Research
Cinnamon Extract
92 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of aromatic herbs and spices in the Mediterranean Diet on glycemic profile in Type 2 Diabetes subjects. Cinnamon, turmeric, ginger, black cumin, and saffron significantly improved fasting glucose levels, with black cumin showing the most significant decrease. Ginger and black cumin improved glycated hemoglobin, while cinnamon and ginger decreased insulin levels.
The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systematic review and dose‐response meta‐analysis of randomized controlled trials
This meta-analysis of 24 RCTs assessed the effects of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus. Cinnamon supplementation significantly reduced fasting blood sugar, insulin resistance, and hemoglobin A1C levels, but did not significantly change serum insulin levels. The findings suggest cinnamon may have clinical potential as an adjunct therapy for managing T2DM.
Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review.
This systematic review evaluated the effects of cinnamon supplementation on metabolic status in women with polycystic ovary syndrome (PCOS). The review found that cinnamon increased high-density lipoprotein and insulin sensitivity while decreasing low-density lipoprotein, triglyceride, and blood glucose levels. Results on body weight and BMI were inconsistent, and further studies are needed to explore the precise mechanisms and effects on oxidative stress and ovarian function.
Impact of Cinnamon Supplementation on cardiometabolic Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 12 RCTs investigating cinnamon supplementation on cardiometabolic biomarkers. Cinnamon supplementation significantly reduced C-reactive protein and malondialdehyde levels, marginally decreased interleukin-6, and increased total antioxidant capacity, but did not significantly change intercellular adhesion molecule-1 levels.
Anti-hypertensive effects of cinnamon supplementation in adults: A systematic review and dose-response Meta-analysis of randomized controlled trials
Systematic review and meta-analysis of 9 RCTs with 641 subjects on the effect of cinnamon supplementation on blood pressure. Cinnamon supplementation significantly reduced systolic and diastolic blood pressure, suggesting its potential as a hypotensive supplement in hypertension management.
The effects of cinnamon supplementation on blood lipid concentrations: A systematic review and meta-analysis.
Systematic review and meta-analysis of 13 RCTs with 750 participants assessing the effect of cinnamon supplementation on blood lipid concentrations. Cinnamon significantly reduced blood triglycerides and total cholesterol concentrations, but had no significant effect on LDL-C and HDL-C.
Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis
Updated systematic review and meta-analysis of 10 RCTs with 543 patients evaluating cinnamon's effect on glycemia and lipid levels in type 2 diabetes. Cinnamon reduced fasting plasma glucose, total cholesterol, LDL-C, and triglycerides, and increased HDL-C, but had no significant effect on hemoglobin A1c. High heterogeneity limits applicability.
Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial.
RCT of 70 subjects with diarrhea symptoms comparing cinnamon water extract (CWE) to placebo for 8 weeks. CWE intake improved diarrhea symptoms, increased colonic transit time, and altered gut microbiota composition, indicating relief through metabolic changes.
A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial
RCT comparing the effects of cinnamon, ginger, and metformin on metabolic health, anthropometric indices, and sexual hormone levels in 83 women with PCOS. Cinnamon and metformin significantly decreased insulin resistance and testosterone levels, while ginger decreased FSH and LH levels. Cinnamon and ginger may serve as alternative treatments for PCOS.
Efficacy of Cinnamon as an Adjuvant in Reducing the Glycemic Biomarkers of Type 2 Diabetes Mellitus: A Three-Month, Randomized, Triple-Blind, Placebo-Controlled Clinical Trial.
This randomized, triple-blind, placebo-controlled clinical trial evaluated the efficacy of cinnamon as an adjuvant treatment in reducing glycemic levels in 160 people with type 2 diabetes. Participants received 3g capsules of cinnamon or placebo for 90 days. The cinnamon group showed statistically significant reductions in glycated hemoglobin and fasting venous glucose compared to placebo, indicating modest improvements in glycemic measures.
A randomized, double-blind clinical trial of a herbal formulation (GlycaCare-II) for the management of type 2 diabetes in comparison with metformin
A randomized, double-blind clinical trial comparing the antihyperglycemic potential of GlycaCare-II, a herbal formulation, against metformin in prediabetic and newly diagnosed diabetic patients over 120 days. GlycaCare-II showed significant improvements in HbA1c, FBS, and PBS, with similar efficacy to metformin, and better PBS reduction in newly diagnosed patients.
