Research
Coenzyme Q10
319 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of coenzyme Q10 analogs on oxidative stress, muscle, and metabolism after exercise: A meta-analysis and systematic review.
Meta-analysis and systematic review of 14 RCTs with 433 subjects examining coenzyme Q10 supplementation effects on postexercise oxidative stress and muscle damage. Coenzyme Q10 elevated blood coenzyme Q10 concentration, reduced blood malondialdehyde and creatine kinase levels, suggesting reduced oxidative stress and muscle protection. No effect on metabolism-related blood lactate and maximal oxygen uptake levels.
Effects of Coenzyme Q10 Supplementation on Glycemic Control Biomarkers: An Umbrella Review of Meta-Analyses of Randomised Controlled Trials.
Umbrella review of meta-analyses of RCTs assessing CoQ10 supplementation on glycemic control biomarkers. CoQ10 is associated with decreased fasting blood glucose, but findings on HbA1c, HOMA-IR, and insulin levels are inconsistent. Overall, CoQ10 may moderately benefit glycemic control in diabetic patients.
The auxiliary effect of oral nutritional supplements on fertility in women with diminished ovarian reserve: a systematic review and meta-analysis.
Systematic review and meta-analysis of 16 studies with 2773 participants evaluating the effects of oral nutritional supplements, including vitamins, coenzyme Q10, and DHEA, on fertility in women with diminished ovarian reserve. The supplements significantly lowered FSH levels, increased AMH levels, AFC counts, retrieved oocyte counts, and clinical pregnancy rates. Coenzyme Q10 alone was more effective than DHEA alone.
Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials
Systematic review and meta-analysis of RCTs assessing CoQ10 supplementation on semen quality and male reproductive hormones. CoQ10 increased total sperm count, motility, and normally formed sperm, and raised serum testosterone and inhibin B levels, supporting its use in male infertility treatment.
Effects of Coenzyme Q10 Supplementation on Depressive Symptoms and Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 5 RCTs with 474 participants evaluating CoQ10 supplementation on depressive symptoms and fatigue. CoQ10 significantly reduced depressive symptoms but showed no significant benefit for fatigue.
Can coenzyme Q10 supplementation reduce exercise-induced muscle damage and oxidative stress in athletes? A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of CoQ10 supplementation on oxidative stress and muscle damage biomarkers in athletes. Seventeen trials with 440 participants showed that CoQ10 significantly reduced MDA levels and muscle damage biomarkers LDH and CK, but had no significant effect on TAC. The findings suggest CoQ10 may help reduce exercise-induced oxidative stress and muscle damage, although further high-quality studies are needed.
The effect of coenzyme Q10 supplementation on depressive symptoms and anxiety: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs evaluating CoQ10's effect on depression and anxiety. CoQ10 showed significant improvement in depression severity in some trials but no significant effect on anxiety. Limited evidence suggests potential benefits for depressive symptoms at low doses over short durations.
Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis.
Systematic review and meta-analysis of 7 RCTs with 389 statin-treated patients assessing CoQ10 supplementation for statin-associated muscle symptoms (SAMS). CoQ10 supplementation significantly reduced muscle pain intensity in patients with SAMS.
Effect of micronutrients on fertility and aneuploidy rates in human conceptions: a systematic review and meta-analysis.
Systematic review and meta-analysis on the influence of micronutrient supplementation, specifically CoQ10, on reproductive outcomes. CoQ10 increased oocyte retrieval and live birth rates in women with poor ovarian response, and increased pregnancy rates in women with POR or PCOS. CoQ10 also improved oocyte maturation and reduced aneuploidy rates in women of advanced maternal age. Resveratrol showed no effect.
Effects of Carnitine and Coenzyme Q10 on Sperm Quality and Pregnancy Rates in Men with Unexplained Infertility: A Systematic Review and Network Meta-Analysis.
Systematic review and network meta-analysis of 16 studies examining the effects of carnitine and coenzyme Q10 on sperm quality and pregnancy rates in men with unexplained infertility. CoQ10 significantly increased sperm concentration, while L-carnitine improved progressive sperm motility.
Effects of Coenzyme Q10 Supplementation on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 16 RCTs evaluating CoQ10 supplementation in Type 2 Diabetes patients. CoQ10 reduced systolic and diastolic blood pressure but did not change lipid profiles. Effects on lipid profiles were more pronounced with lower doses and shorter study durations.
Clinical efficacy of adjunctive use of coenzyme Q10 in non-surgical periodontal treatment: A systematic review.
