Research
Gymnema Sylvestre
117 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta-analysis.
Systematic review and meta-analysis of six RCTs examining the effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults. GS supplementation significantly decreased triglycerides, total cholesterol, low-density lipoprotein, fasting blood sugar, and diastolic blood pressure, suggesting potential improvements in cardiovascular risk factors.
The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes mellitus. Analyzing 10 studies with 419 participants, it found significant reductions in fasting blood glucose, postprandial blood glucose, glycated hemoglobin, triglycerides, and total cholesterol compared to baseline, suggesting GS supplementation as an effective therapy for managing T2DM and its complications.
Efficacy and Tolerability of a Food Supplement Based on Zea mays L., Gymnema sylvestre (Retz.) R.br.ex Sm, Zinc and Chromium for the Maintenance of Normal Carbohydrate Metabolism: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
A randomized, double-blind, placebo-controlled clinical trial on 81 individuals with mildly impaired fasting blood glucose. The study tested a food supplement based on Zea mays, Gymnema sylvestre extracts, zinc, and chromium. The supplement significantly reduced fasting blood glucose and glycated haemoglobin levels compared to placebo, without affecting other metabolic parameters or causing kidney and liver toxicity.
Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study
Randomized study comparing Gymnema sylvestre and berberine in 50 obese patients over 3 months. Berberine significantly decreased body weight, blood pressure, and certain adipokine gene expressions, while Gymnema sylvestre decreased fasting glucose and resistin gene expression. Both showed minimal side effects.
The Effect of a 14-Day gymnema sylvestre Intervention to Reduce Sugar Cravings in Adults
RCT of 58 healthy adults examining a 14-day gymnema sylvestre intervention to reduce sugar cravings. The intervention group consumed fewer chocolates initially, but no differences were found between groups at day 15. No significant changes in sweet food intake were observed over the study period.
Hypoglycaemic Effect of Alcoholic Extracts of the Leaves of Abroma Augusta & Gymnema Sylvestre Plants in Type II Diabetes Mellitus Patients
RCT comparing the hypoglycaemic effects of alcoholic extracts of Abroma augusta and Gymnema sylvestre in Type II Diabetes mellitus patients. Both extracts showed statistically significant hypoglycaemic effects, with Gymnema sylvestre being slightly more effective.
A systematic review of Gymnema sylvestre in obesity and diabetes management.
Systematic review of Gymnema sylvestre effects on obesity and diabetes management. Gymnemic acid, an active component, has anti-obesity and antidiabetic properties, decreases body weight, inhibits glucose absorption, and prevents triglyceride accumulation.
An evidence-based systematic review of gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration.
Systematic review of gymnema (Gymnema sylvestre) covering scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
The effect of a 14-day Gymnema sylvestre intervention to reduce sugar intake in people self-identifying with a sweet tooth.
This randomised crossover study investigated the effects of Gymnema sylvestre (GS) on sugar cravings and sweet food consumption in adults with a 'sweet tooth'. The ad libitum regimen reduced sugar-sweetened beverage intake by 42% and sugar cravings by 28% compared to placebo. Both regimens reduced pleasantness and desire for chocolate.
The Effect of Gymnema Sylvestre on Motivation to Consume Sweet Foods-A Qualitative Investigation.
Qualitative investigation of a placebo-controlled randomized cross-over trial examining the effects of Gymnema sylvestre on motivation to consume sweet foods. Participants reported that Gymnema sylvestre made sweet foods unpleasant to eat and increased mindful eating, leading to increased motivation to avoid sweet foods.
Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance
A randomized, double-blind, placebo-controlled clinical trial in 30 patients with impaired glucose tolerance evaluated the effects of Gymnema sylvestre. The study found significant reductions in 2-h OGTT, A1C, body weight, BMI, and LDL cholesterol levels, with an increase in insulin sensitivity as measured by the Matsuda index.
Participants with pharmacologically impaired taste function seek out more intense, higher calorie stimuli.
RCT with 51 healthy subjects using Gymnema sylvestre to temporarily diminish sweet taste perception. GS treatment reduced sweet intensity perception, reduced liking for sweet foods, and increased desired sucrose content. A 1% reduction in sweet taste response was associated with a 0.40 g/L increase in optimal sucrose concentration.
A multi-centric double-blind randomized homoeopathic pathogenetic trial of Gymnema sylvestre
A multi-centric double-blind randomized trial was conducted to elicit the pathogenetic response of Gymnema sylvestre in homoeopathic potencies on 63 healthy volunteers. The study found that Gymnema sylvestre produced symptoms in each potency in most parts of the body, expanding its potential use.
A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro.
The study investigates the effects of a novel Gymnema sylvestre extract, Om Santal Adivasi (OSA(R)), on insulin secretion and blood glucose levels in patients with Type 2 diabetes mellitus. Oral administration of OSA(R) increased circulating insulin and C-peptide levels and reduced fasting and post-prandial blood glucose. In vitro studies showed direct stimulatory effects on insulin secretion from human islets.
