Research
Fisetin
53 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review.
This systematic review investigates fisetin's effects and mechanisms in attenuating ischemia-reperfusion injuries (IRIs) in myocardial, cerebral, renal, and hepatic tissues. Fisetin reduces reactive oxygen species, upregulates antioxidant enzymes, and inhibits pro-inflammatory pathways, contributing to its protective effects against IRIs.
The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review.
Systematic review summarizing recent research on the pharmacological effects of fisetin, a flavonoid, in treating several neurological diseases. Fisetin is highlighted for its neuroprotective effects and potential to reverse cognitive abnormalities through multifaceted biological activity.
Recent advances in potential of Fisetin in the management of myocardial ischemia-reperfusion injury-A systematic review.
Systematic review of fisetin's potential in managing myocardial ischemia-reperfusion injury. Fisetin shows cardioprotective effects by delaying clotting time, preserving mitochondrial function, reducing oxidative stress, and inhibiting GSK 3β, but fails to protect diseased cardiomyocytes. The review highlights fisetin's action on signaling pathways like PI3K, JAK-STAT, Nrf2, PKC, JNK, and autophagy, with dosage and co-morbidities affecting its efficacy.
The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial.
This double-blind, parallel-group randomized controlled trial investigated the effects of interval resistance-aerobic training combined with fisetin supplementation on adipokines in obese men. The study found that the training plus fisetin group achieved significant weight loss, reductions in pro-inflammatory adipokines, and improvements in lipid profiles compared to the placebo group.
Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study.
This study investigated the pharmacokinetics of a novel fisetin formulation (FF-20) compared to unformulated fisetin (UF) in 15 healthy volunteers using a double-blinded, cross-over protocol. The FF-20 formulation significantly increased fisetin bioavailability, with plasma concentrations 26.9-fold greater than UF. No adverse events were reported.
eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
The study investigates the eIF3A R803K mutation's role in chemotherapy resistance in small cell lung cancer (SCLC). It was found that this mutation promotes cellular senescence and increases resistance to chemotherapy. Fisetin, a senolytic drug, showed a synergistic effect with chemotherapy in cells with the eIF3A R803K mutation, suggesting its potential to reverse chemotherapy resistance.
Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial.
Double-blind randomized placebo-controlled clinical trial evaluating fisetin's potential to extend the therapeutic window of rt-PA treatment in stroke patients. Fisetin improved treatment outcomes in patients with delayed onset-to-treatment time, as indicated by lower NIHSS scores and reduced serum levels of MMP-2, MMP-9, and CRP.
Inhibitory effect of Fisetin against the aggregation process of SOD1 E100K mutant: computer-based drug design as a potential therapeutic for ALS disease
The study used molecular docking and MD simulations to identify Fisetin as a potential flavonoid drug that may inhibit the amyloidogenic activity of the SOD1 E100K mutant associated with ALS. Fisetin increased structural stability and reduced β-sheets in the mutant, suggesting therapeutic potential against ALS.
Hyaluronic Acid-Coated Nanoliposomes as Delivery Systems for Fisetin: Stability, Membrane Fluidity, and Bioavailability
The study investigated the use of hyaluronic acid-coated nanoliposomes for encapsulating and delivering fisetin, addressing its water insolubility, poor stability, and low bioaccessibility. The HA coating improved the storage, thermal stability, digestive stability, and bioaccessibility of fisetin, suggesting potential for controlled delivery in functional foods.
Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients.
Double-blind, randomized placebo-controlled trial of 37 colorectal cancer patients undergoing chemotherapy, assessing the effect of 100 mg fisetin supplementation on inflammatory markers and matrix metalloproteinase levels. Fisetin significantly reduced plasma levels of IL-8 and hs-CRP, and suppressed MMP-7 levels, suggesting improved inflammatory status.
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches
The study evaluated the effects of intermittent oral supplementation with fisetin on frailty and grip strength in old mice. Fisetin improved physical function and decreased cellular senescence in skeletal muscle, with effects comparable to genetic clearance of senescent cells and synthetic senolytic ABT-263. Fisetin had no effects in young mice.
