Research
EGCG (Green Tea Extract)
188 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Preclinical evidence construction for epigallocatechin-3-gallate against non-alcoholic fatty liver disease: a meta-analysis and machine learning study.
Meta-analysis of 17 preclinical studies involving 293 animals to evaluate the efficacy of EGCG in treating NAFLD. EGCG significantly reduced ALT, AST, hepatic triglyceride, serum TG, hepatic TC, and serum TC, and modulated key signaling pathways such as PI3K/Akt/AMPK, TGF-β/Smad, Nrf2, NF-κB, and ROS/MAPK.
Relationship Between Depression and Epigallocatechin Gallate from the Perspective of Gut Microbiota: A Systematic Review.
Systematic review examining the relationship between depression and epigallocatechin gallate (EGCG) from the perspective of gut microbiota. The review discusses how EGCG, a major component of green tea, may alleviate depression through interactions with gut microbiota and other mechanisms.
Green Tea and Epigallocatechin Gallate (EGCG) for Cancer Prevention: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 43 studies, including 7 RCTs and 36 cohort studies, assessing the effects of green tea and EGCG on cancer prevention. The meta-analysis found that green tea and EGCG intake reduced the risk of various cancers, with notable effects on prostate, oral, gallbladder, and hematological cancers. A significant negative linear correlation was observed between high doses, long-term consumption of green tea, and cancer risk.
EGCG as a therapeutic agent: a systematic review of recent advances and challenges in nanocarrier strategies.
This systematic review explores the challenges and advancements in using nanocarrier strategies to enhance the stability, bioavailability, and pharmacological activity of EGCG, a bioactive polyphenol from green tea. The review highlights the enhanced antioxidative, anti-inflammatory, anticancer, and antimicrobial effects of EGCG-loaded nanoparticles compared to free EGCG.
Chemoprophylaxis Effect of EGCG on the Recurrence of Colorectal Cancer: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of five RCTs involving 1389 participants to assess the effect of EGCG on colorectal cancer recurrence. The study found that patients taking EGCG had a statistically significant lower recurrence rate of CRC compared to placebo.
The Effects of Epigallocatechin-3-Gallate Nutritional Supplementation in the Management of Multiple Sclerosis: A Systematic Review of Clinical Trials.
Systematic review of nine clinical trials involving 318 participants assessing the effects of EGCG supplementation in multiple sclerosis patients. EGCG improved metabolic health markers, gait speed, balance, and mood, but showed minimal impact on primary disease progression markers like EDSS scores and MRI lesions.
Therapeutic effects of epigallocatechin-3-gallate for inflammatory bowel disease: A preclinical meta-analysis.
Preclinical meta-analysis of 19 studies involving 309 animals evaluating the effects of epigallocatechin-3-gallate (EGCG) on inflammatory bowel disease (IBD). EGCG was found to ameliorate IBD-related pathology, reduce inflammation and oxidative stress indicators, and was most effective when administered orally at 32-62 mg/kg/day.
Effect of dietary antioxidants on the risk of prostate cancer. Systematic review and network meta-analysis.
Systematic review and network meta-analysis of 14 RCTs with 73,365 males assessing the impact of 10 dietary antioxidants on prostate cancer risk. Green tea catechins significantly reduced the risk of prostate cancer, followed by vitamin D and vitamin B6, with folic acid having the lowest impact.
The effects of green tea extract supplementation on body composition, obesity-related hormones and oxidative stress markers: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials.
This systematic review and meta-analysis investigated the effects of green tea extract supplementation on body composition, obesity-related hormones, and oxidative stress markers. The analysis included 59 studies with 3802 participants and found that GTE supplementation significantly reduced body mass, body fat percentage, BMI, and malondialdehyde levels, while increasing adiponectin and total antioxidant capacity.
Cardioprotective effect of epigallocatechin gallate in myocardial ischemia/reperfusion injury and myocardial infarction: a meta-analysis in preclinical animal studies.
This meta-analysis of 25 preclinical animal studies involving 443 animals evaluates the efficacy of Epigallocatechin gallate (EGCG) in myocardial ischemia-reperfusion injury. EGCG was found to reduce myocardial infarct size and improve cardiac function, serum myocardial injury enzyme, and oxidative stress levels, indicating a cardioprotective effect.
Hepatotoxicity with High-Dose Green Tea Extract: Effect ofGenotypes.
The study investigated the influence of genotypes on liver injury biomarkers in response to high-dose green tea extract supplementation among postmenopausal women. Participants were randomized to consume high-dose GTE or placebo for 12 months. The study found that certain genotypes may be risk factors for serum transaminase elevations with long-term high-dose GTE supplementation.
Green Tea Extract to Prevent Colorectal Adenomas, Results of a Randomized, Placebo-Controlled Clinical Trial.
