Research
Guayusa
16 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance.
RCT assessing the effects of guayusa extract and Nordic Lion's Mane on cognition using a crossover design. Guayusa significantly improved cognitive performance, mental clarity, focus, mood, and stress tolerance over 2 hours. Lion's Mane improved working memory, complex attention, and reaction time.
Unlocking thePotential: Volatile Composition, Antioxidant, Antidiabetic, and Hemolytic Activities, with In Silico Molecular Docking and ADMET Analysis of Hydroethanolic Extracts.
The study explores the biochemical profile of Ilex guayusa, focusing on its antioxidant and antidiabetic activities. It highlights the influence of geographical and ontogenetic factors on its phenolic and flavonoid content, demonstrating promising antioxidant and hypoglycemic activity with low toxicity.
Green Processing of: Antioxidant Concentration and Caffeine Reduction Using Encapsulation by Supercritical Antisolvent Process.
The study investigated the supercritical antisolvent extraction (SAE) process to produce a low-caffeine, antioxidant-rich product from guayusa leaves. The process concentrated chlorogenic acid while reducing caffeine content, and co-precipitation with polyvinylpyrrolidone improved recovery yield and encapsulation of bioactive compounds.
Green-based methods to obtain bioactive compounds fromLoes. using polar solvent.
The study conducted chemical analysis of guayusa leaves using various extraction techniques with water and ethanol as solvents. The extracts were evaluated for phenolic content and antioxidant capacity, identifying caffeine, theobromine, and 5-caffeoylquinic acid as main substances. Guayusa is suggested as a natural source of bioactive compounds with potential applications.
Effect of solvent-solvent partition on antioxidant activity and GC-MS profile ofLoes. leaves extract and fractions.
The study investigates the antioxidant activity and volatile compounds of guayusa leaves extract and fractions. The ethyl acetate fraction showed the highest inhibition against DPPH radical and ferric reducing antioxidant power, suggesting strong antioxidant properties related to phenolic acids, flavones, flavonols, and other compounds identified by GC-MS.
Exploring the Impact of Infusion Parameters and In Vitro Digestion on the Phenolic Profile and Antioxidant Capacity of Guayusa (Loes.) Tea Using Liquid Chromatography, Diode Array Detection, and Electrospray Ionization Tandem Mass Spectrometry.
The study investigates the impact of infusion parameters and in vitro digestion on the phenolic profile and antioxidant capacity of Guayusa tea. It examines the effects of infusion time, temperature, and solvent conditions on the tea's phenolic content and antioxidant capacity, identifying chlorogenic acid and its derivatives as predominant compounds. The study also explores changes in phenolic and flavonoid compounds during in vitro digestion.
In vitro mineral apposition analysis of two Colombian plant extracts on Amelogenesis imperfecta teeth.
In vitro study comparing the remineralizing effects of Piper marginatum Jacq. and Ilex guayusa Loes plant extracts on teeth with Amelogenesis imperfecta against commercial products Clinpro-3M and Recaldent™. Both plant extracts exhibited phosphate and orthophosphate mineral apposition, with P. marginatum Jacq. showing better results.
Antioxidant and anti-inflammatory properties of Ilex guayusa tea preparations: a comparison to Camellia sinensis teas.
The study compares the antioxidant and anti-inflammatory properties of Ilex guayusa tea to Camellia sinensis teas. I. guayusa teas showed significant antioxidant and anti-inflammatory activities, with polyphenolic content and radical scavenging capacities nearly half of those in C. sinensis teas. The teas provided 60-80% protection from oxidative stress and reduced nitric oxide production by 10-30% in cellular assays.
Guayusa (Ilex guayusa L.) new tea: phenolic and carotenoid composition and antioxidant capacity.
The study analyzed the phenolic and carotenoid composition and antioxidant capacity of guayusa leaves. It identified 14 phenolic compounds and five carotenoids, with chlorogenic acid and lutein being prominent. Blanched guayusa retained phenolic compounds and antioxidant capacity, while fermentation reduced bioactive content.
Ilex Guayusa Tea Improves Glycaemia and Autonomic Modulation in Female Streptozotocin-Induced Diabetic Rats.
The study evaluated the effects of Ilex guayusa tea on cardiovascular, autonomic, metabolic, and oxidative stress parameters in streptozotocin-induced diabetic rats. Ilex guayusa tea consumption mitigated metabolic and autonomic dysfunction, suggesting a potential therapeutic role in managing diabetic complications.
Guayusa (Loes.) Ancestral Plant of Ecuador: History, Traditional Uses, Chemistry, Biological Activity, and Potential Industrial Uses.
This narrative review explores the potential of guayusa, a medicinal plant from Ecuador, analyzing its ethnobotanical aspects, traditional uses, secondary metabolites, and research. It highlights guayusa's uses as a physical and mental stimulant, analgesic, antioxidant, antimicrobial, anti-inflammatory, anti-diabetic, and phytohormonal agent.
Changes in phytochemical composition, bioactivity and in vitro digestibility of guayusa leaves (Ilex guayusa Loes.) in different ripening stages.
The study assessed the influence of leaf age on phenolic compounds, carotenoids, bioactivity, and digestibility of guayusa leaf extracts. Young leaves showed higher phenolic content and significant antioxidant and anti-inflammatory activity, though no antibacterial activity was observed.
General and Genetic Toxicology of Guayusa Concentrate (Ilex guayusa).
Various studies evaluated the general and genetic toxicology of a standardized liquid concentrate of guayusa (GC). Guayusa concentrate was negative in in vitro genotoxicity tests and had an oral median lethal dose (LD50) >5,000 mg/kg for female rats. In a 90-day subchronic study, effects in GC-treated rats were comparable to a caffeine control group, with no signs of incremental toxicity from other components of guayusa.
Ritualistic use of the holly Ilex guayusa by Amazonian Jívaro Indians.
The paper discusses the ritualistic use of Ilex guayusa leaf decoctions by Amazonian Jívaro Indians as a morning stimulant due to its high caffeine content. Ritualistic vomiting is practiced to manage caffeine intake and prevent undesirable CNS effects.
A critical review of the composition and history of safe use of guayusa: a stimulant and antioxidant novel food.
This narrative review assesses the safety of guayusa as a novel food, examining its taxonomy, chemical composition, toxicology, ethnobotany, and history of safe use. Guayusa is traditionally consumed in the western Amazon and is considered to have antioxidant and stimulant properties. The review concludes that guayusa has a well-documented chemical composition and history of safe use, supporting its potential authorization as a novel food in the EU.
Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice.
Animal study evaluating the effects of traditional European plant treatments on glucose homeostasis in normal and streptozotocin diabetic mice. Guayusa and mushroom retarded the development of hyperglycaemia and improved several diabetic parameters, suggesting potential antidiabetic properties.