Fisetin Clears Senescent Cells Through the Pi3k‐Akt‐Bcl‐2/Bcl‐xl Pathway to Alleviate Diabetic Aortic Aging
The study investigates fisetin's potential in alleviating diabetic aortic aging by clearing senescent cells in a T2DM mouse model. Fisetin treatment reduced aortic senescent cell burden and improved vascular aging markers, with enhanced effects when combined with metformin.
Alleviation of obesity cardiomyopathy by Fisetin through the inhibition of NF-κB/MAPK signaling.
The study evaluated the effects of Fisetin on obesity cardiomyopathy in vitro and in vivo. Fisetin significantly inhibited myocardial pro-inflammatory cytokines and reduced cardiac inflammation, myocardial hypertrophy, and fibrosis in C57BL/6J mice fed a high-fat diet by inhibiting the NF-κB and MAPK signaling pathways.
Harnessing Nature for Breast Cancer Management: Effects of Fisetin-Loaded Nigellasomes Embedded in Microneedles Improve Tumor Suppression and Reduce Oxidative Stress
The study investigates the use of fisetin-loaded Nigella sativa oil nanovesicles embedded in microneedles for breast cancer management. The combination showed improved drug stability, penetration, and apoptotic activity, resulting in enhanced anticancer effects, reduced oxidative stress, and decreased inflammatory markers in vitro and in vivo.
Fisetin exerts neuroprotective effects in vivo and in vitro by inhibiting ferroptosis and oxidative stress after traumatic brain injury
The study investigates the neuroprotective effects of fisetin in traumatic brain injury (TBI) through in vivo and in vitro experiments. Fisetin was shown to reduce post-TBI injury, inhibit ferroptosis, activate the PI3K/AKT/NRF2 signaling pathway, and reduce oxidative stress, thereby alleviating tissue damage and cognitive dysfunction.
Fisetin orchestrates neuroinflammation resolution and facilitates spinal cord injury recovery through enhanced autophagy in pro-inflammatory glial cells.
The study investigates the effects of Fisetin on neuroinflammation and spinal cord injury recovery in a rat model. Fisetin enhanced autophagy in pro-inflammatory glial cells, reduced neuronal apoptosis, and improved neurological function recovery through the AMPK-mTOR signaling pathway.
New Mitochondria-Targeted Fisetin Derivative Compromises Mitophagy and Limits Survival of Drug-Induced Senescent Breast Cancer Cells
The study synthesized a mitochondria-targeted fisetin derivative (mito-fisetin) and investigated its anticancer activity in ER-positive breast cancer models in vitro and in vivo. Mito-fisetin induced apoptosis in senescent breast cancer cells by affecting mitochondrial function and impairing mitophagy, suggesting its potential as an anticancer and senotherapeutic strategy.
Fisetin alleviates cerebral ischemia/reperfusion injury by regulating Sirt1/Foxc1/Ubqln1 pathway-mediated proteostasis.
The study investigated the effects of fisetin on protein damage during cerebral ischemia/reperfusion injury (IRI) using in vivo and in vitro models. Fisetin alleviated protein damage, ubiquitinated protein aggregation, and neuronal death, suggesting its neuroprotective role in cerebral IRI through the Sirt1/Foxc1/Ubqln1 signaling axis.
Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway
The study investigated the effects of Fisetin on a DVT mouse model, focusing on its anti-inflammatory and antioxidant mechanisms. Fisetin administration inhibited pro-inflammatory cytokines and activated the NRF2 signaling pathway, suggesting potential therapeutic effects on DVT by attenuating inflammation and oxidative stress.
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
The study investigates the effects of fisetin on osteoarthritis progression in rats. Fisetin was found to activate SIRT6, which is negatively correlated with OA severity, and demonstrated chondroprotective effects by reducing cartilage erosion, ECM degradation, apoptosis, and senescence in chondrocytes.
