Research
Cranberry
68 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The Effect of Cranberry Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of randomized controlled trials assessing the effect of cranberry consumption on systolic and diastolic blood pressure. The pooled effect size indicated statistically nonsignificant reductions in blood pressure, suggesting cranberry consumption was not effective in managing SBP and DBP.
Cranberry Research Progress: A Systematic Review of Chemical Composition, Pharmacological Mechanisms, Clinical Applications, and Nutritional Significance.
This systematic review examines the phytochemical composition, pharmacological mechanisms, clinical applications, and nutritional significance of cranberries. Cranberries contain biologically active components with antioxidant, anti-inflammatory, anti-cancer, and urinary tract infection prevention effects, and are used in treating cardiovascular diseases and other conditions.
Prophylaxis Options in Children With a History of Recurrent Urinary Tract Infections: A Systematic Review.
Systematic review and meta-analysis of 23 studies with 3335 participants comparing prophylaxis options for preventing UTI recurrence in children. Cranberry products and nitrofurantoin were found to lower odds of symptomatic UTI episodes compared to control and other treatments. No option reduced kidney scarring.
Cranberry Juice, Cranberry Tablets, or Liquid Therapies for Urinary Tract Infection: A Systematic Review and Network Meta-analysis.
Systematic review and network meta-analysis of 20 trials with 3091 participants comparing cranberry juice, cranberry tablets, and increased liquids for UTI management. Cranberry juice consumption showed a 54% lower rate of UTIs compared to no treatment and a 27% lower rate than placebo liquid. It also resulted in a lower rate of antibiotic use and reduced UTI symptoms.
Comparative evaluation of cranberry extract and sodium fluoride as mouth rinses on S. mutans counts in children: a double-blind randomized controlled trial.
This double-blind randomized controlled trial evaluated the effectiveness of cranberry extract mouth rinse compared to sodium fluoride mouth rinse on Streptococcus mutans counts in 280 children aged 8-12 years. The study found that cranberry mouth rinse was non-inferior to fluoride mouth rinse in reducing S. mutans levels.
Neurocognitive effects of proanthocyanidin in Alzheimer's disease: a systematic review of preclinical evidence.
Systematic review of preclinical studies on the neurocognitive effects of proanthocyanidins in Alzheimer's disease. The review suggests proanthocyanidins have positive effects on neurocognitive function, reducing oxidative stress, acetylcholinesterase activity, amyloid beta, and facilitating cholinergic transmission.
The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 16 RCTs assessing cranberry's effects on lipid and glycemic profiles. Cranberry consumption significantly decreased the TC/HDL-C ratio and HOMA-IR, but did not affect other lipid or glycemic parameters. Dried cranberry forms reduced fasting insulin levels.
Cranberries for preventing urinary tract infections.
Systematic review of 50 studies with 8857 participants assessing cranberry products for preventing UTIs. Cranberry products reduced the risk of UTIs in women with recurrent UTIs, children, and people with susceptibility due to interventions. No significant benefit was found for elderly, pregnant women, or those with bladder dysfunction.
Cranberries for preventing urinary tract infections.
This systematic review updates previous reviews on the effectiveness of cranberry products in preventing urinary tract infections (UTIs). It includes 50 studies with 8857 participants. Cranberry products were found to reduce the risk of symptomatic, culture-verified UTIs in women with recurrent UTIs, children, and people with susceptibility due to interventions. However, there was little or no benefit for elderly institutionalized individuals, pregnant women, or adults with neuromuscular bladder dysfunction.
Cranberries for treating urinary tract infections.
Systematic review assessing the effectiveness of cranberries for the treatment of urinary tract infections (UTIs). No RCTs were found that fulfilled the inclusion criteria, indicating a lack of good quality evidence for cranberry juice's effectiveness in treating UTIs.
Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations: A systematic review and meta-analysis with trial sequential analysis.
This systematic review and meta-analysis evaluated the efficacy of cranberry as adjuvant therapy in preventing urinary tract infections (UTIs) in susceptible populations. The analysis included 23 trials with 3979 participants and found that cranberry-based products significantly reduced the incidence of UTIs, with a relative risk reduction observed in women with recurrent UTIs, children, and patients using indwelling catheters.
The effect of cranberry supplementation oneradication inpositive subjects: a systematic review and meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of four RCTs investigating the effect of cranberry supplementation on eradication in positive subjects. The pooled results showed a positive effect of cranberry on eradication, increasing the chance by 1.27 times, but this was not statistically significant. Moderate between-study heterogeneity was noted.
