Research
Grape Seed Extract
205 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Comparison of the Effects of Dill Seed, Grape Seed and Date Extracts on Postpartum Hemorrhage Rates in the Fourth Stage of Labor: A Randomized Clinical Trial.
RCT of 200 multiparous women comparing the effects of dill seed, grape seed, and date extracts on postpartum hemorrhage rates. The study found that all three extracts, especially dates, can be effective in reducing postpartum hemorrhage.
Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 30 RCTs with 1284 participants examining the effects of grape products intake on anthropometric indices. Grape products intake significantly decreased body weight and BMI in obese participants, with a greater effect observed when grape seed extract was used.
The effect of grape products on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs assessing the effects of grape products on liver enzymes in adults. Grape products intake significantly reduced ALP, with no significant changes in ALT and AST overall. Subgroup analysis showed significant reductions in ALP, ALT, and AST with interventions lasting 12 weeks or more and when grape seed extract was used.
GRAPE SEED EXTRACT’S NEUROPROTECTIVE EFFECT AND PARKINSON’S DISEASE: A SYSTEMATIC REVIEW
This systematic review summarizes the neuroprotective effects of grape seed extract (GSE) in Parkinson's Disease, analyzing 20 studies. GSE is shown to improve biological hallmarks of PD through mechanisms like antioxidant, anti-inflammation, protection of dopaminergic neurons, anti-amyloid effect, anti-apoptotic, neurogenesis, and synaptogenesis.
Impact Of Grape Seed Extract On The Oral Cancer: A Systematic Review
Systematic review of studies on the impact of grape seed extract in treating oral cancer. The review suggests that grape seed extract may reduce the cytotoxicity of chemotherapy or radiotherapy on natural cells, with animal studies supporting its potential therapeutic use in oral cancer treatment.
The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis.
Systematic review and meta-analysis of 19 controlled trials assessing grape seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate in adults. GSE significantly reduced diastolic blood pressure and heart rate but had no significant effects on flow-mediated dilation and systolic blood pressure.
The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta-analysis of controlled trials.
Systematic review and meta-analysis of controlled trials evaluating grape seed extract supplementation on oxidative stress and inflammation. GSE supplementation significantly decreased malondialdehyde, oxidised LDL, and high-sensitivity C-reactive protein, with a marginal increase in total antioxidant capacity, but did not significantly affect C-reactive protein and white blood cell count.
The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials.
This meta-analysis of 17 RCTs with 668 participants investigated the effect of grape products containing polyphenols on CRP levels. Grape polyphenols significantly decreased CRP levels, with higher doses and longer intervention periods showing more significant effects. Grape seed extract and other grape products also reduced CRP levels significantly.
Effects of grape seed extract on dyslipidaemia: a systematic review and dose–response meta-analysis of randomised controlled trials
Systematic review and meta-analysis of 11 RCTs involving 536 participants on the effects of grape seed extract (GSE) on serum lipid profiles. GSE supplementation significantly decreased serum levels of LDL-cholesterol and TAG, with no overall effect on total- and HDL-cholesterol levels.
The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials.
Meta-analysis of 16 randomized controlled trials involving 810 subjects found that grape seed extract significantly reduced systolic and diastolic blood pressure. The effect was more pronounced in younger, obese subjects, and those with metabolic syndrome. No publication bias was detected.
The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials.
Meta-analysis of nine randomized controlled trials with 390 participants assessing the effect of grape seed extract on cardiovascular risk markers. Grape seed extract significantly lowered systolic blood pressure and heart rate, but had no significant effect on diastolic blood pressure, lipid levels, or CRP.
Comparison of the Effectiveness of Grape Seed Extract and Low‐Level Laser Therapy in the Management of Dentin Hypersensitivity: A Randomized Controlled Trial
RCT comparing the effectiveness of grape seed extract (GSE) and its combination with low-level laser therapy (LLLT) in managing dentin hypersensitivity. The GSE + LLLT group showed the greatest reduction in pain sensitivity, but differences were not statistically significant.
The Effect of Combined Exercises and Grape Seed Extract on Some Factors of Oxidative Stress and Antioxidant in Postmenopausal Women with Type 2 Diabetes: A Randomized Controlled Trial
RCT on 80 postmenopausal women with type 2 diabetes, divided into control, exercise, GSE supplement, and exercise + GSE supplement groups. GSE supplementation increased total antioxidant capacity and serum glutathione reduction, and decreased serum malondialdehyde levels, indicating reduced oxidative stress.
Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial
This double-blinded randomized placebo-controlled clinical trial assessed the effect of grape seed extract (GSE) supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in 50 migraine patients. The GSE group showed significant reductions in migraine severity, frequency, duration, migraine disability, systolic blood pressure, and serum levels of CGRP, along with improved quality of life and mental health scores.