Deciphering the Anti‐Diabetic Potential of Gymnema Sylvestre Using Integrated Computer‐Aided Drug Design and Network Pharmacology
The study investigates the anti-diabetic potential of Gymnema Sylvestre's bioactive compounds using network pharmacology, molecular docking, and molecular dynamics. Gymnemic acid I showed promising interactions with diabetes-related targets, particularly AKT1, suggesting potential mechanisms for diabetes management.
Thermal Analytical Characterization of Gymnema sylvestre Using TGA-DTA Technique
The study uses TGA-DTA techniques to analyze the thermal and chemical characteristics of Gymnema sylvestre's powdered leaves, stems, and roots. The analysis provides insights into the stability and composition of the plant, aiding in its identification and standardization for herbal drug analysis.
Network Pharmacology and Molecular Docking Technology-based Strategy to Explore the Potential Mechanism of Diabecon Formulation Botanicals
The study uses network pharmacology and molecular docking to explore the potential mechanisms of action of the diabecon formulation, which includes Gymnema sylvestre, Pterocarpus marsupium, and Asphaltum punjabinum. Bioactive compounds and their targets were identified, with pathway analysis revealing significant enrichment in metabolic and signaling pathways. Molecular docking showed strong binding affinity of (2S)-7-hydroxyflavanone with the DPP-IV enzyme.
Network Pharmacology of Ayurvedic Multicomponent Formulation Diabecon Containing Gymnema sylvestre, Pterocarpus marsupium and Asphaltum punjabinum with Special Reference to Antidiabetic Property
Network pharmacology analysis of the Ayurvedic formulation Diabecon, containing Gymnema sylvestre, Pterocarpus marsupium, and Asphaltum punjabinum, focusing on its antidiabetic properties. The study constructs pharmacological networks to elucidate interactions between bioactive components and molecular targets, providing insights into the formulation's mechanisms of action and potential therapeutic applications in diabetes management.
Chemical variability in gymnemagenin, deacyl gymnemic acid, lupeol and stigmasterol of Gymnema sylvestre R. Br. populations in India
The study investigates the chemical variability of Gymnema sylvestre populations in India, focusing on gymnemagenin, deacylgymnemic acid, lupeol, and stigmasterol content. It highlights the impact of geographic conditions on these compounds and suggests the potential use of high-concentration accessions for herbal drug industries.
Ultrasonic extraction of total phenolics, total flavonoids, and antioxidant activities from Gymnema sylvestre
The study investigates ultrasonic extraction conditions to improve the yield of total phenolic content, total flavonoid content, and antioxidant activity from Gymnema sylvestre leaves using response surface methodology. Optimal extraction conditions were determined for maximizing biologically active compounds.
Gymnema sylvestre Leaf Hydroalcoholic Extract: Promising Source of Antioxidants with Remarkable Yield and Potent Scavenging Activity
The study compared the antioxidant activity and yield of methanolic, hydroalcoholic, and aqueous extracts of Gymnema sylvestre leaves. The hydroalcoholic extract showed the highest yield and promising antioxidant activity, with an IC50 value of 59.09 µg/ml.
Computer-aided identification of Mycobacterium tuberculosis resuscitation-promoting factor B (RpfB) inhibitors from Gymnema sylvestre natural products
The study used computer-aided methods to identify potential inhibitors of Mycobacterium tuberculosis resuscitation-promoting factor B (RpfB) from 131 natural products of Gymnema sylvestre. The top compounds showed high binding affinity and favorable drug likeness, suggesting potential as anti-TB agents.
In-silico Exploration of Phytoconstituents of Gymnema sylvestre as Potential Glucokinase Activators and DPP-IV Inhibitors for the future Synthesis of Silver Nanoparticles for the Treatment of Type 2 Diabetes Mellitus
In-silico study exploring phytoconstituents of Gymnema sylvestre as potential glucokinase activators and DPP-IV inhibitors for type 2 diabetes mellitus treatment. The study used molecular docking to evaluate the effectiveness of these compounds, with several showing potent activity.
Fluorescence and FTIR markers for different taxa of Gymnema drug complex from Maharashtra
The study evaluates four taxa of the Gudmar complex, including Gymnema sylvestre, to develop drug identification markers using fluorescence and FTIR analysis. These markers successfully distinguish individual drug samples, aiding in purity verification.
Suppression of sweet sensing with glucose, but not aspartame, delays gastric emptying and glycemic response.
RCT investigating the effects of Gymnema sylvestre on sweet taste suppression, gastric emptying, and glycemic response. The study found that Gymnema sylvestre delayed gastric emptying and reduced blood glucose and plasma insulin responses during and after glucose ingestion, but not with aspartame.
Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.
A randomized, double-blind, placebo-controlled clinical trial evaluated the effect of Gymnema sylvestre on metabolic syndrome, insulin secretion, and insulin sensitivity in 24 patients. Significant decreases in body weight, BMI, and VLDL levels were observed after administration, without changes in insulin secretion and insulin sensitivity.
Nine undescribed pregnane glycosides from Gymnema sylvestre and their glucose uptake and GLUT4 translocation activities.
Phytochemical investigation of Gymnema sylvestre led to the discovery of nine new pregnane glycosides and ten known analogues. Compounds were tested for biological activity, showing promotion of glucose uptake and GLUT-4 translocation in L6 cells.
