Research
Green Tea Extract
85 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of green tea supplementation on antioxidant status and inflammatory markers in adults: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of 38 RCTs assessing the effects of green tea supplementation on inflammatory and oxidative markers. Green tea improved IL-1β, MDA, TAC, SOD, and GPX levels, indicating enhanced oxidative status, but showed no significant effect on CRP, IL-6, and TNF-α, except for IL-1β.
Effects of green tea supplementation on obesity indices and adipokines in adults: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials
This systematic review and meta-analysis assessed the impact of green tea supplementation on obesity indices and adipokines in adults. Green tea supplementation was found to reduce body weight, BMI, waist circumference, body fat percentage, and leptin levels, but did not significantly change adiponectin levels.
Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial.
The study explored the effects of Mediterranean and green-Mediterranean diets on brain age in the DIRECT PLUS trial. The green-MED diet, high in polyphenols from Mankai and green tea, was associated with improved glycemic control and neuroprotective effects, contributing to a more youthful brain age.
Effect of Green Tea on Blood Pressure in Healthy Individuals: A Meta-Analysis.
Meta-analysis of 9 randomized controlled trials with a total of 680 participants evaluating the effect of green tea on blood pressure in healthy individuals. Green tea supplementation was found to reduce systolic blood pressure by 2.99 mmHg and diastolic blood pressure by 0.95 mmHg.
The effects of green tea supplementation on cardiovascular risk factors: A systematic review and meta-analysis
Systematic review and meta-analysis of 55 RCTs assessing the effects of green tea supplementation on cardiovascular risk factors. Green tea supplementation significantly improved lipid profile, glycemic control markers, and reduced blood pressure, supporting its health benefits on cardiometabolic risk factors.
Potential therapeutic effects of green tea on obese lipid profile - a systematic review.
Systematic review of studies on the effects of green tea on lipid profiles in obese animals and humans. Green tea reduced total cholesterol, triglycerides, and low-density lipoprotein cholesterol in animals but was not effective in humans for controlling obese lipids.
Clinical pharmacokinetics of nadolol: A systematic review.
Systematic review of pharmacokinetic data on nadolol in humans. The review found that the bioavailability of nadolol was greatly reduced by the coadministration of green tea. The review also discusses nadolol's pharmacokinetic parameters and its implications for dosage adjustments.
Antiplaque and antigingivitis efficacy of medicated and non-medicated sugar-free chewing gum as adjuncts to toothbrushing: systematic review and network meta-analysis.
This network meta-analysis assessed the antiplaque and anti-inflammatory efficacy of sugar-free chewing gums with different active ingredients as adjuncts to toothbrushing. SFCG containing green tea and xylitol showed better antiplaque effect over negative controls, but no statistically significant differences were detected among the different active ingredients for both antiplaque and anti-inflammatory efficacy.
Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Systematic review and meta-analysis of 16 RCTs with 760 participants assessing the effects of green tea supplementation on oxidative stress in adults. Green tea supplementation significantly improved total antioxidant capacity (TAC) but showed no consistent relationship with malondialdehyde (MDA) levels, although a dose-dependent effect on MDA was noted.
Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial.
The DIRECT PLUS 18-month randomized controlled trial examined the effect of a green-Mediterranean diet enriched with Mankai, green tea, and walnuts on intrahepatic fat loss in participants with abdominal obesity/dyslipidaemia. The green-MED group achieved almost double the intrahepatic fat percentage loss compared to the MED and HDG groups, with a significant reduction in NAFLD prevalence.
Efficacy of medicinal plant extracts as dental and periodontal antibiofilm agents: A systematic review of randomized clinical trials.
Systematic review of randomized clinical trials evaluating medicinal plant extracts as dental and periodontal antibiofilm agents. Camellia sinensis, Melaleuca alternifolia, Azadirachta indica, and Ricinus communis were among the plants studied, showing varying degrees of efficacy in reducing plaque and gingival indices.
