Research
Fucoidan (Brown Seaweed Polysaccharide)
56 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Fucoidan Treatment Improves Diabetic Hyperglycemia and Dyslipidemia in Rodents: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of studies on fucoidan treatment in diabetic rodents. Fucoidan treatment improved hyperglycemia and dyslipidemia, with a pooled effect size for blood glucose levels of -2.26.
Effects of dietary seaweed on obesity-related metabolic status: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of randomized controlled trials assessing the effects of seaweed on obesity-related metabolic status. Seaweed supplementation showed significant positive effects on BMI, percentage of fat mass, total cholesterol, and low-density-lipoprotein cholesterol in adults with overweight and obesity.
Therapeutic potential of fucoidan in central nervous system disorders: A systematic review.
Systematic review of 39 articles on the pharmacology of fucoidan in CNS disorders. Fucoidan shows neuroprotective effects in in vivo and in vitro models by regulating lipid metabolism, enhancing the cholinergic system, maintaining blood-brain barrier and mitochondrial integrity, inhibiting inflammation, and reducing oxidative stress and apoptosis.
Fucoidan as a Promising Drug for Pain Treatment: Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of fucoidan's analgesic effects, showing it reduces neutrophil infiltration and pain in preclinical studies. Fucoidan has shown some analgesic efficacy in small clinical trials, suggesting it as a promising therapeutic strategy for pain treatment.
The Efficacy of Double-Heart Nursing in Combination with Seaweed Polysaccharide for Patients with Coronary Heart Disease Complicated with Diabetes: A Pilot, Randomized Clinical Trial.
RCT of 214 patients with coronary heart disease and diabetes comparing seaweed polysaccharide alone to seaweed polysaccharide combined with double-heart nursing. The combination group showed improved blood glucose levels, lower incidence of lesions, and better self-efficacy and quality of life scores.
Fucoxanthin activities motivate its nano/micro-encapsulation for food or nutraceutical application: a review.
This systematic review discusses the challenges of using fucoxanthin as a nutraceutical due to its low water solubility, poor stability, and limited bioaccessibility. It explores nano/micro-encapsulation technologies to enhance the stability and bioaccessibility of fucoxanthin for potential use in functional foods and nutraceuticals, particularly for cancer management.
Fucoidan Improves Tumour Control and Liver Function in TACE for Unresectable Hepatocellular Carcinoma: A Randomised Trial.
Randomised, double-blind, placebo-controlled trial of 82 patients with unresectable hepatocellular carcinoma receiving low-molecular-weight fucoidan (LMF) or placebo in addition to TACE. LMF group showed higher disease control rate and preserved liver function, with similar adverse event rates.
The effects of Oligo-Fucoidan on muscle function in community-dwelling older adults: A double-blind, randomized, placebo-controlled trial.
This 12-week randomized, double-blind, placebo-controlled trial investigated the effects of Oligo-Fucoidan supplementation on muscle strength and physical performance in 60 community-dwelling older adults. Oligo-Fucoidan significantly improved grip strength and 6MWT distance, suggesting its potential as a non-pharmacological intervention for sarcopenia.
Effects of 4-month treatment with glycocalyx dietary supplement on endothelial glycocalyx and vascular function after COVID-19 infection.
RCT of 57 convalescent patients post-COVID-19 infection, comparing glycocalyx dietary supplement (GDS) to placebo for 4 months. GDS improved endothelial glycocalyx integrity, vascular function, and oxidative stress markers, with no post-COVID symptoms reported in the GDS group.
Effect of fucoidan supplementation on glycolipid metabolism, systemic inflammation and gut microbiota in prediabetes: A randomized controlled trial.
RCT of 70 Chinese participants with prediabetes assessing the effect of 1000 mg fucoidan supplementation on glycolipid metabolism, systemic inflammation, and gut microbiota over 12 weeks. Fucoidan reduced GSP, TNF-α, IL-6, and LPS levels, and altered gut microbiota composition, suggesting potential benefits for glucose metabolism and inflammation.
The Effect of 4-Month Treatment with Glycocalyx Dietary Supplement on Endothelial Glycocalyx Integrity and Vascular Function in Patients with Psoriasis.
RCT of 50 psoriatic patients comparing glycocalyx dietary supplement (GDS) to placebo for 4 months. GDS improved endothelial glycocalyx integrity and arterial stiffness, with significant reductions in perfused boundary region and pulse wave velocity compared to placebo.
Effect of fucoidan on gut microbiota and its clinical efficacy in Helicobacter pylori eradication: A randomized controlled trial.