Grape seed extract supplementation in non-alcoholic fatty liver disease.
RCT of 50 NAFLD patients comparing grape seed extract (GSE) supplementation to placebo for two months. GSE group showed greater reductions in IL-6 and MDA, and increases in TAC, SOD, and GPx levels, indicating improved oxidative stress. Quality of life measures also improved significantly in the GSE group.
The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.
This double-blind randomized clinical trial studied the effects of grape seed extract (GSE) supplementation on cardiovascular risk factors, liver enzymes, and hepatic steatosis in 50 patients with non-alcoholic fatty liver disease (NAFLD). The GSE group showed significant improvements in insulin resistance, lipid profile, blood pressure, and severity of hepatic steatosis compared to the placebo group.
A 4-week Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Use of Grape Seed Extract for Reducing Plasma Glucose, Lipid Profile, and Blood Pressure in Patients with Type 2 Diabetes Mellitus
A 4-week RCT with 74 patients with type 2 diabetes mellitus comparing grape seed extract (GSE) to placebo. GSE significantly decreased systolic blood pressure and fasting blood sugar, but had no significant effect on lipid profile or diastolic blood pressure.
Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children.
RCT investigating the effects of grape seed extract (GSE) in combination with deferasirox on iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children. GSE significantly reduced serum iron, ferritin, ALT, AST, TNF-α, and hs-CRP levels, and improved oxidative stress markers MDA and GSH.
Evaluation of the Effect of Grape Seed Extract (GSE) on Oral Mucositis in Patients with Head and Neck Radiotherapy History- A Randomized Clinical Trial
Double-blinded randomized clinical trial on 78 patients undergoing head and neck radiotherapy to evaluate the effect of grape seed extract mouthwash on radiation-induced mucositis. The intervention group using grape seed extract showed significant improvement in mucositis grade and incidence compared to the placebo group.
Effect of Combined Grape Seed Extract and L-Citrulline Supplementation on Hemodynamic Responses to Exercise in Young Males
Study examined the effects of grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to exercise in young males. GSE and combined supplementations increased cardiac output and total vascular conductance at high workloads, suggesting improved oxygen delivery to muscles. No additive benefits were observed from the combination.
Effectiveness of Grape Seed Extract in Patients with Nonalcoholic Fatty Liver: A Randomized Double-Blind Clinical Study
Randomized, double-blind clinical trial evaluating the effect of grape seed extract (GSE) on biochemical markers in NAFLD patients. GSE significantly decreased levels of AST, ALT, FBS, TG, HDL, LDL, and cholesterol, and increased HDL levels compared to placebo, but did not significantly change BMI or weight.
Clinical efficacy of grape seed extract as an adjuvant to scaling and root planing in treatment of periodontal pockets.
Randomized clinical trial assessing grape seed extract (GSE) as an adjunct to scaling and root planing (SRP) in 72 patients with periodontal pockets. The test group receiving GSE showed statistically significant reductions in probing depth and relative attachment level after 3 months, suggesting potential benefits in managing periodontal pockets.
Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers.
RCT investigating the effects of grape seed extract (GSEe) on blood pressure and perceived stress in healthy volunteers. GSEe significantly modulated blood pressure and positively affected mood related to stress perception, with pronounced effects in the male subgroup.
Effects of chronic dietary grape seed extract supplementation on aortic stiffness and hemodynamic responses in obese/overweight males during submaximal exercise.
RCT investigating the effect of chronic grape seed extract supplementation on blood pressure and aortic stiffness in overweight and obese males. GSE significantly decreased mean arterial pressure and aortic stiffness at rest and during submaximal exercise, suggesting its potential as a dietary supplement to manage blood pressure in this population.
Leucoselect Phytosome Modulates Serum Eicosapentaenoic Acid, Docosahexaenoic Acid, and Prostaglandin E3 in a Phase I Lung Cancer Chemoprevention Study.
Phase I open-label dose escalation study evaluating leucoselect phytosome, a grape seed procyanidin extract complexed with soy phospholipids, in heavy active and former smokers. Treatment increased serum eicosapentaenoic acid, docosahexaenoic acid, and prostaglandin E3, correlating with reduced bronchial cell proliferation and inhibited lung cancer cell line proliferation.
Effects of Monomeric and Oligomeric Flavanols on Kidney Function, Inflammation and Oxidative Stress in Runners: A Randomized Double-Blind Pilot Study.
This randomized double-blind pilot study investigated the effects of monomeric and oligomeric flavanols (MOF) on kidney function, inflammation, and oxidative stress in recreational runners. MOF supplementation significantly reduced post-race hematuria and lowered urinary IL-6 concentrations, suggesting it may preserve kidney function and reduce inflammation during strenuous exercise and ibuprofen intake.