Effect of green tea consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials
Systematic review and meta-analysis of 31 trials with 3321 subjects assessing the effect of green tea on blood lipids. Green tea intake significantly lowered total cholesterol and LDL cholesterol levels, but did not affect HDL cholesterol or triglycerides.
Effects of green tea consumption on glycemic control: a systematic review and meta-analysis of randomized controlled trials
Systematic review and meta-analysis of 27 RCTs involving 2194 subjects examining the effects of green tea on glycemic control. Green tea significantly lowered fasting blood glucose but did not significantly affect fasting insulin and HbA1c values.
Green tea (Camellia sinensis) for the prevention of cancer.
This meta-analysis updates a previous review on the association between green tea consumption and cancer risk. It includes 142 studies, with 11 experimental and 131 nonexperimental studies. Results show inconsistent evidence for the beneficial effect of green tea on cancer risk, with some studies indicating a potential reduction in cancer incidence but no effect on cancer-related mortality. Adverse effects of green tea extract intake were also reported.
A META-ANALYSIS OF THE EFFECTS OF GREEN TEA COMBINED WITH PHYSICAL ACTIVITY ON BLOOD LIPIDS IN HUMANS
This meta-analysis examined the effects of green tea extract combined with physical activity on serum lipid content in humans. Analyzing 7 RCTs with 608 individuals, the study found no significant decrease in LDL-C, TC, HDL-C, or TG levels. Subgroup analysis showed a significant decrease in TC levels with lower doses of EGCG and physical activity.
Effects of green tea supplementation on serum concentrations of adiponectin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Systematic review and meta-analysis of five RCTs evaluating the effects of green tea supplementation on serum adiponectin concentrations in patients with type 2 diabetes mellitus. The analysis found that green tea supplementation significantly increased adiponectin concentrations compared to control groups.
Effect of Green Tea on Anthropometric Indices and Body Composition in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of randomized controlled trials assessing the effect of green tea on anthropometric indices and body composition in type 2 diabetes mellitus patients. Green tea consumption significantly decreased body weight, BMI, and body fat, particularly in long-term interventions, at lower doses, and in overweight patients.
The effect of green tea supplementation on obesity: A systematic review and dose–response meta‐analysis of randomized controlled trials
Systematic review and meta-analysis evaluated the efficacy and dose–response relationship of green tea supplementation on obesity indices in humans. Results indicated significant reductions in body weight, BMI, and waist circumference, supporting the use of green tea for improving obesity indices.
Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of randomized clinical trials
Systematic review and meta-analysis of 15 RCTs assessing the effects of green tea and catechin on liver enzymes in healthy individuals and those with nonalcoholic fatty liver disease (NAFLD). Overall, green tea had a nonsignificant effect on liver enzymes, but subgroup analyses showed a reduction in liver enzymes in NAFLD patients and a small increase in healthy subjects.
Effects of Coffee, Black Tea and Green Tea Consumption on the Risk of Non-Hodgkin’s Lymphoma: A Systematic Review and Dose–Response Meta-Analysis of Observational Studies
This systematic review and dose-response meta-analysis of observational studies assessed the association between coffee, black and green tea intake and the risk of non-Hodgkin’s lymphoma (NHL). Higher green tea intake was associated with a 39% reduced risk of NHL, while no association was found for coffee or black tea intake.
The effect of green tea on C-reactive protein and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.
This systematic review and meta-analysis investigated the effect of green tea on serum levels of C-reactive protein (CRP) and biomarkers of oxidative stress in patients with type 2 diabetes mellitus. Green tea consumption significantly reduced CRP levels but had no significant effect on plasma levels of total antioxidant capacity (TAC) and malondealdehyde (MDA).
Green Tea Consumption and Risk of Breast Cancer and Recurrence—A Systematic Review and Meta-Analysis of Observational Studies
Systematic review and meta-analysis of observational studies evaluating the association between green tea consumption and breast cancer risk in women. The analysis found an inverse statistically significant relationship, suggesting a potential protective effect of green tea on breast cancer risk and recurrence.