Flavonoid Fisetin Alleviates Ovarian Aging of Laying Chickens by Enhancing Antioxidant Capacity and Glucose Metabolic Homeostasis
The study investigated the effects of fisetin supplementation on ovarian aging in laying chickens. Fisetin improved egg production, eggshell quality, and ovarian antioxidant capacity, reduced follicular atresia, and enhanced energy metabolism by modulating various signaling pathways.
Fisetin-loaded chitosan nanoparticles ameliorate pilocarpine-induced temporal lobe epilepsy and associated neurobehavioral alterations in mice: Role of ROS/TNF-α-NLRP3 inflammasomes pathway.
The study investigates fisetin-loaded chitosan nanoparticles in a murine model of pilocarpine-induced temporal lobe epilepsy. Fisetin NP showed anticonvulsant and neuroprotective effects, reducing seizures, depression-like behavior, and memory impairment. The mechanism involves attenuation of the ROS/TNF-α-NLRP3 inflammasome pathway.
Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.
The study investigates the effects of Fisetin on spinal cord injury (SCI) recovery in mice. Fisetin reduced apoptosis and oxidative damage in PC12 cells, reversed M1 polarization in BV2 cells, and promoted motor function recovery in SCI mice by inhibiting the JAK2/STAT3 signaling pathway and reducing neuroinflammation.
Enhancing the effectiveness of Polymyxin E with a Fisetin Nanoemulsion against a Colistin-resistant Salmonella typhimurium infection.
The study evaluated the synergistic effect of fisetin and polymyxin E against MCR-1-positive S. typhimurium infections. Fisetin inhibited the MCR-1 protein, restoring polymyxin E activity and enhancing therapeutic efficacy. In animal models, fisetin nanoemulsion with polymyxin E increased survival rates, reduced bacterial colonization, and decreased inflammatory factors.
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence
The study assessed fisetin as a senolytic to reduce vascular cell senescence and improve arterial function in old mice. Fisetin decreased cellular senescence and SASP-related inflammation, improved endothelial function, increased NO bioavailability, reduced oxidative stress, and lowered arterial stiffness, suggesting its potential as a therapy for age-related arterial dysfunction.
Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation
The study investigates the cardioprotective role of fisetin against doxorubicin-induced cardiomyopathy in rat and H9c2 cell models. Fisetin treatment alleviated cardiac dysfunction, myocardial fibrosis, and cardiac hypertrophy, and attenuated ferroptosis by activating the SIRT1/Nrf2 signaling pathway.
Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment
The study evaluated the protective effects of fisetin against d-galactose-induced oxidative stress, neuroinflammation, and memory impairment in mice. Fisetin prevented ROS accumulation and regulated antioxidant mechanisms, suggesting potential benefits in age-related neurological disorders.
Enhanced oral bioavailability and neuroprotective effect of fisetin through its SNEDDS against rotenone-induced Parkinson's disease rat model.
The study developed a self-nanoemulsifying drug delivery system (SNEDDS) for fisetin to improve its oral bioavailability and neuroprotective effects in a rotenone-induced Parkinson's disease rat model. The SNEDDS formulation enhanced fisetin's pharmacokinetic profile and demonstrated improved neuroprotection compared to naïve fisetin.
Fisetin Regulates Gut Microbiota and Exerts Neuroprotective Effect on Mouse Model of Parkinson’s Disease
The study investigates the effects of fisetin on a mouse model of Parkinson's disease. Fisetin was found to alleviate MPTP-induced dopaminergic neurodegeneration and alter gut microbiota composition, suggesting its potential as a therapeutic for Parkinson's disease.
Self-nanoemulsifying drug delivery system of fisetin: Formulation, optimization, characterization and cytotoxicity assessment
The paper discusses the formulation and optimization of a self-nanoemulsifying drug delivery system (SNEDDS) for fisetin, a plant-derived flavonoid with anti-cancer, anti-oxidant, and anti-Parkinson's activities. The study characterizes the SNEDDS for droplet size, shape, zeta potential, cell viability, dissolution, and permeability to improve fisetin's oral bioavailability.
