Research
Dan Shen (Salvia miltiorrhiza)
60 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Therapeutic potential of pharmacological components of Salvia miltiorrhiza against atherosclerosis: A preclinical systematic review and meta-analysis.
Systematic review and meta-analysis of 64 animal studies on Salvia miltiorrhiza (Danshen) components against atherosclerosis. Findings show amelioration of atherosclerotic plaque formation, modulation of lipid profiles, inflammatory cytokines, oxidative stress indicators, and endothelial function markers. Machine learning identified an optimal Tanshinone IIA regimen.
A systematic review and meta-analysis of randomized controlled trials on the efficacy and safety of tanshinone IIA sodium sulfonate injection as adjunctive therapy for stroke.
This systematic review and meta-analysis evaluated the efficacy and safety of tanshinone IIA sodium sulfonate injection as adjunctive therapy for ischemic stroke. The analysis included 22 trials with 2289 participants, showing significant improvements in NIHSS scores, hemorheology, lipid profiles, cerebral blood flow, and serum biomarkers. Tanshinone IIA was found to be a relatively safe neuroprotective agent for ischemic stroke.
Effects of Dan Shen () on blood pressure management in hypertensive patients: a randomized controlled trial.
This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of Dan Shen in managing primary hypertension in 320 patients. Dan Shen significantly reduced systolic and diastolic blood pressure, improved lipid and glucose metabolism, and enhanced quality of life in patients with primary hypertension.
Cardioprotective Chinese herbs and antiretroviral drug metabolism: a systematic review of in vitro evidence.
Systematic review of in vitro studies evaluating the effects of six Chinese herbs on cytochrome P450 enzyme activity related to antiretroviral drug metabolism. Dan Shen and Gan Cao were most frequently studied, with Dan Shen showing minimal impact and Gan Cao indicating potential enzyme inhibition. Other herbs showed a tendency toward enzyme induction.
for Viral Myocarditis: Multi-Computational Pharmacological Exploration and Meta-Analytic Efficacy Validation.
The study explores the pharmacological mechanisms of Danshen injection as a supplementary treatment for viral myocarditis using computational approaches and meta-analysis. It identifies key therapeutic targets and active components, suggesting that Danshen suppresses excessive inflammation, improving clinical outcomes and reducing inflammatory markers.
Salviae Miltiorrhizae Radix et Rhizoma protects against doxorubicin-induced cardiotoxicity: A systematic review.
Systematic review of 35 studies on the protective effects of Salvia miltiorrhiza (Danshen) against doxorubicin-induced cardiotoxicity. Danshen ameliorated pathological alterations in cardiac cells and tissues, with mechanisms involving anti-apoptosis, anti-oxidative stress, and other pharmacological activities. No clinical trials specifically evaluated Danshen for doxorubicin-induced cardiotoxicity.
Effectiveness and Safety of Different Methods of Assisted Fat Grafting: A Network Meta-Analysis.
Network meta-analysis of 31 clinical trials involving 1656 patients to evaluate the effectiveness and safety of various assisted fat grafting methods. Adipose-derived stem cells-assisted fat grafting showed the highest survival rate and lowest complication incidence. Salvia miltiorrhiza-assisted fat grafting also demonstrated a high survival rate.
Lipid-lowering effect of Danshen, Fufang Danshen, Shuxuening and Shuxuetong injections: A Systematic Review and Meta-Analysis of Controlled Clinical Trials.
This meta-analysis evaluated the lipid-lowering effects of Danshen, Fufang Danshen, Shuxuening, and Shuxuetong injections across multiple studies. All four injections significantly reduced triglycerides, total cholesterol, and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. Shuxuening injection had the strongest effect, particularly beneficial for patients with cardiovascular disease, while Shuxuetong was more effective for diabetic patients.
Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review.
Systematic review of tanshinone, a compound from Salvia miltiorrhiza, highlighting its cardiovascular protective effects. Tanshinone improves cardiac function, reduces oxidative stress, and inhibits inflammation in animal models, with potential therapeutic applications in cardiovascular diseases.
Salvia miltiorrhiza Bunge (Danshen) based nano-delivery systems for anticancer therapeutics.