Prevention of dental caries by grape seed extract supplementation: A systematic review
Systematic review investigating the use of grape seed extract for dental caries prevention. The review found that grape seed extract inhibits bacterial biofilms and promotes dental remineralization, suggesting potential benefits for caries prevention.
The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta‐analysis of randomized controlled trials
This systematic review and meta-analysis evaluated the effects of grape seed extract (GSE) on glycemic control, serum lipoproteins, inflammation, and body weight. The analysis of 50 trials showed that GSE significantly reduced fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides, and C-reactive protein levels, but did not affect HbA1c, HDL cholesterol levels, or anthropometric measurements.
The Role of Grape Seed Extract in the Treatment of Chemo/Radiotherapy Induced Toxicity: A Systematic Review of Preclinical Studies.
Systematic review of preclinical studies on grape seed extract (GSE) and grape seed proanthocyanidins (GSP) in mitigating chemo/radiotherapy-induced toxicity. GSE/GSP showed potential in reducing cardiotoxicity and neurotoxicity caused by chemotherapeutic agents like doxorubicin and cisplatin.
Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial.
A Phase II double-blind RCT assessed the effect of a combination of 7 micronutrients on overall survival in 53 glioblastoma patients. The treatment group received the micronutrients for 1 year alongside standard chemoradiation therapy. The Kaplan-Meier analysis showed no statistically significant difference in overall survival between the active and placebo groups.
Formulation of Grape seed extract
Double-blind, randomized controlled trial of grape seed extract (GSE) supplementation in 48 type 2 diabetic patients with chronic periodontitis over eight weeks. GSE improved oxidative, inflammatory, and glycaemic biomarkers compared to placebo. Advanced formulation methods were explored to enhance GSE's bioavailability.
Clinical and radiological assessment of grape seed extract versus mineral trioxide aggregates in primary molar pulpotomy: A randomized controlled clinical trial.
This randomized controlled trial compared the clinical and radiological outcomes of grape seed extract (GSE) versus mineral trioxide aggregates (MTA) in primary molar pulpotomy. Both GSE and MTA showed successful outcomes, but MTA was associated with reduced inflammatory reactions, making it more effective.
Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.
This study investigated the effect of 7 days of dietary grape seed extract (GSE) supplementation on cardiac autonomic and hemodynamic responses in males with elevated and stage 1 hypertension. GSE decreased resting diastolic blood pressure and mean atrial pressure compared to placebo, suggesting its potential as a nutraceutical for reducing blood pressure via peripheral vasodilation.
Circadian Modulation of the Antioxidant Effect of Grape Consumption: A Randomized Controlled Trial.
This randomized controlled trial investigated the timing of grape consumption on antioxidant effects in healthy men and women. The study found that grape consumption had a protective effect against morning sensitivity to oxidative stress, with higher tartaric acid and resveratrol excretion levels in the grape group compared to placebo.
A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes: the PRECISE study, a double-blind placebo-controlled cross-over intervention study
The PRECISE study was a double-blind, placebo-controlled, cross-over intervention trial assessing the effects of bilberry and grape seed extract supplementation on cardiometabolic outcomes in individuals at risk of developing type 2 diabetes. The supplementation did not affect glucose and cholesterol outcomes but significantly decreased systolic and diastolic blood pressure. Individual responsiveness was linked to specific gut microbiota and phenolic metabolite profiles.
Antimicrobial efficacy of grape seed extract in terminating the ramifications of plaque microorganisms: a randomized control study
RCT comparing the antimicrobial efficacy of 2% grape seed extract mouthwash to 0.2% chlorhexidine and distilled water in 45 subjects. Grape seed extract significantly reduced colony forming units of microorganisms in plaque and showed potential in controlling plaque and periodontal diseases.
Effects of Grape Seed Extract Supplementation on Endothelial Function and Endurance Performance in Basketball Players.
RCT in 12 elite athletes comparing grape seed extract (GSE) to placebo over 14 days. GSE decreased submaximal VO at 80% and 120% of VO and increased time to exhaustion. GSE also improved endothelial function as measured by flow-mediated dilation, suggesting enhanced vasodilation in active skeletal muscle.
Evaluation of Grape Seed Formulation as an Adjunct to Scaling and Root Planing on Oxidative Stress, Inflammatory Status and Glycaemic Control in Type 2 Diabetic Patients with Chronic Periodontitis: A Randomised Controlled Trial
This double-blind randomized controlled trial evaluated the effect of grape seed formulation as an adjunct to scaling and root planing on oxidative stress, inflammatory status, and glycaemic control in 48 type 2 diabetic patients with chronic periodontitis. The study found significant improvements in oxidative stress, inflammation, and glycaemic control in the test group compared to the control group.
Remineralization potential of grape seeds extract gel versus casein phosphopeptide-amorphous calcium phosphate in white spot lesions in post orthodontic patients: A randomized clinical trial
A single-blinded randomized clinical trial comparing grape seed extract (GSE) gel to Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) paste in managing white spot lesions in post orthodontic patients. No statistically significant difference was found between the two groups, but GSE is suggested to promote remineralization of white spot lesions.