Recent advancement of fisetin-based nanoformulations in the management of psoriasis
The review compiles fisetin's chemical and pharmacological properties and discusses fisetin-loaded nanoformulations like polymeric nanoparticles, liposomes, and nanogels for psoriasis therapy. Preclinical studies show enhanced skin penetration, reduced inflammation, and symptom alleviation in psoriasis models, but clinical trials are needed to assess safety and efficacy.
Fisetin attenuates AlCl3-induced neurodegeneration by modulating oxidative stress and inflammatory cytokine release in adult albino wistar rats.
The study assessed the role of fisetin in reversing oxidative stress and neuroinflammation caused by Aluminum chloride (AlCl3) in adult male Wistar rats. Fisetin pretreatment mitigated the effects of AlCl3-induced neurodegeneration, including lipid peroxidation, decreased antioxidant activity, and altered thalamic histomorphology.
Fisetin as a Senotherapeutic Agent: Evidence and Perspectives for Age-Related Diseases.
The paper reviews the potential of fisetin as a senotherapeutic agent for age-related chronic diseases. It examines evidence from in vitro studies, animal models, and phase I/II trials, suggesting fisetin may help manage chronic diseases by targeting senescent cells and reducing systemic chronic inflammation.
Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review
The review discusses the challenges of fisetin's low bioavailability due to limited solubility and absorption, and explores how nanotechnology and structural modifications can improve its bioavailability and therapeutic efficacy. It highlights the potential of fisetin in treating Alzheimer's disease and cancer, and the need for suitable nanocarriers to enhance its therapeutic potential.
Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
This review discusses fisetin, a naturally derived flavone with antioxidant, anti-inflammatory, antiangiogenic, and anticancer properties. It highlights fisetin's potential in inhibiting tumor growth and metastasis, and explores formulation strategies to improve its bioavailability for anticancer therapy.
The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
This narrative review discusses the neuroprotective effects of fisetin, a natural flavonoid, in neurodegenerative diseases. Fisetin exhibits potent antioxidant properties, reducing oxidative stress, neurotoxicity, and inflammation, and regulates molecular pathways to protect neural cells from degeneration.
Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models
The study investigates the effects of fisetin on psoriasis pathology using 2D and 3D human skin models. Fisetin inhibited key signaling pathways and cytokine production, ameliorating psoriasis-like features and suggesting potential as a treatment for inflammatory skin disorders.
Preparation and optimization of poly (lactic acid) nanoparticles loaded with fisetin to improve anti-cancer therapy.
The study aimed to load fisetin into poly(lactic acid) nanoparticles to improve its solubility and therapeutic efficacy. The optimized nanoparticles showed high encapsulation efficiency and superior antitumor effects against HCT116 colon cancer cells in vitro and in a xenograft 4T1 breast cancer model in vivo compared to free fisetin.
Attenuation of reserpine-induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol
The study evaluated the efficacy of fisetin against reserpine-induced fibromyalgia in rats. Fisetin treatment ameliorated reserpine-induced allodynia, hyperalgesia, and depression, and modulated biogenic amine levels, oxido-nitrosative stress, and ROS levels.
Crosstalk between Fisetin-induced Apoptosis and Autophagy in Human Oral Squamous Cell Carcinoma
The study investigates the effects of fisetin on apoptosis and autophagy in human oral squamous cell carcinoma cell line Ca9-22. Fisetin induced apoptotic cell death, which could be enhanced by inhibiting autophagy, suggesting a potential adjuvant treatment for oral cancer.
Fisetin Inhibited Growth and Metastasis of Triple-Negative Breast Cancer by Reversing Epithelial-to-Mesenchymal Transition via PTEN/Akt/GSK3β Signal Pathway
The study investigated the effects of fisetin on triple-negative breast cancer (TNBC) using in vitro cell lines and an in vivo xenograft model. Fisetin inhibited cell proliferation, migration, and invasion in TNBC cell lines and reversed epithelial to mesenchymal transition (EMT). In vivo, fisetin reduced primary tumor growth and lung metastasis, potentially mediated by the PTEN/Akt/GSK-3β signaling pathway.
Fisetin is a senotherapeutic that extends health and lifespan.