A randomized, double-blind trial of green tea extract (GTE) standardized to 150 mg of EGCG b.i.d. vs placebo over 3 years was conducted to prevent colorectal adenomas in 879 participants. The study found no statistically significant difference in adenoma rates between the GTE and placebo groups.
Salubrious Effects of Green Tea Catechins on Fatty Liver Disease: A Systematic Review
Systematic review of studies on the effects of EGCG or green tea extract on non-alcoholic fatty liver disease (NAFLD) in rodent models and humans. EGCG or GTE supplementation reduced body weight, adipose tissue deposits, and food intake, and had beneficial effects on oxidative stress-related pathways and lipid and glucose metabolism.
Anti-Influenza with Green Tea Catechins: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of eight studies with 5,048 participants examining the effect of green tea catechins (GTCs) on influenza prevention. The meta-analysis found statistically significant effects of GTCs in preventing influenza infection in both RCTs and cohort studies, suggesting green tea consumption is effective in influenza prophylaxis.
Effect of Acute and Chronic Dietary Supplementation with Green Tea Catechins on Resting Metabolic Rate, Energy Expenditure and Respiratory Quotient: A Systematic Review.
Systematic review of 15 studies with 499 participants examining the effects of green tea catechins (GTC) on resting metabolic rate (RMR), energy expenditure (EE), and respiratory quotient (RQ). GTC supplementation showed positive effects on RQ values, but results on RMR and EE were inconclusive. Some studies reported increased RMR, especially with resistance training. GTC may improve metabolic profiles, but further research is needed to determine optimal dosing.
Green tea and green tea extract in oncological treatment: A systematic review.
Systematic review assessing the clinical evidence of green tea catechins, specifically EGCG, in cancer care. Seven studies with 371 patients were included, focusing on breast and prostate cancer. Results showed a small decrease in prostate-specific-antigen levels and effectiveness in reducing odor of fungating malignant wounds. Green tea also showed potential in treating radiation-induced diarrhea. Further studies with higher methodological quality are needed.
Green Tea Catechin Association with Ultraviolet Radiation-Induced Erythema: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis evaluated the effectiveness of green tea catechins in protecting against ultraviolet radiation-induced erythema. Six randomized controlled studies with 100 participants showed that regular oral supplementation of green tea catechins provides favorable protection against erythema inflammation, increasing the minimal dose of radiation required to induce erythema.
A comprehensive insight into effects of green tea extract in polycystic ovary syndrome: a systematic review.
This systematic review evaluates the effects of green tea extract (GTE) on polycystic ovary syndrome (PCOS). It includes four human and four animal studies, showing GTE's positive effects on weight loss, testosterone reduction, and glycemic levels. However, effects on inflammatory parameters and antioxidant status were limited to animal studies.
The effects of green tea on acne vulgaris: A systematic review and meta-analysis of randomized clinical trials.
This systematic review and meta-analysis examined the effects of green tea extract (GTE) on acne. Five randomized-controlled studies were included, showing that topical GTE application significantly reduced inflammatory and non-inflammatory acne lesions, while oral GTE intake had limited effects. The study suggests topical GTE is beneficial for acne treatment without significant adverse events.
Effect of green tea extract on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs examining the effects of green tea extract on lipid profile in type 2 diabetes mellitus patients. The study found that GTE supplementation improved lipid profile by reducing serum triglyceride concentrations, especially with interventions longer than 8 weeks and doses greater than 800 mg/day.
Green Tea Catechin Extract Supplementation Does Not Influence Circulating Sex Hormones and Insulin-Like Growth Factor Axis Proteins in a Randomized Controlled Trial of Postmenopausal Women at High Risk of Breast Cancer.
RCT of 1000 postmenopausal women assessing the effects of decaffeinated green tea extract on circulating sex hormones and IGF proteins. GTE supplementation significantly increased circulating estradiol concentrations but did not affect IGF proteins.
A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer.
RCT of 1,075 postmenopausal women investigating green tea extract supplementation on mammographic density as a potential mechanism for breast cancer prevention. GTE supplementation did not significantly change mammographic density in all women, but reduced percent mammographic density in younger women (50-55 years).
Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans.
Systematic review of 17 RCTs with 1356 participants assessing the effect of green tea epigallocatechin gallate (EGCG) on LDL cholesterol levels. EGCG doses of 107-856 mg/d for 4 to 14 weeks significantly reduced LDL-C by -9.29 mg/dl. The effect was consistent across different baseline lipid levels and doses.
Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial.
This randomized, placebo-controlled trial examined the effects of green tea extract (GTE) high in EGCG on blood lipids in postmenopausal women. GTE supplementation significantly reduced total cholesterol and LDL cholesterol, particularly in women with high baseline TC levels, but increased triglycerides, especially among obese women and statin users.
The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial.
RCT of 1075 postmenopausal women assessing the safety of green tea extract (GTE) supplementation on breast cancer biomarkers. No significant differences in adverse events between GTE and placebo groups, though GTE group had higher nausea and dermatologic adverse events, and more ALT elevations. GTE was generally well tolerated, but 6.7% experienced ALT elevations.
