Research
DHEA
111 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Administration of dehydroepiandrosterone improves endometrial thickness in women undergoing IVF/ICSI: a systematic review and meta-analysis.
Systematic review and meta-analysis of 16 trials with 1973 women undergoing IVF/ICSI. DHEA treatment significantly increased endometrial thickness and improved clinical pregnancy rate, as well as oocyte and embryo quality. The quality of evidence was low to very low, and more research is needed to confirm these findings.
Effect of dehydroepiandrosterone therapy on cognitive performance among postmenopausal women: a systematic review of randomized clinical trial data.
Systematic review of randomized clinical trials evaluating the effect of DHEA supplementation on cognitive performance in postmenopausal women. The review found no overall beneficial effect of DHEA on cognitive performance, with only one study showing a positive outcome in visual-spatial performance. High risk of bias and heterogeneity in study designs were noted.
Efficacy of dehydroepiandrosterone priming in women with poor ovarian response undergoing IVF/ICSI: a meta-analysis.
Meta-analysis investigating the efficacy of DHEA supplementation in women with poor ovarian response or diminished ovarian reserve undergoing IVF/ICSI. DHEA treatment increased antral follicle count and reduced bFSH levels, gonadotropin doses, days of stimulation, and miscarriage rate in RCTs, but did not significantly improve live birth rates. Non-RCTs showed higher clinical pregnancy and live birth rates, but these findings should be interpreted with caution due to potential bias.
Endogenous DHEAS Is Causally Linked With Lumbar Spine Bone Mineral Density and Forearm Fractures in Women.
A 2-sample Mendelian randomization study using genetic predictors of serum DHEAS found that a genetically instrumented increase in DHEAS levels is associated with increased lumbar spine bone mineral density and decreased forearm fracture risk in women. The study suggests that both endogenous and pharmacological DHEA improve bone health in women.
Dehydroepiandrosterone status and efficacy of dehydroepiandrosterone supplementation for bone health in anorexia nervosa: A systematic review and meta-analysis.
Systematic review and meta-analysis assessing DHEA status and supplementation efficacy for bone health in women with anorexia nervosa. Meta-analysis showed elevated serum DHEA and reduced DHEAS levels in patients with AN. DHEA monotherapy did not improve bone mineral density, while combination with oral contraceptives showed benefits in older adolescents and adults but potential harm in younger adolescents.
The effect of dehydroepiandrosterone (DHEA) supplementation on estradiol levels in women: A dose-response and meta-analysis of randomized clinical trials.
This meta-analysis of randomized controlled trials evaluated the effect of DHEA supplementation on estradiol levels in women. The study found that DHEA significantly increased estradiol levels, particularly in postmenopausal women, those aged 60 years and above, and those receiving 50 mg/day of DHEA for 26 weeks or more.
DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 14 studies with 631 participants examining DHEA as a biomarker of acute stress. DHEA levels increased after acute stress, with a peak at the end of stress and a progressive decrease thereafter. DHEA increases following acute mental stress, with variations based on sex, age, and obesity.
Effects of dehydroepiandrosterone (DHEA) supplementation on cortisol, leptin, adiponectin, and liver enzyme levels: A systematic review and meta-analysis of randomised clinical trials.
Systematic review and meta-analysis of randomized clinical trials assessing the effects of DHEA supplementation on cortisol, liver enzymes, and adipokines. DHEA supplementation significantly decreased serum cortisol levels but did not significantly affect adiponectin, leptin, AST, or ALT levels, suggesting potential benefits for managing hypercortisolaemia without liver safety concerns.
DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies.
Meta-analysis of case-control studies examining DHEA levels in women with polycystic ovarian syndrome (PCOS) compared to healthy controls. The analysis found statistically significant higher levels of DHEA in PCOS cases, suggesting a potential role of stress in the pathogenesis of PCOS.
The Use of Androgen Priming in Women with Reduced Ovarian Reserve Undergoing Assisted Reproductive Technology.
Meta-analysis examining the effects of androgen priming with DHEA or testosterone on IVF outcomes in women with diminished ovarian reserve. Results are inconsistent, with DHEA showing no benefit in RCTs, while testosterone showed improved outcomes in low-quality studies but not in those with low-risk bias.
Hyperandrogenism? Increased 17, 20-Lyase Activity? A Metanalysis and Systematic Review of Altered Androgens in Boys and Girls with Autism.
Meta-analysis and systematic review of altered androgen levels in children with autism, focusing on testosterone precursors like DHEA, androstenedione, and androstenediol. Higher levels of these androgens were detected in children with autism, suggesting increased 17, 20-lyase activity.
