Research
Glehnia (Bei Sha Shen)
18 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Glehnia littoralis Fr. Schmidtex Miq.: A systematic review on ethnopharmacology, chemical composition, pharmacology and quality control.
Systematic review of Glehnia littoralis, a traditional Chinese herbal medicine, covering its ethnopharmacology, chemical composition, pharmacological activities, and quality control. The review highlights its clinical applications in traditional medicine and identifies key bioactive compounds such as polyacetylenes and coumarins. The paper calls for further research on its pharmacological effects and quality standards.
Tailoring red, green, and blue LED spectra to improve yield and quality of Glehnia littoralis.
The study proposes a methodology for optimizing light conditions in Controlled Environment Agriculture (CEA) and applies it to the medicinal herb Glehnia littoralis. Using a mixture design and response surface methodology, the optimal light spectrum was identified as R:B = 7:5, enhancing growth and stimulating secondary metabolism, leading to increased biomass and accumulation of medicinally valuable compounds.
Mechanism of Shashen-Maidong herb pair in treating hepatocellular carcinoma using network pharmacology and experimental validation.
The study investigates the mechanism of the Shashen-Maidong herb pair in treating hepatocellular carcinoma (HCC) using network pharmacology and experimental validation. It identifies active components and targets, focusing on the Notch and Apoptosis signaling pathways, and demonstrates immunomodulatory effects in tumor-bearing mice and cell co-culture experiments.
Anti-inflammatory effects of Glehnia littoralis ethyl acetate extract and its active compound phellopterin via inhibition of N-acylethanolamine acid amidase.
The study evaluated the anti-inflammatory potential of the ethyl acetate fraction of Glehnia littoralis and identified phellopterin as a key constituent responsible for inhibiting N-acylethanolamine acid amidase (NAAA). In vitro and in vivo models showed that the extract and phellopterin reduced inflammation markers such as NO, IL-6, and TNF-α, and ameliorated edema, supporting the traditional use of G. littoralis for inflammation relief.
Cytotoxic activity of Cpolyacetylenes from the roots of Glehnia littoralis against drug-resistant colorectal and lung cancer cells.
The study investigates the cytotoxic activity of Cpolyacetylenes from the roots of Glehnia littoralis against drug-resistant colorectal and lung cancer cells. Falcarinol and falcarindiol showed cytotoxic activity against oxaliplatin-sensitive/resistant CRC and gefitinib-sensitive/resistant NSCLC cells. However, some newly purified compounds did not show activity, highlighting the need to consider the stability of Cpolyacetylenes for anticancer development.
Knockdown of long noncoding RNA MALAT1 enhances the anti-cancer effects of polysaccharides Glehnia littoralis in lung cancer cells possibly via the regulation of miR-145/SOX9 axis.
The study investigates the role of MALAT1, miR-145, and the effects of polysaccharides from Glehnia littoralis (PGL) in non-small-cell lung cancer (NSCLC). PGL treatment decreased cell viability and down-regulated MALAT1 in A549 NSCLC cells. Knockdown of MALAT1 enhanced the effects of PGL on NSCLC cell viability, apoptosis, and migration, suggesting a novel MALAT1/miR-145/SOX9 pathway for NSCLC progression.
Standardized extract of Glehnia Littoralis abrogates memory impairment and neuroinflammation by regulation of CREB/BDNF and NF-κB/MAPK signaling in scopolamine-induced amnesic mice model.
The study investigated the neuroprotective and anti-neuroinflammatory effects of a 50% ethanol extract of Glehnia littoralis (GLE) on LPS-stimulated BV-2 cells and scopolamine-induced amnesic mice. GLE treatment ameliorated memory impairment and improved memory function in mice, decreased AChE levels, upregulated neuroprotective markers, and inhibited NF-κB/MAPK signaling and neuroinflammation.
Authentication of commercial processed Glehniae Radix (Beishashen) by DNA barcodes.
The study evaluated the use of ITS2 DNA barcoding to distinguish Glehniae Radix from its common adulterants. The ITS2 region showed 100% identification efficiency, successfully differentiating Glehniae Radix from adulterants using DNA sequences and phylogenetic analysis.
An animal research and a chemical composition analysis of a Chinese prescription for pulmonary fibrosis: Yangfei Huoxue Decoction.