Influence of Cinnamon on Glycemic Control in Individuals With Prediabetes: A Randomized Controlled Trial
This double-blind, placebo-controlled RCT investigated the effects of cinnamon on glucose homeostasis in individuals with prediabetes. Over 12 weeks, cinnamon supplementation improved fasting plasma glucose and glucose tolerance compared to placebo, with no serious adverse events reported.
Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double‐blind placebo‐controlled trial
RCT of 50 migraine patients comparing cinnamon supplementation to placebo for 2 months. Cinnamon reduced serum levels of IL-6 and NO, and decreased frequency, severity, and duration of migraine attacks compared to control.
The impact of cinnamon on anthropometric indices and glycemic status in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials.
Systematic review and meta-analysis of 18 RCTs examining the effects of cinnamon on glycemic status and anthropometric indices in patients with type 2 diabetes. Cinnamon supplementation reduced fasting blood sugar but had no significant effects on HbA1C, body weight, BMI, waist circumference, insulin levels, or insulin resistance.
Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta‐analysis of controlled clinical trials
This systematic review and meta-analysis investigated the effects of cinnamon supplementation on body weight, BMI, waist circumference, waist-hip ratio, and body fat mass in adults, including data from multiple controlled clinical trials.
Assessment of the effeCt of lIfestyle iNtervention plus water-soluble ciNnAMon extract On loweriNg blood glucose in pre-diabetics, a randomized, double-blind, multicenter, placebo controlled trial: study protocol for a randomized controlled trial.
This is a randomized, double-blind, placebo-controlled trial assessing the effect of water-soluble cinnamon extract on preventing the progression from pre-diabetes to diabetes in 428 subjects. The study will evaluate primary outcomes such as conversion to diabetes and the impact on hepatic transaminases, renal function, and QT interval, with secondary outcomes including changes in HbA1c, lipids, waist circumference, weight, blood pressure, and fasting plasma glucose.
Cinnamon intake lowers fasting blood glucose: meta-analysis.
Meta-analysis of eight clinical studies assessing the effect of cinnamon intake on fasting blood glucose in people with type 2 diabetes and/or prediabetes. Cinnamon intake, either as whole cinnamon or as cinnamon extract, results in a statistically significant lowering in fasting blood glucose.
Suppression of the postprandial hyperglycemia in patients with type 2 diabetes by a raw medicinal herb powder is weakened when consumed in ordinary hard gelatin capsules: A randomized crossover clinical trial.
This randomized crossover trial evaluated the acute effect of raw cinnamon consumed either dissolved in water or in gelatin capsules on postprandial hyperglycemia in T2DM patients. Cinnamon dissolved in water decreased the meal-induced glucose spike, while the effect was diminished when taken in capsules. The study suggests cinnamon's antihyperglycemic action is due to its inhibition of carbohydrate-digesting enzymes.
Effect of Aqueous Cinnamon Extract on the Postprandial Glycemia Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.
RCT investigating the effect of aqueous cinnamon extract on postprandial glycemia levels in 36 adults with type 2 diabetes mellitus. The study found no significant difference in glucose response between the cinnamon extract group and the control group during an oral glucose tolerance test.
Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial
A randomized, double-blind, controlled clinical trial with 44 type 2 diabetes patients evaluated the effect of daily three-gram cinnamon supplementation on plasma levels of NF-kB, SIRT1, hs-CRP, IL-6, and TNF-α. After 8 weeks, no significant differences were observed in inflammation markers except for NF-kB, which showed a significant difference between groups.
Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial.
Triple-blind placebo-controlled RCT of 140 patients with type II diabetes mellitus, assessing the effects of cinnamon supplementation on anthropometric, glycemic, and lipid outcomes. Cinnamon improved BMI, body fat, visceral fat, glycemic indices, and lipid profile, with more significant effects in patients with higher baseline BMI.
Comparative evaluation of the chlorhexidine and cinnamon extract as ultrasonic coolant for reduction of bacterial load in dental aerosols
RCT comparing the efficacy of chlorhexidine and cinnamon extract as ultrasonic coolants in reducing bacterial load in dental aerosols during ultrasonic scaling. Both substances were equally effective in reducing bacterial count compared to distilled water.
A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis.
RCT assessing the safety and efficacy of a nasal spray containing a polyphenol-rich standardized extract of cinnamon bark (IND02) for seasonal allergic rhinitis. The IND02 group showed significant reductions in symptom severity and improvements in quality of life, work productivity, and daily activities compared to placebo.
Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial.
Subgroup analysis of a randomized, double-blind, placebo-controlled trial with 103 prediabetic patients assessing the effect of cinnamon extract on electrocardiographic parameters. The study found no significant differences in ECG measures such as QTc interval, QT interval, PR interval, QRS duration, and heart rate between the cinnamon extract and placebo groups.
