Research
Curcumin
581 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of Curcumin/Turmeric Supplementation on Kidney Function in Individuals With Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Systematic review and meta-analysis of 12 RCTs with 1303 participants evaluating curcumin/turmeric supplementation on kidney function in individuals with diabetes. Curcumin/turmeric significantly reduced urea levels but did not significantly affect creatinine, BUN, uric acid, or albumin.
Antihypertensive Effects of Curcumin/Turmeric Supplementation in Prediabetes and Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
This systematic review and meta-analysis evaluated the effects of curcumin or turmeric supplementation on blood pressure in adults with prediabetes or type 2 diabetes. The analysis included 15 RCTs with 855 participants and found that curcumin/turmeric supplementation significantly reduced systolic blood pressure, especially in those with baseline hypertension, but had no significant effect on diastolic blood pressure.
Curcumin Supplementation in Critically Ill Patients: A GRADE‐Assessed Systematic Review and Meta‐Analysis of Randomized Controlled Trial
This meta-analysis assessed the impact of curcumin supplementation on inflammation, liver function, and clinical outcomes in critically ill patients. The analysis of seven trials with 571 participants showed that curcumin significantly improved liver function, albumin levels, SOFA scores, and reduced ICU stay duration, suggesting its potential role in mitigating organ dysfunction.
Curcumin for the clinical treatment of rheumatoid arthritis: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
This meta-analysis evaluated the efficacy and safety of curcumin in the treatment of rheumatoid arthritis, including six studies with 244 participants. Curcumin significantly improved several outcomes related to rheumatoid arthritis, such as ACR 20 response, DAS-28, ESR, CRP levels, VAS score, TJC, SJC, and RF levels, although the evidence certainty was very low.
Research progress of curcumin and its derivatives as anti-inflammatory agents: From molecular mechanism to clinical application.
This systematic review discusses the pharmacological activities of curcumin, focusing on its anti-inflammatory effects and challenges related to its bioavailability. It explores the molecular mechanisms, structural modifications, and novel delivery systems to enhance its clinical application in treating inflammation-related diseases.
Effects of Curcumin/Turmeric Supplementation on Lipid Profile in Subjects With Prediabetes and Diabetes: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of curcumin/turmeric supplementation on lipid profiles in adults with prediabetes and type 2 diabetes. The analysis included 27 RCTs and found that curcumin/turmeric significantly reduced triglycerides, total cholesterol, and LDL-C, while increasing HDL-C. However, significant heterogeneity and low certainty of evidence were noted.
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Umbrella review summarizing the effects of curcumin supplementation on ulcerative colitis (UC) based on seven systematic reviews and meta-analyses. While 11 out of 18 outcomes showed statistical significance, none were supported by high-certainty evidence, highlighting the need for stronger future research.
Role of curcumin and its nanoformulations in the management of oral squamous cell carcinoma: A systematic review.
Systematic review of 35 publications on curcumin and its nanoformulations in the management of oral squamous cell carcinoma (OSCC). The review included 5 clinical studies and 30 cell line studies, showing curcumin's potential to decrease cell proliferation and growth in OSCC. Novel formulations of curcumin showed promising results in managing oral cancer.
Novel approaches involving curcumin in endodontic and periodontal diseases: a scoping review.
This scoping review evaluates the application of curcumin in endodontic and periodontal diseases, focusing on its antibacterial, anti-inflammatory, and tissue regeneration properties. The review includes 31 studies, highlighting curcumin's potential as a photosensitizer in photodynamic therapy and its varied effects in root canal filling and periodontal treatment. Further clinical research is needed to validate its efficacy and support broader clinical application.
Antidiabetic and Metabolic Effects of Turmeric (Curcuma Longa) in Patients with Type 2 Diabetes Mellitus or Hyperglycemia - A Systematic Meta-Review and Meta-Analysis.
This systematic meta-review and meta-analysis evaluated the effectiveness of curcumin in improving glycemic control and lipid profiles in patients with type 2 diabetes mellitus or hyperglycemia. The analysis included 63 randomized controlled trials with 3706 participants, showing significant reductions in fasting blood glucose, HbA1c, LDL cholesterol, and triglycerides, while increasing HDL cholesterol. No significant effects were observed on total cholesterol, blood pressure, body mass index, blood urea nitrogen, or creatinine levels.
Clinical Pharmacokinetic-Pharmacodynamic Relationships of Pharmacological Strategies for Attenuating p-Cresyl Sulfate in Patients with Kidney Disease.
This systematic review evaluated pharmacological strategies to reduce p-Cresyl sulfate (pCS) in patients with chronic kidney disease (CKD). The review included 59 studies with 2593 participants, assessing substances like AST-120, sevelamer, sucroferric oxyhydroxide, prebiotics, probiotics, synbiotics, antibiotics, ketoanalogs, and curcumin. AST-120 and synbiotics showed consistent pCS reductions, while curcumin and others did not demonstrate consistent effects.