RCT assessing fucoidan-assisted standard quadruple therapy (SQT) in Helicobacter pylori eradication and gut microbiota improvement. Fucoidan improved gut dysbiosis and enhanced symptom improvement during H. pylori eradication compared to SQT alone.
The Auxiliary Effects of Low-Molecular-Weight Fucoidan in Locally Advanced Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy Before Surgery: A Double-Blind, Randomized, Placebo-Controlled Study.
Double-blind, randomized, placebo-controlled study of 87 patients with locally advanced rectal cancer receiving neoadjuvant concurrent chemoradiotherapy. The study investigated the effects of low-molecular-weight fucoidan on quality of life, skin rash and itching, fatigue, and gut microbiota composition. Fucoidan improved physical well-being, reduced skin rash and itching, and altered gut microbiota composition.
Effects of Dietary Supplementation of a Microalgae Extract Containing Fucoxanthin Combined with Guarana on Cognitive Function and Gaming Performance.
Double-blind, placebo-controlled RCT with 61 experienced gamers evaluating the effects of microalgae extract containing fucoxanthin combined with guarana on cognitive function and mood. The study found improvements in reaction times, reasoning, learning, executive control, attention shifting, and mood state after acute and 30-day supplementation.
Marginal Impact of Brown SeaweedandExtract on Metabolic and Inflammatory Response in Overweight and Obese Prediabetic Subjects.
RCT of 56 overweight/obese prediabetic subjects testing 500 mg/d brown seaweed extract vs placebo over 12 weeks. No effect on blood glucose or body weight, but significant decreases in plasma C-peptide, heart rate, and inhibition of pro-inflammatory IL-6 increase were observed in the brown seaweed group.
Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study.
Placebo-controlled double-blind pilot study in healthy volunteers assessing the effect of a single 1 g dose of fucoidan on miRNA expression. Fucoidan affected 53 miRNAs and influenced pathways related to immunity, cancer, inflammation, and neurological function.
Effects of dietary fucoidan on the blood constituents, anti-oxidation and innate immunity of juvenile yellow catfish (Pelteobagrus fulvidraco).
RCT investigating the effects of dietary fucoidan on blood constituents, anti-oxidation, and innate immunity in juvenile yellow catfish. Fucoidan significantly influenced blood characters, antioxidant status, and non-specific immune responses, but had no significant effect on mortality rate in a challenge test.
Investigating fucoidan blend supplementation and resistance training in humans: a parallel randomized controlled trial design.
This RCT investigated the effect of fucoidan supplementation combined with resistance training on strength and performance in 20 healthy adults. Fucoidan supplementation significantly increased peak power and relative peak power during a Wingate test and improved body composition by increasing lean body mass and decreasing body fat percentage.
Effects of Supplementation with Microalgae Extract from Phaeodactylum tricornutum (Mi136) to Support Benefits from a Weight Management Intervention in Overweight Women
RCT of 37 overweight women examining the effects of microalgae extract from Phaeodactylum tricornutum containing fucoxanthin during a diet and exercise intervention. Fucoxanthin supplementation did not promote additional weight or fat loss but preserved bone mass, increased bone density, and improved several health markers and quality of life measures.
Impact of dietary supplementation of glycocalyx precursors on vascular function in type 2 diabetes.
The study tested dietary supplementation of glycocalyx precursors (including glucosamine sulfate, fucoidan, superoxide dismutase, and high-molecular weight hyaluronan) on vascular function in type 2 diabetes. In db/db mice, the supplementation restored endothelial glycocalyx length and improved vascular function. However, in a pilot RCT with 22 Veterans with T2D, the supplementation did not enhance endothelial glycocalyx integrity or improve vascular function indices compared to placebo.
Immunomodulatory effects of fucoidan in recreationally active adult males undertaking 3-weeks of intensified training.
This double-blind, placebo-controlled cross-over trial investigated the effects of daily fucoidan supplementation (1g/day) over three weeks on mucosal immune markers in recreationally active men undergoing intensified training. While faecal biomarkers remained stable, salivary IgA showed a greater acute exercise response with fucoidan, and salivary lysozyme showed a trend for a lower post-exercise increase. Mean power improved by 16-19% with no difference between supplement groups.
Effects of fucoidan supplementation on inflammatory and immune response after high-intensity exercise.
This RCT investigated the effects of fucoidan supplementation on inflammatory and immune markers following high-intensity exercise in 16 participants. Fucoidan supplementation resulted in greater interleukin-6 and interleukin-10 concentrations at 30 minutes post-exercise, but no significant effects on other blood markers or performance outcomes. The study suggests a modest effect on inflammatory cytokines, warranting further investigation.