Cinnamon improves metabolic factors without detectable effects on adiponectin in women with polycystic ovary syndrome.
This double-blind randomized controlled trial investigated the effects of cinnamon supplementation on metabolic factors in 84 overweight or obese women with polycystic ovary syndrome (PCOS). Cinnamon significantly improved glycemic indices, serum lipids, and weight compared to placebo, but had no significant effect on serum adiponectin.
The effect of Cinnamon on primary dysmenorrhea: A randomized, double-blind clinical trial.
Randomized, double-blind clinical trial assessing the effect of 1000 mg cinnamon capsules on primary dysmenorrhea. The intervention group showed a significant reduction in pain intensity compared to the placebo group over two menstrual cycles.
Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial
RCT in overweight women with PCOS comparing lifestyle intervention plus herbal medicine to lifestyle alone. The combination group showed a 32.9% reduction in oligomenorrhoea, improved BMI, insulin, luteinizing hormone, blood pressure, quality of life, mood, and pregnancy rates.
Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial.
RCT of 66 women with PCOS assessing the effect of cinnamon powder capsules on insulin resistance and other metabolic parameters. Cinnamon supplementation significantly reduced fasting insulin and insulin resistance compared to placebo.
Cinnamon extract lowers glucose, insulin and cholesterol in people with elevated serum glucose
This placebo-controlled double-blind trial tested the effects of a dried water extract of cinnamon on circulating glucose, lipids, insulin, and insulin resistance in participants with elevated serum glucose. Supplementation with 500 mg of water-extract of cinnamon for two months reduced fasting insulin, glucose, total cholesterol, and LDL cholesterol and enhanced insulin sensitivity.
Effect of Cinnamon Extract and Chlorhexidine Gluconate (0.2%) on the Clinical Level of Dental Plaque and Gingival Health: A 4-Week, Triple-Blind Randomized Controlled Trial.
Triple-blind RCT comparing cinnamon extract, chlorhexidine mouthwash, and placebo on dental plaque and gingivitis in 105 students. Chlorhexidine showed the greatest reduction in plaque and gingival scores, followed by cinnamon extract, though results were statistically insignificant.
A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial
RCT of 62 overweight or obese pre-diabetic subjects evaluating a dietary supplement containing cinnamon, chromium, and carnosine over 4 months. The supplement decreased fasting plasma glucose and increased fat-free mass compared to placebo.
Correction: A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial
RCT of a dietary supplement containing cinnamon, chromium, and carnosine in overweight or obese pre-diabetic subjects. The supplement decreased fasting plasma glucose and increased lean mass.
Effect of Cinnamon Tea on Postprandial Glucose Concentration.
RCT investigating the effect of cinnamon tea (C. burmannii) on postprandial blood glucose levels in nondiabetic adults. Cinnamon tea administration slightly decreased postprandial BGL and significantly lowered postprandial maximum glucose concentration and variation. The tea's high antioxidant capacity may contribute to its effects.
Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes.
Randomized, double-blinded clinical study on the effect of cinnamon extract on glycosylated hemoglobin A(1c) and fasting blood glucose levels in 66 Chinese patients with type 2 diabetes. Both hemoglobin A(1c) and fasting blood glucose levels were significantly reduced in the low- and high-dose cinnamon groups, while the placebo group showed no change.
Evaluating the efficacy of cinnamaldehyde and Echinacea purpurea plant extract in broilers against Eimeria acervulina.
The study evaluated the effects of cinnamaldehyde and Echinacea purpurea plant extract as additives in broilers against Eimeria acervulina. Broilers were assigned to four dietary treatments, and performance traits, oocyst excretion, and intestinal lesions were analyzed. Cinnamaldehyde diets showed lower gross lesion scores at the duodenal level, suggesting potential anticoccidian action.
Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial.
RCT evaluating the effect of cinnamon on HbA1C levels in 109 type 2 diabetics. Cinnamon supplementation lowered HbA1C by 0.83% compared to 0.37% with usual care alone, suggesting cinnamon may help lower HbA1C in addition to usual care.
Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2.
RCT of 79 patients with type 2 diabetes comparing cinnamon extract to placebo over 4 months. The cinnamon group showed a significantly higher reduction in fasting plasma glucose levels compared to placebo, but no significant differences in HbA1c or lipid profiles.
