Research
Ginger
110 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Antioxidant and anti-inflammatory effects of ginger supplementation in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials.
This systematic review and dose-response meta-analysis of 29 RCTs assessed the effects of ginger supplementation on inflammation and antioxidant biomarkers. Ginger supplementation improved biomarkers such as CRP, TNF-α, IL-6, TAC, MDA, and SOD, indicating potential benefits for inflammatory and oxidative status, especially in individuals with underlying health conditions.
The efficacy and safety of complementary and alternative medicine in the treatment of nausea and vomiting during pregnancy: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of complementary and alternative medicine (CAM) therapies for nausea and vomiting during pregnancy (NVP). Ginger was found to have significant effects compared to conventional medicine and placebo in alleviating NVP, although the quality of evidence was low to moderate. The study concludes that CAM therapies, including ginger, can alleviate NVP, but more high-quality RCTs are needed.
The effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 10 RCTs evaluating ginger supplementation in patients with type 2 diabetes. Significant reductions were found in fasting blood sugar (FBS), HbA1C, systolic blood pressure (SBP), and diastolic blood pressure (DBP) after ginger supplementation, with no significant changes in lipid profile.
Efficacy of Ginger in Preventing Postoperative Nausea and Vomiting: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 14 RCTs involving 1417 participants evaluating ginger's efficacy in preventing postoperative nausea and vomiting (PONV). Ginger significantly reduced nausea severity and the need for rescue antiemetics compared to placebo, and showed lower incidence of nausea compared to prophylactic antiemetics.
Impact of Ginger Root Powder Dietary Supplement on Productive Performance, Egg Quality, Antioxidant Status and Blood Parameters in Laying Japanese Quails
This study evaluated the effects of ginger root powder on the performance, egg quality, and blood parameters of Japanese quail. A total of 240 female quails were used in a randomized design with four treatments. Ginger supplementation did not significantly affect egg production or quality but improved feed intake and conversion ratio. It also increased albumen height, Haugh unit, and albumen pH, and reduced blood triglyceride levels.
Efficacy and Safety of Ginger regarding Human Milk Volume and Related Clinical Outcomes: A Systematic Review of Randomized Controlled Trials.
Systematic review of RCTs evaluating ginger's effect on human milk volume. Ginger enhanced milk volume in mothers with vaginal births but not in those with C-sections. Combination products with ginger were also effective. No adverse effects directly related to ginger were reported.
Effect of ginger (Zingiber officinale) supplementation on oxidative stress parameters: A systematic review and meta-analysis.
Systematic review and meta-analysis of 12 RCTs evaluating the effect of ginger supplementation on oxidative stress parameters. Ginger intake significantly increased glutathione peroxidase activity and total antioxidant capacity, and decreased malondialdehyde levels compared to controls.
Effects of ginger supplementation on biomarkers of oxidative stress: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 11 RCTs investigating the effects of ginger on biomarkers of oxidative stress. Ginger supplementation significantly increased glutathione peroxidase (GPx) and reduced malondialdehyde (MDA), but showed no significant change in total antioxidant capacity (TAC).
Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis.
This meta-analysis included 13 studies with 1174 subjects to evaluate the effect of ginger on nausea and vomiting during pregnancy. Ginger significantly improved general symptoms of nausea and vomiting in pregnancy compared to placebo, but not vomiting specifically. Compared to vitamin B6, ginger showed no significant differences in effectiveness.
Effectiveness of Ginger on Pain and Function in Knee Osteoarthritis: A PRISMA Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of randomized clinical trials assessing the effectiveness of ginger for pain relief and knee function improvement in knee osteoarthritis. The review found insufficient evidence to support the use of oral ginger compared with placebo for pain relief and function improvement, with no statistically significant differences found in other comparisons.
The effects of ginger supplementation on markers of inflammatory and oxidative stress: A systematic review and meta-analysis of clinical trials.
Systematic review and meta-analysis of clinical trials investigating the effects of ginger supplementation on markers of inflammatory and oxidative stress. The analysis included 25 studies and found significant effects of ginger on serum CRP, TNF-α, IL-6, TAC, and MDA levels, with marginal significance on serum PGE2.
Does ginger supplementation lower blood pressure? A systematic review and meta‐analysis of clinical trials
Systematic review and meta-analysis of six randomized clinical trials with 345 participants assessing the effect of ginger supplementation on blood pressure. Ginger supplementation was found to reduce systolic and diastolic blood pressure, particularly in studies with participants aged ≤ 50 years, follow-up duration of ≤8 weeks, and ginger doses ≥3 g/d.
