Research
Ecdysterone (Beta-Ecdysterone)
7 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
BIO101 in Sarcopenic Seniors at Risk of Mobility Disability: Results of a Double-Blind Randomised Interventional Phase 2b Trial.
This double-blind randomized interventional Phase 2b trial investigated the effects of BIO101 (20-hydroxyecdysone) on muscle function and physical performance in older sarcopenic patients. The study found that BIO101 350 mg bid treatment showed trends towards improvement in gait speed, particularly in subpopulations at higher risk of mobility disability, and had a good safety profile.
Synergistic Effects of High-Intensity Interval Training andL. Root Extract Supplementation on Metabolic Regulation, Oxidative Stress, and Inflammation in Overweight and Obese Adults.
This randomized controlled trial investigated the effects of high-intensity interval training (HIIT) and asparagus root extract (ARE) supplementation on metabolic parameters, oxidative stress, and inflammation in overweight and obese adults. The combined intervention group showed significant improvements in oxidative and inflammatory status, while HIIT alone primarily enhanced metabolic regulation.
Antiprotozoal effect of steroid hormone 20-hydroxyecdysone in giardiosis patients.
A randomized, double-blinded, placebo-controlled clinical study assessed the antiprotozoal activity of 20-hydroxyecdysone in 76 athletes with G. lamblia infection. The study found that 20-hydroxyecdysone effectively eliminated G. lamblia in 100% of the athletes in its group, showing high antiprotozoal activity.
How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study.
RCT with 28 resistance-trained young men evaluating the anabolic and performance-enhancing potential of a 20-hydroxyecdysone and diosgenin supplement. Significant improvements in performance metrics were observed across both groups, but no group-specific effects were found. The supplement contained significantly less of the active compounds than claimed, and no biological activity was detected in C2C12 cells.
Effects of Asparagus-Derived 20-Hydroxyecdysone Supplementation on Fat Oxidation and Insulin Sensitivity in Resistance-Trained Males.
RCT investigating 20-hydroxyecdysone derived from Asparagus officinalis on fat oxidation and insulin sensitivity in resistance-trained males. The 20E group showed significant reductions in regional fat, increased fat oxidation, and improved insulin sensitivity compared to placebo.
A Phase 1 study for safety and pharmacokinetics of BIO101 (20-hydroxyecdysone) in healthy young and older adults.
Phase 1 study evaluating the safety and pharmacokinetics of BIO101 (20-hydroxyecdysone) in healthy young and older adults. The study involved single and multiple ascending doses, showing a good safety profile and satisfactory pharmacokinetic profile. Reduction of biomarkers such as myoglobin and CK-MB was observed at higher doses.
Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans.
A 10-week intervention study on young men (n=46) investigated the effects of ecdysterone-containing supplements on sports performance. The study found significantly higher increases in muscle mass and one-repetition bench press performance in participants dosed with ecdysterone, with no increase in biomarkers for liver or kidney toxicity.