Research
Garlic Extract
43 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Garlic Extract in Rheumatological Diseases: A Systematic Review.
Systematic review of four articles on garlic extract in rheumatic diseases, including rheumatoid arthritis and osteoarthritis. The studies showed improvements in pain, function, disease activity, and reduced inflammatory biomarkers with garlic extract supplementation.
Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis.
Systematic review and meta-analysis on the effect of garlic powder tablets and aged garlic extract in CAD patients. Garlic showed significant changes in HDL, LDL, apolipoprotein-A, C-RP, IL-6, homocysteine, and CAC score, suggesting garlic reduces CVD risk factors and inflammation.
The effect and underlying mechanisms of garlic extract against cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis of experimental animal studies.
Systematic review and meta-analysis of 13 animal studies evaluating garlic extract's effects on Alzheimer's disease models. Garlic extract reduced cerebral Aβ levels and improved cognitive performance in AD animals, though studies showed moderate risk of bias.
Effects of garlic extract on lipid profile in patients with coronary artery disease: A systematic review and meta-analysis of randomised clinical trials.
This meta-analysis evaluated the effects of garlic extract on lipid profiles in patients with coronary artery disease. Garlic consumption significantly reduced total cholesterol levels but had no significant effects on triglycerides, HDL-c, and LDL-c concentrations.
Randomized, double-blind clinical trial evaluating the impact of freeze-dried garlic extract capsules on blood pressure, lipid profile, and nitric oxide levels in individuals at risk for hypertension.
RCT evaluating freeze-dried garlic extract on blood pressure, lipid profile, and nitric oxide levels in prehypertensive individuals. Significant reductions in SBP, DBP, MAP, TG, LDL, and TC levels, and increases in HDL and NO levels were observed in the intervention group compared to placebo.
Comparative evaluation of the antibacterial effect of Allium sativum, calcium hydroxide and their combination as intracanal medicaments in infected mature anterior teeth: A randomized clinical trial.
This randomized clinical trial compared the antibacterial effects of Allium sativum (garlic extract), calcium hydroxide, and their combination as intracanal medicaments in infected mature anterior teeth. Garlic significantly reduced Enterococcus faecalis compared to calcium hydroxide and their combination, while both garlic and calcium hydroxide reduced Streptococcus bacteria similarly. The combination showed the least bacterial reduction.
Effect of garlic powder supplementation on blood pressure and hs‐C‐reactive protein among nonalcoholic fatty liver disease patients: A randomized, double‐blind, placebo‐controlled trial
This randomized, double-blind, placebo-controlled trial evaluated the effects of garlic powder on blood pressure and hs-CRP in 98 patients with NAFLD. Garlic supplementation significantly reduced systolic and diastolic blood pressure, mean arterial pressure, and hs-CRP levels compared to placebo, suggesting potential cardiovascular benefits.
Effects of garlic powder supplementation on metabolic syndrome components, insulin resistance, fatty liver index, and appetite in subjects with metabolic syndrome: A randomized clinical trial
RCT of 90 subjects with metabolic syndrome comparing 1,600 mg/d garlic powder to placebo for 3 months. Garlic supplementation significantly improved high density lipoprotein-cholesterol, reduced waist circumference, blood pressure, triglycerides, fatty liver index, insulin resistance, and appetite.
Effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile in patients with non-alcoholic fatty liver disease: a double-blind randomised controlled clinical trial
Double-blind RCT of 90 NAFLD patients comparing garlic powder supplementation to placebo for 12 weeks. Garlic supplementation significantly reduced hepatic steatosis, liver enzymes, and improved lipid profile compared to placebo.
Effects of garlic powder supplementation on insulin resistance, oxidative stress, and body composition in patients with non-alcoholic fatty liver disease: A randomized controlled clinical trial.
RCT of 90 NAFLD patients comparing garlic powder supplementation to placebo for 12 weeks. Garlic powder significantly decreased waist circumference, body fat percent, fasting blood sugar, insulin, insulin resistance, and malondialdehyde, while increasing skeletal muscle mass, superoxide dismutase, and total antioxidant capacity.