Non-antibiotic interventions for prevention of urinary tract infections in children: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs evaluating non-antibiotic interventions for UTI prevention in children. Cranberry was as effective as antibiotic prophylaxis and better than placebo in reducing UTI recurrence. Probiotics were more effective than placebo but not better than antibiotics, with a lower risk of antibiotic resistance.
Suppression of Helicobacter pylori infection by daily cranberry intake: A double-blind, randomized, placebo-controlled trial.
This double-blind, randomized, placebo-controlled trial evaluated the effects of proanthocyanidin-standardized cranberry juice and powder on Helicobacter pylori suppression in 522 infected adults. High-proanthocyanidin cranberry juice consumption twice daily for 8 weeks decreased H. pylori infection rate by 20% compared to other dosages and placebo. Cranberry juice was well-tolerated and showed a positive trend in reducing infection over time.
Cranberry for Bacteriuria in Individuals with Spinal Cord Injury: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of six studies on cranberry for bacteriuria in individuals with spinal cord injury. Meta-analysis of four studies with 415 participants found no significant differences between cranberry and control groups. Bias and limitations were noted in the reviewed studies.
Cranberries after pelvic floor surgery for urinary tract infection prophylaxis: A randomized controlled trial.
RCT assessing cranberry capsules as prophylaxis for UTI after pelvic floor surgery in 210 women. No significant difference in UTI prevalence between cranberry and placebo groups, though both were lower than anticipated.
Whole cranberry fruit powder supplement reduces the incidence of culture-confirmed urinary tract infections in females with a history of recurrent urinary tract infection: A 6-month multicenter, randomized, double-blind, placebo-controlled trial.
This 6-month multicenter, randomized, double-blind, placebo-controlled trial investigated the effect of whole cranberry fruit powder on the incidence of culture-confirmed urinary tract infections (UTIs) in females with a history of recurrent UTIs. The cranberry supplement reduced the risk of culture-confirmed UTIs by 52% compared to placebo and showed significant reductions in UTI-related symptoms and the mean total number of UTIs per participant.
Effects of a supplement associatingstrains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study.
Prospective controlled study evaluating a supplement with proanthocyanidin A-rich cranberry and cinnamon extracts in 80 women with recurrent cystitis. Two-thirds of supplemented women experienced no further episodes of cystitis over 6 months, with significantly fewer and less severe urinary symptoms compared to non-supplemented women.
Effect of tablets containing a paraprobiotic strain and the cranberry extract on caries incidence in preschool children: A randomized controlled trial.
RCT investigating the effect of a tablet containing inactivated Ligilactobacillus salivarius CECT 5317 and cranberry extract on caries development in preschool children. The test group showed a significantly lower incidence of initial carious lesions compared to the placebo group after 9 months.
Randomized, placebo-controlled, double-blinded study of prophylactic cranberries use in women with recurrent uncomplicated cystitis.
RCT of 160 women with recurrent uncomplicated cystitis comparing high-dose proanthocyanidins from cranberries to placebo over 12 months. The cranberry group had significantly fewer UTIs and improved Quality of Life, with reduced E. coli isolates in vaginal and rectal swabs.
Antibiotic versus cranberry in the treatment of uncomplicated urinary infection: a randomized controlled trial.
RCT comparing cranberry extract to fosfomycin in patients with uncomplicated urinary tract infections. Cranberry users reported higher well-being and similar leukocyte levels compared to the antibiotic group, suggesting cranberry as a favorable alternative.
Unravelling phenolic metabotypes in the frame of the COMBAT study, a randomized, controlled trial with cranberry supplementation.
This study quantified plasma and urine (poly)phenol metabolites following a 12-week intake of cranberry powder in healthy older adults, identifying three phenolic metabotypes. The study highlights inter-individual variability in metabolite excretion and the role of colonic metabolism in subject clustering.
Methenamine Hippurate With Cranberry Capsules Versus Cranberry Alone for Urinary Tract Infection Prevention in a Short-Term Indwelling Foley Catheter Population After Urogynecologic Surgery: A Double-Blinded Randomized Controlled Trial.
Double-blinded RCT comparing cranberry with methenamine versus cranberry with placebo for UTI prevention in patients with short-term catheters post-pelvic surgery. The methenamine group had significantly lower UTI rates at 1 and 6 weeks postoperatively compared to placebo.