This systematic review and meta-analysis evaluated the effects of coenzyme Q10 in non-surgical periodontal treatment. Ten RCTs were included, with CoQ10 administered either locally or orally. Oral supplementation with CoQ10 showed a greater mean reduction in probing depth and clinical attachment level gain compared to controls, while local application showed no significant effect.
The effectiveness and safety of integrative medicine for chronic heart failure: An umbrella review.
Umbrella review synthesizing evidence from systematic reviews and meta-analyses on integrative medicine for chronic heart failure. Co-enzyme Q10 and Tai Chi may reduce mortality and hospitalisation rates, while acupuncture and intravenous Chinese herbal medicines may improve BNP. Vitamin E may increase hospitalisation rates.
Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis.
Systematic review and meta-analysis of drug therapies in comatose survivors of cardiac arrest, including steroids, coenzyme Q10, and thiamine. The meta-analysis found no significant effect on mortality for these substances, with low certainty of evidence.
Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 20 RCTs with 2617 participants evaluating antioxidants on fertility in women with ovarian aging. Coenzyme Q10 was found to be more effective than melatonin, myo-inositol, and vitamins, significantly increasing oocyte retrieval and pregnancy rates, especially in women under 35 with diminished ovarian reserve.
Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis.
Systematic review and meta-analysis of six RCTs involving 1529 women with diminished ovarian reserve undergoing IVF/ICSI. CoQ10 pretreatment was associated with improved clinical pregnancy rate, number of optimal embryos, and oocytes retrieved, along with reduced cycle cancellation and miscarriage rates.
Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the efficacy and safety of combining trimetazidine and CoQ10 compared to CoQ10 alone in patients with acute viral myocarditis. Sixteen RCTs with 1,364 patients were analyzed, showing that the combined treatment significantly improved therapy effectiveness, myocardial enzyme levels, and cardiac systolic function without increasing adverse events.
The effects of coenzyme Q10 supplementation on biomarkers of exercise-induced muscle damage, physical performance, and oxidative stress: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
This systematic review and meta-analysis assessed the dose-dependent effects of coenzyme Q10 supplementation on exercise-induced muscle damage, physical performance, and oxidative stress in adults. The analysis included 28 RCTs with 830 subjects, finding that CoQ10 significantly reduced biomarkers of muscle damage and oxidative stress, though no significant change in total antioxidant capacity was observed.
Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 12 RCTs with 489 subjects assessing CoQ10 supplementation on endothelial function. CoQ10 significantly increased Flow Mediated Dilation (FMD) but had no effect on VCAM and ICAM. The effect on FMD was dose-dependent.
Coenzyme Q10 supplementation in multiple sclerosis; A systematic review.
Systematic review of CoQ10 supplementation in multiple sclerosis patients, analyzing outcomes on oxidative stress, inflammation, and clinical status. CoQ10 at 500mg/day may improve oxidative stress, inflammation, depression, and fatigue, though effects are dose-dependent and evidence is limited.
Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials.
Meta-analysis of 33 randomized controlled trials assessing coenzyme Q10 in heart failure. Coenzyme Q10 reduced all-cause mortality, hospitalization for heart failure, and improved left ventricular ejection fraction and 6-min walk test results without major adverse effects.
Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the efficacy of coenzyme Q10 in heart failure patients. CoQ-10 significantly reduced HF-related mortality by 40% and improved exercise capacity, but showed no significant difference in left ventricular ejection fraction.
Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
This meta-analysis assessed the efficacy and optimal dose of CoQ10 supplementation on inflammatory biomarkers in the general population. CoQ10 supplementation significantly reduced levels of CRP, IL-6, and TNF-α, and increased circulating CoQ10 concentration. Daily supplementation of 300-400 mg CoQ10 showed superior inhibition of inflammatory factors.
Coenzyme Q10 supplementation in rheumatic diseases: A systematic review.
Systematic review of Coenzyme Q10 (CoQ10) supplementation in rheumatic diseases, including Fibromyalgia, Rheumatoid Arthritis, and Antiphospholipid Syndrome. CoQ10 improved disease activity, inflammatory biomarkers, endothelial function, pain, fatigue, sleep, and mood. The supplement was well tolerated with minor side effects reported.
Alleviating effects of coenzyme Q10 supplements on biomarkers of inflammation and oxidative stress: results from an umbrella meta-analysis
Umbrella meta-analysis evaluating the effects of CoQ10 supplementation on biomarkers of inflammation and oxidative stress. CoQ10 significantly decreased serum CRP and MDA, increased TAC and SOD activity, and had mixed effects on TNF-α and IL-6 levels.
Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
Systematic review of 16 studies on Coenzyme Q10 supplementation in athletes. Found decreased oxidative stress markers, increased antioxidant activity, reduced liver damage markers, and improved anaerobic performance and fatigue indicators.
Effect of coenzyme Q10 on cardiac function and survival in heart failure: an overview of systematic reviews and-analyses.
Systematic review synthesizing evidence on the effects of CoQ10 on cardiac function and quality of life in heart failure. CoQ10 showed a possible beneficial effect on heart function, associated with a reduction in mortality and hospitalisations, though more research is needed to optimize therapy.
Coenzyme Q10 and Dementia: A Systematic Review
Systematic review and meta-analysis of studies measuring CoQ10 levels in dementia patients and controls. Found similar serum/plasma CoQ10 levels in AD patients compared to controls. Reviewed therapeutic effects of CoQ10 in experimental models and humans, showing neuroprotective effects in models but inconclusive results in humans.
Systematic Review on Protocols of Coenzyme Q10 Supplementation in Non-Surgical Periodontitis Therapy.
This systematic review examines different study protocols on CoQ10 as an adjunct in non-surgical periodontitis therapy. It includes 12 RCTs with local and 5 with systemic CoQ10 administration, but the reporting quality was low and risk of bias high or unclear. No definitive statement on CoQ10's effectiveness in this context is possible.
Effects of coenzyme Q10 supplementation on lipid profiles and liver enzymes of nonalcoholic fatty liver disease (NAFLD) patients: A systematic review and meta‐analysis of randomized controlled trials
Systematic review and meta-analysis of randomized controlled trials assessing the effects of CoQ10 supplementation on lipid profiles and liver enzymes in NAFLD patients. The analysis showed an overall non-significant decrease in lipid profiles and liver enzymes, but sensitivity and subgroup analyses indicated significant effects of CoQ10 in certain conditions.
Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
Meta-analysis of 50 RCTs with 2794 participants assessing CoQ10 supplementation effects on lipid profiles. CoQ10 significantly reduced total cholesterol, LDL-C, and triglycerides, and increased HDL-C levels. The optimal dosage for reducing total cholesterol was 400-500 mg/day.
Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation.
Systematic review and economic evaluation of coenzyme Q10 for managing chronic heart failure with reduced ejection fraction. Meta-analysis of 26 trials with 2250 participants suggested a possible benefit on all-cause mortality and cost-effectiveness, though concerns about risk of bias and applicability remain.
Effects of Coenzyme Q10 Supplementation on Biomarkers of Oxidative Stress in Adults: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials
Systematic review and meta-analysis of 34 RCTs with 2012 participants assessing CoQ10 supplementation's effects on oxidative stress biomarkers. CoQ10 significantly increased total antioxidant capacity and reduced malondialdehyde concentrations, with subgroup analyses showing more benefits for individuals with coronary artery disease or type 2 diabetes.
Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 26 RCTs with 1831 subjects assessing the dose-response effect of CoQ10 supplementation on blood pressure in patients with cardiometabolic disorders. CoQ10 significantly reduced systolic blood pressure, with a U-shaped dose-response relation observed, and increased circulating CoQ10 levels.
[Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
Systematic review and meta-analysis evaluating the effect of coenzyme Q10 on all-cause and cardiovascular mortality in patients with chronic heart failure and reduced left ventricular ejection fraction. The analysis included 1139 patients and found a 36% reduction in all-cause mortality and a 55% reduction in cardiovascular mortality associated with Q10 treatment.
Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated the effectiveness of Coenzyme Q10 (CoQ10) supplementation in reducing fatigue across 13 RCTs with 1,126 participants. The CoQ10 group showed a statistically significant reduction in fatigue scores compared to placebo. The effect was consistent across healthy and diseased participants, with greater fatigue reduction correlated with higher doses and longer treatment durations.
Coenzyme Q10 as Adjunctive Therapy for Cardiovascular Disease and Hypertension: A Systematic Review.
Systematic review of 14 studies with 1067 participants examining CoQ10 supplementation in older adults with cardiovascular disease or hypertension. CoQ10 improved functional capacity and reduced major adverse cardiovascular events in heart failure patients, had positive effects on inflammatory markers in ischemic heart disease, and improved myocardial hemodynamics pre-cardiac surgery. Effects on hypertension were inconclusive.
Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 9 RCTs involving 1021 patients evaluating coenzyme Q10 supplementation in the treatment of polycystic ovary syndrome (PCOS). Coenzyme Q10 improved insulin resistance, sex hormone levels, and blood lipids, with no reported adverse effects.