Efficacy of Ginger (Zingiber officinale) in Ameliorating Chemotherapy-Induced Nausea and Vomiting and Chemotherapy-Related Outcomes: A Systematic Review Update and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of ginger supplementation on chemotherapy-induced nausea and vomiting in adult cancer patients. Ginger supplementation reduced the likelihood of acute vomiting and fatigue, but no significant association was found with overall or delayed vomiting, nausea, or other related outcomes.
Effects of Ginger (Zingiber officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Systematic review and meta-analysis of 10 RCTs with 490 individuals assessing ginger's effects on type 2 diabetes mellitus and metabolic syndrome. Ginger showed significant beneficial effects on glucose control, insulin sensitivity, and lipid profile, suggesting it as a promising adjuvant therapy.
A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting.
This systematic review and meta-analysis evaluated the effectiveness and safety of ginger for treating nausea and vomiting during pregnancy. It included 12 RCTs with 1278 pregnant women, finding that ginger significantly improved nausea symptoms compared to placebo, but did not significantly reduce vomiting episodes. Ginger was not associated with significant risks of spontaneous abortion or side-effects like heartburn or drowsiness.
Nausea and vomiting in early pregnancy.
Systematic review evaluating the effectiveness and safety of various interventions for nausea and vomiting in early pregnancy, including acupressure, acupuncture, corticosteroids, ginger, metoclopramide, ondansetron, prochlorperazine, promethazine, and pyridoxine (vitamin B6).
Nausea and vomiting in early pregnancy.
Systematic review evaluating the effectiveness and safety of various interventions for nausea and vomiting in early pregnancy, including ginger and pyridoxine (vitamin B6). The review includes 30 systematic reviews, RCTs, or observational studies.
Nausea and vomiting in early pregnancy.
Systematic review evaluating the effectiveness and safety of various interventions for nausea and vomiting in early pregnancy, including ginger and pyridoxine (vitamin B6). The review includes 22 systematic reviews, RCTs, or observational studies.
Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma.
RCT of 68 adults with prior colorectal adenoma assessing the effect of ginger supplementation on the fecal microbiome. Ginger supplementation showed no significant effect on microbial community structure but led to significant decreases in the relative abundances of CRC-associated taxa Akkermansia, Bacteroides, and Ruminococcus.
Effect of a standardized ginger root powder regimen on chemotherapy-induced nausea and vomiting: a multi-center double-blind placebo-controlled randomized trial.
A double-blind, placebo-controlled randomized trial assessed the effect of ginger on chemotherapy-induced nausea and vomiting (CINV) in 103 chemotherapy-naïve adults. Ginger supplementation improved nausea-related quality of life, reduced delayed nausea severity, and decreased the incidence of malnutrition during chemotherapy cycles.
The Effects of Ginger (Zingiber Officinale Roscoe) on Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blinded Placebo-Controlled Clinical Trial
This randomized double-blinded placebo-controlled clinical trial assessed the effects of ginger supplementation in 76 patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease. Ginger supplementation significantly improved systolic and diastolic blood pressures, serum insulin levels, insulin resistance (HOMA-IR), and HDL-cholesterol levels, but did not significantly affect inflammatory markers or fibroscan imaging indices.
Effect of Ginger Root Powder on Gastrointestinal Bacteria Composition, Gastrointestinal Symptoms, Mental Health, Fatigue, and Quality of Life: A Double-Blind Placebo-Controlled Trial.
A double-blind placebo-controlled trial investigated the effects of 1.2 g/d ginger root powder on gastrointestinal bacteria composition and associated outcomes in 51 healthy adults. Ginger supplementation increased the relative abundance of certain bacterial phyla and improved indigestion symptoms, but did not affect alpha or beta diversity, bowel function, mood, or quality of life.
Ginger supplementation does not increase energy expenditure in female adults.
This study is a secondary analysis of a randomized, double-blind, placebo-controlled clinical trial evaluating the effect of long-term consumption of dry ginger extract on resting energy expenditure (REE) in female adults with high body adiposity. The study found that ginger extract consumption for 3 months did not change the REE, anthropometric, and clinical data of the participants.
What is the efficacy of dietary, nutraceutical, and probiotic interventions for the management of gastroesophageal reflux disease symptoms? A systematic literature review and meta-analysis.
Systematic review and meta-analysis of dietary, nutraceutical, and probiotic interventions for GERD symptoms. Ginger-containing supplements showed improved GERD symptom alleviation in meta-analysis. Other interventions like probiotic yoghurt, psyllium husk, and specific supplements showed improvements in qualitative synthesis.
Comparison of the effect of ginger and aloe vera mouthwashes on xerostomia in patients with type 2 diabetes: A clinical trial, triple-blind.
Triple-blind clinical trial comparing the effects of ginger and aloe vera mouthwashes on xerostomia in patients with type 2 diabetes. Both ginger and aloe vera mouthwashes significantly reduced symptoms and severity of xerostomia compared to normal saline.