This systematic review summarizes recent progress in nano-delivery systems for the active constituents of Salvia miltiorrhiza (Danshen) used in anti-tumor therapeutics. It discusses how these systems improve bioavailability, tumor targeting, and biological barrier permeability of Danshen's active components.
The effects of Salvia miltiorrhiza and ligustrazine injection combined with ACEI/ARB on diabetic kidney disease: A systematic review and meta-analysis.
Systematic review and meta-analysis assessing the efficacy and safety of Salvia miltiorrhiza and ligustrazine injection combined with ACEI/ARB for diabetic kidney disease. The combination improved renal function, proteinuria, hyperglycemia, blood pressure, dyslipidemia, and inflammatory response without significant adverse events.
Traditional Chinese medication for oral submucous fibrosis: A systematic review and network meta-analysis of randomized controlled trials.
Systematic review and network meta-analysis of 31 RCTs with 2986 patients on treatments for oral submucous fibrosis. The combination of oral Chinese herbal medicine formulas and intralesional Salvia miltiorrhiza was most effective for improving mouth opening. Intralesional steroids with oral Salvia miltiorrhiza reduced burning pain effectively. IS combined with ISM had the highest effective proportion and lowest side effects.
Clinical effect of Danshen decoction in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the clinical efficacy of Danshen decoction combined with conventional treatment for heart failure. The analysis included nine RCTs with 855 patients, showing significant improvements in clinical efficacy rate, left ventricular ejection fraction, and reductions in left ventricular dimensions, brain natriuretic peptide, and hypersensitive C-reactive protein levels. The study concludes that Danshen decoction is an effective and safe treatment option for heart failure, though more rigorous trials are needed.
The protective effect of an extract of Salvia miltiorrhiza Bunge (Danshen) on cerebral ischemic injury in animal models: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the protective effect of Tanshinone IIA (TSA) from Salvia miltiorrhiza (Danshen) on cerebral ischemic injury in animal models. TSA significantly reduced markers of inflammation and oxidative stress, inhibited cell apoptosis, and improved neurological outcomes.
Efficacy and safety of Salvia miltiorrhiza (Salvia miltiorrhiza Bunge) and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease: A systematic review and meta-analysis.
Systematic review and meta-analysis of 22 trials with 1939 patients evaluating the efficacy and safety of Salvia miltiorrhiza and ligustrazine injection as an adjunctive therapy for early-stage diabetic kidney disease. The combination showed better efficacy than conventional western medicine alone, reducing urinary albumin excretion rate, serum creatinine, β-microglobulin, and inflammatory markers like interleukin-6, interleukin-18, and tumor necrosis factor-α.
Chemical composition, quality control, pharmacokinetics, pharmacological properties and clinical applications of Fufang Danshen Tablet: A systematic review.
Systematic review of Fufang Danshen Tablet (FDT), a traditional Chinese medicine formula, analyzing its chemical composition, quality control, pharmacokinetics, pharmacological properties, and clinical applications. FDT is used for cardiovascular and cerebrovascular diseases, with recommendations for future research on quality control and clinical effectiveness.
Liver function monitoring: a prospective nested case-control study of Salvia miltiorrhiza polyphenol injection.
A nested case-control study and meta-analysis assessed adverse drug reactions (ADRs) of Salvia miltiorrhiza polyphenol injections, focusing on liver dysfunction. Among 2633 patients, 58 experienced abnormal liver function, with risk factors including sulfa drug allergy and co-administration of other drugs. The study found a higher incidence of liver dysfunction than reported in drug instructions.
Efficacy of Salvia miltiorrhiza injection combined with steroids in the treatment of oral submucous fibrosis: A meta-analysis of randomized controlled trials.
Meta-analysis of 13 randomized controlled trials involving 1190 patients to evaluate the efficacy of Salvia miltiorrhiza injection combined with steroids in treating oral submucous fibrosis. The combination significantly improved maximal mouth opening, decreased oral mucosal lesion area, improved burning sensation, and reduced adverse drug reactions compared to conventional treatment.
Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis: A meta-analysis of randomized controlled trials.
Meta-analysis of 16 RCTs with 1144 patients assessing Xuebijing injection combined with routine treatment for sepsis. The study found that combined therapy reduced 28-day mortality, APACHE II scores, and body temperature, but did not significantly reduce mortality during treatment. The evidence quality was moderate to low, indicating a need for more rigorous trials.
Different network pharmacology mechanisms of Danshen-based Fangjis in the treatment of stable angina.
Meta-analysis of 444 RCTs comparing the network pharmacological mechanisms of 5 Danshen-based injections for treating stable angina. All preparations were effective, with clinical improvement rates of 72.4%-91.6% and ECG improvement rates of 54.5%-71.6%. Danhong injection showed unique effects on signaling pathways related to lipoprotein metabolism, oxidation, and inflammation.
How Efficacious is Danshen (Salvia miltiorrhiza) Dripping Pill in Treating Angina Pectoris? Evidence Assessment for Meta-Analysis of Randomized Controlled Trials.
Meta-analysis of 109 RCTs with 11,973 participants comparing danshen dripping pill (DSP) to isosorbide dinitrate (ISDN) for treating angina pectoris. DSP showed better efficacy than ISDN in symptomatic and ECG improvements, but evidence strength was low due to high risk of bias and heterogeneities.
A comparative study of Danhong injection and Salvia miltiorrhiza injection in the treatment of cerebral infarction: A systematic review and meta-analysis.
Systematic review and meta-analysis comparing Danhong injection (DI) and Salvia miltiorrhiza injection (SMI) in the treatment of cerebral infarction. DI was found to be about 27% superior to SMI in clinical total effective rate and improved neurologic impairment. No serious adverse drug reactions were reported.
The Efficacy of Danshen Injection as Adjunctive Therapy in Treating Angina Pectoris: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 10 RCTs involving 944 anginal patients, evaluating Danshen injection as adjunctive therapy for angina pectoris. Danshen injection combined with antianginal agents showed better symptom and ECG improvement compared to antianginal agents alone.
Danshen injection as adjuvant treatment for unstable angina pectoris: A systematic review and meta-analysis.
Systematic review and meta-analysis of 17 RCTs involving 1,433 participants evaluating Danshen Injection as an adjuvant treatment for unstable angina pectoris. The combined use of Danshen and Western medicine was significantly superior to Western medicine alone in terms of effectiveness rate of angina pectoris and ECG improvements. Some adverse drug reactions were reported.
Meta-analysis of traditional herbal medicine in the treatment of nonalcoholic fatty liver disease.
Meta-analysis evaluating the efficiency and safety of Danshen in the treatment of nonalcoholic fatty liver disease (NAFLD). The analysis included 8 RCTs with 800 patients, showing Danshen increased total effectiveness rate and improved liver function markers compared to placebo.
Compound Danshen (Salvia miltiorrhiza) dripping pill for coronary heart disease: an overview of systematic reviews.
Overview of systematic reviews on Compound Danshen dripping pill (CDDP) for coronary heart disease (CHD), including 13 SRs with 34,071 participants. Most SRs suggested potential benefits of CDDP for CHD, such as improving symptoms and ECG results, but the overall quality of evidence was poor.
Salvia miltiorrhiza injection on pulmonary heart disease: a systematic review and meta-analysis.
Systematic review and meta-analysis of 35 RCTs involving 2,715 patients with cor pulmonale, evaluating the efficacy and safety of Salvia miltiorrhiza and complex Salvia miltiorrhiza injection. The treatment showed better outcomes compared to routine medicine alone, with higher clinical effectiveness, improved PaO2, decreased PaCO2, improved hemorheology, and alleviated mPAP. No obvious adverse effects were reported, but methodological flaws limit the conclusions.
Dan Shen agents for acute ischaemic stroke.
Meta-analysis of six trials involving 494 patients assessing Dan Shen agents for acute ischaemic stroke. Dan Shen was associated with a significant increase in patients showing improvement in neurological deficit. No deaths were reported, but the methodological quality of the studies was poor.
Dan Shen agents for acute ischaemic stroke.