Variation of the clinical spectrum and genotype-phenotype associations in Coenzyme Q10 deficiency associated glomerulopathy.
Systematic review and registry analysis of 251 patients with primary Coenzyme Q10 deficiency, focusing on genotype-phenotype associations in glomerulopathy. The study highlights significant variability in clinical presentations and disease severity, with kidney disease onset and progression differing based on genetic variants.
The efficacy of coenzyme Q10 treatment in alleviating the symptoms of primary coenzyme Q10 deficiency: A systematic review
Systematic review of studies on primary CoQ10 deficiency (PCoQD) patients treated with CoQ10 supplementation. Out of 89 cases, 24 reported improvements after CoQ10 treatment, while 5 cases deteriorated after stopping treatment. Improvements were partial and only in some symptoms, with weak evidence for efficacy.
THE EFFECT OF COENZYME Q10 ON PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CLINICAL TRIALS.
Systematic review and meta-analysis of clinical trials assessing the efficacy of coenzyme Q10 gel in periodontitis patients. Coenzyme Q10 significantly reduced Plaque Index, Bleeding Index, Pocket Depth, clinical attachment level, and gingival index. Intra-pocket administration showed stronger effects than topical application.
Coenzyme Q10 and Parkinsonian Syndromes: A Systematic Review
Systematic review and meta-analysis of studies on CoQ10 concentrations in Parkinson's disease (PD) and other parkinsonian syndromes (PS). PD patients showed decreased CoQ10 levels in various tissues, while therapeutic effects of CoQ10 in PD showed a lack of improvement. The role of CoQ10 therapy in multiple system atrophy (MSA) and selected PD groups requires further study.
Discovering the Potential Value of Coenzyme Q10 in Oxidative Stress: Enlightenment From a Synthesis of Clinical Evidence Based on Various Population.
Meta-analysis of 21 randomized clinical trials evaluating CoQ10 supplementation on oxidative stress parameters. CoQ10 increased antioxidant enzyme levels (SOD, CAT) and decreased malondialdehyde levels, indicating improved oxidative stress. No significant effect on total antioxidant capacity or glutathione peroxidase activity.
Dietary interventions and nutritional supplements for heart failure: a systematic appraisal and evidence map.
Systematic review and evidence map of 122 RCTs assessing dietary interventions and nutritional supplements on heart failure outcomes. Coenzyme Q10 was associated with lower all-cause mortality, while vitamin E increased the risk of HF hospitalization. Thiamine, vitamin D, iron, and L-carnitine showed beneficial effects on left ventricular ejection fraction.
Coenzyme Q10 for heart failure.
This meta-analysis reviewed 11 studies with 1573 participants to assess the safety and efficacy of coenzyme Q10 in heart failure. Coenzyme Q10 probably reduces all-cause mortality and hospitalisation for heart failure, but evidence is inconclusive for myocardial infarction, stroke, left ventricular ejection fraction, and exercise capacity. The quality of evidence was downgraded due to high risk of bias and imprecision.
Diabetes, Age, and Duration of Supplementation Subgroup Analysis for the Effect of Coenzyme Q10 on Oxidative Stress: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 17 trials with 972 participants evaluating CoQ10 supplementation on oxidative stress. CoQ10 increased serum total antioxidant capacity and superoxide dismutase levels, and decreased malondialdehyde levels significantly compared to placebo, indicating improved antioxidant defense.
Effects of coenzyme Q10 supplementation on statin-induced myopathy: a meta-analysis of randomized controlled trials.
Meta-analysis of randomized controlled trials assessing the effect of CoQ10 supplementation on statin-induced myopathy. The analysis included 8 studies with 472 patients and found no significant benefit of CoQ10 in improving creatine kinase activity or muscle pain.
Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis.
Meta-analysis of six studies with 371 participants assessing CoQ10 supplementation for migraine prophylaxis. CoQ10 reduced the duration and frequency of migraine attacks but did not significantly reduce the severity of headaches.
Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
A 12-week prospective, randomized, double-blind, placebo-controlled trial in 207 ME/CFS patients examined the effects of CoQ10 and NADH supplementation. The study found significant reductions in cognitive fatigue perception and improvements in health-related quality of life, sleep duration, and habitual sleep efficiency within the experimental group.
Coenzyme Q10 and Male Infertility: A Systematic Review
Systematic review examining the effect of Coenzyme Q10 supplementation on male infertility, focusing on semen quality and pregnancy rates. All studies report beneficial effects on semen parameters, though optimal dosage and combinations with other antioxidants remain unclear.
