Research
Garcinia cambogia (HCA)
17 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effects of Garcinia cambogia on glycaemic control and liver enzymes in adults: a systematic review and meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of nine RCTs with 444 participants evaluating the effects of Garcinia cambogia on glycaemic control and liver enzymes. The study found no significant effect on fasting blood sugar, insulin, ALT, or AST levels compared to control groups, though longer intervention duration may decrease insulin levels.
The effects of Garcinia cambogia (hydroxycitric acid) on serum leptin concentrations: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of eight RCTs with 330 participants evaluating the effect of Garcinia cambogia on serum leptin levels. The analysis showed a significantly decreased effect of Garcinia cambogia on leptin compared with placebo, with significant heterogeneity between studies.
The effects of Garcinia cambogia (hydroxycitric acid) on lipid profile: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 14 trials involving 623 subjects to assess the effects of Garcinia cambogia on lipid profiles. The analysis found significant reductions in total cholesterol and triglycerides, and an increase in HDL-C levels, with no significant effect on low-density lipoprotein cholesterol. The effects were more pronounced for interventions longer than 8 weeks.
Effect of Garcinia cambogia supplement on obesity indices: A systematic review and dose-response meta-analysis.
This systematic review and dose-response meta-analysis examined the effect of Garcinia cambogia supplement on obesity indices in human RCTs. The analysis included eight trials with 530 subjects and found that Garcinia cambogia significantly reduced weight, BMI, percentage of fat mass, and waist circumference compared to placebo.
Evaluation of the Therapeutic Potential of Garcinia cambogia Alone or in Combination With Silodosin in the Management of LUTS/BPH: A Prospective Randomized Controlled Study.
Prospective RCT evaluating Garcinia cambogia alone or with Silodosin in patients with LUTS/BPH. Significant improvements in Qmax, IPSS, and PVR were observed in all groups, with the combination group showing the best results. PV was reduced in groups B and C, and PSA decreased significantly in these groups.
Food-Effect on (-) - Hydroxycitric Acid Absorption After Oral Administration of Garcinia cambogia Extract Formulation: a Phase I, Randomized, Cross-Over Study.
Phase I, open-label, randomized, single-dose, cross-over study in healthy women to determine pharmacokinetic parameters of Garcinia cambogia extract/(-)-hydroxycitric acid (HCA) and evaluate food effects on HCA absorption. Plasma HCA concentrations were significantly reduced in the fed state, with peak plasma concentration and area under the curve lower in fed conditions.
The effect of hydroxy citric acid supplementation with calorie-restricted diet on metabolic, atherogenic and inflammatory biomarkers in women with non-alcoholic fatty liver disease: a randomized controlled clinical trial.
RCT of 40 overweight/obese women with NAFLD comparing calorie-restricted diet with and without hydroxy citric acid (HCA) supplementation. The HCA group showed significant improvements in metabolic factors such as BMI, waist circumference, and lipid profile, but no significant effect on inflammation.
Short-term effects of a green coffee extract-, Garcinia c ambogia- and L-carnitine-containing chewing gum on snack intake and appetite regulation.
Prospective crossover study with 57 subjects evaluating the effects of chewing gum containing Garcinia cambogia, green coffee extract, and L-carnitine on snack intake and appetite regulation. The active gum reduced high-fat sweet snack intake and total caloric intake compared to placebo and no gum, and both active and placebo gums reduced hunger and increased fullness.
IQP-GC-101 reduces body weight and body fat mass: a randomized, double-blind, placebo-controlled study.
This randomized, double-blind, placebo-controlled study investigated the efficacy and safety of IQP-GC-101, a blend of Garcinia cambogia, Camellia sinensis, unroasted Coffea arabica, and Lagerstroemia speciosa, in reducing body weight and body fat mass in overweight Caucasian adults. The study found that IQP-GC-101 resulted in significant weight and body fat reduction compared to placebo, with good tolerability.
Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial.
RCT with 86 overweight subjects testing Glycine max leaves extract (EGML) and Garcinia cambogia extract (GCE) for weight-loss and cholesterol effects. EGML increased HDL-C levels but neither supplement promoted weight-loss or significantly lowered total cholesterol.
Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity.
Double-blind randomized study evaluating the efficacy of Garcinia cambogia and Amorphophallus konjac extracts in treating obesity. The treatment significantly reduced total cholesterol and LDL-c levels but had no significant effect on anthropometric parameters, REE, triglycerides, or glucose levels.
Efficacy of Slim339 in reducing body weight of overweight and obese human subjects.
Double-blind, randomized, placebo-controlled study evaluating Slim339, a combination of Garcinia cambogia extract and other herbal extracts, on body weight in overweight and obese volunteers. The Slim339 group showed a 4.67% average reduction in body weight over 60 days compared to 0.63% in the placebo group.
Evaluation of the satiating properties of a nutraceutical product containing Garcinia cambogia and Ascophyllum nodosum extracts in healthy volunteers.
RCT evaluating the satiating properties of a nutraceutical product containing Garcinia cambogia, Ascophyllum nodosum extract, and l-carnitine in 28 healthy volunteers. The study found that the product reduced subjective hunger sensations and increased satiety and fullness ratings, with an increased preference for sweet foods.
Hypolipemic effect of Garcinia cambogia in obese women.
RCT analyzing the effect of Garcinia cambogia on lipid profile and other parameters in obese women. The treatment group showed a significant reduction in triglycerides compared to placebo, but no significant changes in other lipid profile variables, anthropometric, or calorimetric parameters.
Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects.
Double-blind placebo-controlled trial with 44 overweight subjects receiving Garcinia cambogia extract or placebo for 12 weeks. The extract did not significantly alter serum testosterone, estrone, and estradiol levels, nor did it affect hematology, serum triacylglycerol, and serum clinical pathology parameters.
Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects--a randomised double-blind placebo-controlled clinical trial.
RCT evaluating the efficacy of a botanical extract-based weight loss formula on body weight, body composition, and blood chemistry in 98 healthy, overweight subjects. The active extract group showed significant improvements in body composition and body fat loss compared to placebo, although weight and BMI changes were not statistically significant.
Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial.
RCT evaluating the efficacy of Garcinia cambogia (hydroxycitric acid) for body weight and fat mass loss in overweight subjects. Both groups lost weight, but Garcinia cambogia did not produce significant weight or fat mass loss beyond placebo.