Effects of Coffee and Tea Consumption on Glucose Metabolism: A Systematic Review and Network Meta-Analysis
Systematic review and network meta-analysis of 27 RCTs with 1898 participants examining the effects of coffee and tea on glucose metabolism. Green tea, but not caffeinated/decaffeinated coffee or black tea, may reduce fasting blood glucose levels compared to placebo/water, especially in individuals under 55 years old or in Asian-based studies. Oolong tea also showed a decrease in FBG, but with very low quality of evidence.
The Effectiveness of Green Tea or Green Tea Extract on Insulin Resistance and Glycemic Control in Type 2 Diabetes Mellitus: A Meta-Analysis
This meta-analysis evaluated the effect of green tea or green tea extract on insulin resistance and glycemic control in people with pre-diabetes or type 2 diabetes mellitus. Six studies with a total of 382 participants were analyzed, showing no significant differences between green tea/green tea extract and placebo for glycosylated hemoglobin, insulin resistance, fasting insulin, or fasting glucose.
Effect of green tea supplementation on blood pressure among overweight and obese adults: a systematic review and meta-analysis.
Systematic review and meta-analysis of 14 RCTs with 971 participants examining the effect of green tea or green tea extract supplementation on blood pressure among overweight and obese adults. Green tea or GTE produced a small but significant reduction in both systolic and diastolic blood pressure compared with placebo.
[Effect of green tea or green tea extract consumption on body weight and body composition; systematic review and meta-analysis].
Systematic review and meta-analysis evaluated the effect of green tea or its extracts on body weight and body composition. The analysis found no statistically significant effect on weight loss, BMI, or waist and hip circumference, but a small, statistically significant decrease in fat mass percentage was observed, though not clinically relevant.
Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials.
Meta-analysis of 17 randomized controlled trials with 1133 subjects evaluating the effects of green tea on glucose control and insulin sensitivity. Green tea consumption significantly reduced fasting glucose and Hb A1c concentrations, with further reductions in fasting insulin concentrations in high-quality studies.
Effects of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of 7 RCTs involving 510 participants at risk of type 2 diabetes mellitus. The study found no statistically significant effect of green tea or green tea extract on fasting plasma glucose, fasting serum insulin, OGTT-2 h glucose, haemoglobin A1c, and HOMA(IR) index.
Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials.
Meta-analysis of 14 randomized controlled trials with 1136 subjects examining the effect of green tea beverages and extracts on lipid profiles. Green tea consumption significantly lowered total cholesterol and LDL cholesterol concentrations, but had no significant effect on HDL cholesterol.
Matcha Does Not Affect Electroencephalography during Sleep but May Enhance Mental Well-Being: A Randomized Placebo-Controlled Clinical Trial.
A placebo-controlled randomized double-blind parallel-group study on healthy Japanese adults examined the effects of daily matcha consumption on sleep and mental well-being. While no significant differences were observed in objective sleep parameters measured by EEG, subjective sleep satisfaction and emotional stability showed improvement trends.
Long-term green-Mediterranean diet may favor fasting morning cortisol stress hormone; the DIRECT-PLUS clinical trial.
RCT of 294 participants comparing healthy dietary guidelines, Mediterranean diet, and Green-MED diet over 18 months. The Green-MED diet, high in polyphenols, significantly reduced fasting morning cortisol levels, suggesting potential cardiometabolic health benefits.
Clinical efficacy of green tea, aloe vera and chlorhexidine mouthwashes in the treatment of dental biofilm induced gingivitis: A multi-arm, double-blinded, randomized controlled clinical trial.
This multi-arm, randomized, double-blinded, controlled clinical trial evaluated the efficacy of 0.5% green tea, 0.2% chlorhexidine, and aloe vera mouthwashes in managing dental biofilm-induced gingivitis. Green tea mouthwash showed significant reductions in plaque index, gingival index, and sulcular bleeding index, comparable to chlorhexidine, suggesting it as a potent alternative for gingival disease prevention and treatment.