Dehydroepiandrosterone for depressive symptoms: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 15 RCTs with 853 individuals assessing DHEA's effect on depressive symptoms. DHEA improved depressive symptoms compared to placebo, but the quality of evidence was very low. Side effects were uncommon, mild, and transient.
Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trials.
Meta-analysis of randomized controlled trials assessing the impact of DHEA supplementation on testosterone levels and BMI in elderly women. Results showed significant increases in testosterone levels and a decrease in BMI following DHEA administration.
Impact of dehydroepianrosterone (DHEA) supplementation on serum levels of insulin-like growth factor 1 (IGF-1): A dose-response meta-analysis of randomized controlled trials.
This meta-analysis of 24 RCTs examined the impact of DHEA supplementation on serum IGF-1 levels. Results showed a significant increase in IGF-1 levels in the DHEA group compared to control, particularly in women, those supplementing 50 mg/d, participants over 60 years, and those without comorbidities.
Effects of dehydroepiandrosterone (DHEA) supplementation on the lipid profile: A systematic review and dose-response meta-analysis of randomized controlled trials.
Systematic review and dose-response meta-analysis of RCTs on DHEA supplementation effects on lipid profile. DHEA did not change TC, LDL-C, and TG levels but significantly reduced HDL-C levels, particularly in women.
The effects of dehydroepiandrosterone (DHEA) supplementation on body composition and blood pressure: A meta-analysis of randomized clinical trials.
Meta-analysis of randomized clinical trials assessing the impact of DHEA supplementation on body composition and blood pressure. DHEA increased lean body mass and decreased fat mass, but had no significant effect on blood pressure.
Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer's Disease.
Systematic review of studies on DHEA and DHEAS in Alzheimer's disease, discussing their potential preventive and therapeutic applications. Despite mixed results, preclinical studies generally support their involvement in Alzheimer's pathophysiology, but small clinical trials provide little evidence for their therapeutic use.
The influence of dehydroepiandrosterone (DHEA) on fasting plasma glucose, insulin levels and insulin resistance (HOMA-IR) index: A systematic review and dose response meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs assessing the effects of DHEA supplementation on fasting plasma glucose, insulin levels, and insulin resistance in humans. DHEA significantly reduced fasting plasma glucose levels, especially in dosages ≤50 mg/day, treatment duration <12 weeks, and subjects aged ≥60 years. No significant changes were found in insulin levels or insulin resistance.
DHEA use to improve likelihood of IVF/ICSI success in patients with diminished ovarian reserve: A systematic review and meta-analysis.
Systematic review and meta-analysis of DHEA use in patients with diminished ovarian reserve undergoing IVF/ICSI. DHEA was associated with a significant increase in pregnancy likelihood and a reduction in the likelihood of abortion, but no association with the number of oocytes retrieved.
Efficacy of dehydroepiandrosterone (DHEA) supplementation for in vitro fertilization and embryo transfer cycles: a systematic review and meta-analysis.
Systematic review and meta-analysis of six RCTs involving 745 patients evaluating the efficacy of DHEA supplementation in in vitro fertilization. DHEA was associated with significant increases in clinical pregnancy, live birth rate, and endometrial thickness, but showed no influence on Eon hCG day, embryos transferred, and miscarriage rate.
DHEA and DHEA-S levels in posttraumatic stress disorder: A meta-analytic review.
Meta-analysis of studies comparing DHEA and DHEA-S levels in PTSD patients versus controls. No significant differences were found between PTSD and control groups overall, but higher DHEA-S levels were observed in PTSD patients compared to non-trauma-exposed controls. Trauma exposure may increase basal DHEA and DHEA-S levels.
The effect of dehydroepiandrosterone (DHEA) supplementation on women with diminished ovarian reserve (DOR) in IVF cycle: Evidence from a meta-analysis.
Meta-analysis evaluating the effect of DHEA supplementation on ovarian response and pregnancy outcomes in women with diminished ovarian reserve. The analysis included 9 studies with 540 cases and 668 controls. DHEA pre-treatment significantly increased clinical pregnancy rates, though no differences were found in the number of oocytes retrieved, IVF cycle cancellation rate, or miscarriage rate. More RCTs are needed to confirm these findings.
Dehydroepiandrosterone for women in the peri- or postmenopausal phase.
This meta-analysis reviewed 28 trials with 1273 peri- and postmenopausal women to assess the effectiveness and safety of DHEA. The analysis found no evidence that DHEA improves quality of life, but it may slightly improve sexual function compared to placebo. DHEA was associated with androgenic side effects, such as acne.
Clinical review: The benefits and harms of systemic dehydroepiandrosterone (DHEA) in postmenopausal women with normal adrenal function: a systematic review and meta-analysis.
