Research
Guduchi (Tinospora cordifolia / Giloy)
18 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Adhatoda vasica and Tinospora cordifolia extracts ameliorate clinical and molecular markers in mild COVID-19 patients: a randomized open-label three-armed study.
Randomized open-label three-armed study of 136 COVID-19-positive patients with mild symptoms, testing Adhatoda vasica, Tinospora cordifolia, and their combination. Group C (combination) showed quicker viral clearance. Adhatoda vasica reduced markers of hypoxia, inflammation, and thrombosis, while Tinospora cordifolia showed immunomodulatory effects.
Randomized placebo-controlled pilot clinical trial on the efficacy of ayurvedic treatment regime on COVID-19 positive patients.
RCT evaluating the impact of an Ayurvedic treatment regime on asymptomatic COVID-19 patients. The treatment group received Giloy Ghanvati, Swasari Ras, Ashwagandha, Tulsi Ghanvati, and Anu taila. By day 7, 100% recovery was observed in the treatment group compared to 60% in the placebo group. Inflammatory markers were significantly reduced in the treatment group, indicating less severity of infection.
Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial.
RCT comparing Ayurvedic formulations (Tinospora cordifolia, Zingiber officinale, Emblica officinalis, Boswellia serrata) to glucosamine and celecoxib in 440 patients with knee osteoarthritis. Ayurvedic formulations significantly reduced knee pain and improved function, showing equivalence to glucosamine and celecoxib. Some patients experienced increased SGPT levels, requiring further safety assessment.
A Randomized Controlled Exploratory Evaluation of Standardized Ayurvedic Formulations in Symptomatic Osteoarthritis Knees: A Government of India NMITLI Project
RCT evaluating five Ayurvedic formulations with Zingiber officinale and Tinospora cordifolia for symptomatic osteoarthritis knees in 245 patients. No significant differences in pain and knee function were found, but formulation 'C' showed better pain relief and was selected for further development.
Detection of new human metabolic urinary markers in chronic alcoholism and their reversal by aqueous extract of Tinospora cordifolia stem.
The study investigated the urine metabolic signature of chronic alcoholism before and after treatment with Tinospora cordifolia aqueous extract (TCE). TCE treatment significantly reversed the levels of most biomarkers associated with chronic alcoholism, suggesting its potential use in reducing alcohol-induced disorders.
Comparable efficacy of standardized Ayurveda formulation and hydroxychloroquine sulfate (HCQS) in the treatment of rheumatoid arthritis (RA): a randomized investigator-blind controlled study.
RCT comparing standardized Ayurvedic formulations (polyherb with Tinospora cordifolia and Zingiber officinale, and monoherb with Semecarpus anacardium) to hydroxychloroquine sulfate (HCQS) in 121 patients with rheumatoid arthritis. The polyherb formulation showed comparable efficacy to HCQS in improving RA symptoms, with mild adverse events reported.
Immunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patients
RCT assessing the safety and efficacy of Tinospora cordifolia extract (TCE) in 68 HIV positive patients over six months. TCE treatment significantly reduced eosinophil count and hemoglobin percentage, with 60% of patients reporting decreased symptoms. Common complaints included anorexia, nausea, vomiting, and weakness. TCE may serve as an adjunct in HIV/AIDS management.
Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled study.
Prospective double-blind RCT evaluating Tinospora cordifolia as an adjuvant therapy in 50 diabetic patients with foot ulcers. The study found improved wound healing, reduced debridements, and enhanced phagocytosis in the Tinospora cordifolia group, indicating beneficial immunomodulatory effects.
Efficacy of Tinospora cordifolia in allergic rhinitis.
RCT assessing the efficacy of Tinospora cordifolia (TC) extract in 75 patients with allergic rhinitis. TC treatment resulted in significant relief from symptoms such as sneezing, nasal discharge, nasal obstruction, and nasal pruritus compared to placebo. TC also led to changes in leukocyte counts and nasal smear cytology, correlating with clinical improvements.
Moderate alcohol consumption in chronic form enhances the synthesis of cholesterol and C-21 steroid hormones, while treatment with Tinospora cordifolia modulate these events in men.
The study investigated the impact of chronic and moderate alcohol intake on cholesterol homeostasis and steroid hormone synthesis in men, and the effects of Tinospora cordifolia (TCJ) on these parameters. Alcohol intake increased cholesterol synthesis and altered steroid hormone levels, decreasing testosterone and androstenedione synthesis. TCJ intervention normalized steroid levels and improved the testosterone to androstenedione ratio.
Effects of supplementation of Tinospora cordifolia to crossbred cows peripartum.
RCT of guduchi (Tinospora cordifolia) supplementation in 15 crossbred periparturient cows. Guduchi supplemented cows showed faster uterine involution, early commencement of cyclicity, and higher birth weight of calves compared to control. Immunological parameters improved in the treated group.
Characterization, Cytotoxicity and Anti-oxidant Studies of Phytoniosome Loaded with Ethanolic Leaf Extract of Tinospora Cordifolia
The study prepared and characterized phytoniosomes loaded with ethanolic leaf extract of Tinospora cordifolia (nELETC) and compared its antioxidant properties with the extract alone (ELETC). The nELETC showed excellent antioxidant potential and non-toxic nature in vitro, suggesting its potential as a drug carrier for scavenging free radicals.
Efficacy of(Guduchi) against plaque and gingivitis-A clinico-microbiological study.
A nonrandomized before and after trial assessed the clinical and antimicrobial efficacy of T. cordifolia (Guduchi) against plaque and gingivitis in 17 participants over 21 days. Significant reductions in plaque score, gingival score, and colony forming units of gram negative organisms and S. mutans were observed, but not for gram positive organisms.
Antiviral prospective of Tinospora cordifolia on HSV-1
The paper explores the antiviral potential of Tinospora cordifolia against HSV-1, a type of Herpes simplex virus. It discusses the use of various herbal extracts, including T. cordifolia, in reducing symptoms of herpes, though not curing the disease.
Immunotherapy with Tinospora cordifolia: a new lead in the management of obstructive jaundice.
RCT evaluating the effect of Tinospora cordifolia on surgical outcomes in patients with malignant obstructive jaundice. Tinospora cordifolia improved phagocytic and killing capacities of neutrophils and reduced clinical evidence of septicemia, leading to better post-operative survival.
A REVIEW ON TINOSPORA CORDIFOLIA AS A POTENTIAL ANTI-ANGIOGENIC AGENT IN A RANGE OF ANGIOGENIC DISEASES
The review discusses Tinospora cordifolia's potential as an anti-angiogenic agent in diseases like cancer, rheumatoid arthritis, and psoriasis. It highlights TC's pharmacological activities, including immunomodulatory, anti-inflammatory, and antioxidant effects, and its phytoconstituents that may synergistically address inflammation and oxidative stress.
Medicinal use of the unique plant Tinospora Cordifolia: evidence from the traditional medicine and recent research
This review presents a detailed survey of the literature on traditional and modern knowledge of Tinospora cordifolia for health benefits. It discusses its use in traditional medicine for ailments like fever, diabetes, and skin diseases, and highlights its hypoglycemic, antipyretic, anti-inflammatory, antioxidant, and immunomodulatory properties.
Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice
Animal study evaluating the antidepressant and anxiolytic activity of Rasayana Ghana Tablet, an Ayurvedic formulation containing Guduchi, Aamalaki, and Gokshura, in Swiss albino mice. The formulation showed positive effects on depression and anxiety in experimental animals.