A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers.
RCT of 100 moderately stressed adults testing a combination of magnesium, B vitamins, green tea, and rhodiola against placebo. The combination increased EEG resting state theta, attenuated subjective stress, anxiety, and mood disturbance, and heightened subjective and autonomic arousal.
Effectiveness of green tea mouthwash for improving oral health status in oral cancer patients: A single-blind randomized controlled trial.
A single-blind randomized controlled trial evaluated the effectiveness of green tea mouthwash in improving oral health status in oral cancer patients undergoing treatment. The study found that the intervention group using green tea mouthwash showed significantly better oral health status compared to the control group using tap water, with improvements maintained over 4 to 6 months.
The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial.
RCT of 60 healthy Japanese adults aged 30-75 years consuming green tea combined with alpha-glucosyl hesperidin for 12 weeks. The combination prevented weight gain and reduced BMI, with more pronounced effects in participants under 50 years, including decreased triglycerides, body fat percentage, visceral fat, and improved LDL/HDL ratio.
Effects of Daily Matcha and Caffeine Intake on Mild Acute Psychological Stress-Related Cognitive Function in Middle-Aged and Older Adults: A Randomized Placebo-Controlled Study.
RCT comparing the effects of matcha and caffeine on cognitive function under mild acute stress in middle-aged and older adults. Continuous matcha intake improved attention and work performance under stress more effectively than caffeine alone.
Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain.
RCT evaluating diet-modulated autologous fecal microbiota transplantation (aFMT) for weight regain after weight loss. The green-Mediterranean diet, including Mankai, significantly attenuated weight regain and improved glycemic control compared to placebo. The study highlights the role of a high-polyphenols, green plant-based diet in optimizing microbiome for aFMT.
Comparison of antimicrobial efficacy of aqueous ozone, green tea, and normal saline as irrigants in pulpectomy procedures of primary teeth.
RCT comparing the antimicrobial efficacy of aqueous ozone, green tea, and normal saline as irrigants in pulpectomy procedures of primary teeth in 60 children. Ozonated water showed the lowest mean CFU count, followed by green tea, which was significantly more effective than normal saline.
The effect of green tea on inflammatory mediators: A systematic review and meta‐analysis of randomized clinical trials
Systematic review and meta-analysis of randomized clinical trials assessing green tea's effects on inflammatory mediators. Green tea did not significantly decrease serum CRP levels, significantly increased IL-6, and significantly decreased TNF-α levels. The study suggests green tea might not change inflammatory mediators in low inflammation diseases.
The safety of green tea and green tea extract consumption in adults - Results of a systematic review.
Systematic review of toxicology and human intervention studies on green tea and its preparations. Findings indicate hepatotoxicity associated with concentrated, catechin-rich green tea preparations in large bolus doses, but not with brewed tea or extracts in beverages. Safe intake levels of EGCG were derived for different forms of consumption.
Efficacy of green tea-based mouthwashes on dental plaque and gingival inflammation: A systematic review and meta-analysis
Systematic review and meta-analysis of the efficacy of green tea-based mouthwashes on dental plaque and gingival inflammation compared to chlorhexidine in plaque-induced gingivitis patients. Results showed mixed outcomes with some studies favoring green tea and others favoring chlorhexidine.
Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta‐analysis of clinical trials
Systematic review and meta-analysis evaluating the efficacy of green tea supplementation on nonalcoholic fatty liver disease treatment.
The association between green tea consumption and breast cancer risk: A systematic review and meta‐analysis
This systematic review and meta-analysis evaluated the relation between green tea consumption and breast cancer risk, including 14 studies: 9 case-control, 4 cohort, and 1 clinical trial. Case-control studies suggested a 19% reduction in breast cancer risk with high green tea consumption, while cohort studies showed no significant difference. The clinical trial found no effect on mammographic density. Overall, the evidence is inconclusive due to high heterogeneity.