A systematic review for the efficacy of coenzyme Q10 in patients with chronic kidney disease.
Systematic review of 12 studies on CoQ10 supplementation in chronic kidney disease patients. CoQ10 significantly reduced oxidative stress markers and improved inflammation and glucose metabolism. Effects on cardiovascular outcomes were inconsistent, with no impact on lipid profiles.
Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials.
This systematic review and meta-analysis evaluated the efficacy of CoQ10 supplementation on inflammatory markers, oxidative stress parameters, and MMPs/TIMPs in breast cancer patients. CoQ10 supplementation significantly decreased levels of VEGF, IL-8, MMP-2, and MMP-9, indicating a reduction in inflammation and oxidative stress.
Comparative Efficacy and Tolerability of Adjunctive Pharmacotherapies for Acute Bipolar Depression: A Systematic Review and Network Meta-analysis
Systematic review and network meta-analysis of 69 trials with 8,007 participants on adjunctive pharmacotherapies for acute bipolar depression. Coenzyme Q10, among other agents, was found to be more effective than placebo for response in bipolar depression.
Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis.
Systematic review and network meta-analysis of 46 trials involving 6312 women undergoing IVF with poor ovarian response. DHEA and CoQ10 treatments significantly increased clinical pregnancy chances, while CoQ10 also led to the lowest global cancellation rate. Growth hormone (GH) showed improved outcomes in terms of oocyte retrieval and embryo transfer.
Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis.
Systematic review and meta-analysis of Coenzyme Q10 supplementation in patients with statin-associated myalgia. The analysis included 7 studies with 321 patients and found no significant benefit of CoQ10 in relieving muscle pain or improving adherence to statin therapy.
The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials
Systematic review and meta-analysis of 19 RCTs evaluating the effect of CoQ10 supplementation on oxidative stress markers. CoQ10 increased levels of TAC, GPx, SOD, and CAT, and reduced MDA levels, indicating beneficial effects on oxidative stress.
The impact of coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials
Systematic review and meta-analysis of randomized controlled trials evaluating the impact of CoQ10 on metabolic and cardiovascular disease profiles in diabetic patients. The paper synthesizes evidence on CoQ10's protective effects against cardiovascular-related complications.
Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials.
Systematic review and meta-analysis of 17 randomized clinical trials evaluating CoQ10 supplementation on oxidative stress parameters. CoQ10 was associated with a significant decrease in malondialdehyde and an increase in total antioxidant capacity and superoxide dismutase activity, but no significant effects on nitric oxide, glutathione levels, catalase activity, or glutathione peroxidase activities.
Coenzyme Q10 effect on semen parameters: Profound or meagre?
Meta-analysis of three placebo-controlled RCTs evaluating CoQ10's efficacy in improving semen parameters. CoQ10 significantly improved sperm motility and forward motility, with no significant impact on sperm count, morphology, ejaculate volume, or seminal plasma CoQ10 levels. Higher doses and administration for 3-6 months showed better results.
Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of nine RCTs with 509 patients assessed the efficacy of CoQ10 supplementation on inflammatory markers TNF-α and IL-6. CoQ10 supplementation (60-500 mg/day for 8-12 weeks) significantly reduced TNF-α and IL-6 levels, suggesting a positive effect on inflammation in chronic diseases. However, results should be interpreted cautiously due to heterogeneity and limited study numbers.
Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose–response meta-analysis of randomized controlled trials
Systematic review and meta-analysis of randomized controlled trials evaluating Coenzyme Q10 supplementation on migraine. Coenzyme Q10 significantly reduced the frequency of migraine attacks but had no significant effect on severity or duration.
The Effects of Coenzyme Q10 Supplementation on Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 21 controlled trials assessing CoQ10 supplementation on lipid profiles in patients with metabolic disorders. CoQ10 significantly reduced serum triglycerides levels, with non-significant changes in total-cholesterol, LDL-, and HDL-cholesterol levels.
Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Systematic review and meta-analysis of 13 trials involving 765 patients with type 2 diabetes mellitus. Coenzyme Q10 supplementation may decrease HbA1c and fasting blood glucose, but no significant effect on fasting insulin was found. Coenzyme Q10 may assist glycemic control and improve lipid profiles.
The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 17 RCTs with 684 participants assessing the effects of CoQ10 supplementation on blood pressures in patients with metabolic diseases. CoQ10 significantly decreased systolic blood pressure but did not significantly affect diastolic blood pressure.
Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
Meta-analysis of 12 RCTs with 575 patients assessing CoQ10 supplementation on statin-induced myopathy. CoQ10 improved muscle symptoms like pain, weakness, cramp, and tiredness, but did not reduce plasma creatine kinase levels.
The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of coenzyme Q10 supplementation on lipid profiles in patients with coronary artery disease. The analysis included eight trials with 267 participants in the intervention group and 259 in the placebo group. CoQ10 supplementation significantly decreased total cholesterol and increased HDL-cholesterol levels, but had no significant effects on LDL-cholesterol, lipoprotein (a), or triglycerides.
Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials.
Meta-analysis of 14 RCTs with 2149 patients evaluating coenzyme Q10 in cardiac failure. Coenzyme Q10 decreased mortality and improved exercise capacity compared to placebo, but showed no significant differences in left heart ejection fraction and NYHA classification.
Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 9 RCTs involving 428 subjects assessing the effects of CoQ10 on inflammatory markers in people with metabolic diseases. CoQ10 supplementation significantly decreased TNF-alpha levels but showed no significant effect on CRP and IL-6 levels.
Coenzyme Q10 for Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of five RCTs with 981 patients evaluating CoQ10 supplementation for neuroprotection in Parkinson's disease. The analysis found no significant benefit of CoQ10 on motor functions or quality of life as measured by UPDRS and Schwab and England scores.
The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials.
Meta-analysis of randomized controlled trials evaluating the effects of CoQ10 for motor dysfunction in Parkinson's disease patients. The analysis included 8 studies with 899 patients and found no significant difference in motor symptoms between CoQ10 and placebo groups. CoQ10 was well tolerated but not superior to placebo for motor symptoms.
Supplementation with coenzyme Q10 reduces plasma lipoprotein(a) concentrations but not other lipid indices: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effect of CoQ10 supplementation on plasma lipoprotein(a) levels across seven randomized controlled trials with 409 subjects. CoQ10 supplementation resulted in a slight but significant reduction in plasma Lp(a) levels, particularly in patients with higher baseline Lp(a) levels. Other lipid indices were not affected by CoQ10 supplementation.
Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis.
Systematic review and meta-analysis of randomized controlled trials assessing CoQ10 supplementation in diabetes. CoQ10 did not improve glycemic control, lipid profile, or blood pressure, but reduced triglycerides levels. Further trials are needed to determine its effects on metabolic profile in diabetes.
Coenzyme Q10 and male infertility: a meta-analysis.
Meta-analysis evaluating the effect of CoQ10 treatments in male infertility. CoQ10 supplementation did not increase pregnancy rates but showed a significant increase in CoQ10 seminal concentration, sperm concentration, and sperm motility.
WITHDRAWN: Coenzyme Q10 for Parkinson's disease.
Systematic review of four RCTs with 452 patients assessing coenzyme Q10 for Parkinson's disease. Coenzyme Q10 at 1200 mg/d for 16 months showed improvements in activities of daily living and Schwab and England scores, with mild safety concerns. Larger studies are needed to confirm these findings.
Coenzyme Q10 for Parkinson's disease.
Meta-analysis of four RCTs with 452 patients assessing coenzyme Q10 for early and midstage Parkinson's disease. Coenzyme Q10 at 1200 mg/d for 16 months showed improvements in activities of daily living and Schwab and England scores, with mild safety concerns. Further confirmation by larger samples is needed.
Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.
Meta-analysis of 12 clinical trials (362 patients) assessing coenzyme Q10 for hypertension. Coenzyme Q10 significantly reduced systolic and diastolic blood pressure in randomized controlled trials, crossover study, and open label studies without significant side effects.
Coenzyme Q10 Impact on Ovarian Reserve Measures and the Intra-Cytoplasmic Sperm Injection (ICSI) Outcomes in Women with Poor Ovarian Response: A Randomized Controlled Study.
RCT of 100 women with poor ovarian response comparing Coenzyme Q10 plus folic acid to folic acid alone before and during ICSI cycles. CoQ10 improved oocyte count, peak E2, antral follicle count, and endometrial thickness, but did not significantly affect pregnancy rates.
Next-generation liposomal coenzyme Q: from formulation to clinical evidencemetazome technology for improved stability and enhanced oral absorption.
The study developed a stable liposomal CoQ10 formulation using Metazome technology to improve oral bioavailability. In a randomized, open-label, crossover study in healthy volunteers, the new formulation showed significantly improved pharmacokinetics compared to conventional CoQ10, including a 4.3-fold increase in AUC and a prolonged half-life.