Meta-analysis of randomised controlled trials assessing Dan Shen agents for acute ischaemic stroke. Three trials with 304 patients were included, showing a significant improvement in neurological deficit with Dan Shen. However, the methodological quality of the studies was poor, and further high-quality trials are needed.
Salvia miltiorrhiza adjuvant therapy facilitates cardiac function recovery in patients with myocardial infarction.
This randomized controlled trial evaluated Salvia miltiorrhiza as an adjunct therapy for acute myocardial infarction in 120 patients. The SM group showed significantly improved cardiac function and hemodynamic parameters compared to routine treatment, suggesting SM's potential as a safe, effective adjuvant treatment for myocardial infarction.
Oral opening training increases oral opening in patients with oral submucous fibrosis.
RCT comparing local injection of Salvia miltiorrhiza and triamcinolone acetonide with and without mouth opening training in 197 patients with oral submucous fibrosis. The experimental group showed significantly greater improvement in mouth opening over 2 years compared to the control group.
A randomized controlled study on an integrated approach to prevent and treat re-adhesion after transcervical resection of moderate-to-severe intrauterine adhesions.
RCT comparing an integrated treatment approach for preventing and treating intrauterine adhesions after TCRA in 70 patients. The treatment group received Danshen injection and oral Chinese medicine, showing lower re-adhesion rates and higher clinical efficiency compared to the control group.
Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB.
Clinical trials in 58 breast-feeding mothers and animal studies showed that Tanshinone I and Tanshinone IIA/B, combined with Cefprozil, improved outcomes in mastitis treatment. Tanshinones reduced MPO activity and inflammatory cytokines in both human and animal models, suggesting potential benefits through NF-κB regulation.
Effectiveness of Radix astragali and Salvia miltiorrhiza injection in treatment of skeletal muscle injury of aerobics athletes.
RCT of 600 aerobics athletes with skeletal muscle injury comparing Radix astragali and Salvia miltiorrhiza injection to local massage and rehabilitation training. The experimental group showed superior treatment efficiency, improved serum SOD and MDA levels, and better plasma CK and Mb levels compared to the control group.
Post-Marketing Safety Surveillance of the Salvia Miltiorrhiza Depside Salt for Infusion: A Real World Study.
Prospective, multicenter cohort study assessing the safety of Salvia Miltiorrhiza Depside Salt for Infusion (SMDS) in 30180 inpatients across 36 hospitals. The incidences of adverse events, adverse drug events, and adverse drug reactions were 6.40%, 1.57%, and 0.79%, respectively. Several risk factors for adverse drug events were identified, including male gender, more concomitant medications, longer therapy duration, higher drug concentration, and unapproved resolvent use.
Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge.
Systematic review on the roles of reactive oxygen species in anticancer therapy with Salvia miltiorrhiza Bunge (Danshen). The review discusses the potential benefits of Danshen in treating various cancers through mechanisms involving ROS-related anticancer effects, apoptosis, and autophagy.
The effectiveness and safety of a danshen-containing Chinese herbal medicine for diabetic retinopathy: a randomized, double-blind, placebo-controlled multicenter clinical trial.
RCT of 223 NPDR patients assessing the effectiveness and safety of Compound Danshen Dripping Pill (CDDP) for diabetic retinopathy. High-dose and mid-dose CDDP groups showed significantly higher 'Excellent' and 'Effective' ratings in FFA and fundoscopic examination compared to placebo, with no significant adverse events.
The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review.
Systematic review of the anticancer properties of Salvia miltiorrhiza (Danshen), focusing on its bioactive compounds, particularly tanshinones. The review highlights the potent anticancer activities of these compounds and their potential for further research and development.
[Evaluation of a compound with dan-shen root and azone for scar treatment].
RCT evaluating the effect of a compound of Dan-shen root and azone for scar treatment. The permeability of Dan-shen root with azone was significantly higher than distilled water and normal saline. The treatment group showed a higher efficient rate for hypertrophic scar treatment compared to control (91.4% vs. 71.3%).
TCM treatment of extrasystole with huanglian shengmai yin--a report of 357 cases.