The Minnesota Green Tea Trial (MGTT), a randomized controlled trial of the efficacy of green tea extract on biomarkers of breast cancer risk: study rationale, design, methods, and participant characteristics.
The Minnesota Green Tea Trial (MGTT) was a randomized, placebo-controlled, double-blinded trial investigating the effect of daily green tea extract consumption for 12 months on biomarkers of breast cancer risk in healthy postmenopausal women. The study involved 1,075 participants and focused on changes in mammographic density, sex hormones, and oxidative stress biomarkers.
Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population.
This randomized, placebo-controlled trial investigates the effect of green tea extract supplementation, containing 300 mg EGCG, on the recurrence of colon adenomas in patients who have undergone polypectomy. The study aims to enroll 2534 patients, with 2028 expected to complete the study over three years, comparing the incidence, number, and histology of adenomas at endpoint colonoscopy.
Effects of Green Tea Extract Supplementation on Inflammatory Cytokines Among Postmenopausal Women with Overweight or Obesity-A Secondary Analysis of a Randomized Controlled Trial.
Secondary analysis of a randomized controlled trial evaluating the effect of high-dose green tea extract supplementation on inflammatory cytokines in postmenopausal women with overweight or obesity. The study found no significant changes in CRP, IL-6, or TNF-α levels after one year of supplementation.
Green Tea Catechin Plus Inulin Improves Insulin Resistance Without Reducing Visceral Fat and Shows Exploratory Gut Microbiota Signals in Adults with Visceral Obesity: A Double-Blind Randomized Controlled Trial.
Double-blind RCT in Japanese adults with visceral obesity comparing a catechin + inulin beverage to placebo for 12 weeks. The catechin + inulin group showed improved insulin resistance (HOMA-IR) but no reduction in visceral fat. Exploratory gut microbiota analyses suggested potential associations with improved HOMA-IR.
A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study).
Double-blind, randomized, placebo-controlled trial assessing the addition of EGCG to a multimodal lifestyle intervention in APOE-ε4 carriers with subjective cognitive decline. No significant difference was found in the primary endpoint, but exploratory analyses showed cognitive benefits in the EGCG group after a 3-month washout.
A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels.
Phase I dose-escalation study evaluating the safety of Polyphenon E (epigallocatechin gallate) and its effect on liver γ-OHPdG levels in patients with cirrhosis. Polyphenon E was well tolerated up to 1,600 mg/day, with promising suppression of liver γ-OHPdG levels. Recommended starting dose for phase II trial is 1,200 mg.
Evaluation of the clinical efficacy of green tea extract gel as local drug delivery for periodontitis.
RCT comparing the efficacy of green tea extract gel and ornidazole gel as adjuncts to scaling and root planing in periodontitis patients. The green tea extract gel group showed superior outcomes with a significant reduction in probing pocket depths compared to the ornidazole gel group.
Epigallocatechin gallate alleviates non-alcoholic fatty liver disease through the inhibition of the expression and activity of Dipeptide kinase 4.
A clinical randomized controlled trial investigated the efficacy of epigallocatechin gallate (EGCG) in NAFLD patients. EGCG was found to suppress lipid accumulation, inhibit inflammation, and improve NAFLD pathogenesis via inhibition of DPP4 expression and activity.
Improvements in gait and balance in patients with multiple sclerosis after treatment with coconut oil and epigallocatechin gallate. A pilot study.
Pilot RCT with 51 MS patients assessing the impact of 800 mg EGCG and 60 ml coconut oil daily on gait and balance over 4 months. The intervention group showed significant improvements in gait speed, quantitative balance, and muscle strength of the right quadriceps.
The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology.
RCT investigating the effects of EGCG on obesity-related precocious puberty in obese girls using integrated metabolomics and network pharmacology. The study identified key targets and pathways, including AKT1, EGFR, ESR1, STAT3, IGF1, and MAPK1, and pathways such as estrogen, PI3K-Akt, MAPK, and Jak-STAT, suggesting EGCG's preventive role.
Efficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial.
This phase 2 double-blind, placebo-controlled randomized clinical trial evaluated the efficacy of epigallocatechin-3-gallate (EGCG) solution in reducing radiation-induced dermatitis (RID) in 180 breast cancer patients undergoing postoperative radiotherapy. The EGCG group showed a significantly lower incidence of grade 2 or worse RID compared to the placebo group, with reduced RID index and symptom indexes.
Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study).
RCT of 73 children with Down syndrome evaluating the safety and efficacy of EGCG supplementation. EGCG was found to be safe and well-tolerated, but did not improve cognitive or functional performance compared to placebo.
Metabolomics strategy comprehensively unveils the effect of catechins intervention on the biomarkers of exposure to acrylamide and biomarkers of cardiometabolic risk.