Effects of Ginger on clinical manifestations and paraclinical features of patients with Severe Acute Respiratory Syndrome due to COVID-19: A structured summary of a study protocol for a randomized controlled trial
This is a study protocol for a randomized controlled trial investigating the effects of Ginger on clinical manifestations and paraclinical features in patients with confirmed COVID-19. The trial is a double-blind, placebo-controlled study with 84 participants, comparing standard COVID-19 treatment with and without Ginger-based herbal tablets.
Ginger extract versus Loratadine in the treatment of allergic rhinitis: a randomized controlled trial
RCT comparing ginger extract (500 mg) to loratadine (10 mg) in 80 patients with allergic rhinitis over 3 and 6 weeks. Both treatments significantly decreased total nasal symptom scores and improved quality of life, with ginger extract showing additional benefits in nasal cavity volume and fewer side effects.
Effect of ginger on the blood glucose level of women with gestational diabetes mellitus (GDM) with impaired glucose tolerance test (GTT): a randomized double-blind placebo-controlled trial
This randomized double-blind placebo-controlled trial studied the effect of ginger on blood glucose levels in 70 women with gestational diabetes mellitus (GDM) and impaired glucose tolerance. The ginger group showed significant reductions in fasting blood sugar, fasting insulin, and HOMA index after six weeks, but no significant change in 2-hour post-prandial blood sugar levels.
Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: a single-blind clinical trial
Single-blind clinical trial comparing the effects of vitamin D, vitamin E, and ginger on dysmenorrhea severity in 200 female students. Ginger showed the most significant reduction in pain severity, followed by vitamin D and vitamin E.
Does the Oral Administration of Ginger Reduce Chemotherapy-Induced Nausea and Vomiting?: A Meta-analysis of 10 Randomized Controlled Trials.
Meta-analysis of 10 randomized controlled trials assessing the efficacy of ginger in controlling chemotherapy-induced nausea and vomiting (CINV). Results showed ginger significantly reduced acute CINV, particularly acute vomiting, in patients undergoing chemotherapy.
Effect of ginger (Zingiber officinale) on semen quality.
Systematic review summarizing over 35 original articles on the effects of ginger on semen quality and sperm parameters. Evidence suggests ginger enhances semen quality by improving sperm concentration, viability, motility, and morphology, potentially due to increased gonadal hormones and decreased oxidative damage.
A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy.
Systematic review assessing the efficacy of alternative medicine in treating nausea and vomiting of pregnancy. Ginger showed a positive effect on nausea, though one study found it ineffective for vomiting. Ginger was more effective than vitamin B, but over 60 days, vitamin B6 was more effective. Other herbs like matricaria chamomilla, elettaria cardamomum, pomegranate, spearmint syrup, and lemon were also effective.
Interventions for treating nausea and vomiting in pregnancy: a network meta-analysis and trial sequential analysis of randomized clinical trials.
Network meta-analysis of interventions for nausea and vomiting in pregnancy, including acupuncture, chamomile, dimenhydrinate, doxylamine/vitamin B6, ginger, quince, metoclopramide, and vitamin B6. Ginger and vitamin B6 were associated with reduced nausea scores and better vomiting control, with ginger having moderate quality evidence supporting its use.
The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis
Systematic review and meta-analysis of 9 studies evaluating the effect of ginger supplementation on serum CRP, lipid profile, and glycaemia. Ginger supplementation significantly reduced serum CRP and improved glycaemia indexes and lipid profile.
Efficacy of Oral Ginger (Zingiber officinale) for Dysmenorrhea: A Systematic Review and Meta-Analysis
Systematic review and meta-analysis of six RCTs examining oral ginger for dysmenorrhea. Ginger was more effective than placebo in reducing pain severity, but no significant difference was found between ginger and mefenamic acid. The review suggests ginger could be effective for menstrual pain, though findings are limited by small study numbers and methodological quality.
Efficacy of ginger for treating Type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials
Systematic review and meta-analysis of five RCTs assessing ginger supplementation for Type 2 diabetes management. Ginger significantly lowered fasting blood glucose and HbA1c levels, but did not significantly affect fasting blood insulin or HOMA-IR.
Aromatherapy as treatment for postoperative nausea: a randomized trial.
A randomized trial examined the effectiveness of aromatherapy with ginger, a blend of ginger, spearmint, peppermint, and cardamom, or isopropyl alcohol for postoperative nausea (PON) in 301 patients. The study found significant reductions in nausea levels with ginger and the blend compared to saline, but not with alcohol. Aromatherapy reduced the need for antiemetic medications.
Herb remedies during pregnancy: a systematic review of controlled clinical trials.