CHARACTERIZATION OF HERBAL TEA BAGS MADE FROM STARFRUIT LEAVES (AVERRHOA BILIMBI), GOTU KOLA LEAVES (CENTELLA ASIATICA) AND CINNAMON POWDER (CINNAMOMUN BURMANII) AS FUNCTIONAL DRINKS
The study characterized herbal tea bags made from starfruit leaves, gotu kola leaves, and cinnamon powder, focusing on the effects of varying cinnamon powder substitution on antioxidant activity, total polyphenols, and organoleptic properties. The best results were observed with 4% cinnamon powder substitution, showing significant effects on antioxidant activity and sensory attributes.
EFFICACY AND SAFETY OF STANDARDIZED CINNAMON BARK EXTRACT FOR THE PREVENTION OF CHEMOTHERAPY-INDUCED WEIGHT LOSS AND ALOPECIA IN PATIENTS WITH BREAST CANCER: A RANDOMIZED, DOUBLE-BLIND, AND PLACEBO-CONTROLLED STUDY
RCT of 34 female breast cancer patients evaluating the effects of standardized Cinnamon bark extract (IND02) supplementation during chemotherapy. IND02 significantly protected against chemotherapy-induced severe weight loss and alopecia compared to placebo, and was found safe and well-tolerated.
Effects of Cinnamon Consumption on Glycemic Indicators, Advanced Glycation End Products, and Antioxidant Status in Type 2 Diabetic Patients.
Double-blind, randomized, placebo-controlled clinical trial with 44 type 2 diabetic patients, 39 of whom completed the study. Participants received either three grams of cinnamon or placebo daily for eight weeks. No significant effects on glycemic indicators, advanced glycation end products, or antioxidant status were observed.
The Effect of Metformin and Cinnamon on Serum Anti-Mullerian Hormone in Women Having PCOS: A Double-Blind, Randomized, Controlled Trial
Double-blind, randomized, controlled trial comparing the effects of metformin and DLBS3233 (cinnamon) on serum AMH levels in women with PCOS. The study found a significant decrease in serum AMH levels with both treatments, with fewer side effects observed in the DLBS3233 group.
Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial
Phase I clinical trial evaluating the pharmacodynamic properties and safety of Cinnamomum zeylanicum in 30 healthy adults over 3 months. The study found significant reductions in blood pressure, total cholesterol, and LDL-c, with no serious adverse effects reported.
Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers.
The study investigated the acute effect of Ceylon cinnamon hydro-alcoholic extract (CCE) on carbohydrate digestion and post-meal blood glucose reduction. In vitro and in vivo tests showed CCE inhibited pancreatic alpha-amylase activity and reduced glycemic response to starch. In a clinical trial with 18 healthy volunteers, 1 g of CCE lowered postprandial glycemia without stimulating insulin secretion.
Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese.
Double-blind placebo-controlled trial of 22 subjects with impaired fasting glucose and overweight or obesity, testing 250 mg of aqueous cinnamon extract (Cinnulin PF) twice daily for 12 weeks. The cinnamon group showed increased FRAP and plasma thiol groups, decreased plasma MDA levels, and a positive correlation between MDA and plasma glucose, suggesting potential benefits for diabetes and cardiovascular risk factors.
The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study.
Pilot RCT of 15 women with PCOS comparing daily oral cinnamon extract to placebo for 8 weeks. The cinnamon group showed significant reductions in insulin resistance, suggesting potential benefits for insulin sensitivity.
Controlled trial of the effect of cinnamon extract on Helicobacter pylori.
RCT testing the effect of 40 mg alcoholic cinnamon extract twice daily for 4 weeks on H. pylori infection in 15 patients compared to 8 receiving placebo. The cinnamon extract was well tolerated but ineffective in eradicating H. pylori.
Estimation and action mechanisms of cinnamon bark via oxidative enzymes and ultrastructures as antimicrobial, anti-biofilm, antioxidant, anti-Diabetic, and anticancer agents
The study evaluates the antimicrobial, anti-biofilm, antioxidant, anti-diabetic, and anticancer properties of cinnamon bark. It demonstrates significant antimicrobial action against various microorganisms, anti-diabetic properties through enzyme inhibition, antioxidant activity, and antitumor potential against human breast cancer and lung fibroblast cells.
Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats
The study evaluated the effect of cinnamon extract on bowel symptoms in IBS-D rat models. Cinnamon extract reduced defecation frequency and visceral hyperalgesia, and decreased excessive 5-HT levels and Tph1 expression, suggesting its potential as a treatment for IBS.