Effects of curcumin on serum inflammatory biomarkers in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of curcumin on serum inflammatory biomarkers in patients with knee osteoarthritis. The analysis included 21 studies with 1705 patients and found that curcumin significantly reduced serum CRP and TNF-alpha levels compared to placebo, indicating its anti-inflammatory effects. No significant differences were observed for other biomarkers like ESR, IL-1beta, IL-6, or PGE-2.
Evaluating the efficacy and safety of Curcuma longa, Boswellia serrata, and their mixed formulation in treating knee osteoarthritis: A systematic review and network meta-analysis.
Systematic review and network meta-analysis of 20 RCTs with 1633 participants evaluating Curcuma longa (CL) and Boswellia serrata (BS) for knee osteoarthritis. Modified formulations of CL significantly reduced pain, while BS improved joint function. No significant differences in adverse events were observed.
Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical evidence.
Systematic review and meta-analysis of 15 RCTs involving 1,123 adults, evaluating curcumin's effects on depression and anxiety symptoms associated with chronic diseases. Curcumin showed statistically significant improvements in depressive and anxiety symptoms, with identified mechanisms including anti-inflammatory and antioxidant effects.
Effects of Curcuminoids Plus Piperine Co-Supplementation on Serum Lipid Profile in Adults: A Systematic Review and Meta-Analysis of RCTs.
This systematic review and meta-analysis of 16 RCTs with 1038 participants evaluated the effects of curcuminoids plus piperine co-supplementation on serum lipid profiles. The analysis found significant reductions in triglycerides and total cholesterol, and an increase in HDL-C, suggesting beneficial lipid-modulating effects for dyslipidemia management.
Effects of Curcumin on Postmenopausal Women's Health: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated curcumin's impact on postmenopausal women's health, reviewing 14 RCTs with 982 participants. Curcumin was found to reduce systolic and diastolic blood pressure, increase antioxidant capacity, decrease AST levels, and improve vasomotor symptoms, suggesting potential therapeutic roles in managing cardiovascular risk factors, oxidative stress, and vasomotor symptoms.
Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
This systematic review and meta-analysis assessed the effects of curcumin and curcumin plus piperine supplementation on liver enzymes in patients with nonalcoholic fatty liver disease. Curcumin significantly reduced ALT and AST levels, but not ALP. Curcumin plus piperine showed no significant effect on ALT and AST.
Effectiveness and mechanisms of curcumin for colorectal cancer in preclinical models:A systematic review and meta-analysis.
Systematic review and meta-analysis of 22 studies involving 536 animals evaluating curcumin's efficacy in colorectal cancer models. Curcumin significantly reduced tumor volume and weight, with oral administration being more effective. It also showed synergistic effects with chemotherapeutic agents.
Targeting cognitive aging with curcumin supplementation: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating curcumin's effects on cognitive outcomes related to aging. Preclinical in vivo studies showed curcumin improved memory in AD models, while human studies showed no significant effect on global cognitive outcomes but improvements in working memory and processing speed. Adverse events were higher in the curcumin group.
Curcumin Versus Corticosteroids for Symptomatic Oral Lichen Planus: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 11 clinical trials involving 499 OLP patients comparing curcumin to corticosteroids. Curcumin showed significantly better efficacy in reducing pain at 1 week compared to corticosteroids, but no significant differences at later follow-ups. Curcumin and corticosteroids had comparable efficacy in clinical improvement of lesions.
Therapeutic strategies for olfactory impairment in patients with chronic kidney disease: a systematic review.
Systematic review evaluating therapeutic interventions for olfactory impairment in CKD patients, including those on dialysis or post-kidney transplantation. Intranasal theophylline and curcumin showed partial efficacy, while olfactory training demonstrated consistent improvements.
Investigating the Potential of Curcumin in the Treatment of Nonsmall Cell Lung Cancer: A Systematic Review With Meta-Analysis, Network Pharmacology, and Mendelian Randomization.
Systematic review with meta-analysis, network pharmacology, and Mendelian randomization to evaluate curcumin's efficacy in treating NSCLC. Meta-analysis showed curcumin significantly reduced tumor volume in mice. Network pharmacology identified eight hub genes with clinical value, and Mendelian randomization demonstrated a causal relationship between AURKB level and increased NSCLC risk.
Effects of curcumin and Curcuma longa extract on inflammatory biomarkers in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE): a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 7 RCTs involving 314 patients with RA and SLE, assessing the effects of curcumin and Curcuma longa extract on inflammatory biomarkers. The analysis found no significant effect on DAS-28, ESR, or CRP levels, with substantial heterogeneity observed.
Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
A 12-month, randomized, double-blind, placebo-controlled trial with 227 obese individuals with T2DM showed that 1500 mg of curcumin daily significantly reduced liver fat content, liver stiffness, and glycated hemoglobin compared to placebo. Curcumin also improved inflammatory mediators and antioxidant capacity, supporting its use as an adjunctive therapy for liver steatosis.