Systematic review of RCTs on herbal remedies during pregnancy. Ginger was consistently reported to ameliorate nausea and vomiting better than placebo, with efficacy equal to vitamin B6 and dimenhydrinate. Other herbs like Hypericum perforatum, cranberry, raspberry leaf, and garlic showed no significant benefits for their respective uses.
Interventions for nausea and vomiting in early pregnancy.
Systematic review assessing treatments for nausea and vomiting in early pregnancy. It includes trials on anti-histamines, vitamin B6 (pyridoxine), Debendox, P6 acupressure, ginger root, and ACTH injections. Pyridoxine appears effective in reducing nausea severity, while ginger may be beneficial but evidence is weak.
Synergistic Effects of Green Tea Extract and Ginger Supplementation on Endurance Performance and Thermal Perception in Normothermic and Cold Environments: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial.
This randomized, double-blind crossover trial assessed the effects of green tea extract and ginger supplementation on endurance performance and thermal perception in normothermic and cold environments. Green tea and combined supplementation significantly increased time-to-exhaustion and reduced respiratory exchange ratio in normothermic conditions, while combined supplementation improved performance, thermal comfort, and recovery in cold environments.
Effects of Aphrodite (an Herbal Compound) on SSRI-Induced Sexual Dysfunctions and Depression in Females with Major Depressive Disorder: Findings from a Randomized Clinical Trial.
RCT assessing the effects of Aphrodite, an herbal compound, on SSRI-induced sexual dysfunctions and depression in females with major depressive disorder. Aphrodite improved symptoms of sexual dysfunction, depression, and anxiety compared to placebo.
Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial
This randomized clinical trial studied the effect of ginger powder supplementation on patients with non-alcoholic fatty liver disease (NAFLD). Over 12 weeks, the ginger group showed significant decreases in serum levels of ALT, total cholesterol, LDL-C, fasting blood glucose, insulin resistance index, and inflammatory markers compared to placebo.
Effects of aromatherapy massage on pain, functional state, and quality of life in an elderly individual with knee osteoarthritis.
RCT conducted in two nursing homes with 90 elderly individuals with knee osteoarthritis, randomized into aromatherapy, massage, and control groups. Aromatherapy group received massage with ginger and rosemary essential oils in black seed oil, showing significant improvements in pain, functional state, and quality of life compared to massage and control groups at week 4, with sustained effects at week 8.
The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis.
This randomized double-blind placebo-controlled clinical trial investigated the effect of 1500 mg ginger supplementation on gene expression related to immunity and inflammation in 70 patients with active Rheumatoid Arthritis. Ginger supplementation significantly increased FoxP3 gene expression and decreased T-bet and RORγt gene expression, leading to a reduction in disease activity score.
The effect of ginger supplementation on IL2, TNFα, and IL1β cytokines gene expression levels in patients with active rheumatoid arthritis: A randomized controlled trial
RCT of 66 patients with active rheumatoid arthritis comparing 1.5g ginger supplementation to placebo. Ginger supplementation significantly reduced CRP and IL-1β mRNA levels, suggesting an improvement in inflammation.
Comparative Evaluation of Cocoa Bean Husk, Ginger and Chlorhexidine Mouth Washes in the Reduction of Steptococcus Mutans and Lactobacillus Count in Saliva: A Randomized Controlled Trial
RCT comparing the efficacy of cocoa bean husk, ginger, and chlorhexidine mouth rinses on reducing S. mutans and Lactobacillus populations in saliva. Cocoa bean husk and chlorhexidine significantly reduced S. mutans, while ginger significantly reduced Lactobacillus.
Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial.
RCT of 140 lung cancer patients receiving cisplatin-based regimens to test ginger root powder as an adjuvant to standard antiemetic therapy for chemotherapy-induced nausea and vomiting. No significant difference was observed between ginger and placebo groups in reducing nausea and vomiting severity or incidence.
A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP).
Triple blind clinical trial comparing ginger, vitamin B6, and placebo for treating nausea and vomiting in pregnancy (NVP) in 77 women. Ginger and vitamin B6 significantly reduced NVP symptoms compared to placebo, with ginger being more effective for nausea and distress of vomiting.
The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial
Double-blind, randomized, placebo-controlled trial of 51 patients undergoing chemotherapy, testing 1.2 g of standardized ginger extract daily for its effect on chemotherapy-induced nausea-related quality of life. Ginger supplementation improved quality of life related to chemotherapy-induced nausea and vomiting, global quality of life, and reduced fatigue in certain chemotherapy cycles compared to placebo.
The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial
This double-blind randomized clinical trial investigated the effects of ginger on sperm DNA fragmentation (SDF) in 100 infertile men. The study found that ginger significantly decreased SDF compared to placebo after three months of treatment, although there were no significant differences in other semen parameters.
Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer.
RCT of 65 Iranian women with breast cancer undergoing chemotherapy, testing the effect of ginger and chamomile capsules on chemotherapy-induced nausea and vomiting. Both ginger and chamomile significantly reduced vomiting frequency, with ginger also significantly reducing nausea frequency.
The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial
A randomized, double-blind, placebo-controlled trial comparing ginger and artichoke supplementation to placebo in 126 patients with functional dyspepsia over 4 weeks. The supplementation group showed significant improvements in nausea, epigastric fullness, pain, and bloating compared to placebo.
Effects of Supplementation with Ginger (Zingiber officinale Roscoe) on Serum Glucose, Lipid Profile and Oxidative Stress in Obese Women: A Randomized, Placebo-Controlled Clinical Trial
RCT of 80 obese women comparing 2g ginger powder supplementation to placebo over 12 weeks. Ginger group showed significant reductions in serum triglycerides and minor reductions in serum glucose compared to placebo. No significant effects on serum MDA and TAC levels were observed.
Oral intake of encapsulated dried ginger root powder hardly affects human thermoregulatory function, but appears to facilitate fat utilization.
The study investigated the impact of a single oral ingestion of 1.0 g dried ginger root powder on thermoregulatory function and fat oxidation in humans. Ginger ingestion did not affect thermoregulatory parameters but significantly elevated serum free fatty acids and increased fat oxidation by 13.5% in the morning.
Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer.
RCT investigating the effect of 2.0 g/day ginger consumption on COX-1 and 15-PGDH expression in colonic mucosa of participants at normal and increased risk for colorectal cancer. Ginger significantly reduced COX-1 protein levels in participants at increased risk for CRC but did not alter 15-PGDH protein expression in either group.
Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial.
RCT of 120 students with primary dysmenorrhea comparing ginger root powder to placebo. Ginger significantly reduced pain severity and duration in protocol one, and pain severity in protocol two.
Antibacterial activity and mechanism of ginger extract against Ralstonia solanacearum
The study aimed to determine the chemical compositions of ginger extract and assess its antibacterial activities against the ginger bacterial wilt pathogen Ralstonia solanacearum, as well as to screen their mechanisms of action.
Pungent and volatile constituents of dried Australian ginger
The study investigates the chemical composition of three samples of Australian-grown dried ginger, focusing on gingerols, 6-shogaol, and volatile constituents. Significant differences were found in gingerol content, total phenolic content, and antioxidant capacity among the samples. The study identifies 100 volatile compounds, including several reported for the first time in ginger.
Identification of the active substances and mechanisms of ginger for the treatment of colon cancer based on network pharmacology and molecular docking
The study aimed to identify the bioactive components and potential mechanisms of ginger for colon cancer prevention using network pharmacology and molecular docking. Six potential active compounds and 118 intersection targets were identified, focusing on biological processes like phosphatidylinositol 3-kinase signaling and cellular response to oxidative stress. The study suggests ginger's preventive effects against colon cancer by regulating multi-targets and multi-pathways.
The effects of ginger supplementation on inflammatory, antioxidant, and periodontal parameters in type 2 diabetes mellitus patients with chronic periodontitis under non-surgical periodontal therapy. A double-blind, placebo-controlled trial
Double-blind, placebo-controlled trial evaluating ginger supplementation in 46 T2DM patients with chronic periodontitis undergoing non-surgical periodontal therapy. Ginger supplementation significantly reduced inflammatory markers (IL-6, hs-CRP, TNF-α) and improved periodontal indices (CAL, PD) and antioxidant enzyme levels (SOD, GPx) compared to placebo.
A randomized placebo-controlled study of aromatherapy for the treatment of postoperative nausea and vomiting.
A randomized placebo-controlled study comparing the effects of aromatherapy using ginger, lavender, and rose essential oils on postoperative nausea and vomiting (PONV) in 184 patients. Ginger and lavender oils were found to be more effective than rose oil and placebo in reducing nausea and vomiting scores.
A Randomized Double-Blind Trial of Ginger Root for Reducing Muscle Soreness and Improving Physical Performance Recovery Among Experienced Recreational Distance Runners.
This randomized, double-blind, placebo-controlled trial investigated the effects of ginger root supplementation on muscle soreness and physical performance recovery in 32 experienced recreational distance runners. Ginger root supplementation possibly reduced running-induced soreness and had a small benefit on vertical jump, but likely had no meaningful impact on 1.5-mile run performance.
The effect of ginger (Zingiber officinalis) and artichoke (Cynara cardunculus) extract supplementation on gastric motility: a pilot randomized study in healthy volunteers.