Gymnema sylvestre as a Potential Anti-Inflammatory and Anti-Biofilm Agent Against Anaerobic Infections: An In Vitro Study
In vitro study evaluating the antimicrobial, anti-inflammatory, and antioxidant activities of Gymnema sylvestre extract against anaerobic pathogens. The extract significantly reduced biofilms of several pathogens, showed antioxidant activity, and modulated inflammatory cytokines, suggesting potential therapeutic use.
Cytoprotective Effects of Gymnemic Acid 1 in Cellular Models of Neurodegeneration.
The study investigates the cytoprotective potential of Gymnemic Acid 1 (GA1) from Gymnema sylvestre in cellular models of neurodegeneration. GA1 treatment increased cell viability and reduced oxidative stress markers, indicating antioxidant and cytoprotective effects. GA1 also showed agonistic activity at the GLP-1R, suggesting involvement of the GLP-1R/PI3K/Akt signaling pathway in its neuroprotective action.
Synergistic Antioxidant and Antidiabetic Effects of Caesalpinia bonduc (L.) and Gymnema sylvestre (Retz.) in Alloxan‐Induced Diabetic Rats
Study on the synergistic effects of Caesalpinia bonduc and Gymnema sylvestre extracts in alloxan-induced diabetic rats. The combination treatment improved fasting blood glucose, insulin, HbA1c, and oxidative stress markers, and modulated insulin secretion and stress-related gene expression.
Exploring Non-Cytotoxic, Antioxidant, and Anti-Inflammatory Properties of Selenium Nanoparticles Synthesized from Gymnema sylvestre and Cinnamon cassia Extracts for Herbal Nanomedicine.
The study synthesized selenium nanoparticles (SeNPs) using Gymnema sylvestre and Cinnamon cassia extracts, evaluating their antioxidant and anti-inflammatory properties. The PEGylated and lupeol-loaded SeNPs demonstrated no cytotoxic effects and significant antioxidant and anti-inflammatory capabilities, with G. sylvestre outperforming C. cassia in reducing free radicals and pro-inflammatory signals.
Antioxidant Activity of Gymnema sylvestre Leaf Extract and Glibenclamide in Alloxan Treated Albino Rats
The study evaluated the antioxidant activity of Gymnema sylvestre leaf extract in alloxan-induced diabetic rats, comparing it with the hypoglycemic drug glibenclamide. Gymnema sylvestre significantly reduced lipid peroxidation and increased antioxidant enzyme levels in the blood and kidney, suggesting protection against oxidative stress.
Enhanced Antidiabetic Effects of Gymnema sylvestre and Probiotics in Alloxan-Induced Diabetic Rats
The study evaluated the antidiabetic effects of Gymnema sylvestre and probiotics in alloxan-induced diabetic rats. The combination of G. sylvestre and probiotics showed significant reductions in glucose levels and improved lipid profiles, suggesting a synergistic effect for diabetes management.
In vitro and in silico assessment of antidiabetic and antioxidant potencies of secondary metabolites from Gymnema sylvestre.
The study investigated the chemical constituents, antioxidant potential, and antidiabetic activity of Gymnema sylvestre. The extract showed strong free radical scavenging activity and significant enzyme inhibition, suggesting potential for managing hyperglycaemia in type 2 diabetes.
Gymnema Sylvestre Supplementation Restores Normoglycemia, Corrects Dyslipidemia, and Transcriptionally Modulates Pancreatic and Hepatic Gene Expression in Alloxan-Induced Hyperglycemic Rats
The study investigated the effects of Gymnema sylvestre supplementation on beta cell and hepatic activity in alloxan-induced hyperglycemic rats. Gymnema sylvestre significantly reduced blood glucose levels and improved dyslipidemia, with increased plasma insulin levels and transcriptional modulation of pancreatic and hepatic genes.
THE THERAPEUTIC EFFECT OF GYMNEMA SYLVESTRE EXTRACT AGAINST HYPERGLYCEMIA: IN VIVO STUDY
In vivo study examining the therapeutic effect of Gymnema sylvestre extract against hyperglycemia. The study used ethanolic extract and powder forms of Gymnema sylvestre leaves to explore their potential in treating hyperglycemia by examining several blood parameters.
Phytochemical Composition and Antidiabetic Potential of Gymnema sylvestre Extracts and Formulations
The study evaluated the phytochemical composition and antidiabetic potential of Gymnema sylvestre leaf extracts and formulations. The ethanolic extract showed higher phenolic and flavonoid content and demonstrated dose-dependent inhibition of alpha amylase and alpha glucosidase enzymes, indicating antidiabetic potential.
Effect of Gymnema sylvestre Extract on the Regulation of AMPK-GLUT4 Mediated Signaling Pathway on Insulin Resistance in a PCOS Rat Model
The study assessed the effect of Gymnema sylvestre leaf extract on insulin resistance in a PCOS rat model. Gymnema sylvestre treatment reversed estrus irregularity, sex hormonal abnormalities, and insulin resistance in a dose-dependent manner, potentially through activation of AMPK and GLUT4 expression.