Two-year clinical evaluation of a proanthocyanidins-based primer in non-carious cervical lesions: A double-blind randomized clinical trial.
This double-blind randomized clinical trial evaluated the influence of pre-treatment with proanthocyanidins (PA) from grape seed extract on the clinical behavior of a simplified etch-and-rinse adhesive in non-carious cervical lesions over 6 and 24 months. The study found that the application of PA as a primer did not result in clinical advantages after 24 months of clinical service, regardless of the concentration used.
Effect of 8 weeks' supplementation grape seed extract on insulin resistance in iranian adolescents with metabolic syndrome: A randomized controlled trial.
RCT evaluating the effect of grape seed extract (GSE) on insulin resistance in Iranian adolescents with metabolic syndrome. Participants received 100 mg/day of GSE or placebo for 8 weeks. GSE significantly improved insulin concentration and insulin resistance compared to placebo.
Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial.
RCT of 40 obese or overweight individuals receiving 300mg/day grape seed extract or placebo with a restricted-calorie diet for 12 weeks. GSE group showed significant improvements in HDL-C, HDL-C/LDL-C ratio, and reductions in LDL-C, VAI, AIP, total cholesterol, and triglycerides compared to placebo.
Abstract CT207: A phase II trial using grape seed extract for prostate cancer patients with non-metastatic PSA progression after local therapy
Phase II clinical trial investigating grape seed extract (GSE) in prostate cancer patients with non-metastatic PSA progression after local therapy. Patients received 150mg of GSE orally twice daily for 12 months. The study aimed to assess PSA response and change in PSA velocity. GSE was well tolerated without serious adverse effects.
Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males.
The study investigated the effects of acute grape seed extract supplementation on hemodynamics in 20 men (10 obese, 10 normal body weight). GSE supplementation significantly decreased systolic and mean arterial blood pressure in both groups, with a reduction in cardiac output in the obese group and decreased peripheral vasoconstriction in the normal body weight group.
Effect of grape seed extract ointment on cesarean section wound healing: A double-blind, randomized, controlled clinical trial.
Double-blind, randomized, controlled clinical trial with 129 women undergoing cesarean section to assess the effect of grape seed extract ointment on wound healing. The 5% grape seed extract ointment group showed significantly better wound healing scores compared to the 2.5% ointment and petrolatum groups.
The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial
This randomized clinical trial evaluated the effects of grape seed extract supplementation on inflammatory markers, neuropeptide Y, anthropometric measurements, and appetite in obese or overweight individuals. Grape seed extract is known for its anti-inflammatory effects.
Efficacy of grape seed extract gel in the treatment of chronic periodontitis: A randomized clinical study.
RCT assessing the effectiveness of grape seed extract (GSE) gel in treating chronic periodontitis. Significant improvements were observed in gingival index and plaque index after 6 months of GSE gel application compared to control.
Comparative Effect of Grape Seed Extract (Vitis Vinifera) and Ascorbic Acid in Oxidative Stress Induced by On-pump Coronary Artery Bypass Surgery
This randomized trial tested the effects of grape seed extract (GSE) and Vitamin C on oxidative stress and reperfusion injury in 87 patients undergoing coronary artery bypass surgery. Both GSE and Vitamin C groups showed higher total antioxidant capacity and reduced malondialdehyde levels compared to control, indicating antioxidative effects and reduced deleterious effects of CPB.
Effects of grape seed extract as a natural antioxidant on growth performance, carcass characteristics and antioxidant status of rabbits during heat stress.
RCT investigating the effects of grape seed extract (GSE) supplementation on growth performance, carcass traits, and antioxidant status of rabbits under heat stress. Rabbits receiving 300 mg GSE/kg showed the best body weight gain, feed conversion ratio, and lowest mortality. GSE improved carcass weight and antioxidant enzyme levels while reducing plasma lipids and malondialdehyde.
The Effects of Grape Seed Extract Ointment on Approximation of Cesarean Section Wound
This double-blind randomized controlled trial investigated the effects of grape seed extract ointment on cesarean section wound healing in 129 women. The study found that grape seed extract ointment significantly improved wound approximation scores at the sixth and fourteenth post-intervention days compared to placebo.
The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia
A randomized double-blind placebo-controlled clinical trial with 70 patients with mild to moderate hyperlipidemia. The study found that red grape seed extract significantly elevated serum levels of apo-AI, HDL-C, and PON activity, while decreasing TC, TG, and LDL-C concentrations. These changes suggest potential benefits in preventing oxidative stress and atherosclerosis.
Effects of grape pomace in growing lamb diets compared with vitamin E and grape seed extract on meat shelf life.