Pilot randomized cross-over study in 11 healthy volunteers comparing Prodigest® (ginger and artichoke extract) versus placebo. The study found that Prodigest® significantly promotes gastric emptying, with a -24% difference in gastric area after meals compared to placebo.
Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer.
Phase II RCT of 30 subjects assessing the effects of 2.0 g/d ginger on eicosanoid levels in colon mucosa over 28 days. Significant decreases in PGE(2) and 5-HETE were observed when normalized to free arachidonic acid, suggesting ginger may inhibit eicosanoid synthesis. Ginger was found to be tolerable and safe.
Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin.
Randomized, double-blinded crossover study in 48 gynecologic cancer patients receiving cisplatin-based chemotherapy to test ginger's antiemetic effect. Ginger root powder was compared to placebo and metoclopramide. No significant difference in nausea and emesis control between ginger and metoclopramide in both acute and delayed phases. Restlessness occurred more often in the metoclopramide arm.
Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins.
This study investigated the effects of ginger on hyperglycemia-evoked gastric dysrhythmias in 22 healthy humans. Ginger was found to significantly reduce the effects of hyperglycemia on gastric slow wave dysrhythmias, suggesting it may inhibit prostaglandin production. However, ginger did not affect dysrhythmias induced by a prostaglandin E1 analog.
The efficacy of ginger root in the prevention of postoperative nausea and vomiting after outpatient gynaecological laparoscopy.
RCT comparing the anti-emetic effect of ginger, droperidol, and their combination in 120 patients undergoing gynaecological laparoscopy. Ginger, droperidol, or both were ineffective in reducing postoperative nausea and vomiting.
Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease.
Placebo-controlled study examining the effects of ginger and fenugreek on blood lipids, blood sugar, and platelet aggregation in patients with coronary artery disease (CAD) and non-insulin-dependent diabetes mellitus (NIDDM). Ginger reduced platelet aggregation in CAD patients with a single dose but did not affect blood lipids or sugar. Fenugreek decreased blood lipids in CAD patients with NIDDM and reduced blood sugar in mild NIDDM cases.
Zingiber officinale (ginger)--an antiemetic for day case surgery.
Prospective, randomised, double-blind trial comparing powdered ginger root with metoclopramide and placebo in 120 women undergoing elective laparoscopic gynaecological surgery. Ginger and metoclopramide reduced postoperative nausea and vomiting compared to placebo, with ginger showing a lower requirement for postoperative antiemetics.
Ginger root--a new antiemetic. The effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery.
Double-blind, randomized study comparing the effectiveness of ginger root, placebo, and metoclopramide as antiemetic agents in 60 women after major gynaecological surgery. Ginger root significantly reduced incidences of nausea compared to placebo, with similar effectiveness to metoclopramide.
The anti-motion sickness mechanism of ginger. A comparative study with placebo and dimenhydrinate.
A controlled, double-blind study compared the effects of powdered ginger root, placebo, and dimenhydrinate on nystagmus response to optokinetic or vestibular stimuli. Ginger root showed no influence on experimentally induced nystagmus, unlike dimenhydrinate, which reduced the nystagmus response. The study concludes that ginger does not affect the vestibular or oculomotor systems, suggesting its anti-motion sickness effects may be due to its influence on the gastric system.
Ginger root against seasickness. A controlled trial on the open sea.
Double-blind randomized placebo trial tested the effect of powdered ginger root on seasickness in 80 naval cadets. Ginger root significantly reduced vomiting and cold sweating compared to placebo, with a Protection Index of 72% for vomiting.
Comparison of Anti-Obesity Effects of Ginger Extract Alone and Mixed with Long Pepper Extract.
The study evaluated the anti-obesity effects of ginger extract alone and in combination with long pepper extract in a mouse model of high-fat diet-induced obesity. Ginger extract alone significantly reduced body weight gain, fat accumulation, and improved glucose homeostasis and serum lipid profiles compared to the high-fat diet group, with more pronounced effects than the mixture group.
In-vivo and in-silico studies to identify toxicity mechanisms of permethrin with the toxicity-reducing role of ginger
The study investigated the toxic effects of permethrin on Allium cepa L. and the protective role of Zingiber officinale rhizome extract (Zoex). Permethrin decreased the mitotic index and increased chromosomal abnormalities, indicating oxidative damage. Zoex reduced these toxic effects, showing dose-dependent protection, with the most significant improvement in the group treated with 20 µg/mL Zoex.
Rapid screening and sensing of stearoyl-CoA desaturase 1 (SCD1) inhibitors from ginger and their efficacy in ameliorating non-alcoholic fatty liver disease
The study screened for SCD1 inhibitors in ginger using UPLC-MS, identifying gingerols as primary components with 10-gingerol showing the highest affinity. 10-gingerol improved FFA-induced lipid accumulation in human hepatocytes, suggesting its potential in treating non-alcoholic fatty liver disease.
