2025·Journal of the American Nutrition Association·Darinka Korovljev, Jelena Ostojic, Jovana Panic, et al
The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial.
RCTn = 36Brain Health ↑Mood ↑
RCT of 36 perimenopausal and menopausal women evaluating 8-week supplementation with creatine hydrochloride and creatine ethyl ester. Medium-dose creatine hydrochloride improved reaction time, increased frontal brain creatine levels, and favorably modulated serum lipid profiles. It also reduced the severity of mood swings compared to placebo.