Biochemical, structural characterization and in-vitro evaluation of antioxidant, antibacterial, cytotoxic, and antidiabetic activities of nanosuspensions of Cinnamomum zeylanicum bark extract
The study evaluated the bioactivities, biochemical characterization, and bioavailability of nanosuspensions of Cinnamomum zeylanicum bark extract. It found that the extract and nanosuspensions possess antidiabetic, antimicrobial, anticancer, and antioxidant properties, with varying degrees of effectiveness in different assays.
Cinnamaldehyde-Rich Cinnamon Extract Induces Cell Death in Colon Cancer Cell Lines HCT 116 and HT-29
The study investigates the effects of cinnamaldehyde-rich cinnamon extract (CRCE) on colorectal cancer cell lines HCT 116 and HT-29. CRCE treatment decreased cell viability, inhibited cell proliferation and migration, induced mitochondrial stress, and activated apoptotic proteins in a dose- and time-dependent manner.
Antioxidant and Anti-Inflammatory Effect of Cinnamon (Cinnamomum verum J. Presl) Bark Extract after In Vitro Digestion Simulation
The study evaluated the antioxidant and anti-inflammatory bioactivity of cinnamon bark extract after simulated digestion. Results showed that digestion reduces polyphenols but preserves other bioactive compounds like cinnamic acid, maintaining antioxidant and anti-inflammatory effects at the cellular level.
A Comparative Study on Improving Streptozotocin-Induced Type 2 Diabetes in Rats by Hydrosol, Extract and Nanoemulsion Prepared from Cinnamon Leaves
The study analyzed bioactive compounds in Cinnamomoum osmophloeum leaves and compared the effects of hydrosol, extract, and nanoemulsion on type 2 diabetes in rats. The high-dose nanoemulsion was most effective in reducing fasting blood glucose, oral glucose tolerance test values, serum insulin, and insulin resistance index, as well as improving serum biochemical parameters.
Characterization of the Biological Activities of a New Polyphenol-Rich Extract from Cinnamon Bark on a Probiotic Consortium and Its Action after Enzymatic and Microbial Fermentation on Colorectal Cell Lines
The study characterized a polyphenol-rich extract from cinnamon bark, evaluating its antimicrobial activity and prebiotic potential. The extract showed antimicrobial activity against Staphylococcus aureus and Bacillus subtilis, and promoted growth of probiotic strains. It also demonstrated positive protective effects on colorectal cell lines against tumorigenic conditions.
Cinnamon Extract and Probiotic Supplementation Alleviate Copper-Induced Nephrotoxicity via Modulating Oxidative Stress, Inflammation, and Apoptosis in Broiler Chickens
The study assessed the protective effects of cinnamon extract and probiotics against copper-induced nephrotoxicity in broiler chickens over 6 weeks. Cinnamon extract and probiotics showed antioxidant, anti-inflammatory, and antiapoptotic properties, reducing copper content in renal tissues and improving kidney function markers.
Cinnamon Aqueous Extract Attenuates Diclofenac Sodium and Oxytetracycline Mediated Hepato-Renal Toxicity and Modulates Oxidative Stress, Cell Apoptosis, and Inflammation in Male Albino Rats
Animal study evaluating the protective effects of cinnamon aqueous extract against hepato-renal toxicity induced by diclofenac sodium and oxytetracycline in male albino rats. Cinnamon extract ameliorated oxidative damage, apoptosis, and inflammation in hepatic and renal tissues.
Cinnamon extract loaded electrospun chitosan/gelatin membrane with antibacterial activity.
The study develops chitosan/gelatin nanofiber membranes with sustained release capacity to deliver cinnamon extract (CE) for preventing infection. The incorporation of CE enhanced the degradation behavior, antibacterial activity, and biocompatibility of the nanofibers. The release profile showed a burst release in the first 6 hours, followed by a controlled release over the next 138 hours.
Comparison of antibacterial efficacy of cinnamon extract, neem extract as irrigant and sodium hypochlorite against Enterococcus fecalis: An in vitro study
In vitro study comparing the antibacterial effectiveness of cinnamon extract, neem extract, and sodium hypochlorite against E. fecalis in 60 extracted teeth. Cinnamon extract showed the greatest reduction in CFU colonies, followed by sodium hypochlorite, with neem extract showing the least reduction.
In vitro Cariostatic effects of cinnamon water extract on nicotine-induced Streptococcus mutans biofilm
In vitro study examining the effects of cinnamon water extract on nicotine-induced Streptococcus mutans biofilm formation. The presence of 2.5 mg/ml cinnamon water extract inhibited biofilm formation by 34 to 98% at various nicotine concentrations, demonstrating the biofilm inhibitory properties of cinnamon.
