioprotective, neurogenesis, and anti-depressant characteristics. The review suggests Tulsi's potential in promoting health and longevity, and its extracts may reduce chronic inflammation linked to neurological disorders.
TULSI THE SACRED HERB AND HOUSEHOLD MEDICINE
The article explores the historical, cultural, and medicinal significance of Tulsi (Ocimum sanctum L), highlighting its bioactive compounds and potential health benefits such as enhancing the immune system, relieving respiratory problems, promoting digestion, and reducing stress. It discusses the ongoing clinical trials and research into Tulsi's therapeutic properties and genetic variety.
Ocimum Tenuiflorum Linne: A Narrative Review
Narrative review of Ocimum Tenuiflorum Linne (Holy Basil or Tulsi), focusing on its therapeutic potential and applications. The review covers its benefits for metabolic disorders, cardiovascular and cognitive health, infections, cancer prevention, oral health, wound healing, and weight management. The study highlights its adaptogenic and antimicrobial properties and urges further research to explore its medicinal benefits.
Ocimum Basilicum (basil/tulsi): a herbal sustainable treasure and its therapeutic potency
This narrative review explores the therapeutic potential of Ocimum basilicum (basil/tulsi), highlighting its traditional medicinal applications and bioactive therapeutic metabolites. Basil is noted for its anti-inflammatory, antimicrobial, and antioxidant properties, with potential benefits for digestive disorders, hypertension, and immune system strengthening.
An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”
This narrative review discusses the anticancer potential of Ocimum sanctum (tulsi) and its primary phytoconstituent, eugenol, as potential therapeutic agents against various cancer types. The review highlights the anticancer, chemopreventive, and antioxidant effects of tulsi, which is being evaluated in ongoing clinical trials.
Utjecaj fitobiotičkog svetog bosiljka (Ocimum sanctum) na proizvodnju i zdravlje tovnih pilića
This review article discusses the effects of dietary holy basil (Ocimum sanctum) on broilers, highlighting improvements in growth rate, carcass characteristics, gut health, stress relief, immune response, and biochemical blood parameters.
A Systemic Review of Tulsi (Ocimum tenuiflorum or Ocimum sanctum): Phytoconstituents, Ethnobotanical and Pharmacological Profile
This narrative review discusses the phytoconstituents, ethnobotanical, and pharmacological profile of Tulsi (Ocimum tenuiflorum or Ocimum sanctum). It highlights the therapeutic activities of its compounds, including antidiabetic, antioxidant, anti-inflammatory, antimicrobial, antiviral, cardioprotective, and antihypertensive effects.
Ocimum tenuiflorum (holy basil)
This datasheet on Ocimum tenuiflorum (holy basil) covers various aspects including identity, distribution, biology, ecology, impacts, uses, genetics, and food safety.
Chemotherapeutic Role of Polyphenols Present in Ocimum Sanctum.
This narrative review analyzes recent preclinical studies on the chemo-preventive and therapeutic potential of polyphenols present in Ocimum sanctum (Tulsi). It examines the biochemical and molecular mechanisms involved in their antineoplastic actions, highlighting the role of polyphenols in cancer prevention and treatment.
A Quantitative Literature Analysis of the Research on Holy Basil (Tulsi)
The paper presents a bibliometric analysis of the literature on Holy Basil (Tulsi), highlighting its traditional medicinal uses and research focus on antioxidant, antimicrobial, and antibacterial properties. It also notes recent studies on the synthesis of metal oxide nanoparticles from Tulsi.
Implementation of System Pharmacology and Molecular Docking Approaches to Explore Active Compounds and Mechanism of Ocimum Sanctum against Tuberculosis
The study explores the potential of Ocimum sanctum (holy basil) in treating tuberculosis using a network pharmacology approach. Active ingredients were identified, and molecular docking was performed to assess their binding ability with potential targets to suppress TB.
The ethanolic extract of holy basil leaves (Ocimum sanctum L.) attenuates atherosclerosis in high fat diet fed rabbit
Animal study investigating the effect of holy basil leaves extract on atherosclerosis in high-fat diet-fed rabbits. The study found no significant difference in fatty streak area between groups, though there was a trend of decreasing fatty streak area in a dose-dependent manner.
Tulsi (Ocimum sanctum): A Potent Adaptogen
The paper discusses Tulsi (Ocimum sanctum), an adaptogen known for balancing body processes and aiding stress adaptation. It highlights Tulsi's potential in reducing DNA damage, boosting immune responses, and its effects similar to aspirin in elongating clotting time.
Ocimum flavone Orientin as a countermeasure for thrombocytopenia
The study demonstrates that administration of Orientin, a glycosidic flavonoid, or dietary administration of Orientin-containing Tulsi (Holy Basil) leaves, results in a significant increase in circulating platelets in a mouse model. Orientin stimulates megakaryopoiesis and enhances platelet formation without affecting other hematologic parameters.
A review on phytochemical and pharmacological properties of Holy basil (Ocimum sanctum L.)
This narrative review explores the chemical and pharmacological properties of Ocimum sanctum (Holy Basil), highlighting its anticancer, antioxidant, anti-inflammatory, antistress, γ-irradiation protection, antidiabetic, and antileishmanicidal activities. The review discusses over 60 chemical compounds found in O. sanctum and their medicinal importance.
Chemical constituents and pharmacological action of Ocimum sanctum (Indian holy basil-Tulsi)
The paper provides a detailed botanical description, taxonomy, traditional uses, and various pharmacological activity studies of Ocimum sanctum (Tulsi), a plant used in Ayurveda and Siddha medicine for various illnesses.
Radio protective effects of the Ayurvedic medicinal plant Ocimum sanctum Linn. (Holy Basil): A memoir.
This review summarizes the radio protective properties of Ocimum sanctum Linn. (Holy Basil) and its phytochemicals, including orientin, vicenin, and eugenol. It highlights their potential to protect normal tissues against radiation-induced damage without systemic toxicity, based on preclinical and small clinical studies.