The study compared the effects of grape pomace, vitamin E, and grape seed extract in lamb diets on meat shelf life. Vitamin E reduced microbial counts, meat discoloration, and lipid oxidation more effectively than grape seed extract and grape pomace. Grape seed extract and grape pomace showed a non-significant improvement in TBARS values compared to control.
Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension.
Double-blind, placebo-controlled RCT of 70 subjects with pre- and stage I hypertension testing 300 mg/d of grape seed extract (GSE) for 8 weeks. GSE did not significantly lower ambulatory blood pressure compared to placebo, and no effects were observed on vasoactive markers or platelet aggregation.
Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia.
A randomized double-blind placebo-controlled crossover clinical trial with 52 mildly hyperlipidemic individuals tested the effects of 200 mg/day red grape seed extract (RGSE) versus placebo over 8 weeks. RGSE consumption reduced total cholesterol, LDL cholesterol, and oxidized LDL, suggesting beneficial effects on lipid profiles and atherosclerosis risk.
Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting.
Double-blind, placebo-controlled, crossover clinical study evaluating the effectiveness of grape seed extract (GSE) on leg swelling in healthy Japanese women during prolonged sitting. GSE intake significantly suppressed leg volume distension, increase in body extracellular fluid, and leg water.
Effects of dietary polyphenol-rich grape products on intestinal microflora and gut morphology in broiler chicks.
The study evaluated the effects of grape pomace concentrate and grape seed extract on gut health in broiler chicks. Grape products modified gut morphology and intestinal microflora, increasing bacterial biodiversity. Grape seed extract decreased weight gain, while both grape products affected populations of various gut bacteria.
Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome.
RCT investigating the effect of grape seed extract (GSE) on blood pressure in subjects with metabolic syndrome. Subjects were randomized to placebo, 150 mg GSE, or 300 mg GSE per day for 4 weeks. GSE treatment lowered both systolic and diastolic blood pressures compared to placebo, with no significant changes in serum lipids or blood glucose.
Effects of chemical cross-linkers on caries-affected dentin bonding.
The study investigated the effects of glutaraldehyde and grape seed extract-induced cross-linking on dentin bond strengths and collagen stability. Results showed that chemical cross-linking agents significantly enhanced dentin bond strengths and increased collagen stability in both sound and caries-affected dentin.
Beneficial effects of grape seed extract on malondialdehyde-modified LDL.
Single-blind RCT of 61 healthy subjects with LDL cholesterol levels, comparing 0, 200, or 400 mg grape seed extract to placebo over 12 weeks. The 200 mg and 400 mg groups showed significant reductions in malondialdehyde-modified LDL levels, suggesting potential benefits for heart health and prevention of arteriosclerosis.
Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humans.
RCT with 69 volunteers comparing grape seed extract supplementation (1000 mg/day total polyphenols) to placebo for 6 weeks. Supplementation resulted in increased urinary excretion of 3-hydroxyphenylpropionic acid and 4-O-methylgallic acid, indicating metabolism of proanthocyanidins to phenolic acids.
The effect of grape-seed extract on 24 h energy intake in humans.
RCT assessing the effect of grape-seed extract on energy intake in 51 subjects. No overall difference in 24 h energy intake was found between grape-seed extract and placebo, but in a subgroup with higher energy requirements, intake was reduced by 4%. No significant effects on satiety, mood, or tolerance were observed.
Dietary grape seed extract mitigated growth retardation, hormonal delay, and gastrointestinal toxicity induced by insecticide imidacloprid in Nile tilapia
The study investigated the effects of grape seed extract (GSE) on mitigating growth retardation, hormonal delay, and gastrointestinal toxicity induced by the insecticide imidacloprid in Nile tilapia. 240 juvenile tilapias were divided into four groups, with one group receiving a diet containing 2% GSE alongside imidacloprid exposure. GSE improved growth indices, biochemical parameters, and digestive enzyme activity, suggesting it may reduce the adverse effects of imidacloprid exposure.
Assessing the Mechanism of Multiple Targets of Grape Seed for Psoriasis Disorder Via Network Pharmacology, Molecular Docking and Dynamics
The study used network pharmacology, molecular docking, and dynamic simulations to explore the therapeutic targets and mechanisms of grape seed components in treating psoriasis. Grape seed constituents like Epicatechin-3-gallate and Procyanidin b4, b6 showed promising anti-psoriatic properties by regulating inflammatory and immunomodulatory pathways.
Effects of dietary supplementation of grape seed extract in comparison with excessive level of vitamin E on growth performance and antioxidant function of broilers
The study evaluated the effects of dietary vitamin E or grape seed extract on growth performance and antioxidant function in broilers. Both supplements improved growth performance, antioxidant enzyme levels, and reduced liver damage in broilers fed oxidized rice bran oil, enhancing antioxidant capacity through the Keap1-Nrf2/ARE signaling pathway.