The study screened flavonoid polyphenols for senolytic activity and identified fisetin as the most potent. Fisetin reduced senescence markers in murine and human tissues, restored tissue homeostasis, reduced age-related pathology, and extended lifespan in mice. These findings suggest potential for translation to human clinical studies.
Fisetin inhibits the generation of inflammatory mediators in interleukin‐1&bgr;–induced human lung epithelial cells by suppressing the NF‐&kgr;B and ERK1/2 pathways
The study investigated the effects of fisetin on inflammatory responses in IL-1β-stimulated A549 human lung epithelial cells. Fisetin significantly inhibited the expression of inflammatory mediators, reduced prostaglandin E2 production, and decreased ICAM-1 expression by suppressing the NF-κB and ERK1/2 signaling pathways.
Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles
The study aimed to improve the oral bioavailability of fisetin by encapsulating it in PLGA nanoparticles as a complex with HPβCD. The encapsulated fisetin showed enhanced anticancer activity and apoptosis in MCF-7 breast cancer cells and improved oral bioavailability in C57BL6 mice.
New agents that target senescent cells: the flavone, fisetin, and the BCL-Xinhibitors, A1331852 and A1155463.
The study investigates the senolytic effects of fisetin, a naturally-occurring flavone, and BCL-Xinhibitors A1331852 and A1155463. Fisetin selectively induces apoptosis in senescent human umbilical vein endothelial cells but not in other cell types, suggesting potential for clinical interventions targeting senescent cells.
Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells
In vitro study investigating the synergistic effects of the dietary flavonoid fisetin with paclitaxel on A549 non-small cell lung cancer cells. The combination induced mitotic catastrophe and autophagic cell death, suggesting potential for novel chemotherapeutic approaches.
Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk
The study investigates the anti-inflammatory mechanisms of fisetin in LPS-stimulated macrophage-like cells. Fisetin reduced nitric oxide release and mRNA levels of inflammatory markers, and inhibited NF-κB activation by blocking Src and Syk phosphorylation.
Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways
The study investigated the effect of fisetin on melanoma cell invasion and epithelial-mesenchymal transition. Fisetin treatment inhibited cell invasion in multiple human malignant melanoma cell lines, particularly in BRAF mutated cells, by decreasing phosphorylation of MEK1/2 and ERK1/2 and inhibiting NFκB signaling. Fisetin also promoted mesenchymal to epithelial transition, reducing mesenchymal markers and increasing epithelial markers.
Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway
The study investigates the effect of fisetin on the migration and invasion of human cervical cancer cells. Fisetin was found to inhibit these aggressive phenotypes by down-regulating urokinase plasminogen activator expression through suppression of the p38 MAPK-dependent NF-κB signaling pathway.
Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice
The study investigated the antiproliferative and antiangiogenic properties of fisetin in vitro and in vivo. Fisetin showed cytotoxicity against Lewis lung carcinoma cells and inhibited endothelial cell migration and capillary-like structure formation. In mice, fisetin inhibited angiogenesis and, when combined with cyclophosphamide, significantly improved antitumour activity with low systemic toxicity.
Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite.
The study investigates the pharmacokinetics and metabolism of fisetin in mice, identifying geraldol as an active metabolite. Fisetin and its metabolite geraldol were compared for cytotoxic and antiangiogenic activities, with geraldol showing higher cytotoxicity and ability to inhibit endothelial cell migration and proliferation.
Senolytics as Modulators of Critical Signaling Pathways: a Promising Strategy to Combat Brain Aging and Neurodegenerative Disorders.
The paper reviews the role of senolytics, such as fisetin, quercetin, and dasatinib, in targeting and destroying senescent cells to combat brain aging and neurodegenerative disorders. It discusses how these compounds reduce oxidative stress and inflammation by modulating critical signaling pathways like mTOR, Nrf2-Keap1, AMPK, and SIRT1.
Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine.
The paper reviews and analyzes various drug delivery strategies to improve the biopharmaceutical properties of fisetin, a bioactive flavonol with therapeutic activities. It discusses the influence of these strategies on fisetin's chemistry, pharmacokinetics, and physicochemical attributes.