Effects of an Extract of the Brown Seaweedon Postprandial Glycaemic Control in Healthy Subjects: A Randomized Controlled Study.
RCT investigating the effects of brown seaweed extract on postprandial glucose and insulin responses in 16 healthy subjects. No significant effects were observed overall, but in a sub-cohort of 10 subjects with higher peak glucose levels, a significant decrease in plasma glucose was noted with 1000 mg of extract compared to control.
Fucoidan and Fucoxanthin Attenuate Hepatic Steatosis and Inflammation of NAFLD through Modulation of Leptin/Adiponectin Axis.
RCT investigating the effects of low molecular weight fucoidan and high stability fucoxanthin (LMF-HSFx) in 42 NAFLD patients over 24 weeks. LMF-HSFx reduced liver enzymes, cholesterol, triglycerides, fasting blood glucose, and hemoglobin A1c. It also reduced liver fibrosis and proinflammatory cytokines, and modulated lipid metabolism and insulin resistance.
Effects of Ingesting Fucoidan Derived fromTokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study.
Randomized, double-blind, placebo-controlled pilot study evaluating the effects of fucoidan derived from Okinawa mozuku on NK cell activity in healthy adults. The fucoidan group showed significantly enhanced NK cell activity at 8 weeks compared to the placebo group, with no adverse events observed.
The combination of wheat peptides and fucoidan protects against chronic superficial gastritis and alters gut microbiota: a double-blinded, placebo-controlled study.
This double-blind, placebo-controlled RCT evaluated the protective effect of wheat peptides and fucoidan (WPF) on chronic superficial gastritis in 106 adults. WPF reduced gastric mucosal damage, decreased gastrointestinal discomforts, and altered gut microbiota composition, suggesting its potential as a nutritional alternative for chronic gastritis.
Effect of a Fucoidan Extract on Insulin Resistance and Cardiometabolic Markers in Obese, Nondiabetic Subjects: A Randomized, Controlled Trial.
RCT in obese, nondiabetic subjects assessing the effect of fucoidan extract on insulin resistance and cardiometabolic markers. No significant differences were found between the fucoidan and placebo groups over 90 days.
Acute Post-Prandial Cognitive Effects of Brown Seaweed Extract in Humans.
RCT examining the impact of brown seaweed extract on cognitive function post-prandially in 60 healthy adults. Seaweed extract led to significant improvements in accuracy on digit vigilance and choice reaction time tasks, suggesting modulation of cognition.
Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with aextract on cholesterol levels in adults with elevated fasting LDL cholesterol who are overweight or have obesity.
This study protocol outlines a double-blind RCT investigating the impact of 12 weeks of supplementation with a polyphenol-rich brown seaweed extract on cholesterol levels, hyperglycaemia, and inflammation in 58 overweight or obese adults with elevated fasting LDL cholesterol. Mood and cognitive function will also be evaluated as exploratory outcomes.
Effect of seaweed-derived laminarin and fucoidan and zinc oxide on gut morphology, nutrient transporters, nutrient digestibility, growth performance and selected microbial populations in weaned pigs.
Two experiments were conducted to evaluate the effects of laminarin and/or fucoidan on gut morphology, nutrient transporter gene expression, and nutrient digestibility in weaned pigs. Laminarin increased the coefficient of total tract apparent digestibility of gross energy and nutrient transporter expression. It also improved average daily gain and gain:feed ratio, showing similar effects to zinc oxide supplementation.
Effect of the interaction of seaweed extracts containing laminarin and fucoidan with zinc oxide on the growth performance, digestibility and faecal characteristics of growing piglets.
A 2x2 factorial experiment investigated the interaction between seaweed extracts (SWE) containing laminarin and fucoidan and zinc oxide (ZnO) on growth performance, digestibility, and faecal characteristics of 192 weaned piglets. SWE and ZnO improved growth performance when given alone, but not in combination. SWE increased nitrogen and organic matter digestibility and decreased faecal Escherichia coli counts, effects not observed with ZnO.
Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination.
A randomized, placebo-controlled, double-blind study with 70 elderly Japanese participants examined the effects of mekabu fucoidan supplementation on immune response to influenza vaccination. The fucoidan group showed higher antibody titers and increased natural killer cell activity compared to the placebo group, suggesting enhanced immune response.
Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects.
The study investigated the anti-thrombotic effects of F-fucoidan (FD) and fucoxanthin (FX) from Laminaria japonica in human subjects. Capsules containing FD, FX, or both were administered to volunteers for 5 weeks. FD or FD+FX significantly shortened thrombus lysis time, while FX alone did not. FD increased H2O2 and prostacyclin secretion, suggesting a mechanism for its anti-thrombotic effects.
