Research
He Shou Wu (Fo-Ti / Polygonum multiflorum)
3 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) fromThunb.: A Systematic Review on Anti-Aging.
This systematic review evaluates the anti-aging properties of TSG, the primary bioactive component of Thunb. (He shou wu, Fo-ti, or Polygoni multiflori radix). TSG exhibits comprehensive anti-aging effects, including lifespan extension, neuroprotection, cardiovascular protection, delay of gonadal aging, reduction in bone loss, and promotion of hair regrowth. Mechanistically, TSG alleviates oxidative stress, inflammation, and apoptosis while enhancing mitophagy, mitochondrial function, telomerase activity, and epigenetic regulation.
Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review.
Systematic review of Polygonum multiflorum, known as Heshouwu, covering its traditional uses, phytochemistry, pharmacology, and toxicology. The plant is used for anti-aging, anti-inflammatory, and neuroprotective effects but can cause hepatotoxicity and nephrotoxicity.
Phytochemistry, pharmacology, toxicology and detoxification of Polygonum multiflorum Thunb.: a comprehensive review
This comprehensive review examines the phytochemistry, pharmacology, toxicology, and detoxification strategies of Polygonum multiflorum Thunb. (PM), also known as Heshouwu. The review highlights PM's pharmacological activities such as anti-aging, wound healing, antioxidant, and anti-inflammatory properties, as well as its toxic effects like hepatotoxicity, nephrotoxicity, and embryotoxicity. The paper emphasizes the need for further exploration of PM's pharmacological and toxicological mechanisms to ensure safe clinical application.