The impact of visible light component bands on polyphenols from red grape seed extract powder encapsulated in alginate–whey protein matrix
The study investigated the impact of visible light component bands on polyphenols from red grape seed extract powder encapsulated in an alginate–whey protein matrix. It found that encapsulation protected polyphenols, flavonoids, and cyanidin-3-O-glucoside when exposed to red-orange light, while the most intense polyphenol degradation occurred under cyan-blue-violet light.
Effectiveness of using hydrophobic silica aerogel and grape seed extract in creating a sunscreen formula
Experimental study evaluating the effectiveness of hydrophobic silica aerogel and grape seed extract in a sunscreen formula. The formulation showed satisfactory UV protection with an SPF value of 28.17073, medium sun protection factor, and demonstrated water resistance and stability under controlled conditions.
Effect of Callus Cell Immobilization on the Textural and Rheological Properties, Loading, and Releasing of Grape Seed Extract from Pectin Hydrogels
The study prepared pectin hydrogels with immobilized Lemna minor callus cells to examine the effect on textural, rheological, and swelling properties, as well as the loading and releasing of grape seed extract (GSE). The study found that cell content affected the hydrogels' properties and the release rate of GSE in different gastrointestinal fluids, indicating potential for controlled release and proanthocyanidin delivery systems.
Impact of grape (Vitis vinifera) seed extract on egg production traits, nutrients digestability, lipid peroxidation and fertility of golden laying hens (Gallus gallus) during early stage of production
Study on the effects of grape seed extract supplementation in 720 golden laying hens. Grape seed extract improved egg production, reduced lipid peroxidation, and enhanced fertility compared to control.
Feeding broilers with wheat germ, hops and grape seed extract mixture improves growth performance
Animal study on broilers fed with a mixture of wheat germ, hops, and grape seed extract (BX) to assess growth performance and other health indicators. Supplementation with 0.2% BX improved growth performance, reduced faecal emissions of H2S and NH3, decreased E. coli and Salmonella levels, and increased Lactobacillus levels.
AMELIORATIVE IMPACTS OF GRAPE SEED EXTRACT ON GROWTH PERFORMANCE, IMMUNE RESPONSE, ANTIOXIDANT CAPACITY AND BIOCHEMICAL CONSTITUENTS IN BROILERS EXPOSED TO FUMONISIN B1
The study assessed the impact of grape seed extract (GSE) on mitigating the toxic effects of Fumonisin B1 (FB1) in broilers. GSE at 250 or 500 mg/kg diet improved growth performance, immune response, antioxidant capacity, and biochemical constituents in broilers exposed to FB1. The 500 mg/kg dose was more effective than 250 mg/kg.
Supplementation with grape seed extract, onion peel extract, or rosemary extract in the diet alleviates growth inhibition, liver damage, and oxidative stress induced by diquat in Lohmann chicks
The study assessed the impact of grape seed extract, onion peel extract, and rosemary extract on diquat-induced growth restriction and oxidative stress in Lohmann chicks. The extracts improved antioxidant capacity and liver function, reducing oxidative stress and enhancing growth performance.
Winery by-products as a feed source with functional properties: dose–response effect of grape pomace, grape seed meal, and grape seed extract on rumen microbial community and their fermentation activity in RUSITEC
The study evaluated the nutritional and functional effects of grape seed meal, grape pomace, and grape seed extract on ruminal microbiota and fermentation characteristics using a rumen simulation technique. Different diets were tested, showing that winery by-products or grape seed extract could reduce excessive ammonia production and alter the rumen microbial community.
The effect of dry grape seed extract on the antioxidant properties of mixed feeds for fish
The study evaluated the antioxidant efficiency of compound feed with grape seed extract (95% proanthocyanides) for fish. The introduction of antioxidants into the fish diet aims to protect against stress by compensating for the effects of free radicals.
Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract
The study investigates the effects of a sunscreen formulation containing grape seed extract on Asian skin, focusing on its potential to provide additional protection against photoaging due to UV radiation.
Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract
The study developed bioadhesive polymeric patches using acacia gum and polyvinylpyrrolidone, loaded with grape seed extract (GSE) and cyclic dextrin. The patches demonstrated mechanical resistance and sustained release of GSE, promoting keratinocyte growth and exhibiting antibacterial and antioxidant activities.
EFFECT OF DIETARY GRAPE SEED EXTRACT SUPPLEMENTATION ON PRODUCTIVE PERFORMANCE OF AGED TWO LOCAL STRAINS OF LAYING HENS
The study investigated the effects of dietary grape seed extract supplementation on the productive performance of aged laying hens from two local strains. Hens fed with 1200 mg GSE/kg diet showed the highest egg production, egg mass, and best feed conversion ratios compared to control and other treatment groups.