The microbiological and immunomodulatory effects of spray-dried versus wet dietary supplementation of seaweed extract in the pig gastrointestinal tract.
The study compared the effects of spray-dried versus wet seaweed extract (SWE) supplementation on the microbiological and cytokine profile of the gastrointestinal tract in newly weaned pigs. No differences in cytokine expression were observed between the formulations, but the wet SWE formulation increased bifidobacteria counts in the ileum, indicating a prebiotic effect lost in the spray-dried form.
Addition of seaweed (Laminaria digitata) extracts containing laminarin and fucoidan to porcine diets: influence on the quality and shelf-life of fresh pork.
The study investigated the effect of dietary supplementation with seaweed extracts containing laminarin and fucoidan on the quality and shelf-life of pork. Supplementation did not affect plasma total antioxidant status or various quality indices of pork, but a significant reduction in lipid oxidation was observed in pork from pigs fed with wet seaweed extract compared to controls.
The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat.
A 16-week double-blind, randomized, placebo-controlled study on 151 obese premenopausal women with NAFLD and NLF. Xanthigen supplementation resulted in significant reductions in body weight, waist circumference, body and liver fat content, and improved liver enzymes and serum triglycerides. It also increased resting energy expenditure in NAFLD subjects.
Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells.
Clinical trial evaluating the effects of fucoidan ingestion on circulating CD34(+) cells and CXCR4 expression. Fucoidan increased CD34(+) cells in peripheral blood and significantly amplified the CXCR4(+) HPC population, suggesting potential for improved HPC mobilization.
A quantitative method to detect fucoidan in human plasma using a novel antibody.
The study developed an antibody-based method to assess plasma uptake of Undaria-derived fucoidan after oral ingestion by human volunteers. Using a competitive ELISA, the study quantified fucoidan in plasma samples from volunteers ingesting different forms of fucoidan or a placebo over 12 days, showing detectable levels of fucoidan in plasma.
A Randomized Placebo-controlled Trial of an Oral Preparation of High Molecular Weight Fucoidan in Patients with Type 2 Diabetes with Evaluation of Taste Sensitivity.
A randomized, double-blind, placebo-controlled study on the effects of fucoidan in 30 patients with type 2 diabetes. Fucoidan intake increased stool frequency and enhanced taste sensitivity. In subjects with normal insulin resistance, hemoglobin A1c and fasting plasma GLP-1 levels decreased, suggesting potential benefits for diabetes control.
The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer.
Open label non-crossover study in breast cancer patients taking letrozole or tamoxifen, investigating the effect of co-administration of fucoidan derived from Undaria pinnatifida on the pharmacokinetics of these drugs. No significant changes in plasma concentrations of letrozole, tamoxifen, or its metabolites were detected, and fucoidan was well tolerated.
Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults.
A randomized, double-blind, placebo-controlled clinical trial evaluated the effect of fucoidan on insulin secretion and sensitivity in 25 overweight or obese adults. Fucoidan administration for 3 months decreased diastolic blood pressure and LDL-C concentrations, while increasing insulin levels, HOMA β-cell function, and insulin resistance.
Effects of supplementing dietary laminarin and fucoidan on intestinal morphology and the immune gene expression in the weaned pig.
A 2x2 factorial experiment investigated the effects of laminarin and fucoidan supplementation on gut morphology and immune gene expression in weaned pigs. Laminarin supplementation improved intestinal structure and reduced inflammatory cytokine gene expression, suggesting potential benefits for gut health.
Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease.
Single-centre open-label trial of 13 patients with HAM/TSP treated with 6 g fucoidan daily for 6-13 months. Fucoidan therapy resulted in a 42.4% decrease in the HTLV-1 proviral load without affecting host immune cells. Fucoidan inhibited cell-to-cell transmission of HTLV-1 in vitro and is a potential therapeutic agent for HTLV-1-associated diseases.
Pilot clinical study to evaluate the anticoagulant activity of fucoidan.
Pilot clinical trial assessing the safety and clinical effects of orally ingested fucoidan on hemostasis in 20 human volunteers. The study found that fucoidan did not exhibit significant oral anticoagulant activity in vivo, likely due to low intestinal absorption, but demonstrated strong in-vitro anticoagulant activity.
Preventive effects of sea cucumber-derived fucoidan on-induced gastritis: a mechanistic investigation based on regulation of the gut microbiota and metabolic products.