Effect of green tea on plasma leptin and ghrelin levels: A systematic review and meta-analysis of randomized controlled clinical trials.
This meta-analysis of 11 RCTs assessed the effect of green tea on serum leptin and ghrelin concentrations. The analysis found that green tea did not significantly affect leptin and ghrelin levels compared to placebo, although there were increases in leptin in studies longer than 12 weeks and in ghrelin among women and non-Asians.
Effect of Green Tea on Plasma Adiponectin Levels: A Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials.
Systematic review and meta-analysis of 14 RCTs assessing the effect of green tea on serum adiponectin concentrations. The analysis showed that green tea did not significantly affect adiponectin levels compared to placebo. Subgroup and metaregression analyses did not identify factors explaining study heterogeneity.
[Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review].
Systematic review of 15 studies assessing the effects of green tea and its EGCG content on body fat and body weight in humans. Daily consumption of green tea with EGCG doses between 100 and 460 mg/day showed effectiveness in reducing body fat and weight over 12 weeks or more, with caffeine intake also playing a role.
Green tea effects on cognition, mood and human brain function: A systematic review.
Systematic review of 21 studies assessing the effects of green tea on cognition, mood, and brain function. Evidence suggests green tea reduces anxiety, benefits memory and attention, and activates working memory. Effects are attributed to the combined influence of caffeine and l-theanine.
Effect of green tea supplementation on blood pressure among overweight and obese adults: a protocol for a systematic review
This is a protocol for a systematic review aiming to summarize the evidence from RCTs on the effect of green tea supplementation or green tea extract on blood pressure among overweight and obese adults. The review will include a meta-analysis to pool results and conduct subgroup analyses based on various factors.
Green tea and lung cancer: a systematic review.
Systematic review of 84 articles on green tea for lung cancer treatment and prevention. Phase I trials showed no objective tumor responses at maximum tolerated doses. Green tea decreased DNA damage in smokers but did not alter enzyme activity in human studies. In vitro evidence suggests green tea may reduce the effectiveness of bortezomib. Insufficient evidence supports green tea as a treatment or preventative agent for lung cancer.
The effects of green tea on weight loss and weight maintenance: a meta-analysis.
Meta-analysis of 11 studies examining the effects of green tea supplementation on weight loss and weight maintenance. Catechins significantly decreased body weight and maintained weight after weight loss. Habitual caffeine intake and ethnicity were identified as potential moderators of the effect.
The Effects of Green Tea Consumption on Incidence of Breast Cancer and Recurrence of Breast Cancer: A Systematic Review and Meta-analysis
Systematic review and meta-analysis of observational studies assessing the effect of green tea consumption on breast cancer incidence and recurrence. The pooled relative risk for breast cancer development was not statistically significant, while green tea consumption showed a possible preventive effect on recurrence in early-stage breast cancer.
Salivary levels of catalase, total antioxidant capacity and interleukin-1β and oral health-related quality of life after matcha and green tea consumption for patients with gingivitis: A randomized clinical trial.
RCT evaluating the effects of matcha and green tea consumption on oral health in 40 gingivitis patients. Both teas improved oral health-related quality of life and reduced gingivitis extent, with significant TAC increase after matcha consumption.
Matcha consumption maintains attentional function following a mild acute psychological stress without affecting a feeling of fatigue: A randomized placebo-controlled study in young adults.
RCT with 42 young adults consuming 2g of matcha daily for 2 weeks. Matcha maintained attentional function after mild acute psychological stress, with improved reaction times on the Stroop test and increased correct hits in emotion perception compared to placebo.
Efficacy of green tea and its extract, epigallocatechin-3-gallate, in the reduction of cariogenic microbiota in children: a randomized clinical trial.