Anti-Tumor Potential of Gymnema sylvestre Saponin Rich Fraction on In Vitro Breast Cancer Cell Lines and In Vivo Tumor-Bearing Mouse Models
The study evaluated the cytotoxicity potential of Gymnema sylvestre saponin rich fraction (GSSRF) on breast cancer cell lines and its anti-tumor activity in tumor-bearing mouse models. GSSRF showed promising dose-dependent cytotoxic effects on breast cancer cell lines and significant tumor weight reduction in mice, comparable to cisplatin.
Antidiabetic and antiglycation potential of zinc nanoparticles encompassed Gymnema sylvestre R. Br. extract
The study synthesized zinc nanoparticles using Gymnema sylvestre as a capping and reducing agent. These nanoparticles were tested for antidiabetic and antiglycation potential in vitro, showing higher alpha-amylase inhibition and AGE formation prevention compared to Gymnema sylvestre extracts. The zinc nanoparticles demonstrated strong antioxidant activity, similar to ascorbic acid.
Elucidating type 2 diabetes mellitus risk factor by promoting lipid metabolism with gymnemagenin: An in vitro and in silico approach
The study investigates gymnemagenin, a compound from Gymnema sylvestre, for its role in lipid metabolism using in vitro and computational methods. Gymnemagenin improved triglyceride metabolism by upregulating lipase genes and anti-inflammatory genes, suggesting its potential as an anti-obesity and anti-diabetic compound.
In vitro cytotoxic potential of Gymnema sylvestre fractions on HT-29 cell line
In vitro study investigating the anti-cancer efficacy of Gymnema sylvestre extracts on HT-29 colon cancer cell line. The active fractions caused cell cycle arrest and programmed cell death, with IC50 values observed for methanolic and chloroform fractions.
Anti-Diabetic Potential of Gymnema Sylvestre: In Vitro and in Silico Analysis
The study evaluated the antidiabetic potential of methanolic leaf extract of Gymnema sylvestre through in vitro α-amylase and α-glucosidase inhibition activity. Fraction C showed the best α-glucosidase inhibitory activity, while fraction A had the best α-amylase activity. Molecular docking analysis indicated strong binding interactions of compounds like Orcinol with α-amylase and α-glucosidase, suggesting antidiabetic potential.
Optimisation and evaluation of Gymnema sylvestre extract loaded polymeric nanoparticles for enhancement of in vivo efficacy and reduction of toxicity
The study developed and evaluated Gymnema sylvestre extract loaded sustained release polymeric nanoparticles for enhanced bioavailability and reduced nephrotoxicity. In vivo studies in a diabetic rat model showed that the nanoparticles lowered blood glucose levels and increased insulin secretion without toxicity, indicating potential for diabetes treatment.
In vivo study of homoeopathic preparation of Gymnema sylvestre mother tincture, 30C and 200C on streptozotocin-induced diabetic rats
In vivo study assessing the efficacy of homoeopathic preparation of Gymnema sylvestre in streptozotocin-induced diabetic rats. HPGS mother tincture and HPGS 200C significantly reduced blood glucose levels, suggesting its efficacy in lowering blood glucose in diabetic conditions.
Acute and sub-acute toxicity profile of crude extract and fractions of Gymnema sylvestre
The study investigated the acute and sub-acute toxicity of crude extract and fractions of Gymnema sylvestre on biochemical and hematological parameters in Wistar rats. At doses of 300 and 600 mg/kg BW, the extract and fractions caused significant alterations in liver and kidney function indices, while 100 mg/kg BW did not cause significant changes.
Evaluation of α-glucosidase inhibition, antioxidant and antibacterial effects of Gymnema sylvestre R. Br.
In vitro study of Gymnema sylvestre leaf extracts showing significant antioxidant, α-glucosidase inhibition, and antibacterial effects. Methanol, acetone, and aqueous extracts showed high DPPH and ABTS scavenging potential, while chloroform extracts had high flavonoid and iron content. The extracts inhibited E. ammni, E. coli, and S. aureus, suggesting potential for antioxidant and antidiabetic medicine preparation.
Assessment of the antidiabetic potential of Gymnemic acid as α-amylase and α-Glucosidase inhibitor using invitro and insilico tools
The study evaluates the inhibitory potential of Gymnemic acid on α-amylase and α-glucosidase activities using in vitro and in silico methods. Gymnemic acid shows potential as a natural alternative to synthetic drugs for managing blood glucose levels in diabetes.
Gymnema sylvestre Extract Restores the Autophagic Pathway in Human Glioblastoma Cells U87Mg
The study investigated the effect of Gymnema sylvestre extract on human glioblastoma cells U87Mg. GS extract displayed significant cytotoxicity, inhibited cell growth, and altered metabolic activity. It reduced phosphorylation levels of mTOR and P70 S6 kinase, indicating autophagy induction, and affected key regulators of type II programmed cell death.