Systematic review and meta-analysis of 23 RCTs involving 1188 postmenopausal women with normal adrenal function. DHEA use was not associated with significant improvement in libido, sexual function, or selected metabolic markers. Evidence suggests low confidence in these results due to imprecision and risk of bias.
Dehydroepiandrosterone supplementation in elderly men: a meta-analysis study of placebo-controlled trials.
Meta-analysis of 25 double-blind, placebo-controlled RCTs involving 1353 elderly men, examining the effects of DHEA supplementation. DHEA was associated with a reduction in fat mass, but no significant effects were observed on lipid and glycemic metabolism, bone health, sexual function, or quality of life.
Effect of dehydroepiandrosterone on muscle strength and physical function in older adults: a systematic review.
Systematic review of 8 studies with 661 participants evaluating DHEA supplementation on muscle strength and physical performance in older adults. Some studies showed improvements in specific muscle strength measures, but overall results were inconclusive. DHEA did not consistently benefit physical function or performance.
Dehydroepiandrosterone for systemic lupus erythematosus.
Meta-analysis of seven RCTs with 842 participants assessing DHEA for systemic lupus erythematosus. DHEA showed modest improvement in health-related quality of life but had little effect on disease activity. Increased risk of androgenic adverse events was noted.
Effects of vaginal dehydroepiandrosterone and estradiol on dyspareunia, a symptom of vulvovaginal atrophy in postmenopausal women - a randomized controlled trial.
RCT of 172 postmenopausal women comparing vaginal DHEA and estradiol for dyspareunia due to vulvovaginal atrophy. DHEA improved dyspareunia more than estradiol, especially in severe cases, while estradiol improved clinical signs of atrophy more.
Effects of topical dehydroepiandrosterone therapy in women after pelvic organ prolapse surgery.
RCT comparing the effects of topical DHEA, estradiol, or antibiotic therapy in 90 women after pelvic organ prolapse surgery. Both DHEA and estradiol improved vaginal maturation index, vaginal pH, and reduced vaginal symptoms, with DHEA providing similar benefits to estradiol without systemic exposure to increased sex steroid levels.
A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA supplementation of bone mineral density in healthy adults.
Systematic review and meta-analysis of randomized placebo-controlled trials assessing DHEA supplementation on bone mineral density (BMD) in healthy older adults. DHEA supplementation significantly increased hip and trochanter BMD in women compared to placebo, but not in men. IGF-1 levels improved in women but not in men.
Association of endogenous DHEA/DHEAS with coronary heart disease: A systematic review and meta-analysis.
Systematic review and meta-analysis of 26 studies examining the association between endogenous DHEA(S) and coronary heart disease (CHD). The study found that decreased DHEAS may be associated with increased CHD risk, but no significant association was found between DHEA concentration and CHD risk.
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
A phase III RCT evaluated the effects of daily intravaginal 0.50% DHEA (Prasterone) on symptoms of vulvovaginal atrophy in postmenopausal women. The study found significant improvements in parabasal and superficial cell percentages, vaginal pH, dyspareunia, and vaginal dryness compared to placebo, with minimal side effects.
Dehydroepiandrosterone (DHEA) for Depression: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis investigating the effectiveness of DHEA compared to placebo in treating depressive symptoms in individuals with depression not resulting from other comorbidities. The meta-analysis found a significant effect in favor of DHEA treatment.
Efficacy of intravaginal dehydroepiandrosterone (DHEA) for symptomatic women in the peri- or postmenopausal phase.
Systematic review of recent research on intravaginal DHEA for menopausal women, focusing on sexual function. Randomised controlled trials showed that vaginal DHEA improved sexual dysfunction and was superior to placebo and comparable to vaginal oestrogens.
Systemic and local effects of vaginal dehydroepiandrosterone (DHEA): NCCTG N10C1 (Alliance).
This RCT evaluated the impact of vaginal DHEA on hormone concentrations, bone turnover, and vaginal cytology in postmenopausal women with a history of cancer. DHEA increased circulating DHEA-S and testosterone levels dose-dependently and improved vaginal cytology compared to a plain moisturizer control. Estradiol increased only in the higher DHEA dose group, and bone formation biomarkers were unchanged.
The effects of dehydroepiandrosterone on sexual function: a systematic review.
Systematic review evaluating the effect of DHEA on sexual function. DHEA improved aspects such as sexual interest, lubrication, pain, arousal, orgasm, and sexual frequency, particularly in perimenopausal and postmenopausal women with sexual dysfunction.
Dehydroepiandrosterone treatment in women with poor ovarian response undergoing IVF or ICSI: a systematic review and meta-analysis.