Lignan and flavonoid support the prevention of cinnamon against oxidative stress related diseases.
The study investigates the antioxidant capacity of cinnamon and its constituents, identifying cinnamaldehyde, pinoresinol, and a flavonol as inhibitors of oxidative stress. These compounds activate the Nrf2-mediated antioxidant response, protecting human lung epithelial cells against oxidative insults.
Review on the Explores the pharmacological potential of cinnamon bark Extract and plant profile of Ashwagandha root and licorice root powder for treatment on Insomnia
This narrative review explores the pharmacological potential of cinnamon extract, Ashwagandha root powder, and licorice for treating insomnia and enhancing immunity. Cinnamon and Ashwagandha show synergistic effects for sleep improvement, while licorice supports immunity and sleep. The review highlights cinnamon's benefits for brain health, gut health, and cardiovascular function, and Ashwagandha's potential for stress reduction and physical performance enhancement.
Advances in pharmacological effects and mechanism of action of cinnamaldehyde
This review discusses the pharmacological effects and mechanisms of cinnamaldehyde, highlighting its therapeutic potential in treating inflammatory conditions, bacterial infections, cancer, diabetes, and cardiovascular and kidney diseases. It operates by inhibiting the NF-κB pathway, modulating pro-inflammatory mediators, disrupting bacterial cells, and inducing apoptosis in cancer cells. Cinnamaldehyde enhances metabolic health and offers cardiovascular protection.
Prospective Nutraceutical Effects of Cinnamon Derivatives Against Insulin Resistance in Type II Diabetes Mellitus—Evidence From the Literature
Narrative review of cinnamon derivatives' effects on insulin resistance in Type II Diabetes Mellitus. Cinnamon is reported to have antidiabetic, anti-inflammatory, and anti-hypertriglyceridemic benefits, improving conditions like hyperglycemia, dyslipidemia, and oxidative stress. The review discusses cinnamon's potential mechanisms and factors affecting its efficacy.
Aqueous Extract of Cinnamon (Cinnamomum spp.): Role in Cancer and Inflammation
This review discusses the preparation techniques and bioactive components of aqueous cinnamon extract, highlighting its anticancer and anti-inflammatory properties. The extract shows potential therapeutic benefits by altering apoptotic and angiogenic factors, with a synergistic effect between its components.
The Anti-Cancer Effect of Cinnamon Aqueous Extract: A Focus on Hematological Malignancies
Narrative review discussing the potential anti-cancer effects of cinnamon aqueous extract, focusing on hematological malignancies. The review examines in vitro and in vivo studies showing cinnamon's impact on cellular pathways and its potential use in combination with traditional drugs like doxorubicin.
Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review
This review provides an overview of the effects of cinnamon on clinical parameters of diabetes and summarizes the molecular mechanisms of action on glucose and lipid metabolism. Cinnamon improved glycemic and lipidemic indicators and possesses an anti-inflammatory effect, beneficial in diabetes. It regulates glucose metabolism by insulin-mimetic effect and enzyme activity improvement, and decreases cholesterol and fatty acid absorption in the gut.
Safety of Cinnamon: An Umbrella Review of Meta-Analyses and Systematic Reviews of Randomized Clinical Trials
Umbrella review of meta-analyses and systematic reviews on the safety of cinnamon. No significant toxic or side effects were found between cinnamon and placebo groups, regardless of dose and duration. The review suggests cinnamon can improve health status as an adjuvant treatment.
Safety assessment and biochemical evaluation of biogenic silver nanoparticles (using bark extract of C. zeylanicum) in Rattus norvegicus rats
The study assessed the potential toxicity of biosynthesized silver nanoparticles using Cinnamomum zeylanicum bark extracts in Rattus norvegicus rats. AgNPs were administered orally at different doses for 14 days. No significant changes were observed in body weight, biochemical parameters, oxidative stress biomarkers, or histopathologic features, suggesting the safety of these AgNPs at the tested doses.
Green Biosynthesized Selenium Nanoparticles by Cinnamon Extract and Their Antimicrobial Activity and Application as Edible Coatings with Nano-Chitosan
The study investigates the antimicrobial activity of selenium nanoparticles phytosynthesized using cinnamon bark extract, combined with chitosan nanoparticles, against bacterial food-borne pathogens. The composites showed significant antibacterial effects, with potential applications as edible coatings.
Cinnamon: A Natural Feed Additive for Poultry Health and Production—A Review
This review discusses the use of cinnamon as a natural feed additive in poultry diets, highlighting its beneficial impacts on nutrient digestibility, gut health, blood biochemical profile, gene expression, and immune response. Cinnamon is presented as a potential alternative to antibiotics in the poultry industry, offering health and economic benefits.