Topical curcumin in the treatment of denture stomatitis: a systematic review of clinical efficacy.
Systematic review evaluating the efficacy of topical curcumin in different drug delivery systems for treating denture stomatitis. Five randomized clinical trials with 207 participants were included, showing a reduction in C. albicans colony count. The quality of evidence is moderate due to inconsistencies and risk of bias.
Effect of curcumin on inflammatory markers and disease activity in patients with rheumatoid arthritis: A meta-analysis.
Meta-analysis of seven randomized controlled trials evaluating curcumin supplementation in rheumatoid arthritis patients. Curcumin significantly reduced Disease Activity Score in 28 joints, rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein, indicating improvements in disease activity and systemic inflammatory markers.
Comparative evaluation of the efficacy of herbal and benzydamine mouthwashes in preventing radiation-induced oral mucositis among head and neck cancer patients: a systematic review and network meta-analysis.
Systematic review and network meta-analysis comparing the efficacy of herbal mouthwashes (curcumin, turmeric, sumac-rose) to benzydamine mouthwash in preventing radiation-induced oral mucositis in head and neck cancer patients. Curcumin mouthwash was most effective in reducing incidence and severity of oral mucositis, followed by turmeric and sumac-rose.
The effect of highly bioavailable forms of curcumin on lipoprotein(a) plasma levels: A systematic review and meta-analysis of randomized clinical studies.
Systematic review and meta-analysis of randomized clinical studies on highly bioavailable forms of curcumin. The analysis suggests that curcumin supplementation significantly reduces lipoprotein(a) levels, indicating potential vascular protective effects.
An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.
This umbrella review and updated meta-analysis assessed the effects of curcumin supplementation on lipid profiles. Curcumin significantly reduced total cholesterol, LDL-c, and triglycerides, and increased HDL-c. The study confirmed curcumin's anti-lipidemic effect, particularly in patients with metabolic-related diseases, and highlighted the benefits of enhanced bioavailability forms and supplementation for at least 8 weeks.
The Effect of Curcumin on Postmenopausal Symptoms: A Systematic Review Based on Randomized Controlled Trials.
This systematic review evaluated the effect of curcumin on postmenopausal outcomes in women, analyzing RCTs from the last decade. Conflicting reports were found on serum estradiol levels, bone density markers, and vasomotor symptoms, with no significant effects on physical, psychological, or sexual functions. Long-term curcumin intake showed improvements in cardiometabolic biomarkers, while its antioxidant and anti-inflammatory effects may improve osteoporosis symptoms.
Effect of curcumin on cardiometabolic diseases in the elderly: A systematic review of randomized controlled trials.
Systematic review of seven RCTs evaluating curcumin supplementation in elderly individuals with cardiometabolic diseases. Curcumin showed significant improvements in metabolic and inflammatory markers, including reductions in CRP, systolic blood pressure, fasting blood sugar, HOMA-IR, triglyceride levels, and an increase in HDL. However, effects on other cardiovascular indices were inconsistent.
Efficacy of curcumin/turmeric on inflammation and oxidative stress in prediabetes and type 2 diabetes: a systematic review and dose-response meta-analysis.
This systematic review and meta-analysis evaluated the effects of curcumin/turmeric supplementation on inflammatory and oxidative stress biomarkers in individuals with prediabetes and diabetes. The analysis included data from 28 RCTs and found that curcumin/turmeric significantly reduced CRP, TNF-α, IL-6, and MDA, while increasing GSH and TAC. The study suggests potential benefits of curcumin/turmeric in modulating inflammation and oxidative stress, though further high-quality RCTs are needed.
Curcumin as a therapeutic agent in liver cancer: a systematic review of preclinical models and mechanisms.
Systematic review of 26 preclinical studies evaluating curcumin's effects in liver cancer models. Curcumin showed anti-proliferative, pro-apoptotic, anti-inflammatory, and anti-metastatic effects, with significant induction of apoptosis and inhibition of NF-κB activation. The review highlights the need for standardized protocols and clinical trials.
The Effects of Curcumin Plus Piperine Co-administration on Inflammation and Oxidative Stress: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of RCTs assessing curcumin plus piperine co-administration on oxidative stress and inflammatory markers. The combination significantly increased SOD activity and GSH levels, decreased MDA concentrations, and reduced TNF-α and IL-6 concentrations, indicating reduced oxidative stress and inflammation.
Curcumin in prostate cancer: a systematic review of molecular mechanisms and nanoformulated therapeutic strategies.
This systematic review synthesizes preclinical evidence on curcumin's molecular mechanisms in prostate cancer and evaluates nanoformulation strategies to enhance its pharmacokinetics and therapeutic efficacy. Curcumin modulates pathways like PI3K/Akt/mTOR and NF-κB, promoting apoptosis and inhibiting cancer progression. Nanoformulations improve bioavailability and tumor-targeted delivery, with synergistic combinations enhancing anti-cancer effects.
Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models.
Systematic review of 29 preclinical studies using rodent models of dementia to assess curcumin's effects on oxidative stress, inflammation, and cognitive outcomes. Curcumin reduced oxidative stress and inflammation, and improved cognitive performance in most studies, highlighting its potential as a neuroprotective compound.
Chitosan-Based Systems for Curcumin Delivery: Evidence for Therapeutic Applications.
This systematic review evaluates chitosan-based delivery systems for curcumin, focusing on their potential to enhance therapeutic outcomes in cancer treatment and wound healing. The review included 387 studies, highlighting improved bioavailability and therapeutic effects of curcumin in cancer and enhanced biocompatibility and regenerative capacity in wound healing.
Advances in Supportive Therapy for Patients With Thalassemia: A Systematic Review.
Systematic review of supportive therapies for thalassemia patients, highlighting the efficacy of curcumin in improving lipid metabolism and reducing inflammation. Green Tea and Vitamin E were effective in reducing oxidative damage, with Green Tea also lowering serum ferritin and liver iron concentration. Spirulina improved cardiac T2*, contributing to cardioprotection.
The protective role of curcumin in mitigating drug-induced toxicity in male reproductive system.
Systematic review of 25 studies examining curcumin's protective role against drug-induced toxicity in the male reproductive system. Curcumin showed potential in reducing side effects of medications like sertraline and methotrexate, improving sperm motility, density, and morphology.
Systematic Review and Meta-analysis Indicating Curcumin to Enhance the Synergistic Potential of Paclitaxel and Reduce Cell Viability, Tumor Volume, and Drug Resistance in Different Cancers.
Systematic review and meta-analysis evaluating the combined effect of Paclitaxel and curcumin compared to Paclitaxel alone in in vitro and in vivo environments. The combination therapy significantly decreased cell viability, tumor volume, and the growth of drug-resistant cancer cells.
The effect of turmeric/curcumin supplementation on anthropometric indices in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
This systematic review and dose-response meta-analysis of 20 RCTs assessed the impact of turmeric/curcumin supplementation on anthropometric indices in individuals with prediabetes and type 2 diabetes mellitus. The analysis found that turmeric/curcumin significantly decreased body weight, waist circumference, fat mass percentage, and hip circumference, but had no effects on body mass index and waist-to-hip ratio.
Effect of curcumin on lipid mediators, glycemic index, and oxidative stress and inflammation biomarkers in polycystic ovary syndrome: Future directions and current knowledge - A systematic review.
This systematic review evaluates the effect of curcumin supplementation on polycystic ovary syndrome (PCOS). It includes seven animal studies and five clinical trials, finding that curcumin has beneficial effects on folliculogenesis, ovarian histomorphology, and luteinization processes, as well as improving dyslipidemia and reducing levels of LH, FSH, and testosterone. The effects are attributed to curcumin's antioxidant and anti-inflammatory properties.
Curcumin on Human Health: A Comprehensive Systematic Review and Meta-Analysis of 103 Randomized Controlled Trials.
This meta-analysis reviewed 103 RCTs involving 7216 participants to assess the effects of curcumin on various health outcomes. Significant positive effects were found on fasting blood sugar, C-reactive protein, high-density lipoprotein, and weight, among others. The evidence quality varied from high to very low across different outcomes.
Curcumin Attenuates Hyperglycemia and Inflammation in Type 2 Diabetes Mellitus: Quantitative Analysis of Randomized Controlled Trial.
Meta-analysis of 18 trials with 1382 T2D patients showing that curcumin supplementation significantly decreased fasting blood glucose and glycated hemoglobin levels, as well as C-Reactive Protein, compared to placebo. The study suggests curcumin can ameliorate hyperglycemia and inflammation in T2D.
Curcumin effects on glycaemic indices, lipid profile, blood pressure, inflammatory markers and anthropometric measurements of non-alcoholic fatty liver disease patients: A systematic review and meta-analysis of randomized clinical trials.
This systematic review and meta-analysis evaluated the effects of curcumin supplementation on glycaemic indices, lipid profile, blood pressure, inflammatory markers, and anthropometric measurements in NAFLD patients. Curcumin supplementation was associated with significant reductions in FBG, HOMA-IR, TG, TC, LDL, weight, and BMI, but no significant changes in HbA1C, plasma insulin, QUICKI, HDL, SBP, DBP, CRP, TNF-α, and WC.
Evaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the efficacy of curcumin in managing oral potentially malignant disorders (OPMDs). Sixteen randomized controlled trials with 1,089 patients were analyzed. Curcumin showed comparable efficacy to conventional treatments in alleviating pain and improving tongue protrusion in oral submucous fibrosis (OSF) and reducing pain and facilitating clinical remission in oral lichen planus (OLP). The study suggests curcumin as an alternative treatment for OPMDs with lower toxicity than steroids.