Systematic review and meta-analysis of 21 studies on DHEA supplementation in women with poor ovarian response undergoing IVF/ICSI. DHEA pretreatment increased clinical pregnancy rate, live birth rate, implantation rate, and antral follicle count while reducing miscarriages. Oocyte numbers and anti-Müllerian hormone levels were also enhanced, but endometrial thickness and estradiol levels were similar between groups.
Serum steroids remain within the same normal postmenopausal values during 12-month intravaginal 0.50% DHEA.
RCT analyzing serum levels of DHEA and its metabolites in postmenopausal women with vulvovaginal atrophy after daily intravaginal 0.50% DHEA for 52 weeks. All serum steroids remained within normal values, confirming no significant systemic estrogen exposure.
A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection.
Meta-analysis evaluating the effectiveness of DHEA supplementation in women with diminished ovarian reserve undergoing IVF/ICSI. DHEA increased the clinical pregnancy rate, but effects on oocyte retrieval, implantation, and abortion were not significant.
The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: a systematic review.
Systematic review of studies on the use of DHEA in treating depression and depressive symptoms in various psychiatric and medical illnesses. Significant improvements were observed in patients with depression, schizophrenia, anorexia nervosa, HIV, and adrenal insufficiency, but not in fibromyalgia. Results in autoimmune diseases and healthy individuals were contradictory.
Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis.
Meta-analysis investigating the efficacy of DHEA as an adjuvant to improve ovarian response and IVF outcomes in women with diminished ovarian reserve. No significant difference was found in clinical pregnancy and miscarriage rates, and the number of oocytes retrieved was significantly lower in the DHEA group.
The use of androgens or androgen-modulating agents in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis.
This meta-analysis evaluated the role of androgens or androgen-modulating agents on pregnancy achievement in poor responders undergoing IVF. Transdermal testosterone pretreatment was associated with increased clinical pregnancy and live birth rates. No significant benefits were observed with DHEA, aromatase inhibitors, rLH, or rhCG.
A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects on quality of life in women with adrenal insufficiency.
Systematic review and meta-analysis of randomized controlled trials assessing DHEA effects on health-related quality of life in women with adrenal insufficiency. DHEA showed a small improvement in HRQOL and depression, with no significant effects on anxiety and sexual well-being.
[Dehydroepiandrosterone (DHEA), review of its efficiency in the managing of the libido decrease and other symtoms of aging].
Systematic review analyzing the efficiency of DHEA in managing symptoms of aging, including libido decrease. The review included 152 articles, with 25 used for meta-analysis. Results suggest no significant support for DHEA's usefulness in reducing aging symptoms, though it may affect carbohydrate metabolism and insulin efficiency.
Effects of dehydroepiandrosterone supplementation on cognitive function and quality of life: the DHEA and Well-Ness (DAWN) Trial.
Double-blind, randomized controlled trial of 225 older adults examining the effects of 50mg daily DHEA supplementation versus placebo for 1 year. No significant differences were found between the DHEA and placebo groups in cognitive function, mood, life satisfaction, or sexual function.
WITHDRAWN: Dehydroepiandrosterone (DHEA) supplementation for cognitive function.
Systematic review of randomized controlled trials investigating the effects of DHEA/S on cognitive function in older adults. Some studies found significant improvements in specific cognitive tasks, while others found no significant effects. Overall, the data do not support a clear improvement in cognitive function following DHEA treatment in normal older people.
Dehydroepiandrosterone (DHEA) supplementation for cognitive function .
Systematic review of randomized controlled trials investigating the effects of DHEA/S on cognitive function in older adults. Some studies found significant improvements in specific cognitive tasks, while others found no significant effects. The review concludes that current data do not support a clear improvement in cognitive function with DHEA supplementation.
DHEA on Sexual Function in Sheehan Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial.
This randomized double-blind placebo-controlled crossover trial studied the effects of DHEA supplementation on sexual function in 28 women with Sheehan syndrome. DHEA significantly improved the Female Sexual Functioning Index score compared to placebo, with no significant metabolic side effects observed.
Serum concentrations of oxytocin, DHEA and follistatin are associated with osteoporosis or sarcopenia in community-dwelling postmenopausal women
Cross-sectional study of 478 postmenopausal women investigating biomarkers for osteoporosis and sarcopenia. DHEA was positively related to muscle strength and function, and bone mass. Lower DHEA levels were associated with sarcopenia, while lower oxytocin levels were associated with osteoporosis.
Targeting hypothalamic-pituitary-adrenal axis hormones and sex steroids for improving cognition in major mood disorders and schizophrenia: a systematic review and narrative synthesis.
Systematic review and narrative synthesis of studies targeting the HPA axis and sex steroids to improve cognition in schizophrenia, MDD, and BD. Positive trials were found for mifepristone in BD, dehydroepiandrosterone and fludrocortisone in MDD, and dehydroepiandrosterone, raloxifene, and pregnenolone in schizophrenia.