RCT involving 65 adults and additional animal studies to assess the effect of catechins on acrylamide toxicity. Catechins promoted excretion of acrylamide metabolites and improved metabolic disorders, reducing cardiometabolic risk. EGCG and EC interventions showed beneficial effects on biomarkers related to acrylamide exposure.
Green tea catechin EGCG could prevent obesity-related precocious puberty through NKB/NK3R signaling pathway.
This study explored the regulatory pathways of EGCG in preventing obesity-related precocious puberty. A human RCT and animal experiment were conducted, showing that EGCG intervention could delay puberty onset and modulate NKB/NK3R signaling in obese girls and rats. EGCG reduced serum NKB levels and delayed vaginal opening in rats on a high-fat diet.
Epigallocatechin Gallate in Relapsing-Remitting Multiple Sclerosis: A Randomized, Placebo-Controlled Trial.
RCT assessing the safety and efficacy of EGCG as an add-on to glatiramer acetate in patients with relapsing-remitting multiple sclerosis. The study found no significant difference between EGCG and placebo groups in MRI and clinical disease activity over 18 months. EGCG was well tolerated but did not affect immune response or disease progression.
Epigallocatechin Gallate in Progressive MS: A Randomized, Placebo-Controlled Trial.
Phase II RCT with 61 patients with progressive multiple sclerosis testing oral EGCG (up to 1,200 mg daily) versus placebo for 36 months. The study found no significant effect of EGCG on brain atrophy or other clinical and radiologic disease parameters, though it was safe and well tolerated.
Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study.
Pilot RCT with 51 MS patients comparing EGCG and coconut oil intervention to placebo over 4 months. The intervention group showed significant decreases in IL-6 and fat percentage, and increases in BuChE, βHB, PON1, albumin, and functional capacity. BuChE was positively correlated with PON1 activity, fat percentage, and triglycerides in the intervention group.
Topical epigallocatechin-3-gallate in the treatment of vitiligo.
A 6-month clinical trial assessed the efficacy and safety of topical Epigallocatechin-3-gallate (EGCG) in treating vitiligo. Both EGCG and pimecrolimus were effective in repigmentation, with no statistically significant difference in VASI and PGA scores between treatments. No serious side effects were observed.
N-Oleoyl-Phosphatidyl-Ethanolamine and Epigallo Catechin-3-Gallate Mitigate Oxidative Stress in Overweight and Class I Obese People on a Low-Calorie Diet.
This double-blind placebo-controlled study investigated the effects of 2 months' supplementation with EGCG complexed with NOPE on plasma oxidative status in overweight and class I obese subjects. The NOPE-EGCG group showed significantly lower mean changes of Ox-LDL and higher antioxidant capacity compared to the placebo group, suggesting amelioration of oxidative stress-related markers.
The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients.
Pilot RCT with 51 MS patients assessing the impact of 800 mg EGCG and 60 mL coconut oil on IL-6 levels, anxiety, and functional disability. The intervention group showed decreased state anxiety and improved functional capacity, with IL-6 levels decreasing in both groups.
Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.
RCT investigating the effects of EGCG on obesity and metabolic profiles in obese human subjects. EGCG significantly decreased fasting plasma triglyceride levels, systolic and diastolic blood pressure, and serum kisspeptin levels after 8 weeks, but had no effect on body weight, BMI, or adipocyte lipolysis and browning.
Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia: A double-blind, randomized and placebo-controlled clinical study.
Double-blind, randomized, placebo-controlled clinical study of 350 pregnant women with severe pre-eclampsia comparing oral nifedipine with and without EGCG. The NIF+EGCG group showed significantly shorter time to control blood pressure and longer interval before a new hypertensive crisis, with no differences in maternal adverse effects or neonatal complications.
Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial.
Double-blind RCT of 404 pregnant women with gestational diabetes mellitus, comparing 500 mg daily EGCG supplementation to placebo. The EGCG group showed significantly improved maternal diabetic parameters and fewer neonatal complications compared to placebo.
Chemoprevention of prostate cancer in men with high-grade prostatic intraepithelial neoplasia (HGPIN): a systematic review and adjusted indirect treatment comparison.
Systematic review and meta-analysis of chemoprevention agents in HGPIN patients. Green tea catechins significantly decreased prostate cancer incidence compared to other agents, showing superiority in reducing cancer risk.
Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: A systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs on EGCG consumption to assess its effects on energy expenditure and fat oxidation. EGCG supplementation showed a significant mean difference in respiratory quotient and energy expenditure compared to placebo, suggesting a moderate acceleration of energy expenditure. However, changes in fat oxidation did not reach statistical significance.
Green Tea Extract and Catechol-O-Methyltransferase Genotype Modify Fasting Serum Insulin and Plasma Adiponectin Concentrations in a Randomized Controlled Trial of Overweight and Obese Postmenopausal Women.