Influence of Diet on the Bioavailability of Active Components from Zingiber officinale Using an In Vitro Digestion Model
The study assessed the bioavailability of active substances from ginger rhizomes using an in vitro digestion model. It found that ginger polyphenols had the best bioavailability with a high-fiber diet compared to standard and basic diets.
Synergistic Inhibition of Pro-Inflammatory Pathways by Ginger and Turmeric Extracts in RAW 264.7 Cells
In vitro study investigating the synergistic anti-inflammatory effects of ginger and turmeric extracts in LPS-induced RAW 264.7 cells. The combination significantly attenuated pro-inflammatory mediators and inhibited key signaling pathways more effectively than individual components.
8-paradol from ginger exacerbates PINK1/Parkin mediated mitophagy to induce apoptosis in human gastric adenocarcinoma.
The study evaluated the effect of 8-paradol, a phenolic compound from ginger, on gastric cancer. 8-paradol showed potent cytotoxicity and promoted PINK1/Parkin-associated mitophagy, mediating cell apoptosis in AGS cells and xenograft models. The study suggests 8-paradol as a potential therapeutic agent for gastric cancer by targeting the mitophagy pathway.
Manjarix attenuated pain and joint swelling in a rat model of monosodium iodoacetate-induced osteoarthritis.
The study assessed the effects of Manjarix, a herbal combination of ginger and turmeric extracts, on osteoarthritis in a rat model. Manjarix significantly reduced knee joint swelling, decreased serum inflammatory markers, and prevented pain behavior, demonstrating chondroprotective effects and potential as a therapeutic product for osteoarthritis.
Functionalization of ginger derived nanoparticles with chitosan to design drug delivery system for controlled release of 5-amino salicylic acid (5-ASA) in treatment of inflammatory bowel diseases: An in vitro study
In vitro study on chitosan-bound ginger nanocarriers for controlled release of 5-amino salicylic acid (5-ASA) in treating inflammatory bowel diseases. The study demonstrated slow and controlled release of 5-ASA, with over 50% drug loading capacity and entrapment efficiency, favorable at gastrointestinal pH.
Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies
The study investigates the molecular interactions between 12 active ginger components and human cytochrome P450 enzymes using molecular docking and pharmacokinetic modeling. It predicts potential drug interactions via CYP inhibition and evaluates the ADMET profiles of ginger components, finding a high risk of interaction with CYP2C9 and CYP3A4, but low risk with CYP2C19. Ginger components showed favorable ADMET profiles and no significant effect on warfarin metabolism, but a synergistic effect with nifedipine on platelet aggregation.
Effects of ginger root (Zingiber officinale) on laying performance and antioxidant status of laying hens and on dietary oxidation stability.
The study investigated the effects of ginger root supplementation on laying performance and antioxidant status of laying hens. Ginger powder supplementation improved egg mass and increased serum and egg yolk antioxidant enzymatic activities. It also enhanced dietary oxidation stability in a dose-dependent manner, with optimal supplementation between 10 and 15 g/kg of diet.
Chemical composition and antioxidant properties of ginger root (Zingiber officinale)
The study determined the chemical composition and antioxidant activity of ginger root (Zingiber officinale) using various extracts. Antioxidant components such as polyphenols, vitamin C, β carotene, flavonoids, and tannins were analyzed. Antioxidant activity was higher in solvent extracts compared to water extracts.
Development of SCAR (sequence-characterized amplified region) markers as a complementary tool for identification of ginger (Zingiber officinale Roscoe) from crude drugs and multicomponent formulations.
The study developed DNA-based SCAR markers to identify and differentiate Zingiber officinale (ginger) from closely related species Zingiber zerumbet and Zingiber cassumunar. The markers were tested in non-Zingiber species and successfully applied for detection of Z. officinale in multicomponent formulations.
Zingiber officinale does not affect gastric emptying rate. A randomised, placebo-controlled, crossover trial.
A double-blind crossover trial with 16 healthy volunteers investigated the effect of 1 g of ginger on gastric emptying rate using the oral paracetamol absorption model. Ginger ingestion did not affect gastric emptying, and no adverse effects were noted.
Effects of ginger on motion sickness susceptibility and gastric function.
RCT evaluating the effects of ginger on motion sickness and gastric function in 28 human volunteers. Ginger did not provide protection against motion sickness nor significantly alter gastric function during motion sickness.
Vertigo-reducing effect of ginger root. A controlled clinical study.
Double-blind crossover placebo trial with 8 healthy volunteers studying the effect of powdered ginger root on vertigo and nystagmus following caloric stimulation of the vestibular system. Ginger root significantly reduced induced vertigo compared to placebo, with no significant effect on nystagmus duration or maximum slow phase velocity.