Garlic powder intake and cardiovascular risk factors: a meta-analysis of randomized controlled clinical trials
Meta-analysis of randomized controlled trials assessing the effects of garlic powder on cardiovascular risk factors. Garlic powder intake significantly reduced total cholesterol, LDL cholesterol, fasting blood glucose, and blood pressure, providing evidence for its beneficial effects on cardiovascular health.
Oral post-exercise garlic extract supplementation enhances glycogen replenishment but does not up-regulate mitochondria biogenesis mRNA expression in human-exercised skeletal muscle.
The study investigated the effects of post-exercise garlic extract supplementation on glycogen replenishment and mitochondrial biosynthesis in human skeletal muscle. Garlic extract enhanced glycogen replenishment during the recovery period but did not up-regulate mitochondria biogenesis mRNA expression.
Effect of garlic extract on weight loss and gut microbiota composition in obese women: A double-blind randomized controlled trial
Double-blind RCT of garlic extract (Allium) on weight loss and gut microbiota composition in 32 obese women. Both Allium and placebo groups showed a decrease in BMI, with slight changes in gut microbiota composition, including increased Faecalibacterium and Bifidobacterium in the Allium group.
Garlic extract favorably modifies markers of endothelial function in obese patients -randomized double blind placebo-controlled nutritional intervention.
RCT of 92 obese subjects comparing 400mg garlic extract to placebo daily for 3 months. Garlic extract reduced arterial stiffness index, hsCRP, PAI-1, LDL cholesterol, and increased total antioxidant status, suggesting benefits for endothelial function and cardiovascular risk.
Effect of garlic powder consumption on body composition in patients with nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial
RCT of 110 subjects with NAFLD comparing garlic powder supplementation to placebo. The intervention group showed significant reductions in body weight and body fat mass compared to the control group, suggesting garlic supplementation can aid in weight and fat mass reduction.
Evaluation of TNF-α serum level in patients with recalcitrant multiple common warts, treated by lipid garlic extract.
RCT evaluating the use of lipid garlic extract (LGE) in treating recalcitrant multiple common warts (RMCW) in 50 patients. The LGE group showed a 96% complete response rate, with no recurrence observed, indicating LGE as an effective and safe treatment modality.
Preventing airborne infection with an intranasal cellulose powder formulation (Nasaleze travel).
RCT with 52 volunteers testing Nasaleze cellulose extract alone or combined with powdered garlic extract (PGE) for preventing airborne infections. The active treatment group with PGE experienced significantly fewer infections and fewer days with infection compared to the control group.
No effect of garlic extract supplement on serum lipid levels in hypercholesterolemic subjects.
RCT assessing the effects of an enteric-coated Thai garlic extract tablet on serum lipid levels in 136 hypercholesterolemic subjects. No significant changes in serum cholesterol, triglycerides, LDL, or HDL cholesterol were observed after 12 weeks of treatment.
Structure-Based Discovery of Symmetric Disulfides from Garlic Extract as Pseudomonas aeruginosa Quorum Sensing Inhibitors.
The study investigates the inhibitory activity of diallyl disulfide from garlic extract against the quorum sensing system of Pseudomonas aeruginosa. It synthesized 39 disulfide bond-containing analogs and found that p-hydroxyphenyl substitution can maintain strong biological activity. Compound 2i showed the strongest inhibitory effect on elastase production and synergistic inhibition with antibiotics. It successfully inhibited P. aeruginosa infection in a Galleria mellonella larvae model.
Evaluating the effect of garlic extract on serum inflammatory markers of peritoneal dialysis patients: a randomized double-blind clinical trial study.
This randomized double-blind clinical trial evaluated the effect of garlic extract on serum inflammatory markers in 42 peritoneal dialysis patients. The study found that administering 400 mg of standardized garlic extract twice a day for 8 weeks significantly reduced IL-6, CRP, and ESR levels, suggesting garlic extract may help attenuate inflammation in these patients.
Performance of crossbred calves with dietary supplementation of garlic extract.
RCT with 12 crossbred calves studying the effect of garlic extract supplementation on performance. The treatment group showed significant increases in body weight gain and feed intake, and a decrease in severity of scours compared to the control group.
Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study.
RCT examining the effects of garlic extract on platelet aggregation and serum thromboxane and lyso-platelet activating factor in healthy men. No significant differences were found in platelet aggregation or serum markers between treatment groups. In vitro aggregation with collagen decreased with higher garlic extract concentrations, but these were higher than achievable in vivo.