Lipid Flip-Flop-Inducing Antimicrobial Phytochemicals from Gymnema sylvestre are Bacterial Membrane Permeability Enhancers
The study investigates the antimicrobial properties of a methanol extract from Gymnema sylvestre, which contains terpenoids, flavonoids, and an alkaloid. These phytochemicals induce lipid flip-flop in bacterial membranes, enhancing permeability and antibacterial activity against E. coli, S. aureus, and P. aeruginosa. The extract also synergistically increases the efficacy of certain antibiotics by enhancing their permeability into bacteria.
In silico evaluation of naturally isolated triterpene glycosides (TG) from Gymnema sylvestre towards diabetic treatment
In silico and in vitro study evaluating triterpene glycosides from Gymnema sylvestre for their inhibitory role against disaccharidase enzymes. The study found that these compounds competitively inhibited yeast α-glucosidase and exhibited significant inhibitory activity against mammalian sucrase and maltase, suggesting potential as a nutraceutical for managing blood glucose.
Sensory-Guided Multidimensional Exploration of Antisweet Principles from Gymnema sylvestre (Retz) Schult.
The study explores the antisweet principles of Gymnema sylvestre through sensory-guided fractionation and molecular characterization. It identifies six known and three new gymnemic acids, with gymnemic acids XV and XIX showing the highest sweet suppressing activity in a sweet taste receptor assay.
Gymnemic Acid-Rich Fraction from Gymnema Sylvestre Leaves Ameliorates Post Prandial Hyperglycaemia in In-vitro and In-vivo Studies
The study evaluates the gymnemic acid-rich fraction of Gymnema sylvestre in in-vitro and in-vivo models to control postprandial hyperglycemia. In vitro, GARF showed dose-dependent enzyme inhibition, while in vivo, it significantly reduced blood glucose levels in normal and diabetic rats.
Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities
Chemical investigation of Gymnema sylvestre led to the isolation of four new C21 steroidal glycosides and four known compounds. Compounds 1-6 promoted glucose uptake, with compound 1 showing the most potent effect. Compounds 1 and 5 also promoted GLUT-4 fusion with the plasma membrane in L6 cells, indicating potential anti-diabetic properties.
A COMPARISON OF THE EFFICACY OF GYMNEMA SYLVESTRE 6 CH AND GYMNEMA SYLVESTRE MOTHER TINCTURE IN CASES OF TYPE 2 DIABETES MELLITUS
The study compared the efficacy of Gymnema sylvestre 6 CH and Gymnema sylvestre mother tincture in 30 cases of type 2 diabetes mellitus. Over 6 months, both groups showed significant reductions in fasting and postprandial blood sugar levels, indicating a beneficial anti-diabetic effect.
Antimicrobial Effect and Antioxidant Activity of Triterpenes Isolated from Gymnema sylvestre R. Br.
The study evaluated the antimicrobial effects of Gymnema sylvestre extracts and isolated triterpenes on six bacterial poultry pathogens. It assessed the minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of all extracts and triterpenes, as well as their cytotoxicity and antioxidant activity.
A new antidiabetic polyherbal formulation for diabetes
The study evaluated the antidiabetic activity of a polyherbal aqueous extract containing Gymnema sylvestre, Momordica charantia, Syzygium cumini, and Mangifera indica in Streptozotocin induced diabetic rats. The polyherbal extract showed significant antidiabetic activity, reducing blood sugar levels more effectively than Gymnema sylvestre alone or Glibenclamide, and normalized pancreatic histopathology.
A novel Gymnema sylvestre extract protects pancreatic beta‐cells from cytokine‐induced apoptosis
The study investigated the effect of Gymnema sylvestre extract (OSA®) on protecting pancreatic beta-cells from cytokine-induced apoptosis. OSA® maintained cell membrane integrity and significantly protected MIN6 cells and mouse islets from apoptosis by reducing caspase-3 activity and activating cell survival pathways.
Hypoglycemic and antihyperglycemic activities of the aqueous ethanolic extracts of Gymnema sylvestre (RETZ) R. Br. Ex SCHULT and Sclerocarya birrea (A RICH) HOCHST
The study evaluated the effect of aqueous ethanolic extracts of Gymnema sylvestre and Sclerocarya birrea on glycemia in mice. The extracts did not significantly affect basal plasma glucose but significantly reduced peak hyperglycemia, with the combination of both extracts showing a greater effect than either alone.
Effect of Gymnema sylvestre leaf extract on Streptozotocin induced diabetic rats
The study evaluated the anti-diabetic activity of Gymnema sylvestre leaf extract in Streptozotocin induced diabetic wistar albino rats. The extract showed the presence of various phytoconstituents and confirmed anti-diabetic activity through oral administration.
Flavor Alterations Associated with Miracle Fruit and Gymnema sylvestre
The study examines the effects of miracle fruit and Gymnema sylvestre on the perception of flavor in various foods. Miracle fruit added sweetness to sour foods, reducing sourness, while Gymnema sylvestre reduced sweetness in sweet foods and those sweetened by miracle fruit. The study highlights the complex interactions between sweet and sour tastes in flavor perception.
