Research
Chlorophyll
9 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
An evidence-based systematic review of chlorophyll by the Natural Standard Research Collaboration.
Systematic review by the Natural Standard Research Collaboration consolidating safety and efficacy data on chlorophyll. Includes analysis of clinical trials, expert opinion, history, pharmacology, interactions, adverse effects, and dosing.
Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin.
RCT evaluating chlorophyllin as a chemopreventive agent in individuals at high risk for aflatoxin exposure. Chlorophyllin administration led to a 50% reduction in urinary excretion of aflatoxin-N(7)-guanine, a biomarker associated with liver cancer risk. No toxicities were observed, indicating chlorophyllin is a safe and effective agent.
Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer.
RCT in Qidong, China, testing chlorophyllin's effect on aflatoxin-DNA adducts in 180 adults. Chlorophyllin reduced median urinary levels of aflatoxin biomarkers by 55%, suggesting potential for cancer prevention.
Identification and characterization of chlorin e(4) ethyl ester in sera of individuals participating in the chlorophyllin chemoprevention trial.
A randomized, double-blind clinical trial in Qidong, China, investigated the absorption and bioavailability of chlorophyllin derivatives in humans. Serum samples from participants receiving chlorophyllin contained copper chlorin e(4) ethyl ester and copper chlorin e(4), suggesting these components may contribute to chlorophyllin's chemopreventive action.
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.
Animal study using a dose-dose matrix design to examine chlorophyll's effects on DBC-induced DNA adduct formation, tumor incidence, and gene regulation in trout. Chlorophyll co-treatment reduced DBC-DNA adducts and inhibited tumor incidence and multiplicity at certain DBC doses, but failed to inhibit and even enhanced tumor multiplicity at higher doses.
Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt.
RCT with 16 healthy volunteers assessing the effect of cruciferous vegetables, yogurt, and chlorophyllin on DNA damage from high-temperature cooked meat. The inhibitor diet decreased DNA damage in colorectal cells, suggesting dietary factors can reduce fried-meat associated carcinogenesis.
[Can chlorophyll reduce fecal odor in colostomy patients?].
Randomized, double-blind, cross-over study of 75 mg chlorophyll tablets thrice daily in 28 colostomy patients. Chlorophyll did not differ from placebo in reducing unpleasant fecal odor according to patients' subjective assessments.
Effect of chlorophyllin on urinary odor in incontinent geriatric patients.
This randomized, double-blind, crossover, placebo-controlled study involved 20 incontinent geriatric patients to assess the effect of chlorophyllin on urinary odor. Chlorophyllin treatment was associated with about a 21-percent decrease in mean urinary odor intensity, whereas placebo increased the odor by about 9 percent. However, the effect of chlorophyllin was not significantly greater than that of placebo.
Effects of a water-soluble chlorophyllin ointment on gingival inflammation.
RCT studying the effects of a water-soluble chlorophyllin ointment on gingival inflammation.