Efficacy of Dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): A proof of principle double blinded randomized placebo controlled trial.
A double-blinded, placebo-controlled RCT evaluated the effect of DHEA supplementation on IVF outcomes in 60 women with poor ovarian reserve. The study found no significant improvement in ovarian response, oocyte quality, or live birth rates with DHEA supplementation compared to placebo.
Effect of Dehydroepiandrosterone and Testosterone Supplementation on Systemic Lipolysis.
This 2-year randomized, double-blind, placebo-controlled trial studied the effect of DHEA and testosterone supplementation on systemic lipolysis in 60 elderly women and 92 elderly men with low hormone levels. The study found no significant effect on insulin suppression of systemic lipolysis during mixed-meal tolerance and intravenous glucose tolerance tests, except for a small lowering of palmitate rate of appearance in women receiving DHEA.
Dehydroepiandrosterone improves follicular fluid bone morphogenetic protein-15 and accumulated embryo score of infertility patients with diminished ovarian reserve undergoing in vitro fertilization: a randomized controlled trial
RCT evaluating the effect of DHEA on infertility patients with diminished ovarian reserve undergoing IVF. DHEA treatment increased BMP-15 levels in follicular fluid, improved AMH levels, reduced FSH and E2 levels, and resulted in a higher accumulated embryo score compared to controls.
Gene expression of cumulus cells in women with poor ovarian response after dehydroepiandrosterone supplementation.
The study investigated the effects of dehydroepiandrosterone (DHEA) supplementation on gene expression in cumulus cells of women with poor ovarian response (POR). DHEA supplementation led to upregulation of genes related to extracellular matrix formation and downregulation of genes involved in cell development, differentiation, and apoptosis regulation, suggesting a positive effect on ovarian function.
DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function.
The study evaluated the effect of DHEA supplementation on spontaneous pregnancies in women with diminished ovarian function. Two groups were studied: young women under 40 and women over 40, both treated with DHEA. The spontaneous pregnancy rate significantly increased after DHEA treatment, with higher pregnancy rates observed in both groups compared to controls.
Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women.
This study was a 2-year, double-blind, randomized, placebo-controlled trial examining the effects of DHEA and testosterone replacement on adiposity, meal fat partitioning, and postabsorptive lipolysis in elderly men and women with low hormone levels. The study found that aging is associated with changes in fat metabolism, which are not corrected by DHEA and only partly corrected by testosterone replacement.
A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido.
A 52-week randomized, double-blind, placebo-controlled trial with 93 postmenopausal women assessed the effects of 50 mg/day DHEA on sexual function, well-being, and menopausal symptoms. No significant improvements in sexual function or well-being were observed compared to placebo, though more androgenic effects were reported in the DHEA group.
Dehydroepiandrosterone for myotonic dystrophy type 1.
RCT investigating the efficacy and safety of DHEA in myotonic dystrophy type 1 patients. Seventy-five adults received either 100 mg/d or 400 mg/d of DHEA, or placebo. No significant differences were found between the DHEA and placebo groups in muscle strength or secondary outcomes after 12 weeks.
Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial.
Double-blind RCT of 106 subjects with Addison's disease receiving 50 mg daily of micronized DHEA or placebo for 12 months. DHEA increased circulating DHEAS and androstenedione, improved bone mineral density at the femoral neck, enhanced lean mass, and improved one subscale of psychological well-being. No significant effects on fatigue, cognitive, or sexual function were observed.
Placebo-controlled trial of dehydroepiandrosterone (DHEA) for treatment of nonmajor depression in patients with HIV/AIDS.
RCT assessing the efficacy of dehydroepiandrosterone (DHEA) for treating subsyndromal depression in HIV-positive adults. DHEA showed superior response rates compared to placebo, with 56% response in intent-to-treat analysis and 62% in completer analysis. Few adverse events were reported, and no significant changes in CD4 cell count or HIV RNA viral load were observed.
DHEA in elderly women and DHEA or testosterone in elderly men.
A 2-year, placebo-controlled, randomized, double-blind study involving 87 elderly men and 57 elderly women with low levels of DHEA and testosterone. DHEA increased plasma levels of sulfated DHEA but had no significant effect on body composition, physical performance, or quality of life. Testosterone increased bioavailable testosterone and fat-free mass in men, with both treatments increasing BMD at specific sites. No major adverse effects were observed.
Improvement of sustained attention and visual and movement skills, but not clinical symptoms, after dehydroepiandrosterone augmentation in schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial.