RCT evaluating the antimicrobial efficacy of green tea and its extract epigallocatechin-3-gallate (EGCG) as a mouthwash in 47 children at high caries risk. EGCG showed a higher reduction in cariogenic microorganisms compared to green tea and distilled water, but less than chlorhexidine.
Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial.
RCT evaluating the effect of yerba mate and green tea on serum leptin and paraoxonase-1 levels in 142 overweight or obese individuals with dyslipidemia. Yerba mate intake significantly increased serum PON-1 levels and was associated with increased HDL-c, suggesting a protective role against atherosclerotic diseases. Green tea showed no significant effect on PON-1 or leptin levels.
Green tea extract outperforms metformin in lipid profile and glycaemic control in overweight women: A double-blind, placebo-controlled, randomized trial.
RCT comparing green tea extract and metformin in 120 non-diabetic overweight women over 12 weeks. Green tea extract improved glycaemic control and lipid profile, reducing fasting glucose, total cholesterol, and LDL-c, while metformin increased HbA1c and reduced body weight and lean mass.
Is tea consumption associated with the serum uric acid level, hyperuricemia or the risk of gout? A systematic review and meta-analysis
Systematic review and meta-analysis examining the associations of tea consumption with serum uric acid level, hyperuricemia, and risk of gout. No significant association was found between tea consumption and these outcomes, except for a positive association between green tea consumption and serum uric acid level in a subgroup analysis.
The Effect of Green Tea and Sour Tea (Hibiscus sabdariffa L.) Supplementation on Oxidative Stress and Muscle Damage in Athletes.
RCT of 54 male soccer players assessing the effects of green tea and sour tea supplementation on oxidative stress and muscle damage. GTE and STE supplementation decreased MDA levels, with STE increasing TAC levels. No significant effects on muscle damage indices were observed.
Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial.
Randomized open-label active-controlled clinical trial assessing the efficacy and safety of green tea extract for knee osteoarthritis. The green tea group showed significant reductions in VAS pain, total WOMAC, and WOMAC physical function scores compared to the control group. No significant differences were observed in WOMAC pain and stiffness scores. Only one patient reported gastric upset in the control group.
Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation.
RCT investigating the effect of a green tea-caffeine mixture on weight maintenance after weight loss in moderately obese subjects. The mixture improved weight maintenance in low caffeine consumers through thermogenesis and fat oxidation, while high caffeine consumers showed no additional effects.
Randomized controlled trial for an effect of green tea consumption on insulin resistance and inflammation markers.
RCT conducted on 66 patients with borderline diabetes or diabetes to study the effects of green tea polyphenols on insulin resistance and inflammation. The intervention group consumed green tea extracts containing 544 mg polyphenols daily for 2 months. No significant differences were found between the intervention and control groups in terms of blood glucose, Hb A1c, insulin resistance, or inflammation markers.
Stress-Reducing Function of Matcha Green Tea in Animal Experiments and Clinical Trials.
The study examined the stress-reducing effects of matcha green tea in both animal experiments and a clinical trial. In humans, participants consuming test-matcha showed significantly lower anxiety levels compared to those consuming placebo-matcha. The stress-reducing effect was linked to high contents of theanine and arginine, with effectiveness dependent on the molar ratio of caffeine and EGCG to theanine and arginine being less than two.
Impact of green tea intake on clinical improvement in chronic periodontitis: A randomized clinical trial.
RCT of 30 patients with chronic periodontitis comparing green tea consumption to no intervention for 6 weeks. The green tea group showed greater reductions in probing depth and bleeding index compared to the control group, suggesting a positive impact on periodontal disease treatment.
Lack of pharmacokinetic interaction between fluvastatin and green tea in healthy volunteers.
A randomized three-phase crossover study assessed the effects of green tea and its catechin component EGCG on the pharmacokinetics of fluvastatin in 11 healthy volunteers. Despite in vitro inhibition of CYP2C9 activity by EGCG and brewed green tea, no significant effects were observed on fluvastatin plasma concentrations in vivo.