Genetic and Chemical Profiling of Gymnema sylvestre Accessions from Central India: Its Implication for Quality Control and Therapeutic Potential of Plant
The study investigates the genetic and chemical diversity of 14 accessions of Gymnema sylvestre from Central India using ISSR and HPLC fingerprinting methods. It identifies polymorphic ISSRs and universal type peaks that could aid in the selection of high gymnemic acid yielding accessions and the identification of G. sylvestre-based herbal preparations.
An open label study on the supplementation of Gymnema sylvestre in type 2 diabetics.
Quasi-experimental study on Gymnema sylvestre supplementation in type 2 diabetics. The experimental group received 500 mg of the herb per day for 3 months, resulting in reduced polyphagia, fatigue, blood glucose levels, glycated hemoglobin, and improved lipid profiles.
Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus.
RCT administering 400 mg/day of Gymnema sylvestre extract (GS4) to 27 patients with insulin-dependent diabetes mellitus. GS4 reduced insulin requirements, fasting blood glucose, and glycosylated haemoglobin levels, and improved serum lipid levels, suggesting enhanced endogenous insulin production.
Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients.
RCT investigating the effect of GS4, a Gymnema sylvestre leaf extract, in 22 Type 2 diabetic patients on conventional oral anti-hyperglycaemic agents. GS4 supplementation led to significant reductions in blood glucose, glycosylated haemoglobin, and glycosylated plasma proteins, allowing some patients to reduce or discontinue conventional medication.
Protective Effect of Gymnema Sylvestre and Rosmarinus Officinalis Leaves Against Hepatorenal Toxicity of Paracetamol in Experimental Rats
Animal study investigating the protective effects of Gymnema sylvestre and Rosemary leaves against paracetamol-induced hepatorenal toxicity in rats. Rats were divided into groups receiving different treatments, including rosemary and Gymnema sylvestre leaf powders.
The use of Gymnema sylvestre in the treatment of diabetes: The available evidence and expert opinion
This paper reviews the available evidence supporting the use of Gymnema sylvestre in diabetes, highlighting its hypoglycemic and lipid-lowering effects. It also discusses the availability and cost-effectiveness of Gymnema sylvestre compared to other supplements like fenugreek, cinnamon, and lipoic acid.
Ethnopharmacological Importance of Gymnema sylvestre
The review documents the traditional and modern pharmacological uses of Gymnema sylvestre, a medicinal herb used for various health conditions including diabetes, obesity, inflammation, and cardiac problems. It discusses the plant's phytochemicals and their potential health benefits.
Gymnema Sylvestre- An Indian Drug in Homoeopathy
The article discusses Gymnema Sylvestre, known as 'Gurmar', in the context of homoeopathy, highlighting its historical use in diabetes management. It reviews scientific aspects, human proving, and literature on the drug, emphasizing its cost-effectiveness and therapeutic activity without side effects.
EXPLORING ANTIDIABETIC POTENTIAL OF GYMNEMA SYLVESTRE
The study evaluated the antidiabetic potential of Gymnema sylvestre extracts on streptozotocin-induced diabetic rats. Blood glucose levels in treated rats decreased to normal levels, with the aqueous extract showing a 59% decline, indicating significant antidiabetic activity.
Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation
The study explored the anti-diabetic effects of aqueous extracts of Gymnema sylvestre, Trigonella foenum-graecum, and their combination in alloxan-induced diabetic rabbits. Both plants significantly decreased fasting blood glucose and increased insulin secretion, with effects comparable to metformin. The extracts also improved serum biochemical parameters, suggesting potential as alternative medicine for diabetes management.
Evaluation of Gymnema sylvestre R. Br. against Letrozole Induced Polycystic Ovarian Syndrome in rats
The study evaluated the therapeutic potential of Gymnema sylvestre leaf ethanolic extract against letrozole-induced polycystic ovarian syndrome (PCOS) in rats. The extract improved glucose utilization, regularized menstrual irregularity, and corrected hormonal imbalances, promoting ovulation and normal ovarian histology in a dose-dependent manner.
Anti-inflammatory and antioxidant activities of Gymnema Sylvestre extract rescue acute respiratory distress syndrome in rats via modulating the NF-κB/MAPK pathway
The study investigated the effects of hydroalcoholic extract of Gymnema Sylvestre (HAEGS) on LPS-induced lung injury and ARDS in in vitro and in vivo models. HAEGS significantly reduced inflammatory cytokine/chemokine expression, ROS levels, and lung injury by modulating the NF-κB/MAPK and NRF2 pathways. Fraction 6, rich in gymnemic acid derivatives, showed superior anti-inflammatory effects.
Identification of Potential Plant-Derived Pancreatic Beta-Cell-Directed Agents Using New Custom-Designed Screening Method: Gymnema sylvestre as an Example
This review identifies criteria for screening plant extracts as potential β-cell-directed agents for treating type 2 diabetes mellitus. Gymnema sylvestre extract was used to validate the screening method, showing effectiveness as an insulin-releasing agent and maintaining β-cell function and mass.
Comprehensive Review on Origin, Distribution, Micropropagation and Agronomical Practices of Gymnema sylvestre R. Br
Comprehensive review of Gymnema sylvestre, covering its origin, distribution, micropropagation, and agronomical practices. The herb is used in traditional medicine for its potential to reduce blood glucose levels and is recognized for its antioxidant, antibacterial, anti-inflammatory, antiviral, gastro- and hepatoprotective, anti-cancer, and lipid-lowering properties.