A 12-week, double-blind, randomized, placebo-controlled, crossover trial investigated the efficacy and safety of DHEA augmentation in schizophrenia patients. DHEA did not significantly improve clinical symptoms or quality-of-life scores but did improve cognitive functions of visual sustained attention and visual and movement skills compared to placebo.
Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly people.
Meta-analysis reviewing randomized controlled trials on DHEA supplementation for cognitive function in healthy elderly people. The analysis found no consistent beneficial effect of DHEA on cognitive function, with some trials showing no significant effects and one trial showing impairment in visual memory recall under stress.
A randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgia.
RCT of DHEA supplementation (50 mg/day) in postmenopausal women with fibromyalgia. After 3 months, DHEA increased blood levels but did not improve well-being, pain, fatigue, cognitive function, mood, or functional impairment. Androgenic side effects were more common during DHEA treatment.
Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin.
The study investigates the effects of topical dehydroepiandrosterone (DHEA) on collagen metabolism in human skin. DHEA increased procollagen synthesis and inhibited collagen degradation by modulating MMP-1 and TIMP-1 levels. Topical application of DHEA significantly increased procollagen expression and decreased MMP-1 expression in aged skin, suggesting its potential as an anti-skin aging agent.
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
RCT of 56 elderly persons assessing the effects of 50 mg/d DHEA supplementation for 6 months. DHEA significantly decreased visceral and subcutaneous abdominal fat and improved insulin sensitivity compared to placebo.
DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study.
RCT comparing the efficacy and tolerability of DHEA versus placebo in 58 subjects with Alzheimer's disease over 6 months. DHEA did not significantly improve cognitive performance or overall ratings of change in severity, though a transient improvement in cognitive performance was noted at month 3.
Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men.
RCT investigating the effects of a supplement containing DHEA, androstenedione, and herbal extracts on immune function in middle-aged men. The supplement increased serum androgen levels but had minimal effect on immune function.
Effects of prasterone on corticosteroid requirements of women with systemic lupus erythematosus: a double-blind, randomized, placebo-controlled trial.
Double-blind, randomized trial of 191 female SLE patients receiving prednisone, treated with placebo, 100 mg, or 200 mg of oral prasterone for 7-9 months. The study evaluated the ability to reduce prednisone dosage while maintaining stable or reduced disease activity. Response rates were higher in the 200 mg prasterone group compared to placebo, with acne as the most common mild adverse event.
Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men.
RCT investigating the effects of a nutritional supplement containing androstenediol and various herbs on hormone levels in men aged 30 to 58. The supplement increased serum androstenedione, free testosterone, DHT, and estradiol, but did not prevent the formation of estradiol and DHT. Serum HDL-C concentrations were reduced.
Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study
Retrospective cohort study of 151 poor ovarian responders undergoing IVF cycles, comparing outcomes with and without DHEA supplementation. DHEA supplementation improved IVF outcomes, including higher numbers of retrieved oocytes, fertilized oocytes, and higher pregnancy rates. Women with lower serum DHEA-S levels showed greater benefits from DHEA supplementation.
Phase II Study of Dehydroepiandrosterone in Androgen Receptor-Positive Metastatic Breast Cancer.
Phase II study of dehydroepiandrosterone (DHEA) in combination with an aromatase inhibitor in patients with androgen receptor-positive metastatic breast cancer. The study found DHEA to be well tolerated but with poor activity, as only 1 of 12 patients obtained prolonged clinical benefit. The study was closed after the first stage due to poor activity.
Investigation of the relationship between salivary cortisol, dehydroepiandrosterone sulfate, anxiety, and depression in patients with hyperemesis gravidarum.
Case-control study investigating the relationship between salivary levels of DHEA-S and cortisol with depression and anxiety in 40 patients with hyperemesis gravidarum compared to 40 controls. Positive correlation found between increased depression and anxiety levels and increased salivary levels of cortisol and DHEA-S.
DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.
This study investigated the mechanism of DHEA's antidepressant effects by examining plasma levels of neurosteroids in men and women with midlife depression. DHEA increased androsterone levels, which may contribute to its antidepressant effects. The study found that androsterone levels increased post-DHEA treatment, particularly in clinical responders.
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing - A behavioral and electrophysiological approach.
The study explored the effects of DHEA and DHEAS on emotional processing in 21 young women using a visual task with implicit emotional content. Higher DHEAS/DHEA and DHEA/cortisol ratios were associated with faster brain processing and reduced processing of negative emotional stimuli, suggesting potential mood enhancement effects.
A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders.
Randomized, double-blind, placebo-controlled pilot study evaluating DHEA supplementation in 32 women with anticipated poor ovarian response. DHEA supplementation resulted in higher serum DHEA-S and free androgen index but showed no statistically significant improvement in ovarian response markers, ovarian response to gonadotropin stimulation, or IVF outcomes.
