Research
Hawthorn Berry
23 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effect of hawthorn (Crataegus spp.) on blood pressure: A systematic review
Systematic review of RCTs evaluating hawthorn mono-preparations on blood pressure. Four trials with 254 participants showed that hawthorn significantly reduced blood pressure in patients with pre-hypertension or stage 1 hypertension over 12-16 weeks. No serious adverse side effects were reported.
Survival and prognosis: investigation of Crataegus extract WS 1442 in congestive heart failure (SPICE)--rationale, study design and study protocol.
The SPICE study is a randomized, placebo-controlled, double-blind trial investigating the effect of Crataegus Special Extract WS 1442 on mortality in patients with congestive heart failure. Up to 2300 patients will be treated over 24 months, with primary outcomes including cardiac death, non-lethal myocardial infarction, and hospitalization due to heart failure progression.
Berries, Leaves, and Flowers of Six Hawthorn Species (Crataegus L.) as a Source of Compounds with Nutraceutical Potential
The study aimed to obtain bioactive preparations from the fruits, leaves, and flowers of six hawthorn species using solid phase extraction. Hawthorn fruit preparations showed high antioxidant, antidiabetic, and anticancer activity, while flower preparations showed anti-inflammatory activity and biocompatibility with normal colon cells.
Evaluation of physicochemical characteristics, nutritional composition and antioxidant capacity of Chinese organic hawthorn berry ( Crataegus pinnatifida )
The study evaluates the physicochemical characteristics, nutritional composition, and antioxidant capacity of Chinese organic hawthorn berry (Crataegus pinnatifida). It finds that hawthorn berries have higher levels of dietary fiber, pectin, ascorbic acid, minerals, and antioxidant capacity compared to some common fruits, making them excellent sources for dietary supplements and functional foods.
Chemical composition, antibacterial activity and action mechanism of different extracts from hawthorn (Crataegus pinnatifida Bge.)
The study compared the total flavonoids and polyphenols contents and antibacterial activity of hawthorn extracts with different polarities. Methanol extract exhibited the strongest antibacterial activity against Staphylococcus aureus, with mechanisms including damage to cell wall and membrane integrity, inhibition of enzyme activity, and induction of apoptosis.
Could hawthorn have a cardioprotective impact against obesity-induced cardiac injury in rats via antioxidant, hypolipidemic, anti-inflammatory, antiapoptotic, and antifibrotic properties?
The study investigated the cardioprotective effects of hawthorn berry extract (HBE) against obesity-induced cardiac injury in rats. HBE supplementation significantly protected against weight gain, cardiac inflammation, apoptosis, fibrosis, and oxidative stress compared to the high-fat diet group without HBE.
Hawthorn or semen cassiae-alleviated high-fat diet-induced hepatic steatosis in rats via the reduction of endoplasmic reticulum stress.
The study investigated the effects of hawthorn and semen cassiae on high-fat diet-induced hepatic steatosis in rats. The treatment effectively downregulated hepatocyte ER stress and reduced PPAR-γ expression and related lipid synthesis, suggesting a protective effect against obesity-related hepatic steatosis.
LC-MS based plasma metabolomics study of the intervention effect of different polar parts of Hawthorn on hyperlipidemia rats.
Animal study evaluating the effects of four different polar components of hawthorn on hyperlipidemia rats. Hawthorn n-butanol and ethyl acetate extracts showed the highest efficacy in alleviating hyperlipidemia, while the water fraction had a partial effect and petroleum ether extract was ineffective. LC-MS metabolomics analysis indicated that hawthorn modulates lipid metabolism, energy metabolism, oxidative stress, and amino acid metabolism.
The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions
This review discusses the bioactive ingredients and beneficial functions of hawthorn (Crataegus pinnatifida Bge.) fruit, highlighting its antioxidant, anti-inflammatory, antibacterial, antidiabetic, intestinal protection, cardiovascular protection, hepatoprotection, anti-cancer, and neuroprotection properties. The review also covers its potential molecular mechanisms and food-related applications.
Hawthorn with “homology of medicine and food”: a review of anticancer effects and mechanisms
This narrative review explores the anticancer properties of hawthorn, a medicinal food homology plant. It discusses the bioactive ingredients such as vitexin, isoorientin, ursolic acid, and maslinic acid, and their mechanisms in modulating cancer-related pathways. The review integrates literature to highlight hawthorn's potential in cancer prevention and treatment.
Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn (Crataegus anamesa Sarg.) extracts in cardiovascular diseases.
Narrative review of the vascular protective effects and molecular mechanisms of hawthorn extracts on cardiovascular diseases. Hawthorn reduces oxidative stress and inflammation, regulates lipid levels, and protects vascular endothelial function. Clinical trials show benefits in reducing adverse effects of CVDs on blood lipids, blood pressure, and heart function.