Evaluation of cinnamon extract effects on clbB gene expression and biofilm formation in Escherichia coli strains isolated from colon cancer patients
The study evaluated the effects of cinnamon extract and cinnamaldehyde on clbB gene expression and biofilm formation in E. coli strains isolated from colon cancer patients. Cinnamon essential oil and cinnamaldehyde showed antibacterial activity, reducing clbB gene expression and biofilm formation in E. coli isolates.
Antidepressant Effect of Cinnamon (Cinnamomum burmannii) Bark Extract in Chronic Stress-Induced Rats
The study evaluated the antidepressant effects of cinnamon (Cinnamomum burmannii) extract in chronic stress-induced rats. Cinnamon extract reduced immobility duration and improved serotonin levels in the hippocampus, suggesting potential antidepressant efficacy by inhibiting inflammation.
Application of cinnamon and gotu kola supplements for increasing quail hematological status (Coturnixcoturnix-australica)
The study analyzed the hematological status of Australian strain quail by supplementing their feed with cinnamon bark powder and gotu kola leaf flour. The combination of cinnamon and gotu kola supplements significantly affected hemoglobin levels and erythrocyte counts, with the 5% cinnamon and 10% gotu kola combination showing the highest increase.
Antibacterial Activity of Cinnamon Extract (Cinnamomum burmannii) against Staphylococcus aureus and Escherichia coli In Vitro
In vitro study testing the antibacterial activity of cinnamon extract (Cinnamomum burmannii) against Staphylococcus aureus and Escherichia coli. Cinnamon extract showed effectiveness with specific concentrations inhibiting bacterial growth, evidenced by inhibition zones and minimum bactericidal concentrations.
Cinnamon and Gotu Kola Supplementation to Produce High Antioxidant and Low Cholesterol of Quail Pectoral Meat
The study investigated the effects of cinnamon and gotu kola supplementation on quail meat, aiming to produce meat with high antioxidant levels and low cholesterol. The results indicated that cinnamon and gotu kola supplements increased body weight, antioxidant levels, and reduced cholesterol in quail meat, with the best effects observed at specific concentrations.
In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology
The study evaluated the long-term toxicity and genotoxicity of cinnamon extract (Cinnamomum cassia) in compliance with OECD guidelines. A 13-week repeat-dose oral toxicity study in rats showed potential nephrotoxicity and hepatotoxicity at high doses (2000 mg/kg), with increased kidney and liver weights and elevated cholesterol levels. Genetic toxicity tests indicated that cinnamon extract was not mutagenic or clastogenic.
Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways.
The study investigated the anti-inflammatory effects of cinnamon extract and its active compounds on TLR2 and TLR4 signaling pathways. Trans-cinnamaldehyde and p-cymene were identified as key compounds reducing IL-8 secretion and phosphorylation of Akt and IκBα, with synergistic effects observed in combination with other compounds.
Antibacterial Activity of Ethanolic Extract of Cinnamon Bark, Honey, and Their Combination Effects against Acne-Causing Bacteria
The study investigated the antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination against acne-causing bacteria P. acnes and S. epidermidis. The combination showed additive activity with potential against acne-causing bacteria.
The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy
The study investigated the effect of aqueous extract of cinnamon on the metabolome of Plasmodium falciparum in vitro using 1HNMR spectroscopy. The 50% inhibitory concentration of cinnamon was determined to be 1.25 mg/mL, and various metabolites and metabolic cycles were identified, suggesting potential drug targets.
The aqueous extract of cinnamon bark ameliorated cisplatin-induced cytotoxicity in vero cells without compromising the anticancer efficiency of cisplatin.
The study evaluated the protective potential of the aqueous extract of Cinnamomum cassia (cinnamon) against cisplatin-induced cytotoxicity in Vero cells. The extract suppressed apoptosis markers in Vero cells without affecting the anticancer efficiency of cisplatin in breast and liver cancer cells.
Effects of Cinnamon extract on biochemical enzymes , TNF-α and NF-κB gene expression levels in liver of broiler chickens inoculated with Escherichia coli 1
The study investigated the effects of cinnamon extract on liver enzymes and inflammatory markers in broiler chickens infected with E. coli. Cinnamon extract significantly reduced TNF-α and NF-κB gene expressions and certain liver enzymes, suggesting protective effects against inflammation and liver damage.