RCT of 357 cases using Huanglian Shengmai Yin for treating ventricular, atrial, and nodal arrhythmia. The formulation, including Radix Astragali and Rhizoma Coptidis, showed effects of strengthening myodynamia, increasing coronary flow, and resisting arrhythmia. Some patients experienced gastric discomfort and poor appetite, but no toxic or adverse reactions were noted.
Randomized, double-blind, placebo-controlled phase I dose escalation study of Dan Qi Tong Mai tablet in healthy volunteers.
Phase I dose escalation study of Dan Qi Tong Mai tablet, containing Salvia miltiorrhiza and Panax notoginseng, in 84 healthy volunteers. The study assessed tolerability and safety, finding no serious adverse events. The most frequent adverse event was an increase in the number of daily stools.
Hot Compress with Chinese Herbal Salt Packets Reducing PICC Catheter Complications: A Randomized Controlled Trial.
RCT of 720 hospitalized patients undergoing PICC, comparing hot compress with Chinese herbal salt packets (CHSP) to conventional care. The treatment group showed increased vessel diameter during catheterization, higher success rate of single catheter, and lower incidence of superficial phlebitis compared to control.
The effect of Danshen extract on lipoprotein-associated phospholipase Alevels in patients with stable angina pectoris: study protocol for a randomized controlled trial - the DOLPHIN study.
This randomized, single-blind, placebo-controlled trial investigates the effect of Danshen extract on lipoprotein-associated phospholipase A levels in 156 patients with stable angina. The primary outcome is the serum level of Lp-PLA, with secondary outcomes including angina frequency score improvement and carotid intima-media thickness.
Efficacy and safety of Yirui capsule in patients with hyperlipidemia: study protocol for a multicenter, randomized, double-blind, placebo-controlled trial.
This is a study protocol for a multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of Yirui capsules in patients with hyperlipidemia. The trial aims to assess the impact of Yirui capsules on blood lipid levels, including low-density lipoprotein cholesterol, in comparison to placebo.
A randomized placebo controlled trial of an innovative herbal formula in the prevention of atherosclerosis in postmenopausal women with borderline hypercholesterolemia.
RCT of 165 postmenopausal women with early hypercholesterolemia comparing D&G herbal formula to placebo over 12 months. D&G group showed significant decreases in LDL cholesterol, total cholesterol, and carotid intima-media thickness, suggesting potential for atherosclerosis prevention.
Effect of Chinese herbal fomentation on arteriovenous fistula maturation.
RCT examining the effects of Chinese herbal fomentation with Dan Shen and Hong Hua on radiocephalic arteriovenous fistula maturation in 62 patients. The treatment reduced early thrombosis and increased the proportion of fistulas suitable for dialysis.
The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients.
RCT of 100 coronary patients evaluating adjunctive treatment with Salvia miltiorrhiza (danshen) and Pueraria lobata (gegen) for 24 weeks. The D&G group showed significant improvements in brachial flow-mediated dilation and carotid intima-media thickness compared to placebo. The treatment was well tolerated with few adverse events.
[Effect of dandi tablet on blood lipids and sex hormones in women of postmenopausal stage].
RCT of 73 postmenopausal women comparing Dandi Tablet (DDT) to nylestriol over 3 months. DDT improved blood lipid metabolism and elevated estrogen levels, suggesting a preventive effect on coronary heart disease.
Effect of Salvia Miltiorrhiza Polyphenolic Acid Injection on Improving Limb Use and Cognitive Impairment in Patients with Acute Stroke.
Retrospective study of 90 acute stroke patients comparing injectable salvianolic acid to conventional treatment. The salvianolic acid group showed significant improvements in NIHSS score, cerebral infarct volume, cognitive function, and motor function compared to the control group, with high safety and no significant adverse events.
Effect of Salvia Miltiorrhiza Injection in Patients With Autologous Fat Grafting to the Breast: A Preliminary Comparative Study.
Preliminary comparative study on the effect of Salvia miltiorrhiza injections in autologous fat grafting for breast augmentation. The SM group showed a higher fat graft retention rate and good breast morphology compared to the non-SM group.