The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity.
RCT investigating the effects of pregnenolone and DHEA on resting-state amygdala connectivity using fMRI. Pregnenolone reduced connectivity between amygdala and several brain regions, while DHEA reduced connectivity between amygdala and periamygdala and insula. Reductions in connectivity were associated with less self-reported negative affect.
Measurements of serum DHEA and DHEA sulphate levels improve the accuracy of the low-dose cosyntropin test in the diagnosis of central adrenal insufficiency.
The study examined the value of measuring serum DHEA and DHEA-S levels during low-dose cosyntropin stimulation in diagnosing central adrenal insufficiency. It found that patients with impaired HPA function had lower baseline and stimulated levels of cortisol, DHEA, and DHEA-S compared to normal subjects, suggesting that DHEA measurements improve diagnostic accuracy.
A randomized double-blinded placebo-controlled trial on the effect of dehydroepiandrosterone for 16 weeks on ovarian response markers in women with primary ovarian insufficiency.
This randomized, double-blinded, placebo-controlled trial assessed the effect of DHEA on ovarian response markers in 22 women with primary ovarian insufficiency. The DHEA group showed higher antral follicle count and ovarian volume at weeks 12 and 20, but no significant changes in serum AMH and FSH levels.
Effect of DHEA supplementation on serum IGF-1, osteocalcin, and bone mineral density in postmenopausal, glucocorticoid-treated women.
RCT of DHEA supplementation in 19 postmenopausal women on long-term glucocorticoid therapy. DHEA significantly increased serum IGF-1, osteocalcin, and bone mineral density in the lumbar spine and femoral neck, suggesting a beneficial role in treating steroid-induced osteoporosis.
Dehydroepiandrosterone sulfate linked to physiologic response against hot spring immersion.
The study investigated the acute effect of a 30-min hot spring immersion on insulin resistance measures in 16 male subjects, in relation to DHEA-S levels. Hot spring immersion increased heart rate and reduced diastolic blood pressure, with a drop in DHEA-S concentration. Insulin resistance increased only in the Low DHEA-S group, with opposing cortisol changes observed between Low and High DHEA-S groups.
Effect of intravaginal DHEA on serum DHEA and eleven of its metabolites in postmenopausal women.
RCT measuring systemic bioavailability of DHEA and its metabolites following daily intravaginal application in 40 postmenopausal women. The study found increased maturation value of vaginal epithelial cells and decreased vaginal pH without significant changes in serum estrogens, suggesting local benefits against vaginal atrophy.
Analysis of clinical symptomatology, extrapyramidal symptoms and neurocognitive dysfunction following dehydroepiandrosterone (DHEA) administration in olanzapine treated schizophrenia patients: a randomized, double-blind placebo controlled trial.
RCT of 40 schizophrenia patients stabilized on olanzapine, randomized to receive DHEA or placebo for 12 weeks. DHEA improved negative symptoms and showed some improvement in Parkinsonism and akathisia. No change in psychosis was noted, but DHEA appeared to stabilize glucose levels and improve cognitive performance, particularly memory.
Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study.
A randomized, placebo-controlled study of DHEA in 40 HIV patients on stable antiretroviral therapy. DHEA improved quality of life but had no significant effects on viral replication, immunity, or body composition.
Changes in serum sex hormone profiles after short-term low-dose administration of dehydroepiandrosterone (DHEA) to young and elderly persons.
RCT evaluating the effects of 25 mg DHEA administration for two weeks in 22 healthy Japanese males aged 26-63. Serum DHEA, DHEAS, androstenedione, and estradiol levels increased, with significant negative correlations between serum DHEA and fasting insulin, HOMA-R, leptin, and high-sensitivity C-reactive protein.
Effects of dehydroepiandrosterone and alprazolam on hypothalamic-pituitary responses to exercise.
Double-blind, crossover, placebo-controlled study examining the effects of DHEA and alprazolam on HPA axis activity in 15 men. DHEA significantly increased the AVP response to exercise, while alprazolam blunted plasma cortisol, ACTH, AVP, and DHEA responses. The combination of DHEA and alprazolam increased the GH response to exercise.
Pilot clinical trial of dehydroepiandrosterone (DHEA) versus placebo for Sjögren's syndrome.
A 24-week randomized, double-blinded pilot trial compared oral DHEA (200 mg/day) to placebo in 28 subjects with Sjögren's syndrome. The study found no significant differences between the DHEA and placebo groups in symptoms or objective measures of dryness, and concluded that DHEA showed no evidence of efficacy in treating Sjögren's syndrome.
Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women.