Biomedical Efficacy of Garlic‐Extract‐Loaded Core‐Sheath Plasters for Natural Antimicrobial Wound Care
The study explores the use of garlic extract in polymeric core-sheath fibers for wound therapy. The fibers, produced using core-sheath pressurized gyration technology, show rapid antibacterial activity against E. coli and S. aureus, improved cell adhesion, and biocompatibility, highlighting their potential for integrative medicine applications.
Potential Antibacterial Efficacy of Garlic Extract on Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae: An In vitro Study
In vitro study evaluating the antibacterial effect of garlic extract against clinical isolates of Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. Garlic extracts showed a high range of antibacterial effect against both Gram-negative and Gram-positive bacteria.
Phytochemicals in Garlic Extract Inhibit Therapeutic Enzyme DPP-4 and Induce Skeletal Muscle Cell Proliferation: A Possible Mechanism of Action to Benefit the Treatment of Diabetes Mellitus
The study investigates the antidiabetic effects of ultrasonication assisted garlic bulb extract. In vitro assays showed that garlic extract inhibited 50% DPP-4 activity and exhibited antioxidant activity. Molecular docking simulations suggested potential binding of phytochemicals at the DPP-4 druggable region, indicating a possible mechanism for its antidiabetic effects.
Hepatoprotective Effects of Garlic Extract against Carbon Tetrachloride (CCl4)-Induced Liver Injury via Modulation of Antioxidant, Anti-Inflammatory Activities and Hepatocyte Architecture
The study investigates the hepatoprotective effects of garlic extract against CCl4-induced liver injury through in vivo and in vitro assays. Garlic extract showed significant antioxidant and anti-inflammatory activities, reducing liver enzyme levels and pro-inflammatory markers in treated animals, and ameliorating hepatocyte architecture.
Allicin Inhibits Proliferation by Decreasing IL-6 and IFN-β in HCMV-Infected Glioma Cells
The study examined the antitumor effect of allicin on HCMV-infected glioblastoma multiforme cells. Allicin inhibited glioblastoma cell proliferation, decreased cytokine release, upregulated p53 activity, and increased sensitivity to radiotherapy, suggesting its effectiveness against HCMV-infected glioblastomas.
Garlic extract therapy in children with hypercholesterolemia.
RCT of garlic extract therapy in 30 pediatric patients with familial hyperlipidemia. The study found no significant effect of garlic extract on fasting lipid profile parameters or cardiovascular risk factors, except for a small effect on apolipoprotein A-I.
Garlic extract in prosthesis-related infections: a literature review
This literature review explores the antibacterial and antibiofilm activities of garlic extract and its potential use in treating periprosthetic joint infections (PJI), particularly in the context of multi-drug resistant bacteria and biofilm formation.
Preventive Study Garlic Extract Water (Allium sativum) Toward SGPT, SGOT, and the Description of Liver Histopathology on Rat (Rattus norvegicus), which were exposed by Rhodamine B
Animal study investigating the preventive effects of garlic extract water on liver health in rats exposed to Rhodamine B. Garlic extract at a dose of 1.5 mL/0.2 kg body weight decreased SGPT and SGOT levels and improved liver histopathology in rats.
Polyvinylpyrrolidone/cellulose acetate electrospun composite nanofibres loaded by glycerine and garlic extract with in vitro antibacterial activity and release behaviour test
The study used electrospinning to encapsulate garlic extract and glycerine in polyvinylpyrrolidone/cellulose acetate nanofibrous mats. The encapsulated garlic extract retained its antibacterial activity, and the release behavior was tested in vitro.
Anti-biofilm activity of garlic extract loaded nanoparticles.
The study describes a solgel based nanoparticle system loaded with garlic extract (GE-np) that enhances antimicrobial and antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) biofilms. GE-np showed slow and sustained release, stabilization of active components, and significant enhancement of activity compared to free garlic extract.
Effects of dietary Garlic extract on some blood, immunity and growth parameters of Common Carp fingerlings (Cyprinus carpio)
The study investigated the effects of dietary garlic extract on blood, immunity, and growth parameters in common carp fingerlings. Fish fed with 5 g/kg garlic extract showed improved blood and immune parameters, including higher white blood cells, lymphocytes, lysozyme, and IgM levels, compared to the control group. However, growth parameters did not significantly differ from the control group.