Phase Ia/b Multicenter Study of BPM31510IV Targeting Mitochondrial Metabolism/Warburg Effect as Monotherapy and Combination Chemotherapy in Solid Tumor Patients.
Phase Ia/Ib study of BPM31510IV, an intravenous coenzyme Q10 formulation, as monotherapy and in combination with chemotherapy in patients with advanced solid tumors. The study found BPM31510IV to be safe with preliminary evidence of antitumor activity, achieving high plasma CoQ10 levels and inducing changes in tumor metabolism.
The clinical outcome of Montelukast versus co-enzyme Q10 in adult patients with sepsis: A randomized controlled clinical trial.
RCT comparing montelukast and CoQ10 as adjunctive therapies in 90 adult septic patients. CoQ10 showed potential benefits in reducing vasopressor duration and improving SOFA score, TNF-α, and MDA levels. CoQ10 was associated with hypotension in 20% of patients.
Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized Trial.
This randomized, double-blind, placebo-controlled crossover study assessed the effects of CoQ10, tryptophan, and magnesium supplementation in 89 fibromyalgia patients. Fatigue improved significantly in the placebo group, with a non-significant reduction in the supplement group. Pain intensity decreased in both groups, while sleep quality and functional impact improved significantly in the supplement group. The supplement was efficacious in improving physical aspects of FM and showed good tolerability.
Effect of coenzyme Q10 on post-extraction tissue healing in wisdom tooth Surgery: double-blind randomized clinical trial.
This double-blind randomized clinical trial evaluated the efficacy of Coenzyme Q10 supplementation in improving post-extraction tissue healing and reducing temporomandibular disorders (TMD) and dry socket following wisdom tooth extraction. The CoQ10 group showed significant improvements in tissue healing and reduced incidence of TMD and dry socket compared to placebo.
Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study.
Double-blind, randomized placebo-controlled study of 50 acute ischemic stroke patients assessing the effects of 600 mg/day CoQ10 supplementation for 30 days. CoQ10 reduced oxidative stress and inflammation, increased BDNF levels, and showed potential neuroprotective benefits.
Impact of coenzyme Q10 as an adjuvant therapy to letrozole on spermiogram results and sex hormone levels in Iraqi men with infertility; randomized open label comparative study.
This randomized, open-label study evaluated the impact of adding coenzyme Q10 to letrozole on spermiogram results and sex hormone levels in 67 Iraqi men with idiopathic oligoasthenoteratozoospermia. The combination treatment improved sperm concentration, morphology, total sperm count, motility, serum testosterone, and FSH levels, while reducing estradiol levels after three months.
Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway.
RCT investigating Coenzyme Q10 supplementation in MI patients and its effects on cardiac function recovery and inflammation. CoQ10 improved cardiac function and reduced inflammation by inhibiting CCR2 macrophage recruitment and NLRP3/IL1β pathway activation.
Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
RCT of 60 patients with MASLD comparing 240mg daily coenzyme-Q10 supplementation to placebo over 6 months. Coenzyme-Q10 group showed reduced liver steatosis and improved endothelial, vascular, and myocardial function, with significant improvements in micro- and macro-vasculature function.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.
Double-blind placebo-controlled RCT of 60 burn patients receiving 300 mg/day CoQ10 or placebo for 10 days. CoQ10 had no effect on inflammatory markers or oxidative stress, but significantly increased serum albumin levels compared to placebo.
Comparative Study Of Combined Co-Enzyme Q10 And Clomiphene Citrate Vs Clomiphene Citrate Alone For Ovulation Induction In Patients With Polycystic Ovarian Syndrome.
RCT comparing combined Co-Enzyme Q10 and Clomiphene Citrate versus Clomiphene Citrate alone for ovulation induction in 136 patients with PCOS. The addition of CoQ10 increased the chances of successful ovulation induction.
Coenzyme Q10 as a potential add-on treatment for patients suffering from painful diabetic neuropathy: results of a placebo-controlled randomized trial.
RCT of 112 patients with painful diabetic neuropathy comparing CoQ10 + pregabalin to placebo + pregabalin over 8 weeks. CoQ10 supplementation resulted in significantly greater pain relief and improved sleep interference scores compared to placebo.
Coenzyme Q10 supplementation improves cholesterol efflux capacity and antiinflammatory properties of high-density lipoprotein in Chinese adults with dyslipidemia.
