Research
Graviola (Soursop / Annona muricata)
6 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The safety and tolerability of Annona muricata leaf extract: a systematic review
Systematic review summarizing literature on the safety and tolerability of Annona muricata leaf extract and its acetogenins, commonly used for cancer treatment.
The effects of soursop supplementation on blood pressure, serum uric acid, and kidney function in a prehypertensive population in accordance with the 2017 ACC/AHA guideline.
RCT of 143 prehypertensive subjects assessing soursop supplementation effects on blood pressure and serum uric acid levels. The treatment group consuming soursop juice showed significantly lower systolic and diastolic blood pressure and serum uric acid levels compared to the control group after 12 weeks.
The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial.
RCT of Annona muricata leaf extract in 30 colorectal cancer patients post-tumor resection, comparing extract to placebo over 8 weeks. The supplemented group showed higher cytotoxicity against colorectal cancer cell lines and monitored nutritional status.
Anti-cancer effects of green synthesized gold nanoparticles using leaf extract of Annona muricata. L against squamous cell carcinoma cell line 15 through apoptotic pathway
In vitro study of gold nanoparticles synthesized using Annona muricata leaf extract, evaluating their anti-cancer activity against squamous cell carcinoma cell line SCC-15. The nanoparticles induced apoptosis in cancer cells, with increased expression of pro-apoptotic genes p53 and Bax, and decreased expression of anti-apoptotic Bcl-2.
Anticancer Activity of Acetogenins from Annona Muricata Fruit
This review focuses on the phytochemistry, medicinal uses, biological activities, and mechanisms of action of Annona muricata fruit extracts and acetogenins, highlighting their anticancer properties and potential neurotoxic effects in rats.
AKTIVITAS KOMBINASI EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.) DAN DAUN PEGAGAN (Centella asiatica L.Urb) TERHADAP KELARUTAN KALSIUM BATU GINJAL SECARA IN VITRO
In vitro study testing the combination of soursop leaf ethanol extract and gotu kola leaf extract for dissolving calcium kidney stones. The combination of 0.5% soursop and 3.75% gotu kola was found to be effective in dissolving calcium kidney stones.