MegaNatural®‐BP grape seed extract and maintenance of normal blood pressure: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
The paper evaluates the scientific substantiation of a health claim related to MegaNatural®‐BP grape seed extract and maintenance of normal blood pressure. Two human intervention studies were reviewed; one showed an effect on blood pressure, while the other did not. The evidence was insufficient to establish a cause and effect relationship.
Effect of Grape Seed Extract on Tibial Dyschondroplasia Incidence, Liver Weight, and Tibial Angiogenesis in Chickens
The study evaluated the effect of grape seed extract (GSE) on tibial dyschondroplasia (TD) in chickens. GSE treatment reduced TD scores, inflammation, and lesions, while increasing body weight gain, liver weight, and angiogenesis in affected chickens.
Grape Seed Extract Supplementation and the Effects on the Biomarkers of Oxidative Stress and Metabolic Profiles in Female Volleyball Players: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
This randomized, double-blind, placebo-controlled clinical trial studied the effects of grape seed extract (GSE) supplementation on oxidative stress and metabolic profiles in 40 female volleyball players. GSE supplementation significantly increased plasma glutathione levels and decreased malondialdehyde levels, serum insulin concentrations, and insulin resistance markers compared to placebo.
Anti-inflammatory effects of grape seed extract in hemodialysis patients; a pilot study
Pilot RCT investigating the anti-inflammatory effects of 200 mg/day grape seed extract in 30 hemodialysis patients. The study found no statistically significant changes in markers of inflammation, lipid profiles, and blood factors after one month of treatment.
Safety assessment of 4-week oral intake of proanthocyanidin-rich grape seed extract in healthy subjects.
A clinical study assessed the safety and tolerability of oral doses of proanthocyanidin-rich grape seed extract (GSE) in 29 healthy Japanese adults over 4 weeks. Serum Fe levels decreased in two subjects in the 2500 mg group but returned to near baseline after the study. GSE intake up to 2500 mg was generally safe and well tolerated.
Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial.
A randomised, double-blinded, placebo-controlled trial tested grape seed extract (GSE) in middle-aged adults with pre-hypertension. GSE significantly reduced systolic and diastolic blood pressure after 6 weeks, with greater reductions in subjects with higher initial BP. Fasting insulin and insulin sensitivity tended to improve, while no significant changes were observed in other metabolic indices.
The effect of grape seed extract on estrogen levels of postmenopausal women: a pilot study.
A randomized, double-blind, dose-finding early-phase trial on the effect of grape seed extract (GSE) on estrogen levels in postmenopausal women. The study found that GSE in doses of 200, 400, 600, or 800 mg daily for 12 weeks did not significantly decrease estrogen or increase androgen precursors.
Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: results from a vehicle controlled, double-blind, randomized study.
A randomized, controlled, double-blinded study in 30 healthy volunteers assessed the effectiveness of SPF 30 sunscreen supplemented with an antioxidant cocktail (grape seed extract, vitamin E, ubiquinone, and vitamin C) in protecting human skin against IRA radiation-induced MMP-1 upregulation. The antioxidant-supplemented sunscreen significantly reduced MMP-1 expression compared to sunscreen alone, indicating effective photoprotection.
The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers.
Open label, randomized, cross-over study examining the pharmacokinetic interaction between grape seed extract (GSE) and dextromethorphan in 30 healthy volunteers. GSE supplementation did not significantly affect the urinary dextromethorphan to dextrorphan metabolic ratio, indicating GSE is safe to combine with drugs metabolized by CYP2D6.
Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome - randomized, cross-over, placebo-controlled study
Randomized, cross-over, placebo-controlled study on the effect of grape seed extract (GSE) on postprandial oxidative stress and metabolic responses in 12 subjects with metabolic syndrome. GSE enhanced postprandial plasma antioxidant status and reduced the glycemic response to a high-fat, high-carbohydrate meal, but did not change inflammatory markers.
Effect of dietary grape seed extract and Cistus ladanifer L. in combination with vegetable oil supplementation on lamb meat quality.
RCT with 36 Merino Branco lambs testing dietary grape seed extract and Cistus ladanifer with vegetable oil supplementation on meat quality. Grape seed extract and C. ladanifer protected meat against lipid oxidation, but did not affect meat colour or sensory properties.
Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity.
Double-blind randomized placebo-controlled trial of grape seed extract (GSE) in 32 Type 2 diabetic patients at high cardiovascular risk. GSE significantly improved markers of inflammation, glycaemia, and a marker of oxidative stress over a 4-week period, suggesting a potential therapeutic role in decreasing cardiovascular risk.
The effect of OPC Factor on energy levels in healthy adults ages 45-65: a phase IIb randomized controlled trial.