The Effects of Using Garlic Extract for Quail Hatching Egg Disinfection on Hatching Results and Performance
The study investigates the effects of using garlic extract for disinfecting quail hatching eggs on hatching results and performance. The specific outcomes and findings are not detailed in the abstract.
S-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from gut
The study investigated the effects of S-allyl-L-cysteine sulfoxide (ACSO), a garlic odor precursor, on ethanol metabolism and absorption in rats. ACSO and garlic extract with high ACSO content suppressed plasma ethanol and acetaldehyde concentrations, promoted alcohol and aldehyde dehydrogenase activities, and inhibited ethanol absorption from the stomach and jejunum.
HSPA6 augments garlic extract-induced inhibition of proliferation, migration, and invasion of bladder cancer EJ cells; Implication for cell cycle dysregulation, signaling pathway alteration, and transcription factor-associated MMP-9 regulation
The study investigates the molecular mechanism of garlic extract (GE) in inhibiting bladder cancer EJ cell proliferation, migration, and invasion. GE induces G2/M-phase cell cycle arrest and affects signaling pathways, including ATM-CHK2 and MAPK/AKT. Overexpression of HSPA6 enhances GE's inhibitory effects on EJ cells.
Antifungal activity, kinetics and molecular mechanism of action of garlic oil against Candida albicans
The study investigated the antifungal activity, kinetics, and molecular mechanism of garlic oil against Candida albicans. Garlic oil was found to penetrate cellular membranes, leading to organelle destruction and cell death. RNA sequencing and protein analysis indicated significant disruption of C. albicans metabolism and stress responses to garlic oil treatment.
Efficacy of Co-administration of Garlic Extract and Metformin for Prevention of Gentamicin–Renal Toxicity in Wistar Rats: A Biochemical Study
Pre-clinical study on 70 male Wistar rats evaluating the effects of garlic extract and metformin on gentamicin-induced nephrotoxicity. The study found that administration of garlic, metformin, or their combination reduced serum BUN and creatinine levels, indicating protective and curative effects against renal toxicity.
Hypoglycemic and antioxidant effects of oral administration of garlic extract in the livers of type 1 diabetic rats
The study investigated the effects of garlic extract on glucose levels, liver enzyme activities, nitric oxide levels, oxidative stress status, and liver histology in type 1 diabetic rats. Garlic extract administration reduced glucose levels, liver enzyme activities, MDA, TOS, and NO levels, while increasing TAC levels significantly towards normal levels.
Efficacy of garlic extract and chlorhexidine mouthwash in reduction of oral salivary microorganisms, an in vitro study
In vitro study comparing the antimicrobial effect of garlic extract and chlorhexidine mouthwash against oral salivary microorganisms. Garlic extract showed a reduction in microbial colony count, suggesting it can be an alternative to chlorhexidine mouthwash.
Dentinal tubule disinfection with 2% chlorhexidine, garlic extract, and calcium hydroxide against Enterococcus faecalis by using real-time polymerase chain reaction: In vitro study
In vitro study comparing the efficacy of garlic extract, 2% chlorhexidine, and calcium hydroxide in disinfecting dentinal tubules contaminated with Enterococcus faecalis. Garlic extract showed moderate efficacy, with 2% chlorhexidine being the most effective.
Comparative evaluation of garlic extract mouthwash and chlorhexidine mouthwash on salivary Streptococcus mutans count - an in vitro study.
The study assessed the antibacterial effect of garlic extract compared to chlorhexidine and a negative control mouthwash against Streptococcus mutans. In vitro, a 3% concentration of garlic extract showed a zone of inhibition. In vivo, 45 dental students used the mouthwashes for 7 days, with garlic extract showing a significant reduction in S. mutans counts compared to chlorhexidine and the negative control.
Garlic extract inhibits the enhanced peroxidation and production of lipids in carbon tetrachloride-induced liver injury.
The study investigated the therapeutic effects of garlic extract on carbon tetrachloride-induced liver injury in mice. Garlic extract reduced lipid peroxidation and hepatic triglyceride accumulation, showing a positive effect on liver health compared to vitamin E.