The Minnesota Green Tea Trial was a 12-month RCT involving 237 overweight and obese postmenopausal women, examining the effects of decaffeinated green tea extract (GTE) on anthropometric variables and obesity-associated hormones. GTE did not affect body weight, BMI, or waist circumference but decreased fasting insulin concentrations in participants with elevated baseline insulin levels. The COMT genotype influenced insulin and adiponectin concentrations.
Effect of green tea catechins on breast carcinogenesis: a systematic review of in-vitro and in-vivo experimental studies.
Systematic review of in vitro and in vivo studies on the effect of green tea catechins on breast carcinogenesis. Evidence suggests green tea catechins modulate breast cell carcinogenesis, demonstrating a protective effect, though high concentrations are needed for significant results.
A green tea extract high in catechins reduces body fat and cardiovascular risks in humans.
A 12-week double-blind parallel multicenter trial investigated the effects of green tea extract high in catechins on body fat and cardiovascular risks in Japanese adults with visceral fat-type obesity. The catechin group showed greater reductions in body weight, body fat, waist circumference, systolic blood pressure, and LDL cholesterol compared to the control group.
Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene.
RCT evaluating the effect of EGCG on folate levels in 39 reproductive-aged women, with or without uterine fibroids. Participants received EGCG alone or in combination with clomiphene or letrozole for 30 days. Folate levels remained normal, suggesting EGCG is well-tolerated and not associated with folate deficiency.
Gel Containing Catechin and Mesoporous Silica Nanoparticles for Protecting Root Dentin Against Erosion: An In Situ Study.
This randomized, controlled, cross-over study evaluated the anti-erosive effect of gels containing epigallocatechin-3-gallate (EGCG) and EGCG adsorbed on mesoporous silica nanoparticles (EGCG/MSN) on eroded dentin in 11 volunteers. The study found that EGCG/MSN may reduce dentin wear under erosive conditions, showing no significant difference from the positive control group.
A green tea extract confection decreases circulating endotoxin and fasting glucose by improving gut barrier function but without affecting systemic inflammation: A double-blind, placebo-controlled randomized trial in healthy adults and adults with metabolic syndrome.
A double-blind, placebo-controlled randomized trial examined the effects of a catechin-rich green tea extract confection on serum endotoxin, intestinal permeability, and fasting glucose in healthy adults and adults with metabolic syndrome. The GTE confection decreased serum endotoxin and fasting glucose, improved gut barrier function, but did not affect systemic inflammation.
Epigallocatechin gallate enhances sympathetic heart rate variability and decreases blood pressure in obese subjects: a randomized control trial.
This randomized controlled trial investigated the effects of epigallocatechin gallate (EGCG) on blood pressure and autonomic nervous system in obese subjects. After 8 weeks of EGCG treatment, systolic and diastolic blood pressure significantly decreased, and the LF/HF ratio increased, indicating a shift toward sympathetic dominance.
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women.
This study assessed the hepatic safety of 800 mg of EGCG daily, alone or in combination with clomiphene citrate or letrozole, in reproductive-aged women. The study found that EGCG was well-tolerated and not associated with liver toxicity or folate deficiency.
Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies.
Two randomized, double-blind, placebo-controlled crossover studies evaluated the acute effects of green tea catechins (GTC) and coffee chlorogenic acid (CCA) on postprandial glucose, insulin, and incretin responses in healthy men. The combined ingestion of GTC and CCA significantly altered incretin response and suppressed glucose and insulin levels, suggesting an effective minimum dose of 540 mg GTC and 150 mg CCA.
Efficacy and safety of epigallocatechin-3-gallate in treatment acute severe dermatitis in patients with cancer receiving radiotherapy: a phase I clinical trial.
Phase I clinical trial evaluating the safety and effectiveness of epigallocatechin-3-gallate (EGCG) solution for treating acute severe dermatitis in cancer patients receiving radiotherapy. EGCG significantly reduced grade III radiation-induced dermatitis to grade I or II and relieved symptoms such as burning, tractive sensation, tenderness, erythema, itching, and pain. No adverse events were reported.
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study.
This randomized cross-over study investigated the effects of epigallocatechin gallate (EGCG) ingestion on catecholamine metabolism during graded cycle exercise in eight males. EGCG supplementation reduced circulating catecholamines but did not affect metanephrine, glucose, or lactate responses. Lipid oxidation rate was lower in the EGCG group, although cycle time to exhaustion was similar between groups.
The influence of green tea extract on nintedanib's bioavailability in patients with pulmonary fibrosis.
RCT investigating the interaction between green tea extract (GTE) and nintedanib in 26 patients with pulmonary fibrosis. Nintedanib's AUC was 21% lower when administered with GTE, indicating a significant herb-drug interaction that could impair treatment efficacy.
The effect of (-)-epigallocatechin gallate as an adjunct to non-surgical periodontal treatment: a randomized clinical trial.
A double-blind, randomized controlled trial evaluated the adjunctive effect of (-)-epigallocatechin gallate (EGCG) solution as a coolant during scaling and root planing in 15 patients with chronic periodontitis. The study found that using EGCG solution instead of water improved the bleeding index at the 12-week review, but other clinical parameters showed no additional benefit.
Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers.
A randomized, open, 2-phase crossover study in 10 healthy Japanese volunteers investigated the effect of green tea extract (GTE) on the pharmacokinetics of fexofenadine and pseudoephedrine. GTE significantly decreased the plasma concentration and urinary excretion of fexofenadine by 70% and 67%, respectively, but did not affect pseudoephedrine. The study suggests GTE inhibits OATP1A2-mediated intestinal absorption of fexofenadine.
Effect of Green Tea Extract Ingestion on Fat Oxidation during Exercise in the Menstrual Cycle: A Pilot Study.
This randomized, double-blind, crossover study investigated the effect of green tea extract (GTE) on fat oxidation during exercise in different menstrual cycle phases in 10 women. GTE ingestion improved fat oxidation during the luteal phase compared to placebo, suggesting a positive effect on fat metabolism.
Randomized Phase II Trial of Polyphenon E versus Placebo in Patients at High Risk of Recurrent Colonic Neoplasia.
RCT of Polyphenon E (green tea polyphenol preparation) in 39 subjects with rectal aberrant crypt foci, a precursor of colorectal cancer. Polyphenon E was well tolerated but did not significantly reduce rectal ACF number compared to placebo over 6 months.
Concomitant use of tea catechins affects absorption and serum triglyceride-lowering effects of monoglucosyl hesperidin.
Two randomized controlled trials investigated the effects of combined ingestion of green tea catechins (GTC) and monoglucosyl hesperidin (GHES) on pharmacokinetics and serum triglycerides. Study 1 found no significant difference in pharmacokinetics of hesperetin between treatments. Study 2 showed that 4 weeks of GHES and GTC ingestion significantly decreased fasting serum triglyceride levels.
The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals.
This RCT investigated the effects of decaffeinated green tea extract (dGTE) with or without additional antioxidants on fat oxidation, body composition, and cardio-metabolic health in 27 overweight individuals engaged in regular exercise. The dGTE+ group showed improved maximal fat oxidation and substrate utilization during exercise, and lowered LDL-c levels after 8 weeks, but body composition and other cardio-metabolic markers were largely unaffected.
Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults.
This randomized, single-blind, placebo-controlled, crossover trial investigated the acute effects of green tea extract (GTE) on muscle microvascular blood flow and glucose uptake in 12 healthy older adults. GTE increased microvascular blood volume but did not significantly alter leg glucose uptake compared to placebo.
Effects of green tea extract supplementation and endurance training on irisin, pro-inflammatory cytokines, and adiponectin concentrations in overweight middle-aged men.
RCT assessing the effects of green tea extract (GTE) supplementation combined with endurance training on irisin, pro-inflammatory cytokines, and adiponectin in overweight middle-aged men. The ET+GTE group showed greater decreases in IL-6, hs-CRP, bodyweight, BMI, body fat percentage, and visceral fat area, and increased adiponectin and irisin levels compared to ET+P and P groups.
Catechin-based Dentin Pretreatment and the Clinical Performance of a Universal Adhesive: A Two-year Randomized Clinical Trial.
This randomized clinical trial evaluated the two-year effect of dentin pretreatment with epigallocatechin-3-gallate (EGCG) on the clinical performance of restorations of noncarious cervical lesions with Single Bond Universal adhesive. The study found that EGCG pretreatment did not impair the clinical performance of the adhesive, with retention rates of 97.0% for ER and ER-EGCG, and 94.1% for SE and 94.2% for SE-EGCG at 24 months.
Does green tea extract enhance the anti-inflammatory effects of exercise on fat loss?
RCT with 30 overweight women comparing endurance training with and without green tea extract (GTE) supplementation. GTE combined with exercise led to greater reductions in body weight, BMI, waist to hip ratio, and body fat percentage, as well as greater increases in adiponectin and decreases in hs-CRP compared to exercise alone.
Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers.
Open-label, randomized, 2-phase crossover study in 10 healthy subjects evaluating the effect of green tea extract on lisinopril pharmacokinetics. Green tea extract significantly impaired the intestinal absorption of lisinopril, reducing its maximum plasma concentration and area under the curve, but did not affect the absorption rate or renal clearance.
A prospective, three-arm, randomized trial of EGCG for preventing radiation-induced esophagitis in lung cancer patients receiving radiotherapy.
Phase II RCT of EGCG as a radioprotector in lung cancer patients receiving chemoradiation. Patients were randomized into prophylactic EGCG, therapeutic EGCG, or conventional therapy groups. EGCG significantly reduced maximum esophagitis grade, pain, and dysphagia compared to conventional therapy, with prophylactic use showing slight advantages.
Effect of epigallocatechin gallate on the body composition and lipid profile of down syndrome individuals: Implications for clinical management.