A comprehensive and systematic review on Curcumin as a promising candidate for the inhibition of melanoma growth: From pre-clinical evidence to molecular mechanisms of action.
This systematic review and meta-analysis evaluated the potential of curcumin to inhibit melanoma growth in animal models. The analysis included 40 studies with 989 animals, showing that curcumin significantly reduced tumor volume and weight, decreased lung tumor nodules and microangiogenesis, and extended survival time. Optimal dosage range was identified as 25-50 mg/kg with a treatment duration of 10-20 days.
Does curcumin improve liver enzymes levels in nonalcoholic fatty liver disease? A systematic review, meta-analysis, and meta-regression.
This meta-analysis investigated the effects of curcumin supplementation on liver aminotransferases in subjects with nonalcoholic fatty liver disease (NAFLD) across 15 randomized clinical trials. Curcumin did not affect serum alanine aminotransferase but reduced aspartate aminotransferase levels. High heterogeneity was noted, with the duration of intervention and relative curcumin dose identified as sources of heterogeneity.
Cardioprotective effects of curcumin against Diabetic Cardiomyopathies: A systematic review and meta-analysis of preclinical studies.
Systematic review and meta-analysis of 32 preclinical trials with 681 animals examining curcumin's effects on diabetic cardiomyopathy (DCM). Curcumin significantly improved cardiac function indices and decreased markers of myocardial injury, showing antioxidant, anti-inflammatory, autophagy-enhancing, and anti-apoptotic effects.
Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effect of curcumin supplementation on anxiety symptoms. A total of eight RCTs with 567 participants were analyzed, showing a significant positive effect of curcumin on alleviating anxiety symptoms.
Safety and efficacy of curcumin in the treatment of ulcerative colitis: An updated systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of eight RCTs involving 482 patients evaluating curcumin as an adjunctive treatment for ulcerative colitis. Curcumin significantly improved clinical remission and clinical improvement, with no serious adverse events reported. Further large-scale RCTs are needed due to study heterogeneity.
Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial
This randomized, double-blind, placebo-controlled trial assessed the efficacy of curcumin (1500 mg/day) in improving type 2 diabetes in 272 obese patients over 12 months. The curcumin-treated group showed significant improvements in fasting blood glucose, HbA1c, β-cell function, insulin resistance, adiponectin levels, leptin levels, and body mass index compared to the placebo group.
The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
RCT of 227 obese patients with type 2 diabetes evaluating curcumin's effect on atherogenic risk. Curcumin significantly reduced pulse wave velocity and improved cardiometabolic risk biomarkers, including LDL cholesterol and inflammatory markers.
Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.
RCT of 227 obese type 2 diabetes patients evaluating curcumin's effect on depression severity. Curcumin significantly improved depression severity, increased serotonin levels, and reduced pro-inflammatory cytokines compared to placebo. Antioxidant activities were elevated in the curcumin group.
The Efficacy of Curcumin Application to Melanoma in Mice: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 18 randomized controlled trials assessing curcumin's efficacy in treating melanoma in mice. Results indicate curcumin inhibits melanoma growth and proliferation, with lower IC50, tumor volume, and tumor weight compared to controls, though no significant difference in apoptosis rate.
The Role of Curcumin Supplementation in Patients with Migraine: A Meta-Analysis of Randomized Controlled Trial
Meta-analysis of randomized controlled trials assessing curcumin supplementation in migraine patients. Curcumin showed a significant reduction in migraine severity and duration, particularly in patients over 35 years of age and at high doses.
Current evidence and future direction on evaluating the anticancer effects of curcumin, gingerols, and shogaols in cervical cancer: A systematic review.
This systematic review evaluates the anticancer properties of turmeric and ginger bioactive compounds, specifically curcumin, 6/10-gingerol, and 6/10-shogaol, in cervical cancer through in-vitro and in-vivo models. The review includes 27 studies and indicates that these compounds exert anticancer action through modulation of cell signalling pathways and mediators. Further research is needed to understand their combined efficacy and effects on chemoresistant cervical cancer cells.
Therapeutic potential of curcumin on the cognitive decline in animal models of Alzheimer's disease: a systematic review and meta-analysis.
Systematic review and meta-analysis of 33 articles on curcumin's effects on cognitive decline in animal models of Alzheimer's disease. Meta-analysis of 29 publications showed significant positive effects of curcumin on cognitive performance, with global estimated effects for acquisition and retention being significant.
Curcumin in the treatment of inflammation and oxidative stress responses in traumatic brain injury: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of curcumin on traumatic brain injury (TBI) in animal models. Curcumin significantly reduced inflammatory cytokines and oxidative stress markers, improved cerebral edema, and upregulated neuroprotective factors, suggesting its potential as a therapeutic agent for TBI.