Molecular Mechanisms of Hawthorn Extracts in Multiple Organs Disorders in Underlying of Diabetes: A Review
This narrative review examines the therapeutic and protective effects of hawthorn extracts against diabetic-related complications in various organs. It highlights molecular mechanisms such as decreasing triglyceride and cholesterol levels, increasing antioxidant activity, and improving insulin secretion and resistance.
Food Applications and Potential Health Benefits of Hawthorn
Narrative review of hawthorn (Crataegus), highlighting its chemical composition, nutritional value, and potential health benefits. The paper discusses hawthorn's antioxidant, anti-inflammatory, anticancer, anti-cardiovascular disease, and digestive enhancing properties, and its applications in dietary supplements and functional foods.
Potential Roles and Key Mechanisms of Hawthorn Extract against Various Liver Diseases
Narrative review discussing the potential roles and mechanisms of hawthorn extract in treating various liver diseases. Hawthorn extracts are associated with improvements in hepatic injury, lipid accumulation, inflammation, fibrosis, and cancer, largely by enhancing the hepatic antioxidant system and involving mechanisms like AMPK signaling and apoptosis.
Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties
This narrative review provides an overview of the therapeutic potential of hawthorn (Crataegus spp.) on human health, highlighting its medicinal and nutraceutical properties. Various parts of the herb, including berries, flowers, and leaves, are noted for their rich nutrient and bioactive compound content.
Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?
The study investigates the effects of Crataegus extract WS®1442 on cardiomyogenesis and angiogenesis from stem cells. The extract stimulated cardiomyogenesis from murine and human embryonic stem cells and promoted differentiation of cardiovascular progenitor cell populations. It also stimulated angiogenesis ex vivo in progenitor cells from adult mice hearts, suggesting potential therapeutic benefits for heart regeneration.
Comparing Physicochemical Properties of Hawthorn Superfine and Fine Powders
The study investigates the effect of superfine grinding technology on the physicochemical properties of hawthorn products. Superfine hawthorn powder showed increased surface area, higher dispersion stability, and improved antioxidant ability compared to fine hawthorn powder. The study suggests potential benefits for hawthorn in deep processing applications.
Hypolipidemic and cardioprotective benefits of a novel fireberry hawthorn fruit extract in the JCR:LA-cp rodent model of dyslipidemia and cardiac dysfunction.
Animal study on JCR:LA-cp rats showing that supplementation with fireberry hawthorn berry and English hawthorn leaf extracts significantly reduced heart weight, fasting LDL-C, and improved heart function. The berry extract also reduced fasting triglyceride and myocardial fibrosis, suggesting cardioprotective benefits.
Hawthorn ethanolic extracts with triterpenoids and flavonoids exert hepatoprotective effects and suppress the hypercholesterolemia-induced oxidative stress in rats
The study investigated the bioactive constituents and biological effects of Crataegus monogyna ethanolic extracts on hypercholesterolemia in rats. The extracts showed hypocholesterolemic, antioxidant, and hepatoprotective effects, comparable to orlistat, by lowering serum hepatic enzyme levels and lipid peroxidation, protecting against hepatic thiol depletion, and improving lipid profile and hepatic damage.
Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances
This narrative review summarizes recent studies on the phytochemical composition and bioactivities of hawthorn (Crataegus spp.), focusing on its cardiovascular health benefits. It highlights the polyphenolic compounds and other bioactive constituents of hawthorn that contribute to its health-promoting properties.
Phytochemical and Pharmacological Activity Profile of Crataegus oxyacantha L. (Hawthorn) - A Cardiotonic Herb.
Narrative review of Crataegus oxyacantha (hawthorn), focusing on its cardiotonic effects and phytochemistry. The review highlights its cardiovascular efficacy through mechanisms like positive inotropic and negative chronotropic effects, increased coronary blood flow, and enzyme inhibition, supporting its cardioactive efficacy. Other bioactivities include hypotensive, antihyperlipidemic, antihyperglycemic, anxiolytic, immunomodulatory, and antimutagenic effects.
Comparative protective effect of hawthorn berry hydroalcoholic extract, atorvastatin, and mesalamine on experimentally induced colitis in rats.
Animal study investigating the protective effect of hawthorn berry extract (HBE) on acetic acid-induced colitis in rats. HBE showed anti-inflammatory and antioxidant effects, reducing colitis-induced edema, neutrophil infiltration, and oxidative stress markers.
Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease
This narrative review examines the therapeutic benefits of hawthorn (Crataegus spp.) preparations for cardiovascular disease, focusing on mechanisms of action, clinical trials, and safety profile. While clinical trials show largely positive outcomes, a recent study suggests a negative outcome for long-term use in heart failure prognosis. Overall, hawthorn is suggested as a potentially safe and effective treatment for CVD and ischemic heart disease.