Double-blind phase II clinical trial comparing the effect of EGCG to placebo on body composition and lipid profile in 77 young adults with Down syndrome. EGCG treatment prevented weight and BMI increase observed in the placebo group, with significant effects in males. Changes in body composition were associated with changes in lipid profile.
A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin.
Double-blind randomized controlled trial evaluating the effects of topical EGCG application on cutaneous scarring in 62 human volunteers. EGCG reduced mast cells, increased M2 macrophages, down-regulated VEGFA and CD31, reduced scar thickness, and increased scar elasticity and hydration.
ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer.
Phase II RCT assessing the feasibility and acceptability of green tea catechins and lycopene in men at increased risk of prostate cancer. The study used a 3x3 factorial design with green tea drink or capsules and lycopene-rich foods or capsules over 6 months. The interventions were well tolerated, with higher lycopene and EGCG levels in active groups compared to placebo.
Population nutrikinetics of green tea extract.
Population nutrikinetic study of standardized green tea extract in 84 healthy participants. Participants took capsules with 150 mg EGCG twice a day for 5 days. Significant interindividual variability in catechin pharmacokinetics was observed, with genetic polymorphisms in drug transporters potentially explaining variability.
Effects of green tea extract on overweight and obese women with high levels of low density-lipoprotein-cholesterol (LDL-C): a randomised, double-blind, and cross-over placebo-controlled clinical trial.
This randomized, double-blind, crossover, placebo-controlled clinical trial studied the effects of green tea extract on overweight and obese women with high LDL-C levels. Over 6 weeks, GTE supplementation resulted in a 4.8% reduction in LDL-C and a 25.7% increase in leptin, though no significant changes were observed in total cholesterol, triglycerides, or HDL levels.
Green tea extracts for the prevention of metachronous colorectal polyps among patients who underwent endoscopic removal of colorectal adenomas: A randomized clinical trial.
RCT of 176 subjects who underwent endoscopic removal of colorectal adenomas, comparing 0.9g/day green tea extract supplementation to no supplementation for 12 months. The GTE group showed a reduced incidence of metachronous adenomas compared to the control group, suggesting a favorable outcome for chemoprevention.
Epigallocatechin Gallate Extends Therapeutic Window of Recombinant Tissue Plasminogen Activator Treatment for Brain Ischemic Stroke: A Randomized Double-Blind and Placebo-Controlled Trial.
RCT assessing the effect of epigallocatechin gallate (EGCG) in extending the therapeutic window of rt-PA treatment for brain ischemic stroke. EGCG improved treatment outcomes in patients with delayed onset-to-treatment time, as evidenced by improved NIHSS scores and reduced plasma levels of MMP-2 and 9.
Randomized, placebo-controlled trial evaluating the safety of one-year administration of green tea catechins.
Randomized, placebo-controlled trial evaluating the safety of a decaffeinated catechin mixture containing 200 mg EGCG BID in 97 men with high-grade prostatic intraepithelial neoplasia or atypical small acinar proliferation. The study found that the catechin mixture was well tolerated and did not produce treatment-related adverse effects over one year.
Effects of ω-3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial.
This randomized controlled trial evaluated the effects of fish oil (DHA + EPA) and green tea supplement (EGCG) on fatty acid synthase (FAS) and Ki-67 levels in prostate tissue of 89 men. The study found no significant differences in pre-to-post-intervention changes of FAS or Ki-67 levels between treatment groups and placebo.
Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.
Double-blind, placebo-controlled phase 2 trial of EGCG and cognitive training in 84 young adults with Down's syndrome. EGCG group showed significant improvements in visual recognition memory, inhibitory control, and adaptive behaviour compared to placebo. No significant differences in adverse effects were noted.
Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial.
RCT of 80 post-adolescent women with acne comparing 1500 mg of decaffeinated green tea extract (GTE) to placebo for 4 weeks. GTE group showed significant reductions in inflammatory lesions on the nose, perioral area, and chin, as well as reductions in total cholesterol levels.
Green tea extract and catechol-O-methyltransferase genotype modify the post-prandial serum insulin response in a randomised trial of overweight and obese post-menopausal women.
RCT examining the effects of green tea extract (GTE) supplementation on post-prandial insulin response in 60 overweight and obese post-menopausal women. GTE with high-activity COMT genotype showed higher insulin concentrations post-meal compared to placebo, but no differences in leptin, ghrelin, adiponectin, or satiety.
Long-Term Supplementation of Green Tea Extract Does Not Modify Adiposity or Bone Mineral Density in a Randomized Trial of Overweight and Obese Postmenopausal Women.
The Minnesota Green Tea Trial was a 12-month randomized, double-blind, placebo-controlled clinical trial in 937 postmenopausal women, with a substudy of 121 overweight/obese participants. The study found no significant differences in BMI, total fat mass, body fat percentage, or bone mineral density between the green tea extract and placebo groups. However, interactions suggested potential benefits of green tea extract for reducing tissue and gynoid %fat in individuals with higher BMI.
Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial.
RCT of 102 women with central obesity comparing high-dose green tea extract (EGCG) to placebo for 12 weeks. The treatment group showed significant weight loss, reduced BMI and waist circumference, decreased total cholesterol and LDL levels, and changes in hormone peptides without side effects.
Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention.
RCT of 97 men with high-grade prostatic intraepithelial neoplasia (HGPIN) and/or atypical small acinar proliferation (ASAP) testing Polyphenon E, a green tea catechin mixture. No significant difference in prostate cancer rates between PolyE and placebo groups, but a decrease in ASAP diagnoses and serum PSA levels was observed in the PolyE group.
A randomized controlled trial of green tea catechins in protection against ultraviolet radiation-induced cutaneous inflammation.
A double-blind, randomized, placebo-controlled trial examined the effect of green tea catechins (GTCs) with vitamin C on UVR-induced inflammation in healthy adults. The study found no significant reduction in skin erythema, leukocyte infiltration, or eicosanoid response after supplementation.
Effects of dietary supplementation with green tea polyphenols on digestion and meat quality in lambs infected with Haemonchus contortus.
The study examined the effects of green tea polyphenol supplements on nutrient digestibility and meat quality in lambs infected with Haemonchus contortus. While infections did not affect digestion, 2g of GTP/kg feed decreased nutrient digestibility. Appropriate levels of GTP supplementation improved meat quality despite infections, though lower doses negatively affected digestion.
Results of a phase II randomized, double-blind, placebo-controlled trial of Polyphenon E in women with persistent high-risk HPV infection and low-grade cervical intraepithelial neoplasia.
RCT of Polyphenon E (green tea catechin extract) in 98 women with persistent high-risk HPV infection and low-grade cervical intraepithelial neoplasia. The study found no significant difference in HPV clearance or progression between the Polyphenon E and placebo groups.
Effects of epigallocatechin gallate on lipid metabolism and its underlying molecular mechanism in broiler chickens.
This study investigated the effects of epigallocatechin gallate (EGCG) on fat metabolism in broiler chickens. EGCG supplementation reduced abdominal fat deposition, decreased serum triglycerides and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. It downregulated genes related to fat synthesis and upregulated genes involved in lipid catabolism, suggesting EGCG alleviates fat deposition by inhibiting fat anabolism and stimulating lipid catabolism.
Acute effects of green tea extract intake on exogenous and endogenous metabolites in human plasma.
This double-blind study investigated the acute effects of green tea extract (GTE) on plasma metabolites in healthy males. A single dose of GTE was administered, and changes in catechin concentrations and endogenous metabolites were measured. Sixteen out of 163 metabolites were affected by GTE ingestion, including caffeine, salicylate, and serotonin.
Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial.
RCT of 83 obese pre-menopausal women examining the effects of 300 mg/d EGCG supplementation on body composition, energy metabolism, cardiometabolic risk factors, and liver function. No significant differences were found between the EGCG and placebo groups in terms of weight loss, fat mass, energy metabolism, insulin resistance, cholesterol levels, or liver function markers.
Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women.
Double-blind, randomized, placebo-controlled intervention study in 103 postmenopausal women assessing the effects of green tea catechin EGCG as PPE on hormone, lipid, and glucose markers. LDL-cholesterol decreased significantly in PPE groups, while glucose and insulin levels showed non-significant decreases compared to placebo. No consistent changes in hormone levels were observed.
Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects.
This randomized, double-blind, placebo-controlled trial assessed the effects of a combination of bioactive food ingredients (epigallocatechin gallate, capsaicins, piperine, and L-carnitine) on metabolic changes in 86 overweight subjects over 8 weeks. The supplemented group showed significant improvements in insulin resistance, leptin/adiponectin ratio, LDL-cholesterol levels, and inflammatory markers compared to the placebo group.
The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight: a double-blind, randomized control trial.
Double-blind RCT of 50 overweight adults evaluating the effect of a supplement containing NOPE and EGCG on dietary compliance and body composition. The supplement improved compliance and mood at 4 weeks but not at 8 weeks, with no significant effects on body mass, composition, hunger, or binge eating after eight weeks.
Effects of Green Tea Catechins and Theanine on Preventing Influenza Infection among Healthcare Workers: A Randomized Controlled Trial
A randomized, double-blind, placebo-controlled trial of 197 healthcare workers tested the effects of green tea catechins and theanine on preventing influenza infection. The catechin/theanine group had a significantly lower incidence of clinically defined influenza infection compared to the placebo group, suggesting potential prophylactic benefits.
Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trial.
RCT of 68 obese individuals with type 2 diabetes comparing 1,500 mg decaffeinated green tea extract (GTE) to placebo for 16 weeks. No statistically significant differences were found between groups, but within-group analysis showed reductions in HbA1C, waist circumference, HOMA-IR index, and insulin levels in the GTE group.