Effects of cranberry beverages on oxidative stress and gut microbiota in subjects withinfection: a randomized, double-blind, placebo-controlled trial.
RCT of 171 H. pylori positive subjects comparing high-dose and low-dose cranberry beverages to placebo over 4 weeks. High-dose cranberry significantly increased total antioxidant capacity and decreased lipid peroxidation. Both cranberry doses reduced Pseudomonas in the gut microbiota, suggesting improved antioxidant status and gut health.
Effect of cranberry supplementation on liver enzymes and cardiometabolic risk factors in patients with NAFLD: a randomized clinical trial.
RCT of 110 patients with NAFLD comparing 144 mg cranberry capsule to placebo for 6 months. Cranberry supplementation significantly lowered total cholesterol, triglycerides, insulin, and HOMA-IR levels, and decreased hepatic steatosis compared to placebo.
Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections.
Placebo-controlled study assessing the impact of daily cranberry consumption on the gut microbiome in women with recurrent UTIs. Cranberry consumption had limited effects on the overall gut microbiome, with only one unnamed Flavonifractor species showing significant difference between groups.
Cranberry capsules are not superior to placebo capsules in managing acute non-haemorrhagic radiation cystitis in prostate cancer patients: A phase III double blinded randomised placebo controlled clinical trial.
Phase III double-blinded RCT with 101 prostate cancer patients testing cranberry capsules versus placebo for managing acute radiation cystitis. Cranberry capsules performed worse than placebo in terms of day time frequency and bladder control using the RICAS scale.
Efficacy of Daily Intake of Dried Cranberry 500 mg in Women with Overactive Bladder: A Randomized, Double-Blind, Placebo Controlled Study.
RCT of 98 women with overactive bladder comparing daily intake of 500 mg dried cranberry powder to placebo over 24 weeks. The cranberry group showed significant reductions in daily micturitions, urgency episodes, and Patient Perception of Bladder Condition scores in per protocol analysis, but no significant differences in intent-to-treat analysis.
The effects of cranberry on cardiovascular metabolic risk factors: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effect of cranberry supplementation on cardiovascular metabolic risk factors. Cranberry administration significantly reduced systolic blood pressure and body mass index, with a notable increase in high-density lipoprotein in younger adults.
Supplementation with Highly Standardized Cranberry Extract Phytosome Achieved the Modulation of Urinary Tract Infection Episodes in Diabetic Postmenopausal Women Taking SGLT-2 Inhibitors: A RCT Study.
RCT evaluating the effect of 120 mg cranberry extract phytosome supplementation on UTI prevention in diabetic postmenopausal women taking SGLT-2 inhibitors. The cranberry group showed a steady rate of UTI episodes compared to an increase in the placebo group over six months, indicating reduced UTI recurrence with cranberry supplementation.
A Multiomics Evaluation of the Countermeasure Influence of 4-Week Cranberry Beverage Supplementation on Exercise-Induced Changes in Innate Immunity.
This RCT examined the effect of a 4-week unsweetened cranberry beverage supplementation on exercise-induced changes in innate immunity in 25 non-elite cyclists. Cranberry supplementation led to a significant increase in cranberry-related metabolites and a modest post-exercise elevation in selected oxylipins and proteins associated with the innate immune system, but no differences in the gut microbiome.
Polyphenol-Rich Cranberry Beverage Positively Affected Skin Health, Skin Lipids, Skin Microbiome, Inflammation, and Oxidative Stress in Women in a Randomized Controlled Trial.
RCT with 22 women using a cross-over design to test a polyphenol-rich cranberry beverage versus placebo for six weeks. The cranberry beverage reduced UVB-induced erythema, improved skin elasticity and smoothness, and enhanced SOD activities. Effects were more pronounced in women over 40. The beverage also modulated skin lipids and microbiome.
Daily consumption of cranberry improves endothelial function in healthy adults: a double blind randomized controlled trial.
A double-blind, randomized controlled trial in 45 healthy male adults assessed the effects of daily consumption of freeze-dried whole cranberry on vascular function. Cranberry consumption significantly increased flow-mediated dilation (FMD) at 2 hours and after 1 month, indicating improved endothelial function, while other cardiovascular markers remained unchanged.
Predictive models built upon annotated and validated intake biomarkers in urine using paired or unpaired analysis helped to classify cranberry juice consumers in a randomized, double-blinded, placebo-controlled, and crossover study.