A 24-week randomized, double-blind, placebo-controlled trial in 101 dyslipidemic individuals showed that CoQ10 supplementation significantly improved HDL-mediated cholesterol efflux capacity and reduced the HDL inflammatory index compared to placebo. The effects were more pronounced in elderly, female, or non-obese individuals.
A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial
RCT comparing the efficacy of coenzyme Q10 and amitriptyline in the prophylactic treatment of migraine headaches in 72 children aged 5-15. Coenzyme Q10 showed good therapeutic effects, especially in long-term use, with fewer side effects compared to amitriptyline. Clinical outcomes and quality of life improvements were similar between the two groups after 3 months.
Coenzyme Q10 in the Treatment of Attention Deficit Hyperactivity Disorder in Children: A Randomized Controlled Trial.
RCT of 60 children with ADHD non-responsive to atomoxetine, comparing atomoxetine plus coenzyme Q10 to atomoxetine plus placebo for 6 months. Coenzyme Q10 improved symptoms significantly, with a 33.87% improvement in CPRS-48 total score versus 18.24% in the placebo group.
Effects of coenzyme Q10 on health-related quality of life, clinical disease activity and blood pressure in patients with mild to moderate ulcerative colitis: a randomized clinical trial
RCT of 88 UC patients comparing CoQ10 (200 mg/day) to placebo for 8 weeks. CoQ10 significantly reduced SCCAI scores and blood pressure, and improved IBDQ-32 scores, suggesting benefits for disease severity, blood pressure, and quality of life.
A randomized controlled trial on the coloprotective effect of coenzyme Q10 on immune-inflammatory cytokines, oxidative status, antimicrobial peptides, and microRNA-146a expression in patients with mild-to-moderate ulcerative colitis.
This randomized controlled trial evaluated the effects of CoQ10 supplementation on inflammation, antioxidant status, antimicrobial peptides, and microRNA-146a expression in 88 patients with mild-to-moderate ulcerative colitis. CoQ10 significantly reduced serum IL-17 levels, NF-κB p65 activity, and SCCAI score, while increasing IL-10 serum concentrations and IBDQ-32 score. CoQ10 also increased serum levels of cathelicidin LL-37, indicating its potential as an anti-inflammatory agent in UC patients.
The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome.
Double-blinded, placebo-controlled RCT of 55 women with PCOS receiving 100mg/day CoQ10 or placebo for 12 weeks. CoQ10 supplementation significantly improved mental health scores, reduced inflammatory markers, and improved hormonal profiles compared to placebo.
Efficacy of 0.1% crosslinked hyaluronic acid, coenzyme Q10 and vitamin E in the management of dry eye disease in menopause patients receiving antidepressants
This prospective, double-blind, single-center study tested the non-inferiority of crosslinked hyaluronic acid (CLHA) eyedrops compared to carmellose sodium in managing dry eye disease in menopause patients on antidepressants. The study found that a lower dose of CLHA achieved similar efficacy in tear stability and subjective dry eye sensation as a higher dose of carmellose.
Diagnostic utility of fluid biomarkers in multiple system atrophy: a systematic review and meta-analysis.
Systematic review and meta-analysis of 28 studies identifying fluid biomarkers for multiple system atrophy (MSA). Biomarkers such as phosphorylated tau, α-synuclein, and coenzyme Q10 were evaluated for their diagnostic utility in distinguishing MSA from healthy controls and Parkinson's disease.
Efficacy of coenzyme Q10 in patients with chronic kidney disease: protocol for a systematic review
This systematic review protocol aims to assess the efficacy and safety of CoQ10 supplementation in patients with chronic kidney disease (CKD). The review will evaluate CoQ10's effects on cardiovascular events, mitochondrial function, and oxidative stress in CKD patients.
Effects of coenzyme Q10 intervention on diabetic kidney disease: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effectiveness of Coenzyme Q10 combined with other western medicine for diabetic kidney disease therapy. The analysis included 8 articles (4 RCTs and 4 experimental studies) and found statistical differences in laboratory parameters such as fasting plasma glucose, Hemoglobin A1c, total cholesterol, HDL-C, triglyceride, and malondialdehyde amelioration after DKD therapy compared with control group. However, LDL-C and Urea level for RCTs and Urine output and Glucose for experimental studies were not superior to control group.
The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of CoQ10 supplementation on biomarkers of inflammation and oxidative stress in patients with coronary artery disease. CoQ10 significantly increased superoxide dismutase and catalase levels, and reduced malondialdehyde and diene levels, but had no significant effect on C-reactive protein, TNF-alpha, IL-6, and glutathione peroxidase levels.