Zingiber Officinale Roscoe: The Antiarthritic Potential of a Popular Spice—Preclinical and Clinical Evidence
This narrative review examines the anti-inflammatory and analgesic activities of ginger rhizomes (Zingiber officinale Roscoe) in treating inflammatory arthritis. It discusses preclinical and clinical evidence of ginger's therapeutic benefits for diseases like osteoarthritis and rheumatoid arthritis, as well as drug delivery systems to enhance its bioavailability.
The “root” causes behind the anti-inflammatory actions of ginger compounds in immune cells
This narrative review summarizes the literature on the immunomodulatory actions of ginger compounds, focusing on their anti-inflammatory effects. It discusses how ginger constituents like gingerols and shogaols influence immune cell function and target multiple signaling pathways.
A comprehensive review on Ginger (Zingiber officinale) as a potential source of nutraceuticals for food formulations: Towards the polishing of gingerol and other present biomolecules.
This narrative review discusses the potential of ginger as a source of nutraceuticals for food formulations, focusing on biologically active molecules like gingerols, shogaols, and zingerone. It reviews recent advancements in extraction methods and highlights safety and dosage concerns related to ginger extracts.
Ginger: a representative material of herb-derived exosome-like nanoparticles
This review discusses herb-derived exosome-like nanoparticles (HELNs), focusing on ginger-derived exosome-like nanoparticles (GELNs) as a representative example. It covers the extraction, purification, physical and biochemical characteristics, and therapeutic potential of GELNs, promoting further research into their properties.
The Effect of Ginger and Its Sub-Components on Pain
Narrative review analyzing 16 studies on the effects of ginger and its sub-components, [6]-gingerol and [6]-shogaol, on mechanical, spontaneous, and thermal pain in rodents. The review discusses the analgesic effects and mechanisms involving serotonergic receptors, TRPV1, NMDA receptors, and other pathways.
Dietary supplementation of gingerols- and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites in rats with spinal nerve ligation.
Animal study evaluating the effects of ginger root extracts rich in gingerols and shogaols on neuropathic pain in rats. Both extracts reduced pain- and anxiety-like behaviors and modulated gut microbiota and metabolites, suggesting ginger's potential in managing neuropathic pain.
Ginger from Farmyard to Town: Nutritional and Pharmacological Applications
This narrative review discusses the nutritional and pharmacological applications of ginger, highlighting its bioactive components and protective effects against conditions such as male infertility, nausea, pain, diabetes, obesity, and inflammation. It also covers molecular docking studies and clinical trials supporting ginger's health benefits.
Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer
This narrative review examines the chemopreventive and therapeutic properties of ginger extracts in cancer. It summarizes data from in vitro, in vivo, and clinical studies, highlighting ginger's mechanisms of action such as cell cycle arrest, induction of cancer cell death, and inhibition of cancer cell proliferation and migration.
The protective effect of cinnamon and ginger hydro‐alcoholic extract on carbon tetrachloride‐induced testicular damage in rats
Animal study evaluating the protective effect of cinnamon and ginger extract on testicular damage induced by carbon tetrachloride in male Wistar rats. The study found that pre-treatment with ginger and cinnamon extract significantly improved oxidative stress markers and histological alterations in testicular and epididymal tissue compared to the CCl4 group.
Pharmacokinetic herb‐drug interaction between ginger and crizotinib
Case report of a pharmacokinetic herb-drug interaction between ginger and the anticancer drug crizotinib, highlighting serious consequences for the patient. Emphasizes the need for awareness of potential interactions between herbs and prescribed drugs.
A recent update on the multifaceted health benefits associated with ginger and its bioactive components.
This narrative review summarizes the pharmacological potential of ginger and its bioactive components, such as 6-gingerol and 6-shogaol. It discusses their antioxidant properties and potential to reduce or delay the progression of diseases like cancer, diabetes, and obesity through modulation of genetic and metabolic activities.
Ginger and Heart Health: From Mechanisms to Therapeutics.
This narrative review discusses the phytochemical properties and health benefits of ginger, focusing on its cardioprotective effects. It highlights ginger's cardiotonic, antihypertensive, anti-hyperlipidemia, and anti-platelet effects, as well as the molecular mechanisms underlying these benefits.
Thrombolytic Activity, Drug Likeness Property and ADME/T Analysis of Isolated Phytochemicals from Ginger (Zingiber officinale) Using In Silico Approaches
In silico study analyzing thrombolytic activity and drug likeness of phytochemicals from Ginger (Zingiber officinale). Isovanillin showed better docking score and drug likeness, suggesting potential thrombolytic activity, while Beta-sitosterol violated Lipinski’s rule of five.