Research
Colloidal Silver
17 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Anti-inflammatory activity of Silver Nanoparticles (AgNPs): An Updated Systematic review from in vivo, and in vitro studies.
This systematic review summarizes recent developments in the anti-inflammatory potential of silver nanoparticles (AgNPs) from 2015-2025. It discusses their physicochemical characteristics, synthesis strategies, and molecular mechanisms, highlighting their ability to regulate key inflammatory pathways and their application in conditions like arthritis and inflammatory bowel disease.
Use of an antiseptic rinse (NanArgol) for the oral hygiene maintenance of subjects with fixed appliances: A randomized clinical trial.
RCT of 80 patients with fixed orthodontic appliances comparing standard oral hygiene regimen with and without adjunctive rinses of non-ionic colloidal silver solution. The test group showed significantly lower oral hygiene indices after 1 and 6 months, indicating a beneficial effect on oral hygiene.
A re-assessment of the safety of silver in household water treatment: rapid systematic review of mammalian in vivo genotoxicity studies.
Systematic review of mammalian in vivo genotoxicity studies on silver micro and nanoparticles. Most studies showed evidence of genotoxicity unless using very low doses. One human study reported severe DNA damage in silver jewellery workers exposed to silver particles.
Applying a Silver-containing Dressing to the Incision Site and Its Effect on the Development of Surgical Site Infection After Ostomy Closure: A Prospective Randomized Clinical Pilot Study.
This prospective randomized clinical pilot study evaluated the effect of a silver hydrofiber dressing on the development of surgical site infections (SSIs) after ostomy closure. The study included 32 patients, with the study group receiving a silver-containing dressing and the control group receiving standard sterile gauze. The study found that no SSIs were observed in the silver dressing group, while the control group had a 26.7% SSI rate, indicating a statistically significant reduction in SSIs with the use of silver dressings.
Assessing orally bioavailable commercial silver nanoparticle product on human cytochrome P450 enzyme activity.
A prospective, single-blind, controlled in vivo human study assessed the pharmacokinetic interference of orally ingested colloidal silver on cytochrome P450 enzymes. The study found detectable silver in human serum after 14 days but no significant changes in metabolic, hematologic, urinary, physical findings, or cytochrome P450 enzyme activity.
Efficacy of a new medical device based on colloidal silver and carbossimetyl beta glucan in treatment of upper airways disease in children.
RCT comparing the efficacy of a medical device based on colloidal silver and carbossimetyl beta glucan to saline solution in treating nasal symptoms in children with viral rhinitis. The colloidal silver group showed significantly better improvement in CARIFS scores and VAS compared to the saline group, with 90% of subjects completely recovered.
The effectiveness of topical colloidal silver in recalcitrant chronic rhinosinusitis: a randomized crossover control trial.
A randomized crossover control trial assessed the efficacy of colloidal silver as a topical nasal spray in 20 patients with refractory chronic rhinosinusitis without polyposis. The study found no meaningful subjective or objective improvements in SNOT-22 and Lund-Kennedy scores compared to saline.
Negative pressure and nanocrystalline silver dressings for nonhealing ulcer: A randomized pilot study.
A randomized pilot study assessed the effectiveness of combining negative-pressure wound therapy with nanocrystalline silver dressings versus negative pressure wound therapy alone in 17 patients with chronic wounds. The combination reduced wound area and bacterial colonization without reaching toxic silver levels, showing it was as effective and safe as NPWT alone.
Assessment of orally dosed commercial silver nanoparticles on human ex vivo platelet aggregation.
A placebo-controlled, single-blind, cross-over study in 18 healthy human volunteers assessed the effect of daily oral silver nanoparticle ingestion on platelet aggregation. No enhanced ex vivo platelet activation was detectable at peak serum silver concentrations below 10 µg/L.
Green Synthesis of Silver Nanoparticles UsingLeaf Extract and its Antioxidant-Mediated Ameliorative Activity against Doxorubicin-Induced Toxicity in Dalton's Lymphoma Ascites (DLA)-Bearing Mice.
The study synthesized silver nanoparticles (AgNPs) using leaf extract and evaluated their ameliorative effects against doxorubicin-induced toxicity in Dalton's lymphoma ascites (DLA) mice. AgNPs reduced serum toxicity markers and increased antioxidant activities, showing higher free-radical scavenging activities compared to the leaf extract.
Advances in silver nanoparticles: a comprehensive review on their potential as antimicrobial agents and their mechanisms of action elucidated by proteomics
This narrative review explores the antimicrobial properties of silver nanoparticles (AgNPs), their mechanisms of action, and their potential applications in combating antibiotic-resistant pathogens. It highlights the proteomic mechanisms by which AgNPs exert their effects against bacteria, fungi, viruses, and Mycobacterium, and discusses their use in biomedical applications.
Novel green synthesis and characterization of a chemotherapeutic supplement by silver nanoparticles containing Berberis thunbergii leaf for the treatment of human pancreatic cancer
The study synthesized and characterized silver nanoparticles containing Berberis thunbergii leaf for their potential anti-human pancreatic cancer effects. The AgNPs showed dose-dependent anti-cancer effects against common human pancreatic cancer cell lines with low cell viability.
Silver Nanoparticles: Mechanism of Action and Probable Bio-Application
This review discusses the medical application of silver nanoparticles produced through 'green' synthesis using various living organisms. It highlights the proposed mechanisms of AgNPs synthesis and their action mechanisms on target cells.
Antibacterial activity and mechanism of silver nanoparticles against multidrug-resistant Pseudomonas aeruginosa
The study investigates the antibacterial activity and mechanism of silver nanoparticles (AgNPs) against multidrug-resistant Pseudomonas aeruginosa. AgNPs showed a strong bactericidal effect, impairing bacterial morphology and structure, and causing excessive production of reactive oxygen species (ROS). The study suggests that AgNPs act by disrupting the balance of oxidation and antioxidation processes in the bacteria.
Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses
Study using Drosophila melanogaster to explore adverse effects of dietary silver nanoparticles (AgNPs). Lethal doses caused developmental delays and lethality, while sublethal doses shortened lifespan and compromised oxidative stress tolerance. AgNPs induced ROS-mediated stress responses, including apoptosis, DNA damage, and autophagy.
Adverse effects of nanosilver on human health and the environment.
This narrative review examines the adverse effects of nanosilver on human health and the environment. It discusses the antimicrobial properties of silver nanoparticles and the potential health complications from repeated exposure through various routes. The review highlights the need for updated information on threshold limits and safe doses of nanosilver.
Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects
This narrative review discusses the mechanism of antimicrobial action, synthesis methods, medical applications, and toxicity effects of silver nanoparticles. It highlights the unique properties of silver nanoparticles in diagnostics and therapies, and explores the challenges and alternatives in their synthesis, as well as their antimicrobial and anti-inflammatory applications.