Eff ect of Gymnema sylvestre in the Control of Diabetes: A Review
This review focuses on the folk and ayurvedic usage, pharmacognostic, pharmacological, and phytochemical research of Gymnema sylvestre. It highlights the plant's potential benefits in controlling diabetes, reducing sweet cravings, and its anti-inflammatory, anti-obesity, hypolipidaemic, antidiabetic, free radical scavenging, and antibacterial properties.
Combined effects of Gymnema sylvestre and Pergularia daemia on letrozole-induced polycystic ovarian syndrome in rats
The study investigated the effects of Gymnema sylvestre and Pergularia daemia on letrozole-induced polycystic ovarian syndrome (PCOS) in rats. The combination treatment showed superior ameliorative results in PCOS parameters, including improvements in estrus cycle regularity, serum lipid profile, and reproductive hormone levels.
In Silico Prediction, Computational Physico Chemical Analysis in Gymnemic Acids
The paper provides an overview of gymnemic acids from Gymnema sylvestre, focusing on their therapeutic applications, particularly anti-diabetic activity. It discusses in silico predictive methods for classifying chemical compounds, their physico-chemical properties, and potential as therapeutic agents.
Pharmacognostical Profile of Gymnema sylvestre and its Anti-Hyperglycemic Activity
The paper explores the pharmacognostical profile of Gymnema sylvestre and its documented anti-hyperglycemic activity. It highlights the importance of the species in Ayurveda and discusses its bioactive components. The study confirms the conventional use of this plant in treating diabetes mellitus and suggests its potential as an alternative therapy with minimal adverse effects.
Gymnema Sylvestre - A Review
The paper reviews the potential effects of Gymnema sylvestre extract in reducing sugar levels and its antidiabetic and hypolipidemic properties. Gymnema leaves contain bioactive constituents such as tri-terpenes, glycosides, and saponins, which contribute to its medicinal use in diabetes management.
Impact of Nanoparticulate Drug Delivery System of Herbal Drug in Control of Diabetes Mellitus
The study developed and evaluated polymeric nanoparticles for gymnemic acid to improve its bioavailability and enhance its anti-diabetic activity. The best formulation, GNP3, showed a particle size of 195 nm and effective in vitro drug release, suggesting potential for diabetes mellitus treatment.
Antimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extract.
The study investigates electrospun nanofiber mats containing Gymnema sylvestre extract for wound care. The mats prevent biofilm formation, support human dermal fibroblasts attachment, and exhibit antibacterial properties without cytotoxicity.
Histological Studies on Pancreatic Tissue in High Fat Diet with Low Multiple Dosage of Streptozotocin Induced Type 2 Diabetes After Gymnema Sylvestre Administration
The study investigates the effects of ethanolic extract of Gymnema sylvestre on type 2 diabetes induced by a high-fat diet and low multiple doses of streptozotocin in animals. The results show significant recovery of pancreatic beta cells and control of blood sugar levels, indicating the potential antidiabetic and hypolipidemic properties of Gymnema sylvestre.
High sugar induced changes in gut microflora in Drosophila melanogaster: Protective role of Gymnema sylvestre
The study investigates the protective role of Gymnema sylvestre against high sugar-induced changes in gut microflora in Drosophila melanogaster. The paper suggests that Gymnema sylvestre may positively influence gut health by modulating microbial communities.
Effect of Media Strength and pH on the Growth of Hairy Roots and Production of Gymnemic Acid from Gymnema Sylvestre
The study investigates the effect of media strength and pH on the growth of hairy roots and gymnemic acid production from Gymnema sylvestre. Higher media strength (1.5X) and specific pH levels (6.0 for biomass, 5.8 for gymnemic acid) favored production.
De novo in vitro shoot morphogenesis from shoot tip-induced callus cultures of Gymnema sylvestre (Retz.) R.Br. ex Sm
The study developed an efficient system for shoot bud sprouting and indirect plant regeneration from Gymnema sylvestre using callus cultures on MS medium with cytokinins. N6-benzylaminopurine (BAP) was the most effective growth regulator for shoot formation. The regeneration system can be used for genetic transformation studies to produce high-yielding cell lines for anti-diabetic phytochemicals.
Chitosan Nanogel Design on Gymnema sylvestre Essential Oils to Inhibit Growth of Candida albicans Biofilm and Investigation of Gene Expression ALS1, ALS3
The study investigates the encapsulation of Gymnema sylvestre essential oils using Chitosan and Myrestic acid nanogel to enhance antifungal activity against Candida albicans. The nanogel showed higher cell uptake and down-regulated the expression of the biofilm-related gene ALS3, effectively suppressing C. albicans planktonic cells and reducing biofilm biomass.
Chromatography Based Metabolomics and In Silico Screening of Gymnema sylvestre Leaf Extract for Its Antidiabetic Potential
The study investigates the antidiabetic potential of Gymnema sylvestre leaf extract. The extract showed significant antioxidant activity and was analyzed for its metabolites, including gymnemic acid and quercetin. These metabolites were docked with proteins related to glucose metabolism, indicating gymnemic acid's strong binding affinity and potential hypoglycemic effects.