RCT of 20 postmenopausal women comparing micronized DHEA to placebo for 12 months. DHEA improved insulin sensitivity and lipid profile, but did not change glucose tolerance. Suggests potential benefits for cardiovascular risk management in postmenopausal women.
Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause.
This study investigated the effects of 6-month DHEA supplementation in early and late postmenopausal women on circulating steroids, SHBG, beta-endorphin, and gonadotropins. DHEA increased levels of several androgens and estrogens, decreased SHBG in overweight late postmenopausal women, and improved Kupperman scores, particularly vasomotor symptoms.
DHEA replacement in women with adrenal insufficiency--pharmacokinetics, bioconversion and clinical effects on well-being, sexuality and cognition.
Double-blind, placebo-controlled, randomized crossover study of DHEA replacement in 24 women with adrenal insufficiency. DHEA treatment improved well-being, mood, and sexual interest, but had no effect on cognitive performance.
Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men.
RCT studying the effects of ANDRO-6 supplement containing androstenedione and herbal extracts on serum testosterone and resistance training adaptations in young men. Serum androstenedione increased, but testosterone levels and training adaptations were unchanged.
Sex differences in the pharmacokinetics of dehydroepiandrosterone (DHEA) after single- and multiple-dose administration in healthy older adults.
This study evaluated the pharmacokinetics of DHEA and its sulfated metabolite DHEA-S after single- and multiple-dose oral administration of DHEA 200 mg in healthy older adults. Results showed higher DHEA concentrations in women compared to men, while DHEA-S parameter estimates were similar between sexes. DHEA concentrations increased 5- to 6-fold in both sexes, and DHEA-S concentrations increased 5-fold in men and 21-fold in women.
Opposing effects of DHEA replacement in elderly subjects on declarative memory and attention after exposure to a laboratory stressor.
RCT with 75 elderly subjects testing DHEA (50 mg/day) vs placebo for 2 weeks, followed by a stress test. DHEA increased DHEAS levels to those found in young adults. DHEA-substituted subjects showed a trend towards a larger cortisol stress response. Visual memory recall was impaired, but attention was enhanced after stress. No interaction was found for spatial memory.
Benefits of Airway Androgen Receptor Expression in Human Asthma.
The study investigates the association of androgen receptor expression and its ligands, including dehydroepiandrosterone sulfate (DHEA-S), with asthma outcomes. Higher AR expression and androgen levels were linked to better lung function, fewer symptoms, and lower FENO in asthma patients.
The diurnal patterns of the adrenal steroids cortisol and dehydroepiandrosterone (DHEA) in relation to awakening.
The study examined the diurnal patterns of cortisol and dehydroepiandrosterone (DHEA) in relation to awakening. It found that while both steroids showed stability across days, DHEA did not exhibit an awakening stimulatory burst like cortisol. DHEA levels were elevated post-awakening but showed a stable secretory pattern compared to cortisol.
Dehydroepiandrosterone replacement in aging humans.
This 9-month double-blind, cross-over RCT evaluated the effects of 100 mg DHEA replacement therapy in 39 healthy older men. The study found mild and temporary changes in blood values during DHEA use, but no changes in body composition or urological parameters. No significant effects on well-being or sexual function were observed.
Neuroendocrine effect of a short-term treatment with DHEA in postmenopausal women.
The study investigated the neuroendocrine effects of short-term DHEA supplementation in postmenopausal women. After 7 days of DHEA supplementation, there was a significant increase in circulating androstenedione, testosterone, estrone, and estradiol levels. The clonidine test showed a significant increase in plasma beta-endorphin levels after DHEA supplementation, suggesting a restoration of neuroendocrine control.
Dehydroepiandrosterone (Dhea): Pharmacological Effects And Potential Therapeutic Application.
This narrative review discusses the biological and pharmacological effects of DHEA, its mechanism of action, and potential therapeutic use, particularly in CNS disorders. DHEA is suggested as a marker of longevity and has potential neuroprotective, pro-cognitive, anxiolytic, and antidepressant effects.
DHEA in bone: the role in osteoporosis and fracture healing.
This review discusses the history and mechanisms of DHEA in relation to bone health, including its association with increased bone mineral density and potential role in fracture healing. It evaluates DHEA's effects on osteoblast activity and IGF-1 expression.
Beyond Glucocorticoids: Integrating Dehydroepiandrosterone (DHEA) into Animal Welfare Research
The review discusses the integration of dehydroepiandrosterone (DHEA) and its sulfate ester into animal welfare research, highlighting the limitations of relying solely on glucocorticoids as biomarkers. It emphasizes the potential of the glucocorticoid:DHEA(S) ratio as an indicator of immune function, mental health, cognitive performance, and overall welfare.