Comparison of Antimicrobial Efficacy of Green Tea, Garlic with Lime, and Sodium Fluoride Mouth Rinses against Streptococcus mutans, Lactobacilli species, and Candida albicans in Children: A Randomized Double-blind Controlled Clinical Trial
RCT comparing the antimicrobial efficacy of green tea, garlic with lime, and sodium fluoride mouth rinses in 45 children with severe early childhood caries. Significant reduction in colony counts of S. mutans and Lactobacilli spp. was observed with all rinses, but not against C. albicans. No significant differences were found between the rinses.
Development and clinical evaluation of green tea hair tonic for greasy scalp treatment.
A clinical evaluation of a green tea hair tonic for greasy scalp treatment was conducted on 20 volunteers over 28 days. The tonic significantly reduced scalp sebum levels without causing skin irritation, indicating its safety and efficacy for treating scalp greasiness.
Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients.
A randomized, double-blind, placebo-controlled study of 46 obese patients examined the effects of 379 mg of green tea extract supplementation over 3 months. Results showed decreases in body mass index, waist circumference, and levels of total cholesterol, low-density cholesterol, and triglycerides. Increases in total antioxidant level and zinc concentration were observed, along with higher HDL-cholesterol and magnesium levels in the green tea group.
Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome.
RCT comparing green tea beverage and extract supplementation to controls in 35 obese subjects with metabolic syndrome over 8 weeks. Green tea significantly decreased body weight and BMI, and the beverage reduced lipid peroxidation, suggesting benefits for metabolic syndrome.
Acute effect of black and green tea on aortic stiffness and wave reflections.
RCT assessing the acute effect of black and green tea on aortic stiffness and wave reflections in 29 healthy volunteers. Black tea increased pulse wave velocity initially, while both teas increased augmentation index. Both teas had a significant pressor effect, with changes less than those produced by caffeine.
A prospective clinical trial of green tea for hormone refractory prostate cancer: an evaluation of the complementary/alternative therapy approach.
Prospective clinical trial evaluating green tea extract capsules in patients with hormone refractory prostate cancer. The treatment was generally well tolerated but showed minimal clinical activity against the cancer.
Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men.
Randomized, placebo-controlled, double-blind, cross-over study with 14 subjects testing the effects of green tea and Guarana extracts containing caffeine and EGCG on 24 h energy expenditure and fat oxidation. The EGCG-caffeine mixtures significantly increased 24 h energy expenditure by about 750 kJ compared to placebo, but had no effect on lipid oxidation. Blood pressure increased with the mixtures, significantly for 24 h diastolic pressure.
Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement.
RCT with 30 healthy subjects comparing the pharmacokinetic disposition and antioxidant capacity of tea polyphenols after consumption of green tea, black tea, or a green tea extract supplement. Green tea extract supplements enhanced flavanol absorption and increased plasma antioxidant activity compared to green or black tea.
Serum Formulation Containing Salmon DNA and Various Plant Extracts as Antioxidant and Anti-aging on UV-Induced Human Skin Fibroblast Cells
The study evaluated the antioxidant and anti-aging potential of a serum containing salmon DNA and various plant extracts on UV-induced oxidative stress in human skin fibroblast cells. The serum demonstrated strong antioxidant activity, enhanced total antioxidant capacity, suppressed hyaluronidase activity, and increased total protein content, indicating improved fibroblast function and viability.
The Combined Effect of Green Tea, Saffron, Resveratrol, and Citicoline against Neurodegeneration Induced by Oxidative Stress in an In Vitro Model of Cognitive Decline
In vitro study of a combination of green tea, saffron, resveratrol, and citicoline (MIX) against oxidative stress-induced neurodegeneration. MIX improved blood-brain barrier absorption, reduced mitochondrial damage, and regulated cellular energy metabolism and apoptosis, suggesting potential to prevent cognitive decline.