Animal study on Yangfei Huoxue Decoction (YHD) for pulmonary fibrosis in rats. YHD showed inhibitory effects on VEGF and IL-1β expression, suggesting potential anti-inflammatory and anti-fibrotic properties. Chemical analysis identified 55 components in YHD, including lignans, flavonoids, and tanshinones.
PretreatedExtract Prevents Neuronal Death Following Transient Global Cerebral Ischemia through Increases of Superoxide Dismutase 1 and Brain-derived Neurotrophic Factor Expressions in the Gerbil Hippocampal Cornu Ammonis 1 Area.
The study examined the neuroprotective effects of Glehnia littoralis extract (GLE) in a gerbil model of transient global cerebral ischemia. Pretreatment with GLE protected neurons in the hippocampal CA1 area from ischemic damage and increased expressions of SOD1 and BDNF, suggesting a neuroprotective mechanism involving antioxidant and neurotrophic pathways.
Glehnia littoralis Root Extract Induces G0/G1 Phase Cell Cycle Arrest in the MCF-7 Human Breast Cancer Cell Line.
In vitro study of Glehnia littoralis root extract on MCF-7 human breast cancer cells. The extract inhibited cell proliferation in a dose-dependent manner and induced G0/G1 phase cell cycle arrest by increasing p21 and p27 expression and decreasing CDK4 and cyclin D1.
Pyranocoumarins from Glehnia littoralis inhibit the LPS-induced NO production in macrophage RAW 264.7 cells.
The study isolated pyranocoumarins from Glehnia littoralis and evaluated their ability to inhibit LPS-induced nitric oxide production in RAW 264.7 macrophage cells. All compounds showed potential inhibitory effects with IC50 values ranging from 7.4 to 44.3μM.
Anti-inflammatory effects of Glehnia littoralis extract in acute and chronic cutaneous inflammation.
The study investigated the anti-inflammatory effects of Glehnia littoralis extract on skin inflammation in mice. The extract inhibited edema, reduced skin thickness and tissue weight, decreased inflammatory cytokine production, and reduced neutrophil-mediated MPO activity in TPA-induced mouse ear edema. It also reduced inflammatory damage from chronic TPA exposure and inhibited vascular permeability induced by acetic acid.
Anti-inflammatory activity of methylene chloride fraction from Glehnia littoralis extract via suppression of NF-kappa B and mitogen-activated protein kinase activity.
The study investigated the anti-inflammatory effects of the methylene chloride fraction from Glehnia littoralis extract (MCF-GLE) in an inflammatory edema mouse model and in vitro using RAW 264.7 macrophage cells. MCF-GLE inhibited TPA-induced inflammation and suppressed pro-inflammatory mediators and pathways, suggesting its potential as a therapeutic agent.
Antibacterial and antifungal polyine compounds from Glehnia littoralis ssp. leiocarpa.
The study investigates the antibacterial and antifungal properties of Glehnia littoralis ssp. leiocarpa, identifying two new polyine compounds with these properties.
Extract Promotes Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Mouse through Increasing Expressions of Brain-Derived Neurotrophic Factor and Tropomyosin-Related Kinase B.
Study examined the effects of Glehnia littoralis extract on neurogenesis in the hippocampus of adult mice. Treatment with 200 mg/kg significantly increased cell proliferation, neuroblast differentiation, and neuronal maturation, associated with increased BDNF and TrkB protein levels.
A new aromatic glycoside from Glehnia littoralis.
A new aromatic glycoside was isolated from the roots of Glehnia littoralis and identified as vanillic acid 1-O-[β-D-apiofuranosyl-(1 → 6)-β-D-glucopyranoside] ester. In vitro assays showed it has TNF-α secretion inhibitory activity.
The antioxidant effects of aqueous and organic extracts of Panax quinquefolium, Panax notoginseng, Codonopsis pilosula, Pseudostellaria heterophylla and Glehnia littoralis.
The study evaluated the antioxidant effects of aqueous and organic extracts from the roots of several herbs. Glehnia littoralis and Codonopsis pilosula aqueous extracts were most potent in inhibiting erythrocyte hemolysis, while organic extracts of Glehnia littoralis, Panax heterophylla, and Panax quinquefolium were potent in inhibiting lipid peroxidation.