The study evaluated the preventive effects of fucoidan extracted from sea cucumber cooking liquid against gastritis induced by Hp SS1 infection. High-dose fucoidan significantly reduced Hp SS1 colonization and modulated oxidative stress and inflammatory responses, enhancing gut health and reducing inflammation.
Antiangiogenic drugs in combination with seaweed fucoidan: A mechanistic in vitro and in vivo study exploring the VEGF receptor and its downstream signaling molecules in hepatic cancer
The study investigated the use of fucoidan in combination with antiangiogenic drugs sorafenib and Avastin in hepatocellular carcinoma (HCC) both in vitro and in vivo. Fucoidan showed a potent synergistic effect with the drugs, reducing cell viability and affecting cancer cell motility and angiogenic pathways. In a rat model, combination therapies led to increased apoptosis and necrosis in tumor nodules.
Synergistic in vitro anticancer actions of decorated selenium nanoparticles with fucoidan/Reishi extract against colorectal adenocarcinoma cells
In vitro study of selenium nanoparticles decorated with fucoidan and Reishi extract against human colorectal adenocarcinoma cells. The Fu/Re/SeNPs composite showed potent anticancer activity, reducing cell survival and inducing apoptosis with significant molecular damage.
Cellulose acetate membrane electrophoresis and FTIR spectroscopy as methods of identifying a fucoidan in Fucusvesiculosus Linnaeus.
The study identifies fucoidan from brown algae Fucusvesiculosus Linnaeus using cellulose acetate membrane electrophoresis and FTIR spectroscopy. Two slightly different structures were found in dried bladder wrack samples, and a simple analytical procedure was developed.
Advances in fucoidan and fucoidan oligosaccharides: Current status, future prospects, and biological applications.
This comprehensive review explores the current status of fucoidan research, covering its sources, extraction and purification techniques, structural variations, and biological activities. It highlights fucoidan's potential health benefits, including anti-inflammatory, anticancer, antiviral, antithrombotic, hypolipidemic, and immune-modulatory properties.
Fucoidan from Marine Macroalgae: Biological Actions and Applications in Regenerative Medicine, Drug Delivery Systems and Food Industry
This review discusses the structure, chemical composition, and physicochemical properties of fucoidan, a sulfated heteropolysaccharide from brown algae. It addresses the biological actions of fucoidan and its applications in human health, tissue engineering, regenerative medicine, and drug delivery, highlighting its potential as a bioactive material in nutritional and pharmacological sectors.
A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights
This systematic review provides an update on the pharmacological insights of fucoxanthin, a natural antioxidant pigment from marine algae. It discusses its potential benefits for human health and disease management, highlighting its anti-cancer, anti-tumor, and protective effects against various diseases. The review emphasizes the need for more clinical research on fucoxanthin.
Health benefits and potential applications of fucoidan (FCD) extracted from brown seaweeds in aquaculture: An updated review.
This review provides updated information on the use of fucoidan (FCD) extracted from brown seaweeds in aquaculture. It discusses the effects of FCD on growth, intestinal health, antioxidant capacity, and immune responses in finfish and shellfish, as well as its potential to increase resistance against bacterial and viral infections.
Pharmacokinetic and Tissue Distribution of Fucoidan fromafter Oral Administration to Rats.
The study evaluated the pharmacokinetics and tissue distribution of fucoidan in rats after a single-dose oral administration. Fucoidan preferentially accumulates in the kidneys, spleen, and liver, showing a relatively long absorption time and extended circulation in the blood.
The stability and bioaccessibility of fucoxanthin in spray-dried microcapsules based on various biopolymers
The study investigated the stability and bioaccessibility of fucoxanthin encapsulated in spray-dried microcapsules using various biopolymers. Encapsulation improved the thermal stability and intestinal absorption of fucoxanthin, with maltodextrin, gum arabic, and whey protein isolate showing effective protection in gastric acid and increased release in the intestinal tract.
Fucoidan Extract Induces Apoptosis in MCF-7 Cells via a Mechanism Involving the ROS-Dependent JNK Activation and Mitochondria-Mediated Pathways
The study investigates the anti-tumor properties of fucoidan extract (FE) in human carcinoma cells, specifically MCF-7 cells. FE induces apoptosis through a caspase-independent mitochondrial pathway involving ROS-mediated MAP kinase activation and regulation of Bcl-2 family proteins.
Anti-cancer mechanism and possibility of nano-suspension formulations for a marine algae product fucoxanthin.
Narrative review discussing the nutraceutical and therapeutic effects of the marine algae product fucoxanthin, highlighting its antioxidant, anti-obesity, and anticancer activities. The paper suggests that a nano-suspension delivery method may improve its efficacy due to poor solubility.