Plant extracts have dual mechanism on the protection against dentine erosion: action on the dentine substrate and modification of the salivary pellicle
In vitro study investigating the effect of polyphenol-rich plant extracts on dentine protection against demineralization. Green tea and grape seed extracts showed significant protection with a dual mode of action on the dentine surface and salivary pellicle, while Sn^2+/F^− was more effective on the dentine surface.
Effect of Green Tea and Black Seed on Methotrexate Induced Cytotoxicity of the Oral Mucosa, Tongue and the Submandibular Salivary Gland of Albino Rats
The study evaluated the effects of green tea and black seed oil extract on methotrexate-induced oral mucositis and submandibular salivary gland cytotoxicity in albino rats. Rats were divided into four groups, including a control group, a methotrexate-treated group, and groups treated with methotrexate plus either green tea extract or black seed oil.
The Marine-derived, Multi-mineral formula, AquaPT Reduces TNF-a Levels in Osteoarthritis Patients
Study evaluated the effect of Aquamin and AquaPT (Aquamin with green tea and pine bark extract) on inflammatory biomarkers in osteoarthritis patients over 6 weeks. AquaPT treatment reduced serum TNF-α levels, suggesting an anti-inflammatory effect.
Green tea as a cosmetic agent for skin aging: A scoping review
This scoping review investigates the antioxidant and anti-aging effects of whole green tea and its polyphenols, especially EGCG, on human skin. It includes a qualitative analysis of 21 articles, consisting of in vitro studies, reviews, and controlled trials, highlighting green tea's potential as an anti-aging agent in cosmetics.
Health Benefits and Chemical Composition of Matcha Green Tea: A Review
This narrative review compiles the health benefits of matcha green tea, highlighting its unique chemical composition, including theanine, caffeine, chlorophyll, and catechins. The review attributes matcha's health-promoting properties to its high antioxidant and anti-inflammatory content, suggesting potential benefits for physical and mental health.
Interaction of some commercial teas with some carbohydrate metabolizing enzymes linked with type-2 diabetes: a dietary intervention in the prevention of type-2 diabetes.
In vitro study assessing the inhibitory effect of green tea, black tea, and a formulated herbal preparation on α-amylase and α-glucosidase enzymes linked with type-2 diabetes. Green tea showed the highest total phenol content, antioxidant properties, and inhibitory effect on lipid peroxidation, though no significant difference was found in enzyme inhibition among the teas.
Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.
The study assessed the anti-ageing and anti-oxidant properties of 23 plant extracts, focusing on anti-elastase and anti-collagenase activities. White tea showed the highest inhibitory activity against both enzymes and had the highest phenolic content and antioxidant capacity.
Nutritional applications and beneficial health applications of green tea and l-theanine in some animal species: A review.
This narrative review discusses the nutritional applications and health benefits of green tea and l-theanine in animal species. It highlights green tea's potential against diseases such as liver and heart diseases, inflammatory conditions, and metabolic syndromes, and its role in livestock production.
An Update on the Health Benefits of Green Tea
Narrative review focusing on research conducted using human subjects to investigate the health benefits of green tea. The review highlights the anticarcinogenic, anti-inflammatory, antimicrobial, and antioxidant properties of green tea, as well as its benefits in cardiovascular disease and oral health.
The Effects of Green Tea on Obesity and Type 2 Diabetes
The paper reviews various studies on the effects of green tea on obesity and type 2 diabetes, highlighting both positive and equivocal results. It discusses mechanisms by which green tea and its components, such as EGCG, may influence glucose metabolism and obesity, and presents a study on the potential synergistic effects of green tea extract and poly-γ-glutamic acid in mice.
Can green tea do that? A literature review of the clinical evidence.
This non-systematic literature review examines clinical evidence on green tea, its extract, and EGCG. Observational studies suggest trends towards cancer prevention in breast and prostate cancers, while interventional studies show reduced relapses in colorectal adenomas and increased survival in ovarian cancer. Green tea may also protect against hypertension and reduce stroke risk.