This randomized, double-blinded, placebo-controlled, crossover study investigated intake biomarkers of cranberry juice in urine to classify cranberry consumers. Urine samples from 16 healthy women were analyzed, identifying discriminant metabolic features associated with cranberry consumption. The study validated urinary metabolites as potential cranberry intake biomarkers, which may be linked to cranberry's ability to prevent UTIs.
Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trial.
Feasibility randomised trial assessing cranberry extract's effectiveness in reducing antibiotic use for acute uncomplicated urinary tract infections in women. Participants were assigned to immediate antibiotics, antibiotics with cranberry capsules, or cranberry capsules with delayed antibiotics. The study found it feasible to conduct such a trial, with no serious adverse events reported.
Effect of cranberry supplementation on toxins produced by the gut microbiota in chronic kidney disease patients: A pilot randomized placebo-controlled trial.
Pilot randomized placebo-controlled trial evaluating the effects of cranberry dry extract supplementation on plasma levels of LPS and uremic toxins in non-dialysis CKD patients. Cranberry supplementation for two months did not reduce the LPS and uremic toxins plasma levels.
Combined cranberry supplementation and weight loss diet in non-alcoholic fatty liver disease: a double-blind placebo-controlled randomized clinical trial
A double-blind placebo-controlled randomized clinical trial on 41 patients with non-alcoholic fatty liver disease (NAFLD) assessed the effects of cranberry supplementation combined with a weight loss diet over 12 weeks. The cranberry group showed significantly greater reductions in alanine aminotransferase and insulin levels compared to placebo, along with improvements in insulin resistance.
Effect of daily consumption of cranberry beverage on insulin sensitivity and modification of cardiovascular risk factors in adults with obesity: a pilot, randomised, placebo-controlled study.
Pilot RCT of 35 individuals with obesity and elevated fasting glucose or impaired glucose tolerance, testing daily consumption of cranberry beverage for 8 weeks. No significant change in insulin sensitivity was observed, but cranberry consumption decreased 8-isoprostane levels and improved TAG and nitrate levels in participants with high CRP levels.
Antiadhesive natural products against uropathogenic E. coli: What can we learn from cranberry extract?
The study investigates the antiadhesive effects of cranberry extract against uropathogenic E. coli (UPEC). It finds that the antiadhesive activity cannot be attributed to a single compound, with unglycosylated flavones and flavonols contributing to the effect. Urine samples from cranberry-treated volunteers showed significant interaction with the mannose binding domain of type-1 fimbriae, but no influence on the UPEC transcriptome.
Kinetic profile and urinary excretion of phenyl-γ-valerolactones upon consumption of cranberry: a dose-response relationship.
A six-arm acute crossover, randomized, double-blinded, controlled intervention trial was conducted in ten healthy males to evaluate the absorption, metabolism, and urinary excretion of cranberry flavan-3-ols. The study analyzed phenyl-γ-valerolactones and phenylvaleric acids as potential biomarkers of flavan-3-ol intake, showing a dose-dependent relationship with cranberry juice consumption.
The Use of a Combination of Vaccinium Macracarpon, Lycium barbarum L. and Probiotics (Bifiprost®) for the Prevention of Chronic Bacterial Prostatitis: A Double-Blind Randomized Study.
Double-blind randomized study comparing Bifiprost® + Serenoa Repens 320 mg versus Serenoa Repens 320 mg alone in 120 patients with chronic bacterial prostatitis. Group A experienced a significantly larger reduction in prostatitis episodes and NIH-CPSI scores at 24 and 36 weeks, indicating improved prevention and symptom amelioration.
Probiotic and cranberry supplementation for preventing recurrent uncomplicated urinary tract infections in premenopausal women: a controlled pilot study.
This randomized, double-blind, placebo-controlled pilot study assessed the efficacy and safety of Bio-Kult Pro-Cyan, containing Lactobacilli and cranberry extract, for preventing recurrent UTIs in pre-menopausal women. After 26 weeks, significantly fewer women experienced recurrent UTIs with BKPro-Cyan compared to placebo, with improvements in multiple secondary endpoints.
A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (Vaccinium macrocarpon) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis.
A multicenter, randomized, placebo-controlled study evaluated the efficacy of a combination of cranberry and propolis (DUAB) in preventing recurrent cystitis in women. The cranberry + propolis group had fewer cystitis episodes and a longer time to first UTI compared to placebo, indicating significant reduction in UTI incidence and delayed onset.