A phase IIb randomized, placebo-controlled, triple-blind crossover study evaluated the efficacy of OPC Factor, a food supplement containing oligomeric proanthocyanidins, on energy levels in 25 healthy adults aged 45-65. The study found no significant difference in energy levels using the AD ACL Energy subscale, but some measures of global energy change approached or reached statistical significance, suggesting potential benefits.
Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract.
RCT assessing the effects of a flavanol-rich grapeseed extract on platelet reactivity and plasma oxidant defense in male smokers. The supplement significantly decreased ADP-stimulated and epinephrine-stimulated platelet reactivity compared to placebo, suggesting potential cardiovascular benefits.
Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study.
This randomized, double-blind, placebo-controlled study examined the effects of chromium polynicotinate and grape seed extract on lipid profiles in 40 hypercholesterolemic subjects. The combination of chromium and grape seed extract significantly decreased total cholesterol and LDL levels compared to placebo. There was also a trend towards decreased autoantibodies to oxidized LDL in groups receiving grape seed extract.
Chemical Composition, Antioxidant and Immunomodulatory Properties of Syrah Grape Seed Extract.
The study characterized Syrah grape seed extract and demonstrated its immunomodulatory properties in systemic lupus erythematosus (SLE). Grape seed extract increased Th1 cells and upregulated HLA-DR on Th1 cells in both healthy individuals and SLE patients, indicating potential immunomodulatory effects.
Effect of Grape Seed (Vitis vinifera) Extract on Growth and Blood Parameters of Ctenopharyngodon idella (Grass carp) and Carassius auratus (Goldfish)
The study investigated the effects of grape seed extract on growth and blood parameters in grass carp and goldfish over 60 days. Results showed significant improvements in survival rate, growth metrics, and blood parameters, indicating grape seed extract as a potential growth and immunity enhancer for fish.
Postbiotics derived from wine grape seed extract and whey with lactic acid bacteria alleviate muscle atrophy by modulating genes involved in inflammation, myogenesis, and bone metabolism.
Animal study on C57BL/6J mice with immobilized hindlimbs fed different diets including a postbiotic product derived from wine grape seed extract and whey. The WDG group showed significant improvements in muscle mass, gene expression related to muscle growth, and anti-inflammatory effects, suggesting potential benefits for managing sarcopenia.
Nutritional and Functional Values of Grape Seed Flour and Extract for Production of Antioxidative Dietary Supplements and Functional Foods
The study evaluated the nutritional and functional values of grape seed flour and extract from Pinot Noir and Marselan grapes for use as antioxidative dietary supplements and functional foods. The extracts were rich in polyphenols, particularly flavonoids and procyanidins, and showed high inhibitory potential against enzymes affecting diabetes and obesity.
Proteome evaluation of the biological activity of grape seed extract (GSE) on the intestine of rats.
This study investigates the effects of grape seed extract (GSE) on the intestinal proteome of rats. Using SWATH-MS quantitative proteomics, the research highlights significant alterations in metabolic and immune regulatory pathways in the ileum, suggesting potential mechanisms through which GSE affects gastrointestinal function.
Grape Seed Extract NSPCC1 Counteracts Mouse Skin Aging via Modulating MAPK and AMPK Pathways.
The study evaluated a newly processed PCC1-rich grape seed extract (NSPCC1) against UV- and d-galactose-induced skin aging in mice. NSPCC1 supplementation mitigated skin cell death, collagen degradation, and structural atrophy while enhancing antioxidant defenses and modulating MAPK and AMPK pathways.
Abstract 4240: Combining belinostat with red grape seed extract effectively inhibits cell proliferation, induces apoptosis, and reduces tumor resistance to doxorubicin by targeting mutant KRAS and p-ERK in human breast cancer
The study investigates the combination of red grape seed extract (GSE) and Belinostat in breast cancer treatment. In vitro tests on breast cancer cell lines showed that the combination reduced cell proliferation, induced apoptosis, and decreased tumor resistance to Doxorubicin by targeting mutant KRAS and p-ERK. The combination exhibited synergistic effects in MDA-MB-231 cells and significant anticancer activity in an in vivo xenograft model.
Quantitative phenolic profiling and protective effects of grape seed extract on mancozeb-induced cellular and genetic toxicity
The study investigated the protective effects of grape seed extract (GSE) against mancozeb-induced toxicity in Allium cepa L. GSE mitigated adverse effects such as increased micronucleus frequency, chromosomal aberrations, lipid peroxidation, and DNA damage caused by mancozeb, with higher GSE concentrations showing greater efficacy.
Grape seed proanthocyanidins improves growth performance, antioxidative capacity, and intestinal microbiota in growing pigs
The study explored the effect of dietary grape seed proanthocyanidin (GSP) supplementation on growth performance, nutrient digestibility, and intestinal microbiota in 180 growing pigs. GSP supplementation improved growth performance, nutrient digestibility, antioxidative capacity, and altered gut microbiota composition, suggesting potential benefits for animal nutrition.