Effects of Curcumin on the treatment of oral lichen planus symptoms: a systematic review and meta-analysis study.
This systematic review and meta-analysis examined the effects of curcumin on oral lichen planus (OLP) symptoms. The analysis found no significant effect of curcumin on erythema, lesion size, and pain of OLP overall. However, a subgroup analysis indicated that a 2-week treatment duration was significantly associated with a reduction in OLP pain.
The analgesic effect of curcumin and nano-curcumin in clinical and preclinical studies: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of curcumin and nano-curcumin for treating chronic pain in clinical and preclinical studies. The analysis included 59 studies, showing that curcumin strongly reduced pain in preclinical studies, with both intraperitoneal and oral administration methods having pain-relieving effects. Nano-curcumin had a powerful effect on pain reduction in clinical studies compared to placebo.
Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence.
This systematic review synthesizes evidence on curcumin's potential in addressing age-related disorders, focusing on its impact on cognitive function, neurodegeneration, and muscle health in older adults. The review highlights curcumin's antioxidant and anti-inflammatory properties and suggests its potential as a therapeutic agent for promoting healthy aging.
The efficacy of curcumin in relieving osteoarthritis: A meta-analysis of meta-analyses.
Umbrella meta-analysis of meta-analyses assessing curcumin's effects on knee osteoarthritis. The pooled effect from 11 meta-analyses showed significant improvements in VAS and WOMAC scores, supporting curcumin's efficacy in relieving pain, improving joint mobility and stiffness, and reducing medication usage in OA patients.
Effects of Combination of Curcumin and Piperine Supplementation on Glycemic Profile in Patients with Prediabetes and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis evaluating the effects of curcumin and piperine supplementation on glycemic parameters in patients with prediabetes and type 2 diabetes. The review included three studies, with mixed results showing numerical but not statistically significant reductions in FPG, HOMA-IR, and BMI.
The intervention of curcumin on rodent models of hepatic fibrosis: A systematic review and meta-analysis.
Systematic review and meta-analysis of 59 studies evaluating curcumin's effects on hepatic fibrosis in rodent models. Curcumin was found to reduce levels of liver enzymes and fibrosis markers, and increase antioxidant levels, suggesting potential benefits for liver health.
Effects of curcumin/turmeric supplementation on the liver enzymes, lipid profiles, glycemic index, and anthropometric indices in non-alcoholic fatty liver patients: An umbrella meta-analysis.
Umbrella meta-analysis of 11 meta-analyses comprising 99 RCTs with 5546 participants assessing curcumin/turmeric supplementation in NAFLD patients. Curcumin reduced AST, ALT, TG levels, HOMA-IR, BMI, and WC, suggesting beneficial effects on liver function, insulin resistance, and obesity. Effects on other markers were not significant.
Effects of curcumin/turmeric supplementation on obesity indices and adipokines in adults: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
This systematic review and dose-response meta-analysis of 60 RCTs with 3691 participants assessed the effects of curcumin/turmeric supplementation on obesity indices and adipokines. The study found significant reductions in body weight, BMI, waist circumference, body fat percentage, and leptin levels, and an increase in adiponectin levels, indicating improvements in obesity-related measures.
Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis.
Bayesian network meta-analysis of 23 studies with 2175 KOA patients evaluating curcumin's efficacy and safety. Curcumin significantly reduced pain and WOMAC scores compared to placebo and showed reduced adverse reactions compared to NSAIDs. Curcumin, alone or with other treatments, is effective and safe for KOA.
Therapeutic effect of turmeric on radiodermatitis: A systematic review.
Systematic review assessing the efficacy of curcumin supplementation for reducing radiodermatitis severity in cancer patients undergoing radiation therapy. Four out of seven studies showed beneficial effects of curcumin on reducing RD intensity, suggesting potential clinical use in supportive cancer care.
Impact of Curcumin Supplementation on Radiation Dermatitis Severity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of four RCTs with 882 patients assessing the impact of curcumin supplementation on radiation dermatitis severity in breast cancer patients. Curcumin significantly reduced radiation dermatitis severity scores compared to control.
Effects of dietary polyphenol curcumin supplementation on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 13 RCTs with 785 participants assessing curcumin supplementation in patients with metabolic syndrome. Curcumin showed positive effects on waist circumference, fasting blood sugar, diastolic blood pressure, HDL-C, TNF-a, CRP, and MDA, but no significant improvement in systolic blood pressure, triglycerides, IL-6, or hsCRP. Results suggest curcumin may enhance metabolic and inflammatory markers, though further studies are needed due to high heterogeneity.
Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effectiveness and safety of curcumin in rheumatoid arthritis patients. The study includes six publications covering 539 patients, showing significant improvements in inflammation levels and clinical symptoms with curcumin supplementation.
Cardioprotective effects of curcumin against myocardial I/R injury: A systematic review and meta-analysis of preclinical and clinical studies.