Randomized Controlled Study to Evaluate Microbial Ecological Effects of CPP-ACP and Cranberry on Dental Plaque.
This randomized controlled trial evaluated the microbial ecological effects of dentifrices containing CPP-ACP and polyphenol-rich cranberry extracts on dental plaque. The study found that these dentifrices can beneficially modulate the microbial ecology of dental plaque, potentially lowering the risk of developing new caries lesions.
Standardised high dose versus low dose cranberry Proanthocyanidin extracts for the prevention of recurrent urinary tract infection in healthy women [PACCANN]: a double blind randomised controlled trial protocol.
This is a protocol for a double-blind randomized controlled trial assessing the efficacy of cranberry extract capsules standardized in A-type linkage proanthocyanidins (PACs) for preventing recurrent urinary tract infections in women. The trial will recruit 148 women and compare high-dose (37 mg PACs per day) versus low-dose (2 mg PACs per day) cranberry extract over a 6-month period.
[Efficacy and safety of D-mannose (2 g), 24h prolonged release, associated with Proanthocyanidin (PAC), versus isolate PAC, in the management of a series of women with recurrent urinary infections.].
A multicenter randomized double-blind study comparing the efficacy and safety of the dietary supplement Manosar, containing D-mannose and Proanthocyanidin (PAC), versus PAC alone in preventing recurrent urinary tract infections in women. The Manosar group had a lower percentage of UTIs (24%) compared to the PAC group (45%) over six months, with a longer disease-free period.
Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial
RCT of 78 overweight or obese adults consuming a low calorie, high polyphenol cranberry extract beverage for 8 weeks. The study found improvements in glucoregulation, reduced inflammatory biomarkers, and increased HDL cholesterol compared to placebo.
The effects of training and the use of cranberry capsule in preventing urinary tract infections after urostomy.
RCT investigating the effects of cranberry capsule use and training on preventing UTIs after urostomy in 60 patients. Cranberry capsule use significantly reduced the incidence of UTIs compared to the control group.
Consumption of cranberry functional beverage reduces gingival index and plaque index in patients with gingivitis.
This RCT studied the effects of cranberry functional beverage (CFB) on gingival and plaque indices in 50 patients with gingivitis. The CFB group showed significant improvements in gingival and plaque indices compared to the control group, without increasing the risk of caries development.
Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study.
RCT of 96 middle-aged women assessing the effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters. The study found improvements in physical and psychological symptoms of menopause, increased muscle mass, and reduced blood pressure.
Lifestyle and behavioral modifications made by patients with interstitial cystitis.
Prospective study investigating lifestyle and behavioral changes in 86 patients with interstitial cystitis/bladder pain syndrome (IC/BPS) compared to 86 controls. Patients with IC/BPS reported higher cranberry intake and decreased consumption of coffee and spicy food.
Discovery of anthocyanins from cranberry extract as pancreatic lipase inhibitors using a combined approach of ultrafiltration, molecular simulation and spectroscopy.
The study used ultrafiltration, molecular simulation, and spectroscopy to identify anthocyanins from cranberry extract as potent pancreatic lipase inhibitors. Four monomeric anthocyanins were discovered, with cyanidin-3-O-arabinoside showing the highest binding capacity. The findings suggest cranberry anthocyanins could be developed as food supplements for obesity prevention and treatment.
Cranberry, D-mannose and anti-inflammatory agents prevent lower urinary tract symptoms in women undergoing prolapse surgery.
RCT of 40 postmenopausal women undergoing cystocele surgery, comparing a supplement containing cranberry, D-mannose, and anti-inflammatory agents to surgery alone. The supplement group experienced significantly better scores on the filling domain of a LUTS questionnaire, suggesting potential benefits in managing postoperative LUTS.
A randomized, double-blind, placebo-controlled pilot study to assess bacterial anti-adhesive activity in human urine following consumption of a cranberry supplement.
This randomized, double-blind, placebo-controlled pilot study evaluated the urinary anti-adhesion activity against uropathogenic E. coli following consumption of a cranberry supplement. The study found that cranberry consumption significantly increased urinary anti-adhesion activity compared to placebo, suggesting potential benefits for urinary tract health.
Cranberry juice decreases disease activity in women with rheumatoid arthritis.