The Effects of Iontophoretic Injections of Salvia miltiorrhiza on the Maturation of the Arteriovenous Fistula: A Randomized, Controlled Trial.
RCT investigating the effects of iontophoretic administration of Salvia miltiorrhiza on the maturation of arteriovenous fistulas in 40 patients with chronic kidney disease. The intervention group showed significantly higher maturation rates and improved blood flow and shunt diameter compared to the control group.
Clinical efficacy of Rong-Yang-Jyh-Gan-Tang on patients with chronic hepatitis C: A double-blinded randomized placebo-controlled crossover study.
Double-blinded randomized placebo-controlled crossover study evaluating Rong-Yang-Jyh-Gan-Tang (RYJGT) on 36 patients with chronic hepatitis C. RYJGT treatment resulted in a significant decrease in serum HCVRNA levels and improved TCM symptoms compared to placebo.
Panax ginseng and Salvia miltiorrhiza supplementation during eccentric resistance training in middle-aged and older adults: A double-blind randomized control trial.
Double-blind RCT with 23 older adults comparing Panax ginseng and Salvia miltiorrhiza supplementation to placebo during 12 weeks of eccentric resistance training. The herb supplementation did not modulate vascular or inflammatory adaptations and abolished the increase in muscle mass induced by training.
Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial.
Randomized, placebo-controlled, double-blind crossover study evaluating the effect of Danshen on hyperlipidemia and hypertension in 20 participants. Danshen treatment slightly increased LDL-cholesterol without affecting blood pressure, endothelial function, or other risk markers, suggesting no beneficial effect on cardiovascular risk factors.
Absence of an effect of T89 on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers.
This open-label, multi-dose, single-center, sequential, inpatient study evaluated the effects of a two herb combination drug (T89, Danshen plus Sanqi) on the steady-state pharmacodynamics and pharmacokinetics of warfarin in 24 healthy volunteers. The study found that T89 had no effect on the steady-state pharmacodynamics and pharmacokinetics of warfarin, indicating no need for dose adjustments when co-administered.
The Synergistic Effects of Astragalus mongholicus and Salvia miltiorrhiza on Coronary Heart Disease Identified by Network Pharmacology and Experiment
The study investigated the synergistic effects of Astragalus mongholicus and Salvia miltiorrhiza on coronary heart disease using network pharmacology and a myocardial infarction rat model. Results showed improved cardiac function, reduced myocardial infarct size and fibrosis, and better regulation of lipid metabolism and blood viscosity in the combined treatment group.
Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes
Review of salvianolic acid B, extracted from Danshen, highlighting its antitumor and anti-inflammatory effects on various organs and its protective effects in diseases like depression and spinal cord injury. The review discusses its safety, combination therapy potential, and new dosage forms and delivery routes.
Mechanism of Action of Magnesium Lithospermate B against Aging and Obesity-Induced ER Stress, Insulin Resistance, and Inflammsome Formation in the Liver
The study investigates the effects of magnesium lithospermate B (MLB) on insulin sensitivity and related signaling pathways in the liver of aging and obese animal models. MLB supplementation improved glucose tolerance, ameliorated insulin signaling disruption, and suppressed ER stress and inflammasome-related signaling in the liver.
Improved Oral Bioavailability Using a Solid Self-Microemulsifying Drug Delivery System Containing a Multicomponent Mixture Extracted from Salvia miltiorrhiza
The study developed a solid self-microemulsifying drug delivery system (S-SMEDDS) to improve the oral bioavailability of active constituents from Salvia miltiorrhiza. In vitro release and in vivo bioavailability tests in rats showed that the S-SMEDDS enhanced the dissolution rate and oral absorption of both lipophilic and hydrophilic constituents.
Salvia miltiorrhiza Roots against Cardiovascular Disease: Consideration of Herb-Drug Interactions
This review summarizes the effects of bioactive components from Salvia miltiorrhiza roots on the pharmacokinetics of comedicated drugs, focusing on herb-drug interactions. It discusses the impact on enzyme and transporter activity, highlighting the potent inhibitory effects of lipophilic tanshinones on CYPs activities.