This systematic review and meta-analysis evaluated the cardioprotective effects of curcumin on myocardial ischemia-reperfusion injury. It included 24 animal studies with 503 animals and four human studies with 435 patients. Curcumin significantly reduced myocardial infarction size and improved cardiac function in animal studies, and reduced cardiac dysfunction and myocardial infarction incidence in clinical studies, likely due to its anti-inflammatory and anti-oxidative properties.
Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial.
RCT comparing curcumin, omeprazole, and their combination in 206 patients with functional dyspepsia. Significant improvements in dyspepsia symptoms were observed in all groups by day 28 and further enhanced by day 56, with no significant differences among the groups. No serious adverse events occurred.
Efficacy and safety of curcumin in maintaining remission during disease-modifying antirheumatic drug withdrawal in rheumatoid arthritis at 52 weeks: a phase III double-blind, randomized placebo-controlled trial.
This phase III double-blind, randomized placebo-controlled trial investigated the efficacy and safety of curcumin in maintaining remission in rheumatoid arthritis patients during csDMARD withdrawal. 200 patients were randomized to receive curcumin or placebo. The study found no significant difference in flare-free survival between the curcumin and placebo groups at 52 weeks.
Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of 64 RCTs assessed the effects of curcumin/turmeric supplementation on lipid profiles. The analysis found statistically significant improvements in blood levels of total cholesterol, triglycerides, LDL-c, and HDL-c, but not in apolipoproteins Apo-A or Apo-B. The evidence quality was assessed as low to very low.
Effects of curcumin/turmeric supplementation on glycemic indices in adults: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 59 RCTs assessing the impact of turmeric/curcumin supplementation on glycemic control. Findings suggest significant improvements in fasting blood sugar, fasting insulin levels, hemoglobin A1c, and HOMA-IR, indicating potential benefits for managing disturbed glycemia.
The effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta-analyses of randomized controlled trials.
An umbrella review and updated meta-analysis of 50 RCTs evaluated the effect of curcumin supplementation on anthropometric indices. Curcumin significantly reduced BMI, body weight, and waist circumference, with bioavailability-enhanced forms showing greater effects. Significant effects were noted in adults with obesity and diabetes.
Curcumin in the treatment of oral submucous fibrosis: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 13 RCTs evaluating curcumin's efficacy in treating oral submucous fibrosis (OSF). The study found no significant improvement in mouth opening, burning sensation, or tongue protrusion compared to control treatments, except for a marked alleviation of burning sensation compared to placebo after 6 months.
The effect of antioxidants supplementation on oxidative stress and proinflammatory biomarkers in patients with chronic kidney disease: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effect of antioxidant supplementation on oxidative stress and proinflammatory biomarkers in CKD patients. Curcumin/turmeric and vitamin E supplements were found to significantly reduce serum CRP levels, suggesting a positive effect on inflammation.
The effect of curcumin supplementation on functional strength outcomes and markers of exercise-induced muscle damage: A systematic review and meta-analysis.
Systematic review and meta-analysis assessing curcumin's effects on exercise-induced muscle damage (EIMD), delayed onset muscle soreness (DOMS), and inflammation. No statistically significant effects were found for EIMD, DOMS, or inflammation, suggesting further research is needed.
Curcumin/turmeric supplementation could improve blood pressure and endothelial function: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of 35 RCTs examined the effects of curcumin/turmeric supplementation on blood pressure and endothelial function. The findings suggest significant improvements in systolic and diastolic blood pressure, VCAM-1 levels, and flow-mediated vasodilation, but no significant changes in ICAM-1 levels or pulse-wave velocity.
The effect of curcumin supplementation on circulating adiponectin and leptin concentration in adults: a GRADE-assessed systematic review and meta-analysis of randomised controlled trials.
This systematic review and meta-analysis of 13 RCTs with 14 treatment arms assessed the effect of curcumin supplementation on serum adiponectin and leptin levels. Curcumin supplementation significantly increased circulating adiponectin and decreased leptin levels in adults.
Evaluation of curcumin for dermatologic conditions: a systematic review.
Systematic review of 18 RCTs evaluating curcumin for dermatologic conditions such as psoriasis, radiation dermatitis, and pruritus. Psoriasis, cesarean section scar, and pruritus received grade B recommendations, while other conditions received lower grades. Curcumin showed an excellent safety profile, but further research is needed to optimize dosing and treatment parameters.
A systematic review and meta-analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders.
Systematic review and meta-analysis of RCTs assessing the effect of curcumin plus piperine on lipid profiles in patients with metabolic syndrome. The combination significantly decreased total cholesterol and LDL-C, but did not significantly change triglyceride concentrations.
Effects of curcumin/turmeric supplementation on liver function in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 31 RCTs examining turmeric/curcumin supplementation on liver function tests. Turmeric/curcumin significantly reduced ALT and AST levels, but not GGT. The quality of evidence was low for AST and ALT and very low for GGT.