Prospective study with 41 women with rheumatoid arthritis, where the cranberry group consumed 500 mL/d of low-calorie cranberry juice. The cranberry group showed a decrease in Disease Activity Score 28 (DAS28) and anti-CCP antibodies after 90 days, indicating decreased disease activity.
A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease
RCT of 34 cats with stage II-III chronic kidney disease comparing a control diet to a nutraceutical diet containing Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale for 90 days. The nutraceutical diet improved key indicators of renal failure, including creatinine and blood urea nitrogen levels.
The influence of dietary supplementation with cranberry tablets on the urinary risk factors for nephrolithiasis.
RCT investigating the influence of cranberry supplementation on urinary oxalate excretion in 15 participants. Cranberry tablets, both alone and with vitamin C, increased urinary oxalate excretion, suggesting caution for patients at risk of urolithiasis.
Cranberries attenuate animal-based diet-induced changes in microbiota composition and functionality: a randomized crossover controlled feeding trial.
Randomized crossover controlled feeding trial with 11 healthy adults comparing an animal-based diet with and without 30 g/day freeze-dried whole cranberry powder. The cranberry diet attenuated the animal-based diet-induced changes in gut microbiota composition, bile acids, and short-chain fatty acids, suggesting cranberries can modulate gut microbiota.
Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability
An acute double-blind randomized controlled trial in 10 healthy men assessed the absorption, metabolism, and excretion of cranberry (poly)phenols at various intake levels. The study found a linear dose response in total plasma (poly)phenol metabolites, with significant inter-individual variability in metabolite profiles.
Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study.
Pilot study assessing the effectiveness of cranberry dry extract, D-mannose, and probiotics in 33 women with acute uncomplicated cystitis. Significant improvements were observed in typical UTI symptoms and urine test indicators over 60 days.
Glycemic responses to sweetened dried and raw cranberries in humans with type 2 diabetes.
This study assessed the metabolic response to sweetened dried cranberries, raw cranberries, and white bread in humans with type 2 diabetes. SDC-LS was associated with a favorable glycemic and insulinemic response, suggesting potential benefits for glycemic control in diabetics.
Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract.
Study to confirm the absorption of proanthocyanidin into the human body. Four healthy adults were administered 2.0 g of PA-rich grape seed extract, and procyanidin B1 was detected in human serum 2 hours after intake.
Proanthocyanidin from grape seed against rotenone-induced toxicity in Drosophila melanogaster: Insights from behavioural and antioxidant studies
The study investigated the neuroprotective effects of Proanthocyanidin from grape seed extract in Drosophila melanogaster exposed to rotenone toxicity. A 1 mg/g PGS diet significantly enhanced lifespan, mitigated oxidative stress, and improved locomotor activity, suggesting its neuroprotective potential against neurodegenerative effects.
Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect
The study evaluated the effects of a cranberry extract rich in (poly)phenols and oligosaccharides on the gut microbiota of 28 human subjects. After four days, the extract induced a bifidogenic effect and increased the abundance of butyrate-producing bacteria, altering short-chain fatty acids profiles.
Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats
Animal study using a BPH-induced rat model to evaluate the effects of cranberry powder on benign prostatic hyperplasia. The CR8W group showed significant decreases in prostate weight, dihydrotestosterone levels, and 5-alpha reductase levels, indicating potential benefits of cranberry powder for BPH treatment.
Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes.
The study investigates the potential interaction between cranberry juice and the CYP3A enzyme using human intestinal microsomes. Three triterpenes (maslinic acid, corosolic acid, and ursolic acid) were isolated from cranberry and shown to inhibit CYP3A, suggesting they may contribute to the interaction with midazolam observed in a clinical study.
Examination of Complementary Medicine for Treating Urinary Tract Infections Among Pregnant Women and Children
This narrative review discusses the effectiveness of natural products such as cranberry juice/extracts, ascorbic acid, hyaluronic acid, probiotics, and multi-component formulations in treating and preventing UTIs in pregnant women and children. The combination of natural products with prescribed antimicrobial treatments, particularly formulations with high amounts of cranberry extracts, appears most effective in preventing recurrent UTIs.
Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015
Narrative review of cranberry research highlighting its role in modulating gut microbiota and cardiometabolic risk factors. Cranberry proanthocyanidins interfere with pathogenic E. coli colonization and improve gut barrier function. Clinical trials show favorable effects on cardiometabolic health, including lipid profiles, blood pressure, and inflammation markers.