Cinnamon Extract Improves Insulin Sensitivity in the Brain and Lowers Liver Fat in Mouse Models of Obesity
The study investigated the effects of cinnamon extract on insulin sensitivity and liver fat in ob/ob mice. Cinnamon extract improved insulin sensitivity and brain activity, reduced fasting blood glucose levels, and decreased liver fat in the mice.
Cinnamon extract inhibits angiogenesis in zebrafish and human endothelial cells by suppressing VEGFR1, VEGFR2, and PKC-mediated MAP kinase
The study investigates the effects of cinnamon extract on angiogenesis in human endothelial cells and zebrafish embryos. Cinnamon extract inhibited TPA-induced phosphorylation of MAPK and AKT in human cells and suppressed VEGFR1 and VEGFR2 mRNA expression. In zebrafish embryos, cinnamon extract attenuated blood vessel development and caused morphological deformities.
Cinnamon Extract Regulates Gene Expression of Lipid and Carbohydrate Metabolism in Streptozotocin Induced Diabetic Wistar Rats
The study examined the effect of Cinnamon Extract (CE, 200 mg/kg body weight) on gene expression related to lipid and carbohydrate metabolism in Streptozotocin-induced diabetic Wistar rats. CE administration for 2 months normalized triglycerides, cholesterol, VLDL, HDL, and glucose levels, and modulated the expression of several genes involved in metabolism.
The effect of aqueous cinnamon extract on the apoptotic process in acute myeloid leukemia HL-60 cells
In vitro study on the effects of aqueous cinnamon extract on HL-60 cells, a model for acute promyelocytic leukemia. Cinnamon extract inhibited cell growth, stopped the cell cycle in G1 phase, and induced apoptosis in a concentration and time-dependent manner.
Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells.
The study investigated the anti-inflammatory effects of cinnamon extract on antigen-presenting cells and its potential to suppress experimental colitis in mice. Cinnamon extract inhibited maturation of dendritic cells, reduced pro-inflammatory cytokine production, and enhanced IL-10 levels, suggesting its potential as an anti-inflammatory agent.
Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
The study investigates the anti-tumor effects of cinnamon extract, focusing on its ability to induce tumor cell death by inhibiting NFκB and AP1 activities. In vitro and in vivo experiments using various tumor cell lines and a mouse melanoma model showed that cinnamon extract inhibits tumor cell proliferation and promotes pro-apoptotic activity.
Aqueous Cinnamon Extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential
The study investigates the anti-neoplastic activity of aqueous cinnamon extract (ACE-c) on the cervical cancer cell line SiHa. ACE-c was found to alter growth kinetics, reduce colony formation, and induce apoptosis through increased calcium signaling and loss of mitochondrial membrane potential.
Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats.
Animal study evaluating the hepatoprotective activity of aqueous and ethanolic extracts of cinnamon against carbon tetrachloride-induced oxidative stress and liver injury in rats. Cinnamon extracts restored elevated serum AST and ALT levels and improved antioxidant enzyme activities, with the ethanolic extract showing more potent effects.
Protective effects of cinnamon bark extract against ischemia–reperfusion injury and arrhythmias in rat
The study investigated the effects of cinnamon bark ethanolic extract on ischemia-induced arrhythmias and heart injury in a rat model. Cinnamon extract significantly improved myocardial injury, reduced infarct size, and decreased episodes of ventricular tachycardia and ectopic beats. It also stabilized ST segment changes and increased heart rate during ischemia, likely due to its antioxidant properties.
Antibacterial mechanisms of cinnamon and its constituents: A review.
This review compiles the antibacterial mechanisms of cinnamon and its constituents, such as cinnamaldehyde and cinnamic acid, against Gram-positive and Gram-negative bacteria. It describes how these compounds inhibit bacteria through various mechanisms and their synergistic interactions with commercial antibiotics.
A Screening Experiment on a Diabetes Mellitus Herbal Formulation
Screening experiment on a herbal formulation for diabetes mellitus type II using alloxan induced diabetic albino wistar rats. Cinnamomum verum and Azadirachta indica caused the highest change in blood glucose levels individually, while the complete mixture of six herbs registered the lowest reduction.
In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis.
The study investigates the in vitro activity of Cinnamomum zeylanicum against fluconazole-resistant and susceptible Candida species. MICs for C. zeylanicum bark ranged from < 0.05-30 mg/ml, with trans-cinnamaldehyde and O-methoxycinnamaldehyde showing MICs of 0.03-0.5 mg/ml. A pilot study with five HIV patients showed improvement in oral candidiasis after one week of cinnamon preparation.