Antifilarial Activity of Gymnema Sylvestre R. Br Leaves Against Brugia Malayi
The study evaluated the antifilarial activity of Gymnema sylvestre against Brugia malayi in vitro and in vivo. The ethanolic extract showed significant adulticidal and embryostatic effects on B. malayi in Mastomys and jirds, demonstrating promising antifilarial activity.
In Vitro Antidiabetic Effects of Isolated Triterpene Glycoside Fraction from Gymnema sylvestre
In vitro study of triterpene glycoside fraction from Gymnema sylvestre for blood glucose control. The fraction inhibited key enzymes related to glucose metabolism and enhanced insulin secretion and GLUT2 expression without toxicity to β-cells, suggesting potential as a nutraceutical for diabetes management.
A comparative study of antihyperglycemic effect of Gymnema sylvestre and metformin in streptozotocin induced diabetic rats
Comparative study of Gymnema sylvestre extract and metformin in streptozotocin-induced diabetic rats. GS extract reduced blood glucose levels, increased HDL and triglycerides, and showed regenerative changes in pancreas, liver, and kidney, though not statistically significant. Metformin increased serum urea, which was not seen in the GS group.
Evaluation of Antidiabetic Activity of Gymnema sylvestre and Andrographis paniculata in Streptozotocin Induced Diabetic Rats
Animal study evaluating the antidiabetic activity of methanolic extracts of Gymnema sylvestre and Andrographis paniculata in streptozotocin-induced diabetic rats. Both extracts showed significant anti-hyperglycemic and anti-oxidative effects from the first week of treatment.
In Vitro Antioxidant and Anti-Diabetic Potential of Gymnema Sylvestre Methanol Leaf Extract
The study evaluated the antioxidative activity and enzymatic inhibitory potentials of Gymnema sylvestre methanolic leaf extract. The extract showed significant radical scavenging activity and inhibition of alpha-glucosidase and alpha-amylase, suggesting its potential as a natural remedy for managing type 2 diabetes.
Rapid Screening for α-Glucosidase Inhibitors from Gymnema sylvestre by Affinity Ultrafiltration–HPLC-MS
In vitro study of Gymnema sylvestre extract showing significant inhibitory activity against α-glucosidase, indicating potential anti-diabetic activity. The study used affinity ultrafiltration coupled with HPLC-MS to identify 9 compounds with higher enrichment factors as potential α-glucosidase inhibitors.
In vitro antimicrobial potential of extracts and phytoconstituents from Gymnema sylvestre R.Br. leaves and their biosafety evaluation
In vitro study of Gymnema sylvestre leaf extracts showing broad-spectrum antimicrobial activity against 13 pathogens. Ethyl acetate extract demonstrated the highest potency, with significant inhibition zones and microbicidal action. The study suggests potential for developing antimicrobial agents from Gymnema sylvestre.
In vitro antimicrobial potential of extracts and phytoconstituents from Gymnema sylvestre R.Br. leaves and their biosafety evaluation
In vitro study of Gymnema sylvestre leaf extracts showing broad spectrum antimicrobial activity against 13 pathogens. Ethyl acetate extract exhibited the highest potency, with significant inhibition zones and microbicidal action. The study suggests potential for developing antimicrobial agents from Gymnema sylvestre.
In vitro enhancement of pancreatic β cells MIN6 proliferation by insulinotropic Gymnema sylvestre aqueous extracts: evidence-based regenerative therapeutic capacity of a medicinal herb.
In vitro study of Gymnema sylvestre aqueous extracts on pancreatic β cells MIN6 proliferation. The extracts induced significant β-cell expansion and potentiated glucose-stimulated insulin secretion, suggesting potential regenerative therapeutic capacity for anti-obesity-diabetes applications.
Neuroprotective effects of Gymnema sylvestre on streptozotocin-induced diabetic neuropathy in rats.
The study investigated the neuroprotective effects of Gymnema sylvestre on streptozotocin-induced diabetic neuropathy in rats. Treatment with Gymnema sylvestre extract improved pain threshold behavior, reduced serum glucose and proinflammatory cytokines, and ameliorated oxidative stress and histopathological alterations in sciatic nerve tissue.
IN VIVO IMMUNOMODULATORY EFFECTS OF THE METHANOLIC LEAF EXTRACT OF GYMNEMA SYLVESTRE IN SWISS ALBINO MICE
The study investigated the immunomodulatory effects of methanolic leaf extract of Gymnema sylvestre (MLEGS) in Swiss albino mice. Oral administration of MLEGS significantly reduced primary and secondary antibody responses and DTH responses, indicating immunosuppressive effects on the immune system.
In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of Gymnemic Acid Isolated from Gymnema sylvestre R Br
The study analyzed the anti-stress, anti-allergic, and anti-ulcer activity of gymnemic acid isolated from Gymnema sylvestre leaves. In vivo studies on albino mice showed the purified fraction has anti-stress and anti-allergic activity and can inhibit aspirin-induced gastric ulcers.