Effects of curcumin and ursolic acid in prostate cancer: A systematic review.
Systematic review investigating the synergistic effects of curcumin and ursolic acid in prostate cancer. The review identifies potential synergistic target pathways involving NF-κB, Akt, androgen receptors, and apoptosis pathways, highlighting limited human studies and specific effects in prostate cancer.
Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 66 RCTs assessing the effects of turmeric/curcumin supplementation on inflammatory and oxidative markers. The analysis found significant reductions in inflammatory markers such as CRP, TNF-α, and IL-6, and improvements in antioxidant activity, suggesting turmeric/curcumin as a viable intervention for improving inflammatory and oxidative status.
Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial
Systematic review and meta-analysis of 29 RCTs involving 2396 participants with various types of arthritis. Curcumin and Curcuma longa Extract were found to be safe and improved inflammation and pain levels in arthritis patients. However, the conclusions are tentative due to the low quality and small quantity of RCTs.
Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy and safety of curcuminoids (CURs) for knee osteoarthritis (OA) across 15 RCTs with 1670 patients. CURs were significantly more effective than placebo in improving pain and function scores and were not inferior to NSAIDs. CURs did not significantly increase adverse events compared to placebo or NSAIDs.
The Effect of Curcumin on Lipid Profile and Glycemic Status of Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis evaluated the effects of curcumin on lipid profile and glycemic status in patients with type 2 diabetes mellitus. The analysis included nine RCTs with 604 subjects, showing that curcumin supplementation had beneficial effects on triglycerides, total cholesterol, fasting blood glucose, and glycated hemoglobin levels.
The effects of curcumin-containing supplements on inflammatory biomarkers in hemodialysis patients: A systematic review and meta-analysis.
Systematic review and meta-analysis of curcumin-containing supplements on inflammatory markers in hemodialysis patients. The analysis of nine studies with 472 patients showed significant reductions in serum C-reactive protein (CRP) and interleukin-6 (IL-6) levels, but no significant change in tumor necrosis factor-alpha (TNF-α) concentration.
Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis.
Systematic review and meta-analysis of seven randomized controlled trials involving 447 patients with PCOS. Curcumin ingestion decreased body mass index, fasting plasma glucose, insulin, insulin resistance, total cholesterol, and C-reactive protein, while increasing insulin sensitivity. No significant adverse reactions were reported compared to control.
Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis.
Systematic review and meta-analysis of six randomized trials with 385 participants evaluating adjuvant curcumin therapy in ulcerative colitis. Curcumin was effective in inducing clinical remission but not in clinical improvement or endoscopic outcomes. No severe adverse effects were reported.
Efficacy of Curcumin for Wound Repair in Diabetic Rats/Mice: A Systematic Review and Meta-analysis of Preclinical Studies.
Systematic review and meta-analysis of 9 preclinical studies with 262 diabetic animals assessing curcumin's effects on wound healing. Curcumin significantly improved wound healing rate and blood vessel density, with mechanisms involving antioxidation, cell proliferation, collagen formation, and angiogenesis. The anti-inflammatory effects remain controversial.
Effect of curcumin on body mass index and glycemic indices in females with PCOS: a systematic review and meta-analysis of randomized controlled trial
Systematic review and meta-analysis of RCTs assessing curcumin supplementation effects on body mass index and glycemic indices in women with PCOS. Significant beneficial effects were found on fasting blood sugar, insulin level, and HOMA-IR.
A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.
Meta-analysis of 52 studies on nutritional supplementation for osteoarthritis symptoms. Curcumin significantly improved pain and function compared to placebo. Ginger significantly decreased pain and inflammatory markers. Vitamin D decreased pain and function, while omega-3 and vitamin E showed no changes in OA parameters.
Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials: A Meta-Research Study
Meta-research study analyzing methods and reporting regarding the bioavailability of systemic oral curcumin used in RCTs. The study included 165 RCTs and found that 64% used methods to enhance curcumin bioavailability, with piperine being the most common method. Few trials compared different curcumin products.
Preclinical studies of the antitumor effect of curcumin-loaded polymeric nanocapsules: A systematic review and meta-analysis.
Systematic review and meta-analysis of preclinical in vivo studies evaluating the antitumor efficacy of curcumin-loaded polymeric nanocapsules. The analysis shows that these nanocapsules inhibit tumor growth and decrease tumor weight in rodents, suggesting improved antitumor effects compared to nonencapsulated curcumin.
A Systematic Review of Nonclinical Studies on the Effect of Curcumin in Chemotherapy- induced Cardiotoxicity.
Systematic review of 25 nonclinical studies evaluating curcumin's effects on chemotherapy-induced cardiotoxicity. Most studies suggest curcumin protects cardiac cells through antioxidant and anti-inflammatory effects, though some findings indicate increased susceptibility to apoptosis in certain cell lines.